Altering Genotype and Phenotype by DNA-Mediated Gene Transfer

Detection of specific sequences among DNA fragments separated by gel electrophoresis

1975 • 33,059 citations

A new technique for the assay of infectivity of human adenovirus 5 DNA

1973 • 9,740 citations

Screening λgt Recombinant Clones by Hybridization to Single Plaques in Situ

1977 • 4,696 citations

Colony hybridization: a method for the isolation of cloned DNAs that contain a specific gene.

1975 • 3,483 citations

Transformation of yeast.

1978 • 2,267 citations

The isolation of structural genes from libraries of eucaryotic DNA

1978 • 1,877 citations

Transformation of mammalian cells with genes from procaryotes and eucaryotes

1979 • 1,474 citations

Transfer of purified herpes virus thymidine kinase gene to cultured mouse cells

1977 • 1,411 citations

DNA-mediated transfer of the adenine phosphoribosyltransferase locus into mammalian cells.

1979 • 1,339 citations

Biochemical transfer of single-copy eucaryotic genes using total cellular DNA as donor

1978 • 1,284 citations

Changes in size and secondary structure of the ribosomal transcription unit during vertebrate evolution

1975 • 1,188 citations

Expression of a Bacterial Gene in Mammalian Cells

1980 • 788 citations

Deletion of thymidine kinase activity from L cells resistant to bromodeoxyuridine

1963 • 611 citations

Genetic and physical linkage of exogenous sequences in transformed cells

1980 • 486 citations

The transfer and stable integration of the HSV thymidine kinase gene into mouse cells

1978 • 382 citations

DNA methylation: organ specific variations in the methylation pattern within and around ovalbumin and other chicken genes

1979 • 356 citations

Synthesis of rabbit β-globin in cultured monkey kidney cells following infection with a SV40 β-globin recombinant genome

1979 • 355 citations

Studies on In Vitro Transformation by DNA and DNA Fragments of Human Adenoviruses and Simian Virus 40

1974 • 334 citations

THE MOLECULAR GENETICS OF HUMAN HEMOGLOBINS

1980 • 306 citations

The β2-microglobulin gene is on chromosome 15 and not in the HL-A region

1975 • 274 citations

Transfer of the gene for thymidine kinase to thymidine kinase-deficient human cells by purified herpes simplex viral DNA.

1977 • 246 citations

Isolation and partial characterization of three methotrexate-resistant phenotypes from Chinese hamster ovary cells

1976 • 237 citations

Isolation of the chicken thymidine kinase gene by plasmid rescue

1980 • 208 citations

Methylated and unmethylated DNA compartments in the sea urchin genome

1979 • 195 citations

Rabbit β-globin mRNA production in mouse L cells transformed with cloned rabbit β-globin chromosomal DNA

1979 • 191 citations

Biochemical transformation of mouse cells by fragments of herpes simplex virus DNA

1977 • 180 citations

Resistance of cultured human fibroblasts and other cells to purine and pyrimidine analogues in relation to mutagenesis detection

1974 • 174 citations

Cellular localization of the insect prothoracicotropic hormone: In vitro assay of a single neurosecretory cell

1979 • 167 citations

Characteristics of an SV40-plasmid recombinant and its movement into and out of the genome of a murine cell

1980 • 164 citations

THE INOSINIC ACID PYROPHOSPHORYLASE ACTIVITY OF MOUSE FIBROBLASTS PARTIALLY RESISTANT TO 8-AZAGUANINE

1963 • 161 citations

Transformation of mammalian cells with an amplifiable dominant-acting gene.

1980 • 158 citations

Parameters governing the transfer of the genes for thymidine kinase and dihydrofolate reductase into mouse cells using metaphase chromosomes or DNA

1980 • 139 citations

Expression of the chromosomal mouse βmaj-globin gene cloned in SV40

1979 • 135 citations

Isolation and characterization of T antigen-negative revertants from a line of transformed rat cells containing one copy of the SV40 genome

1978 • 126 citations

Structure of genes for human growth hormone and chorionic somatomammotropin.

1979 • 96 citations

Indirect selection of bacterial plasmids lacking identifiable phenotypic properties

1975 • 93 citations

Cellular alterations dependent upon the polyoma virus hr-t function: Separation of mitogenic from transforming capacities

1978 • 93 citations

Significance of rare mRNA sequences in liver

1977 • 77 citations

Ovalbumin is synthesized in mouse cells transformed with the natural chicken ovalbumin gene.

1980 • 76 citations

Transformation of the gene for hypoxanthine phosphoribosyltransferase

1979 • 72 citations

A herpes simplex virus 1 integration site in the mouse genome defined by somatic cell genetic analysis

1978 • 68 citations

Intraspecies transfer via total cellular DNA of the gene for hypoxanthine phosphoribosyltransferase into cultured mouse cells

1979 • 62 citations

Expression of human genes for adenine phosphoribosyltransferase and hypoxanthine-guanine phosphoribosyltransferase after genetic transformation of mouse cells with purified human DNA

1980 • 49 citations

Corrected splicing of a chicken ovalbumin gene transcript in mouse L cells.

1980 • 46 citations

Integration and Activity of Mammary Tumor Virus Genes: Regulation by Hormone Receptors and Chromosomal Position

1981 • 37 citations

The localization of mouse globin genes: a test of the effectiveness of hybridization in situ

1978 • 13 citations