Enhanced Tryptophan Degradation in Systemic Lupus Erythematosus

Derivation of the sledai. A disease activity index for lupus patients

1992 • 4,410 citations

Prevention of Allogeneic Fetal Rejection by Tryptophan Catabolism

1998 • 2,538 citations

Inhibition of T Cell Proliferation by Macrophage Tryptophan Catabolism

1999 • 1,560 citations

Immune response-associated production of neopterin. Release from macrophages primarily under control of interferon-gamma.

1984 • 1,083 citations

Interferon gamma blocks the growth of Toxoplasma gondii in human fibroblasts by inducing the host cells to degrade tryptophan.

1984 • 847 citations

QUINOLINIC ACID AND KYNURENINE PATHWAY METABOLISM IN INFLAMMATORY AND NON-INFLAMMATORY NEUROLOGICAL DISEASE

1992 • 655 citations

Neopterin as a marker for activated cell-mediated immunity: Application in HIV infection

1988 • 573 citations

Simultaneous Measurement of Serum Tryptophan and Kynurenine by HPLC,

1997 • 410 citations

Neopterin as Marker for Activation of Cellular Immunity: Immunologic Basis and Clinical Application

1989 • 373 citations

Induction of pulmonary indoleamine 2,3-dioxygenase by interferon.

1981 • 285 citations

Tryptophan degradation and immune activation in Alzheimer's disease

2000 • 275 citations

Th1 (IL-2, interferon-gamma (IFN-γ)) and Th2 (IL-10, IL-4) cytokine production by peripheral blood mononuclear cells (PBMC) from patients with systemic lupus erythematosus (SLE)

1999 • 236 citations

Decreased production of interleukin-12 and other Th1-type cytokines in patients with recent-onset systemic lupus erythematosus

1998 • 227 citations

Effects of Acute Tryptophan Depletion on Plasma and Cerebrospinal Fluid Tryptophan and 5‐Hydroxyindoleacetic Acid in Normal Volunteers

1999 • 220 citations

Decreased serum tryptophan in patients with HIV-1 infection correlates with increased serum neopterin and with neurologic/psychiatric symptoms.

1990 • 203 citations

Parallel induction of tetrahydrobiopterin biosynthesis and indoleamine 2,3-dioxygenase activity in human cells and cell lines by interferon-γ

1989 • 201 citations

Role of IFN-gamma-induced indoleamine 2,3 dioxygenase and inducible nitric oxide synthase in the replication of human cytomegalovirus in retinal pigment epithelial cells.

1999 • 179 citations

Rapid depletion of plasma tryptophan: a review of studies and experimental methodology

1997 • 178 citations

Multiple interferons in the circulation of patients with systemic lupus erythematosus and vasculitis

1982 • 162 citations

Decreased Th1-like and Increased Th2-like Cells in Systemic Lupus Erythematosus

1998 • 141 citations

L-Tryptophan in Neuropsychiatry Disorders: A Review

1992 • 118 citations

Lupus: Key Pathogenic Mechanisms and Contributing Factors

1995 • 112 citations

Kinetics of cytokine production in experimental systemic lupus erythematosus: involvement of T helper cell 1/T helper cell 2-type cytokines in disease.

1997 • 108 citations

Cytokine abnormalities in human lupus

1992 • 93 citations

Activated Immune System in Patients with Huntington's Disease

1998 • 90 citations

Kynurenine metabolites of tryptophan

1990 • 82 citations

Serum soluble markers of immune activation and disease activity in systemic lupus erythematosus

1995 • 78 citations

Much IDO about pregnancy

1998 • 62 citations

Weight loss in patients with hematological neoplasias is associated with immune system stimulation

1993 • 61 citations

Utilization of tryptophan, nicotinamide and nicotinic acid as precursors for nicotinamide nucleotide synthesis in isolated rat liver cells

1988 • 61 citations

Pathogenesis of Systemic Lupus Erythematosus

1988 • 50 citations

Pathogenesis of systemic lupus erythematosus.

1988 • 49 citations

Urine neopterin as a parameter of disease activity in patients with systemic lupus erythematosus: comparisons with serum sIL-2R and antibodies to dsDNA, erythrocyte sedimentation rate, and plasma C3, C4, and C3 degradation products.

1993 • 38 citations

Quinolinic acid in patients with systemic lupus erythematosus and neuropsychiatric manifestations.

1996 • 33 citations

Serum kynurenine and neopterin concentrations in patients with cardiomyopathy

1992 • 32 citations

Histone mediates glomerular deposition of small size DNA anti-DNA complex

1994 • 32 citations

Biologic and antineoplastic effects of enzyme-mediated in vivo depletion of L-glutamine, L-tryptophan, and L-histidine.

1979 • 30 citations

Neopterin Production and Tryptophan Degradation in Acute Lyme Neuroborreliosis Versus Late Lyme Encephalopathy

1994 • 28 citations

Effects of tryptophan deprivation on L1210 cells in culture.

1974 • 28 citations

T-cell and B-cell function in lupus

1991 • 12 citations

Skeletal Muscle Immune Deposits in Systemic Lupus Erythematosus: Correlation with histologic changes, autoantibodies, and clinical involvement

1998 • 9 citations

An enzyme based assay for the measurement of complement mediated binding of immune complexes to red blood cells

1998 • 5 citations