Expression of TGF‐β type II receptor antisense RNA impairs TGF‐β signaling in vitro and promotes mammary gland differentiation in vivo

TGF-β SIGNAL TRANSDUCTION

1998 • 7,582 citations

High-efficiency transformation of mammalian cells by plasmid DNA.

1987 • 5,377 citations

Mechanism of activation of the TGF-β receptor

1994 • 2,298 citations

The TGF-beta superfamily: new members, new receptors, and new genetic tests of function in different organisms.

1994 • 1,950 citations

The transforming growth factor-β system, a complex pattern of cross-reactive ligands and receptors

1987 • 710 citations

Structure and expression of the membrane proteoglycan betaglycan, a component of the TGF-β receptor system

1991 • 661 citations

Expression cloning and characterization of the TGF-β type III receptor

1991 • 638 citations

TGF-β Family Signal Transduction in Drosophila Development: From Mad to Smads

1999 • 324 citations

Impaired type II glucocorticoid-receptor function in mice bearing antisense RNA transgene

1992 • 313 citations

Mammary tumor suppression by transforming growth factor beta 1 transgene expression.

1995 • 292 citations

Inhibition of mammary duct development but not alveolar outgrowth during pregnancy in transgenic mice expressing active TGF-beta 1.

1993 • 260 citations

Expression of a dominant-negative mutant TGF-beta type II receptor in transgenic mice reveals essential roles for TGF-beta in regulation of growth and differentiation in the exocrine pancreas

1997 • 257 citations

TGFβ-related pathways

2000 • 251 citations

Regulated expression and growth inhibitory effects of transforming growth factor-β isoforms in mouse mammary gland development

1991 • 228 citations

Targeting expression of a transforming growth factor beta 1 transgene to the pregnant mammary gland inhibits alveolar development and lactation.

1993 • 224 citations

Transgenic mice overexpressing a dominant-negative mutant type II transforming growth factor beta receptor show enhanced tumorigenesis in the mammary gland and lung in response to the carcinogen 7,12-dimethylbenz-[a]-anthracene.

1997 • 195 citations

Conversion of Normal Behavior to Shiverer by Myelin Basic Protein Antisense cDNA in Transgenic Mice

1988 • 182 citations

Ectopic TGFβ1 Expression in the Secretory Mammary Epithelium Induces Early Senescence of the Epithelial Stem Cell Population

1995 • 182 citations

Regulation of Msx-1, Msx-2, Bmp-2 and Bmp-4 during foetal and postnatal mammary gland development

1996 • 164 citations

Decreased Frequency of Somatic Hypermutation and Impaired Affinity Maturation but Intact Germinal Center Formation in Mice Expressing Antisense RNA to DNA Polymerase ζ

2001 • 147 citations

Effects of truncated activin and FGF receptors and of follistatin on the inducing activities of BVg1 and activin: does activin play a role in mesoderm induction?

1994 • 145 citations

Functional Roles for the Cytoplasmic Domain of the Type III Transforming Growth Factor β Receptor in Regulating Transforming Growth Factor β Signaling

2001 • 139 citations

Conditional gene expression in secretory tissues and skin of transgenic mice using the MMTV‐LTR and the tetracycline responsive system

1995 • 129 citations

Dominant-negative interference of the transforming growth factor beta type II receptor in mammary gland epithelium results in alveolar hyperplasia and differentiation in virgin mice.

1998 • 113 citations

Characterization of type II activin receptors. Binding, processing, and phosphorylation.

1993 • 83 citations

Phosphorylation-dependent Interaction of the Cytoplasmic Domains of the Type I and Type II Transforming Growth Factor-β Receptors

1995 • 80 citations

Stress, the immune system and vulnerability to degenerative disorders of the central nervous system in transgenic mice expressing glucocorticoid receptor antisense RNA

2001 • 61 citations

Transforming growth factor-β and breast cancer: Lessons learned from genetically altered mouse models

2000 • 49 citations

Transforming Growth Factor-β Inhibits Lactogenic Hormone Induction of β-Casein Expression in HC11 Mouse Mammary Epithelial Cells

1990 • 46 citations

Disruption of Transforming Growth Factor β Signaling by a Novel Ligand-dependent Mechanism

2002 • 41 citations

A kinase-inactive type II TGFβ receptor impairs BMP signaling in human breast cancer cells

2003 • 26 citations

Decreased Glucocorticoid Receptor Activity Following Glucocorticoid Receptor Antisense RNA Gene Fragment Transfection

1991 • 26 citations

Transforming growth factor-β1 inhibits casein secretion from differentiating mammary-gland explants but not from lactating mammary cells

1994 • 25 citations

Decreased glucocorticoid receptor activity following glucocorticoid receptor antisense RNA gene fragment transfection.

1991 • 20 citations

Involvement of autocrine mechanism of transforming growth factor-β in the functional differentiation of pregnant mouse mammary gland

1994 • 12 citations