Dna Methylation in Eukaryote

DNA Methylation and Gene Function

1980 • 2,069 citations

DNA Modification Mechanisms and Gene Activity During Development

1975 • 1,859 citations

Cellular differentiation, cytidine analogs and DNA methylation

1980 • 1,803 citations

Expression of a β-globin gene is enhanced by remote SV40 DNA sequences

1981 • 1,677 citations

Detection of two restriction endonuclease activities in Haemophilus parainfluenzae using analytical agarose-ethidium bromide electrophoresis

1973 • 1,616 citations

X inactivation, differentiation, and DNA methylation

1975 • 1,283 citations

Molecular basis of base substitution hotspots in Escherichia coli

1978 • 1,185 citations

DNA methylation and the frequency of CpG in animal DNA

1980 • 1,146 citations

Personal communication

2017 • 1,128 citations

Multiple new phenotypes induced in and 3T3 cells treated with 5-azacytidine

1979 • 1,101 citations

Effects of methylation on a synthetic polynucleotide: the B--Z transition in poly(dG-m5dC).poly(dG-m5dC).

1981 • 873 citations

The SV40 72 base repair repeat has a striking effect on gene expression both in SV40 and other chimeric recombinants

1981 • 776 citations

5-Methylcytosine in Eukaryotic DNA

1981 • 744 citations

Sequence specificity of methylation in higher plant DNA

1981 • 719 citations

Reactivation of an Inactive Human X Chromosome: Evidence for X Inactivation by DNA Methylation

1981 • 711 citations

DNA methylation in the human γδβ-globin locus in erythroid and nonerythroid tissues

1980 • 634 citations

Identification of DNA sequences required for transcription of the human α1-globin gene in a new SV40 host-vector system

1981 • 624 citations

Tissue-specific DNA cleavages in the globin chromatin domain introduced by DNAase I

1980 • 486 citations

Chromatin structure of endogenous retroviral genes and activation by an inhibitor of DNA methylation

1981 • 475 citations

DNA methylation controls the inducibility of the mouse metallothionein-I gene in lymphoid cells

1981 • 464 citations

Use of restriction enzymes to study eukaryotic DNA methylation

1978 • 442 citations

Adult frogs derived from the nuclei of single somatic cells

1962 • 441 citations

Restriction Endonuclease

1976 • 405 citations

MspI, an isoschizomer of HpaII which cleaves both unmethylated and methylated HpaII sites

1978 • 395 citations

Escherichia coli mutator mutants deficient in methylation-instructed DNA mismatch correction.

1980 • 391 citations

Rare Bases in Animal DNA

1970 • 375 citations

Isolation of Deoxyribonucleic Acid Methylase Mutants of Escherichia coli K-12

1973 • 372 citations

The somatic replication of DNA methylation

1981 • 368 citations

Specific DNA methylation sites in the vicinity of the chicken β-globin genes

1979 • 365 citations

DNA methylation: organ specific variations in the methylation pattern within and around ovalbumin and other chicken genes

1979 • 356 citations

α-globin-gene switching during the development of chicken embryos: Expression and chromosome structure

1981 • 353 citations

Antibodies to left-handed Z-DNA bind to interband regions of Drosophila polytene chromosomes

1981 • 350 citations

Recognition sequence of the dam methylase of Escherichia coli K12 and mode of cleavage of Dpn I endonuclease.

1979 • 339 citations

Restriction and modification enzymes and their recognition sequences

1981 • 317 citations

Methylation of integrated adenovirus type 12 DNA sequences in transformed cells is inversely correlated with viral gene expression.

1980 • 309 citations

Deoxyribonucleic acid in amphibian eggs

1965 • 291 citations

Methylation of CpG sequences in eukaryotic DNA

1981 • 289 citations

Use of restriction enzymes to study eukaryotic DNA methylation

1978 • 281 citations

Composition and structure of chromosomal and amplified ribosomal DNA's of Xenopus laevis

1970 • 269 citations

DNA methylation at a CCGG sequence in the large intron of the rabbit β-globin gene: tissue-specific variations

1978 • 268 citations

5-Methylcytosine localised in mammalian constitutive heterochromatin

1974 • 267 citations

Genes, Chromosomes, and Neoplasia

1981 • 264 citations

Comparison of bisulfite modification of 5-methyldeoxycytidine and deoxycytidine residues

1980 • 243 citations

Altering Genotype and Phenotype by DNA-Mediated Gene Transfer

1980 • 242 citations

Biological function for 6-methyladenine residues in the DNA of Escherichia coli K12

1974 • 232 citations

Selective Silencing of Eukaryotic DNA

1975 • 224 citations

Specificity of<u>Hpa</u>II and<u>Hae</u>II DNA methylases

1977 • 221 citations

Variable patterns of total DNA and rDNA methylation in animals

1980 • 210 citations

Correlation between Hypomethylation of DNA and Expression of Globin Genes in Friend Erythroleukemia Cells

1977 • 209 citations

Dna Methylation and its Possible Biological Roles

1981 • 202 citations

Nudeotide sequence of mouse satellite DNA

1981 • 196 citations

Distribution of 5-methylcytosine in chromatin.

1977 • 196 citations

Methylated and unmethylated DNA compartments in the sea urchin genome

1979 • 195 citations

Sequence analysis of the DNA encoding the Eco RI endonuclease and methylase.

1981 • 194 citations

Distribution of 5-methylcytosine in pyrimidine sequences of deoxyribonucleic acids

1962 • 193 citations

Eukaryotic DNA methylation

1983 • 192 citations

The Methylation of Nucleic Acids

1966 • 191 citations

Methylation of foreign DNA sequences in eukaryotic cells.

1980 • 190 citations

Hemimethylated duplex DNAs prepared from 5-azacytidine-treated cells

1981 • 190 citations

Direct detection of methylated cytosine in DNA by use of the restriction enzyme Mspl

1979 • 188 citations

5-Methylcytosine content of nuclear DNA during chemical hepatocarcinogenesis and in carcinomas which result

1979 • 182 citations

Sequence specificity of the P1 modification methylase (M·Eco P1) and the DNA methylase (M·Eco dam) controlled by the Escherichia coli dam gene

1978 • 181 citations

Methylation of Herpesvirus saimiri DNA in lymphoid tumor cell lines

1979 • 179 citations

The 5-Methylcytosine in DNA of Rats

1973 • 177 citations

Comparative study of DNA methylation in three unicellular eucaryotes

1978 • 176 citations

Tissue-specific DNA methylation in a cluster of rabbit beta-like globin genes.

1980 • 172 citations

A new method for the isolation of replicative chromatin: Selective deposition of histone on both new and old DNA

1981 • 170 citations

The 5-methylcytosine in DNA of rats. Tissue and age specificity and the changes induced by hydrocortisone and other agents.

1973 • 167 citations

DNA sequences of structural genes for Eco RI DNA restriction and modification enzymes.

1981 • 167 citations

The Deoxyribonucleic Acid Modification and Restriction Enzymes of Escherichia coli B

1972 • 164 citations

Activation of globin genes during chicken development

1981 • 164 citations

5-Methylcytosine and 6-Methylaminopurine in Bacterial DNA

1968 • 164 citations

Building for Earthquakes

2004 • 157 citations

DNA methylation in adenovirus, adenovirus-transformed cells, and host cells.

1976 • 155 citations

Methylation of milk-borne and genetically transmitted mouse mammary tumor virus proviral DNA

1980 • 155 citations

The content of 5-methylcytosine in animal DNA: The species and tissue specificity

1973 • 153 citations

Effects of methylation on the stability of nucleic acid conformations. Studies at the polymer level.

1978 • 150 citations

Endonuclease V of Escherichia coli.

1977 • 148 citations

Methylation of Mouse Liver DNA Studied by Means of the Restriction Enzymes Msp I and Hpa II

1979 • 146 citations

Methylation of reiterated sequences in mammalian DNAs Effects of the tissue type, age, malignancy and hormonal induction

1981 • 140 citations

Active gene sequences are undermethylated.

1981 • 139 citations

Differential methylation of mitochondrial and nuclear DNA in cultured mouse, hamster and virus-transformed hamster cells In vivo and in vitro methylation

1973 • 138 citations

The asymmetric segregation of parental nucleosomes during chromosome replication

1979 • 138 citations

DNA methylation and viral gene expression in adenovirus-transformed and-infected cells

1980 • 131 citations

DNA methylation: correlation with DNase I sensitivity of chicken ovalbumin and conalbumin chromatin

1979 • 130 citations

THE ACTION OF PANCREATIC DEOXYRIBONUCLEASE

1955 • 129 citations

Genetic studies on heterochromatin in Drosophila melanogaster and their implications for the functions of satellite DNA

1978 • 128 citations

Structure of the pro α2(I) collagen gene

1981 • 128 citations

Determination of 5-methylcytosine from plant DNA by high-performance liquid chromatography

1981 • 126 citations

MEIOTIC CONJUNCTIVE ELEMENTS NOT INVOLVING CHIASMATA

1964 • 125 citations

The inheritance of methylation patterns in vertebrates

1981 • 119 citations

Physical identity of the SV40 deoxyribonucleic acid sequence recognized by the Eco RI restriction endonuclease and modification methylase

1974 • 118 citations

RNA Methylation and Control of Eukaryotic RNA Biosynthesis

1977 • 118 citations

The kinetics of DNA methylation in cultures of a mouse adrenal cell line

1970 • 112 citations

Calcium-mediated Interactions between the Antidiuretic Hormone and Renal Plasma Membranes

1972 • 110 citations

Nucleotide sequence through the 18S-28S intergene region of a vertebrate ribosomal transcription unit

1980 • 109 citations

More ribosomal spacer sequences from Xenopus laevis

1980 • 106 citations

Mouse nuclear satellite DNA: 5-methylcytosine content, pyrimidine isoplith distribution and electron microscopic appearance

1969 • 105 citations

The in vivo methylation of DNA in mouse fibroblasts

1969 • 104 citations

Assembly of DNA and protein during replication in HeLa cells

1975 • 100 citations

DNA methylase: purification from ascites cells and the effect of various DNA substrates on its activity.

1976 • 97 citations

COMPOSITION OF THE DESOXYPENTOSE NUCLEIC ACIDS OF FOUR GENERA OF SEA-URCHIN

1952 • 97 citations

Replicational Fidelity: Mechanisms of Mutation Avoidance and Mutation Fixation

1979 • 96 citations

The Deoxyribonucleic Acid Modification and Restriction Enzymes of Escherichia coli B

1972 • 96 citations

Organization of 5-methylcytosine in chromosomal DNA

1978 • 95 citations

The nucleotide sequence recognized by the Escherichia coli K12 restriction and modification enzymes

1979 • 93 citations

Unusual properties of the DNA from Xanthomonas phage XP-12 in which 5-methylcytosine completely replaces cytosine

1975 • 93 citations

Mouse DNA methylase: Methylation of native DNA

1979 • 86 citations

Methylation of DNA in mouse early embryos, teratocarcinoma cells an adult tissues of mouse and rabbit

1979 • 86 citations

Sequence arrangement of a highly methylated satellite DNA of a plant, Scilla : A tandemly repeated inverted repeat

1981 • 85 citations

Studies on gene control regions XII. The functional significance of a Lac operator constitutive mutation

1979 • 84 citations

5-Methylcytidylic Acid: Absence from Mitochondrial DNA of Frogs and HeLa Cells

1974 • 84 citations

Restriction and modification enzymes and their recognition sequences

1980 • 84 citations

Methylation of mosquito DNA

1979 • 84 citations

The 5′ flanking region of human ε-globin gene

1980 • 84 citations

Analysis of Calf‐Thymus Satellite DNA: Evidence for Specific Methylation of Cytosine in C‐G Sequences

1977 • 81 citations

Amplified ribosomal RNA genes in a rat hepatoma cell line are enriched in 5-methylcytosine.

1981 • 80 citations

Methylation of the bacterial chromosome: an event at the “replication point”?

1968 • 77 citations

Studies on the in vivo methylation of DNA in Escherichia coli 15T−

1968 • 77 citations

The 5′-cytosine in CCGG¹is methylated in two eukaryotic DNAS and Msp I is sensitive to methylatlon at this site

1980 • 74 citations

5-Methylcytosine content of rat hepatoma DNA substituted with bromodeoxyuridine.

1977 • 73 citations

Satellite DNA in large marker chromosomes of methotrexate-resistant mouse cells

1980 • 72 citations

Mitochondrial DNA from various organisms does not contain internally methylated cytosine in -CCGG- sequences

1979 • 71 citations

Purification and properties of the P15 specific restriction endonuclease from Escherichia coli.

1977 • 68 citations

In vivo methylation by Escherichia coli K-12 mec+ deoxyribonucleic acid-cytosine methylase protects against in vitro cleavage by the RII restriction endonuclease (R. Eco RII)

1976 • 68 citations

Demethylation of CpG sites in DNA of early rabbit trophoblast

1981 • 68 citations

Distribution of 5-methylcytosine in the DNA of somatic and germline cells from bovine tissues

1981 • 66 citations

Physical studies on synthetic DANs containing 5-methylcytosine

1974 • 65 citations

Adenine methylation of Okazaki fragments in Escherichia coli

1976 • 65 citations

Effect of the methionine analogs, ethionine and norleucine, on DNA synthesis in Escherichia coli 15T−

1968 • 63 citations

Methylation of somatic vs germ cell DNAs analyzed by restriction endonuclease digestions

1979 • 63 citations

The structure of poly-5-methylcytidylic acid and its twin-stranded complex with poly-inosinic acid

1966 • 61 citations

Expression of the Viral Thymidine Kinase Gene in Herpes Simplex Virus-Transformed L Cells

1974 • 60 citations

Partial denaturation mapping of cloned histone DNA from the sea urchin Psammechinus miliaris

1976 • 59 citations

The 5‐methylcytosine content of DNA: Tissue specificity

1971 • 59 citations

Methylated bases in mycoplasmal DNA

1980 • 59 citations

Localization of 5-methylcytosine in human metaphase chromosomes by immunoelectron microscopy

1976 • 58 citations

Studies on the biological role of DNA methylation; IV. Mode of methylation of DNA in E. coli cells

1980 • 58 citations

Conformational stability of alternating d (CG) oligomers in high salt solution

1981 • 58 citations

Methylation of chloroplast DNAs in the life cycle of Chlamydomonas

1979 • 55 citations

The relationship between synthesis and methylation of DNA in mouse fibroblasts

1971 • 55 citations

A novel type of secondary modification of two CCGG residues in the human γδβ-globin gene locus

1980 • 53 citations

The Deoxyribonucleic Acid Modification and Restriction Enzymes of Escherichia coli B

1972 • 51 citations

The isolation of nucleic acid fractions from plant leaves and their purine and pyrimidine composition.

1956 • 49 citations

Evidence for methylation of inactive human rRNA genes in amplified regions

1981 • 49 citations

Recognition site of Escherichia coli B restriction enzyme on ϕXsB1 and simian virus 40 DNAs: An interrupted sequence

1978 • 47 citations

Identification of 5-methylcytosine in DNA fragments immobilized on nitrocellulose paper.

1980 • 47 citations

Cell cycle-dependent regulation of thymidine kinase activity introduced into mouse LMTK- cells by DNA and chromatin-mediated gene transfer.

1981 • 46 citations

Nucleotide sequence of the recognition site for the restriction-modification enzyme of Escherichia coli B.

1978 • 44 citations

The sequence specificity of vertebrate DNA methylation

1977 • 44 citations

Deoxyribonucleic Acid Methyltransferase from the Eukaryote, Chlamydomonas reinhardi

1980 • 43 citations

Nucleotide Sequence of HS-β Satellite DNA from Kangaroo Rat Dipodomys ordii

1973 • 42 citations

Methylation of DNA in early development: 5-methyl cytosine content of DNA in sea urchin sperm and embryos

1978 • 42 citations

Genetic Engineering in Mammalian Cells

1981 • 42 citations

Proceedings of the Biochemical Society

1956 • 42 citations

The mat-1 gene in chlamydomonas regulates DNA methylation during gametogenesis

1981 • 42 citations

Newly synthesised DNA is not methylated

1974 • 42 citations

Methylation of parental and progeny DNA strands in Physarum polycephalum

1973 • 42 citations

Mechanism of inhibition of enzymic deoxyribonucleic acid methylation by 2-(acetylamino)fluorene bound to deoxyribonucleic acid

1981 • 41 citations

Transcription and site-specific hypomethylation of the delta-crystallin genes in the embryonic chicken lens.

1981 • 41 citations

Methylation of euchromatic and heterochromatic DNA

1972 • 39 citations

On the 5-methylcytosine found in the DNA extracted from polyoma virus

1967 • 38 citations

Eukaryotic DNA methylation

1980 • 38 citations

Differential activity of DNA methyltransferase in the life cycle of Chlamydomonas reinhardi.

1981 • 36 citations

The effect of 5-azadeoxycytidine on cell growth and DNA methylation

1982 • 36 citations

Structure of animal mitochondrial DNA (base composition, pyrimidine clusters, character of methylation)

1977 • 36 citations

Enzymatic dna methylation in higher eukaryotes

1980 • 36 citations

DNA methylationin normal and tumour virus-transformed cells in tissue culture I. The level of DNA methylation in BHK21 cells and in BHK21 cells transformed by polyoma virus (PyY cells)

1973 • 34 citations

The nucleotide composition and pyrimidine clusters in DNA from beef heart mitochondria

1974 • 34 citations

Correlation between synthesis and methylation of DNA in HeLa cells

1974 • 33 citations

Methylation of rapidly reannealing DNA during the cell cycle of chinese hamster cells

1973 • 31 citations

Transcription of T7 DNA containing modified nucleotides by bacteriophage T7 specific RNA polymerase.

1978 • 30 citations

Methylation of Mammalian Deoxyribonucleic Acid

1972 • 30 citations

Covalent modification and repressed transcription of a gene in hepatoma cells.

1981 • 30 citations

Binding of anti-nucleoside antibodies reveals different classes of DNA in the chromosomes of the kangaroo rat (Dipodomys ordii)

1977 • 30 citations

The sequence specificity of a mammalian DNA methylase

1977 • 30 citations

DNA methylation in isolated nuclei: Old and new DNAs are methylated

1973 • 29 citations

Genetic Control of the Secondary Modification of Deoxyribonucleic Acid in Escherichia coli

1970 • 29 citations

Enzymatic analysis of 5-methylcytosine content in eukaryotic DNA. Study of intracellular Simian Virus 40 DNA.

1980 • 28 citations

The source of cells for regeneration

1980 • 28 citations

Studies on the in vivo methylation of replicating herpes simplex virus type 1 DNA

1977 • 27 citations

Enzymatic DNA modifications in isolated nuclei from developing sea urchin embryos

1972 • 25 citations

Distribution pattern and enzymic hypermethylation of inverted repetitive DNA sequences in P815 mastocytoma cells

1979 • 24 citations

The characterisation of 1SF monomer nucleosomes from hen oviduct and the partial characterisation of a third HMG14/17-like protein in such nucleosomes

1981 • 24 citations

Methylation of Lilium DNA during the meiotic cycle

1971 • 23 citations

Endo R DpnI restriction of Escherichia coli DNA synthesized in vitro. Evidence that the ends of Okazaki pieces are determined by template deoxynucleotide sequence

1977 • 23 citations

Delayed Methylation of DNA in Developing Sea Urchin Embryos

1973 • 23 citations

Enzymatic DNA methylation during repair synthesis in non-proliferating human peripheral lymphocytes

1976 • 23 citations

Methylation of nucleosomal and nuclease sensitive DNA

1977 • 22 citations

Sequence organisation in nuclear DNA from Physarum polycephalum: methylation of repetitive sequences

1981 • 22 citations

Methylation of DNA in L cells on replication

1980 • 22 citations

Methylation of chromatin DNA

1976 • 20 citations

Repair methylation of parental DNA In synchronized cultures of Novikoff hepatoma cells

1975 • 20 citations

Methylation of Deoxyribonucleic Acid during Hormonal Stimulation of Mammary Cells in Vitro

1971 • 20 citations

Enzymatic methylation of replication-DNA intermediates in Ehrlich ascites tumor

1975 • 18 citations

The distribution of modified and non‐modified CG doublets in BHK‐21 cell DNA

1978 • 17 citations

Modification of the methylation pattern in the vicinity of the chicken globin genes in avian erythroblastosis virus transformed cells

1981 • 17 citations

Biochemical mechanisms of drug resistance. IX. Metabolic alterations in leukemic mouse cells following 5-aza-2'-deoxycytidine

1969 • 16 citations

Intragenome distribution of 5-methylcytosine in DNA of healthy and wilt-infected cotton plants (Gossypium hirsutum L.)

1975 • 16 citations

Localization of DNA methyltransferase in the chromatin of Friend erythroleukemia cells

1981 • 16 citations

Structure and expression of human globin genes introduced into mouse fibroblasts.

1981 • 14 citations

Methylation of DNA in Developing Embryos of the Sea UrchinPsammechinus miliaris

1979 • 14 citations

Spurious isotope effects in enzymatic reactions with tritium labelled substrates

1968 • 13 citations

Incorporation of [5‐³H] uridine into DNA

1968 • 13 citations

Enzymatic Methylation of DNA: Patterns and Possible Regulatory Roles

1979 • 13 citations

5-Methylcytosine content of DNA during differentiation in mouse teratocarcinoma cells

1979 • 11 citations

Restriction Endonucleases and Modification Methylases in Bacteria

1978 • 11 citations

Effect of trypsin on DNA methylation in isolated nuclei from developing sea urchin embryos

1973 • 11 citations

Genome modification in two lines of baby hamster kidney fibroblasts (BHK-21)

1978 • 9 citations

Intragenome specificity of DNA methylation in animals. Tissue specificity and variation in the methylation of repeated sequences due to aging, carcinogenesis, and hormonal induction.

1980 • 8 citations

Quality of Radioiodine

1974 • 8 citations

On the source of “Minor thymine” in DNA from a Novikoff rat hepatoma cell line

1973 • 6 citations

DNA methylation in chromatin fraction of chick embryo cells

1980 • 3 citations

Modification of DNA in Chromatin with Methyltransferase from Haemophilus influenzae Rd

1979 • 3 citations

DNA REPAIR PROCESSES AND GENETIC STABILITY

1981 • 1 citations