Monitoring tryptophan metabolism in chronic immune activation

Prevention of Allogeneic Fetal Rejection by Tryptophan Catabolism

1998 • 2,538 citations

Evidence for a tumoral immune resistance mechanism based on tryptophan degradation by indoleamine 2,3-dioxygenase

2003 • 2,177 citations

Inhibition of T Cell Proliferation by Macrophage Tryptophan Catabolism

1999 • 1,560 citations

Tryptophan-derived Catabolites Are Responsible for Inhibition of T and Natural Killer Cell Proliferation Induced by Indoleamine 2,3-Dioxygenase

2002 • 1,060 citations

Potential Regulatory Function of Human Dendritic Cells Expressing Indoleamine 2,3-Dioxygenase

2002 • 1,035 citations

Relationship between interferon‐γ, indoleamine 2,3‐dioxygenase, and tryptophan catabolism

1991 • 1,018 citations

Inhibition of Allogeneic T Cell Proliferation by Indoleamine 2,3-Dioxygenase–expressing Dendritic Cells

2002 • 917 citations

Role of serotonin in the pathophysiology of depression: focus on the serotonin transporter

1994 • 904 citations

Interferon gamma blocks the growth of Toxoplasma gondii in human fibroblasts by inducing the host cells to degrade tryptophan.

1984 • 847 citations

Tolerance, DCs and tryptophan: much ado about IDO

2003 • 752 citations

Indoleamine 2,3-Dioxygenase Production by Human Dendritic Cells Results in the Inhibition of T Cell Proliferation

2000 • 733 citations

QUINOLINIC ACID AND KYNURENINE PATHWAY METABOLISM IN INFLAMMATORY AND NON-INFLAMMATORY NEUROLOGICAL DISEASE

1992 • 655 citations

Association between decreased serum tryptophan concentrations and depressive symptoms in cancer patients undergoing cytokine therapy

2002 • 469 citations

Simultaneous Measurement of Serum Tryptophan and Kynurenine by HPLC,

1997 • 410 citations

Increased neopterin and interferon-gamma secretion and lower availability of L-tryptophan in major depression: Further evidence for an immune response

1994 • 298 citations

Induction of pulmonary indoleamine 2,3-dioxygenase by interferon.

1981 • 285 citations

1-methyl-dl-tryptophan, β-(3-benzofuranyl)-dl-alanine (the oxygen analog of tryptophan), and β-[3-benzo(b)thienyl]-dl-alanine (the sulfur analog of tryptophan) are competitive inhibitors for indoleamine 2,3-dioxygenase

1991 • 279 citations

Tryptophan degradation and immune activation in Alzheimer's disease

2000 • 275 citations

Induction of indoleamine 2,3-dioxygenase: a mechanism of the antitumor activity of interferon gamma.

1988 • 241 citations

Differential pharmacology of newer antidepressants.

1998 • 239 citations

Serum tryptophan decrease correlates with immune activation and impaired quality of life in colorectal cancer

2002 • 228 citations

Neopterin production, tryptophan degradation, and mental depression—What is the link?

2002 • 222 citations

Decreased serum tryptophan in patients with HIV-1 infection correlates with increased serum neopterin and with neurologic/psychiatric symptoms.

1990 • 203 citations

More Rapid Method for Simultaneous Measurement of Tryptophan and Kynurenine by HPLC

2002 • 194 citations

Interferon-γ-Induced Conversion of Tryptophan: Immunologic and Neuropsychiatric Aspects

2003 • 194 citations

Characteristics of interferon induced tryptophan metabolism in human cells in vitro

1989 • 191 citations

Immune activation and degradation of tryptophan in coronary heart disease

2003 • 183 citations

Human macrophages degrade tryptophan upon induction by interferon-gamma

1987 • 182 citations

Induction of Tryptophan DegradationIn VitroandIn Vivo: A γ-Interferon-Stimulated Activity

1986 • 181 citations

Increasing production of homocysteine and neopterin and degradation of tryptophan with older age

2004 • 170 citations

Increased neopterin production and tryptophan degradation in advanced Parkinson's disease.

2002 • 163 citations

Suppression of Inflammatory Neurotoxins by Highly Active Antiretroviral Therapy in Human Immunodeficiency Virus‐Associated Dementia

1998 • 162 citations

Serum kynurenine-to-tryptophan ratio increases with progressive disease in HIV-infected patients

1998 • 155 citations

Decreased plasma tryptophan in pregnancy

1996 • 151 citations

Overexpression of indoleamine 2,3-dioxygenase in human inflammatory bowel disease

2004 • 149 citations

Modulation of neopterin formation and tryptophan degradation by Th1- and Th2-derived cytokines in human monocytic cells

1999 • 142 citations

Immune activation and the anaemia associated with chronic inflammatory disorders

1991 • 141 citations

Increased endogenous interferon-gamma and neopterin correlate with increased degradation of tryptophan in human immunodeficiency virus type 1 infection

1991 • 139 citations

Tryptophan depletion and HIV Tryptophan depletion and HIV infection: a metabolic link to pathogenesis

2003 • 136 citations

Monocyte-derived dendritic cells release neopterin

2002 • 130 citations

Enhanced Tryptophan Degradation in Systemic Lupus Erythematosus

2000 • 125 citations

Interferon gama induced Tryptophan Degradation Neuropsychiatric and Immunological Consequences

2000 • 120 citations

Effective Antiretroviral Therapy Reduces Degradation of Tryptophan in Patients with HIV-1 Infection

2002 • 95 citations

Endogenous release of interferon-gamma and diminished response of peripheral blood mononuclear cells to antigenic stimulation

1989 • 94 citations

Neopterin as a predictive marker for disease progression in human immunodeficiency virus type 1 infection.

1989 • 92 citations

Antioxidants may increase the probability of developing allergic diseases and asthma

2004 • 92 citations

Increased degradation of tryptophan in blood of patients with rheumatoid arthritis.

2003 • 91 citations

Activated Immune System in Patients with Huntington's Disease

1998 • 90 citations

Outcome of patients with HIV-1-related cognitive impairment on highly active antiretroviral therapy

2001 • 90 citations

Depressive Symptoms Reduced in Individuals with HIV/AIDS Treated with Highly Active Antiretroviral Therapy: A Longitudinal Study

2000 • 86 citations

Tryptophan Degradation in Patients Infected by Human Immunodeficiency Virus

1988 • 83 citations

Tryptophan degradation in patients with gynecological cancer correlates with immune activation

2004 • 80 citations

Longitudinal study of tryptophan degradation during and after pregnancy

2002 • 75 citations

Dependence of the in vitro antiproliferative activity of recombinant human gamma-interferon on the concentration of tryptophan in culture media.

1988 • 71 citations

Weight loss in patients with hematological neoplasias is associated with immune system stimulation

1993 • 61 citations

Progress in Tryptophan and Serotonin Research 1986

1987 • 61 citations

Aspirin down-regulates tryptophan degradation in stimulated human peripheral blood mononuclear cells in vitro

2005 • 60 citations

Differential patterns of serum biomarkers of immune activation in human T-cell lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis, and adult T-cell leukemia/lymphoma.

1996 • 60 citations

Kynurenine and Neopterin Levels in Patients with Rheumatoid Arthritis and Osteoporosis During Drug Treatment

2003 • 58 citations

Enhanced enzymatic degradation of tryptophan by indoleamine 2,3-dioxygenase contributes to the tryptophan-deficient state seen after major trauma.

2005 • 55 citations

In vitroEffects of Two Extracts and Two Pure Alkaloid Preparations ofUncaria tomentosaon Peripheral Blood Mononuclear Cells

2004 • 55 citations

Increased serum neopterin in patients with HIV-1 infection is correlated with reduced in vitro interleukin-2 production

1990 • 48 citations

Possible role of cytokine‐induced tryptophan degradation in anaemia of inflammation

2004 • 46 citations

Immune reaction links disease progression in cancer patients with depression

2000 • 40 citations

Decreased Serum Tryptophan in Patients with Cancer Cachexia Correlates with Increased Serum Neopterin

1995 • 40 citations

Tryptophan Concentrations Increase in Cerebrospinal Fluid and Blood after Zidovudine Treatment in Patients with HIV Type 1 Infection

1994 • 38 citations

Neopterin production and tryptophan degradation in humans infected by Streptococcus pyogenes

2001 • 38 citations

Parallel Decrease in Neurotoxin Quinolinic Acid and Soluble Tumor Necrosis Factor Receptor p75 in Serum during Highly Active Antiretroviral Therapy of HIV Type 1 Disease

2000 • 29 citations

Cancer cachexia and depressive states: a neuro-endocrine-immunological disease?

1997 • 27 citations

St. John's wort (Hypericum perforatum) counteracts cytokine-induced tryptophan catabolism in vitro

2004 • 26 citations

Decreased whole blood 5-hydroxytryptamine (serotonin) in AIDS patients.

1988 • 18 citations

THE RELATIVE IMPORTANCE OF DIETARY TRYPTOPHAN AND PREFORMED NICOTINIC ACID AND NICOTINAMIDE AS PRECURSORS OF NICOTINAMIDE NUCLEOTIDE COENZYMES

1987 • 5 citations