Tumor-reactive T-cells accumulate in lung cancer tissues but fail to respond due to tumor cell-derived factor.

Interleukin-2: Inception, Impact, and Implications

1988 • 2,166 citations

Human transforming growth factor-β complementary DNA sequence and expression in normal and transformed cells

1985 • 1,687 citations

Production of transforming growth factor beta by human T lymphocytes and its potential role in the regulation of T cell growth.

1986 • 1,617 citations

Loss of CD45R and gain of UCHL1 reactivity is a feature of primed T cells.

1988 • 930 citations

Interleukin-2 production by tumor cells bypasses T helper function in the generation of an antitumor response

1990 • 926 citations

Human memory T lymphocytes express increased levels of three cell adhesion molecules (LFA-3, CD2, and LFA-1) and three other molecules (UCHL1, CDw29, and Pgp-1) and have enhanced IFN-gamma production.

1988 • 917 citations

Synthesis of messenger RNAs for transforming growth factors alpha and beta and the epidermal growth factor receptor by human tumors.

1987 • 895 citations

Tumor-specific cytolysis by lymphocytes infiltrating human melanomas.

1989 • 511 citations

Identification of specific cytolytic immune responses against autologous tumor in humans bearing malignant melanoma.

1987 • 478 citations

Stress proteins, infection, and immune surveillance

1989 • 477 citations

A highly immunogenic tumor transfected with a murine transforming growth factor type beta 1 cDNA escapes immune surveillance.

1990 • 409 citations

Functional properties of tumor-infiltrating and blood lymphocytes in patients with solid tumors: effects of tumor cells and their supernatants on proliferative responses of lymphocytes.

1986 • 319 citations

Interleukin 2 expanded tumor-infiltrating lymphocytes in human renal cell cancer: isolation, characterization, and antitumor activity.

1988 • 302 citations

Transforming growth factor-beta-induced inhibition of T cell function. Susceptibility difference in T cells of various phenotypes and functions and its relevance to immunosuppression in the tumor-bearing state.

1991 • 266 citations

Generation and decay of the immune response to a progressive fibrosarcoma. I. Ly-1+2- suppressor T cells down-regulate the generation of Ly-1-2+ effector T cells.

1984 • 249 citations

The preferential accumulation of helper‐inducer T lymphocytes in inflammatory lesions: evidence for regulation by selective endothelial and homotypic adhesion

1988 • 230 citations

Destruction of extracellular matrices containing glycoproteins, elastin, and collagen by metastatic human tumor cells.

1980 • 221 citations

Collagenolytic enzymes in human neoplasms.

1972 • 177 citations

Cytotoxic T cell clones isolated from ovarian tumor-infiltrating lymphocytes recognize multiple antigenic epitopes on autologous tumor cells.

1991 • 159 citations

Depression of natural killer cytotoxic activity in lymphocytes infiltrating human pulmonary tumors.

1985 • 129 citations

Purification and characterization of recombinant human interleukin-2 produced in Escherichia coli

1985 • 125 citations

Human tumour—lymphocyte interaction in vitro. V. Comparison of the reactivity of tumour‐infiltrating, blood and lymph‐node lymphocytes with autologous tumour cells

1977 • 119 citations

The Significance of Lymphocytic Infiltration in Neuroblastoma

1972 • 111 citations

Cytotoxic T lymphocyte clones from peripheral blood and from tumor site detect intratumor heterogeneity of melanoma cells. Analysis of specificity and mechanisms of interaction.

1989 • 104 citations

Characterization of an immunosuppressive factor derived from colon cancer cells.

1987 • 96 citations

Quantitation of proliferative and cytotoxic precursor cells directed against human tumours: Limiting dilution analysis in peripheral blood and at the tumour site

1982 • 90 citations

Molecular Analysis of the Interleukin‐2 System

1986 • 89 citations

Inhibition of interleukin 2 production by factors released from tumor cells.

1983 • 87 citations

Autologous melanoma-induced activation of regulatory T cells that suppress cytotoxic response.

1990 • 75 citations

Extravascular natural cytotoxicity in man: Anti‐K562 activity of lymph‐node and tumour‐infiltrating lymphocytes

1981 • 72 citations

Radiosensitive barrier to T-cell-mediated adoptive immunotherapy of established tumors.

1990 • 42 citations

Immunoregulatory Properties of Human Esophageal Tumor Extract

1979 • 32 citations

Oligoclonal T lymphocytes infiltrating human lung cancer tissues

1991 • 31 citations

Cytotoxic activity of lymphocytes to bronchogenic carcinoma cells in patients with lung cancer.

1976 • 31 citations

Differential immune reactivity of tumour-intrinsic and peripheral-blood lymphocytes against autoplastic colorectal carcinoma cells

1981 • 28 citations

Properties of recombinant interleukin 2‐cultured tumor‐infiltrating lymphocytes in human lung cancer

1989 • 24 citations

Role of tumor‐infiltrating lymphocytes in the host defense mechanism against lung cancer

1988 • 23 citations

Cytolytic potential of peripheral blood T-lymphocytes following adoptive immunotherapy with lymphokine-activated killer cells and low-dose interleukin 2.

1991 • 12 citations

Cytolytic profiles of interleukin-2-activated lymphocytes derived from various sites in lung cancer

1992 • 9 citations

Autoreactive T cells from normal mice recognize mycobacterial 65 kd heat-shock protein from Mycobacterium bovis

1991 • 8 citations