mTORC2 Regulates Neutrophil Chemotaxis in a cAMP- and RhoA-Dependent Fashion

Phosphorylation and Regulation of Akt/PKB by the Rictor-mTOR Complex

2005 • 5,837 citations

Cell Migration: Integrating Signals from Front to Back

2003 • 4,755 citations

Methods of Digital Video Microscopy for Colloidal Studies

1996 • 3,534 citations

Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension

1997 • 2,847 citations

Regulation of Myosin Phosphatase by Rho and Rho-Associated Kinase (Rho-Kinase)

1996 • 2,843 citations

Rictor, a Novel Binding Partner of mTOR, Defines a Rapamycin-Insensitive and Raptor-Independent Pathway that Regulates the Cytoskeleton

2004 • 2,574 citations

Prolonged Rapamycin Treatment Inhibits mTORC2 Assembly and Akt/PKB

2006 • 2,561 citations

Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive

2004 • 2,039 citations

Phosphorylation and Activation of Myosin by Rho-associated Kinase (Rho-kinase)

1996 • 1,964 citations

ROCKs: multifunctional kinases in cell behaviour

2003 • 1,866 citations

Two TOR Complexes, Only One of which Is Rapamycin Sensitive, Have Distinct Roles in Cell Growth Control

2002 • 1,831 citations

SIN1/MIP1 Maintains rictor-mTOR Complex Integrity and Regulates Akt Phosphorylation and Substrate Specificity

2006 • 1,365 citations

Ablation in Mice of the mTORC Components raptor, rictor, or mLST8 Reveals that mTORC2 Is Required for Signaling to Akt-FOXO and PKCα, but Not S6K1

2006 • 1,358 citations

Regulation of the mTOR Complex 1 Pathway by Nutrients, Growth Factors, and Stress

2010 • 1,173 citations

The Two TORCs and Akt

2007 • 782 citations

3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase

1997 • 740 citations

Divergent Signals and Cytoskeletal Assemblies Regulate Self-Organizing Polarity in Neutrophils

2003 • 690 citations

mSin1 Is Necessary for Akt/PKB Phosphorylation, and Its Isoforms Define Three Distinct mTORC2s

2006 • 668 citations

Protein kinase A phosphorylation of RhoA mediates the morphological and functional effects of cyclic AMP in cytotoxic lymphocytes.

1996 • 560 citations

Purification and identification of formyl-methionyl-leucyl-phenylalanine as the major peptide neutrophil chemotactic factor produced by Escherichia coli.

1984 • 520 citations

Isoforms of Mammalian Adenylyl Cyclase: Multiplicities of Signaling

2002 • 404 citations

Multiallelic Disruption of the rictor Gene in Mice Reveals that mTOR Complex 2 Is Essential for Fetal Growth and Viability

2006 • 384 citations

Regulation of actin-based cell migration by cAMP/PKA

2004 • 323 citations

Structurally distinct and stage-specific adenylyl cyclase genes play different roles in dictyostelium development

1992 • 307 citations

Serine Phosphorylation Negatively Regulates RhoA in Vivo

2003 • 307 citations

TOR complex 2: a signaling pathway of its own

2009 • 271 citations

Role of a Novel PH-Kinase Domain Interface in PKB/Akt Regulation: Structural Mechanism for Allosteric Inhibition

2009 • 234 citations

Characterization of a new human diploid myeloid leukemia cell line (PLB- 985) with granulocytic and monocytic differentiating capacity

1987 • 219 citations

TOR Complex 2 Integrates Cell Movement during Chemotaxis and Signal Relay in Dictyostelium

2005 • 196 citations

Rapamycin inhibits cell motility by suppression of mTOR-mediated S6K1 and 4E-BP1 pathways

2006 • 189 citations

PIP3-Independent Activation of TorC2 and PKB at the Cell's Leading Edge Mediates Chemotaxis

2008 • 181 citations

Roles of p-ERM and Rho–ROCK signaling in lymphocyte polarity and uropod formation

2004 • 176 citations

Assay of Cdc42, Rac, and Rho GTPase Activation by Affinity Methods

2002 • 173 citations

CRAC, a cytosolic protein containing a pleckstrin homology domain, is required for receptor and G protein-mediated activation of adenylyl cyclase in Dictyostelium.

1994 • 172 citations

Akt1 is critical for acute inflammation and histamine-mediated vascular leakage

2009 • 162 citations

Regulation of Myosin II Dynamics by Phosphorylation and Dephosphorylation of Its Light Chain in Epithelial Cells

2006 • 152 citations

A Ras Signaling Complex Controls the RasC-TORC2 Pathway and Directed Cell Migration

2010 • 151 citations

The Signaling Mechanisms Underlying Cell Polarity and Chemotaxis

2009 • 150 citations

Gö 6976, a selective inhibitor of protein kinase C, is a potent antagonist of human immunodeficiency virus 1 induction from latent/low-level-producing reservoir cells in vitro.

1993 • 138 citations

cAMP and human neutrophil chemotaxis. Elevation of cAMP differentially affects chemotactic responsiveness.

1991 • 128 citations

A novel cytosolic regulator, Pianissimo, is required for chemoattractant receptor and G protein-mediated activation of the 12 transmembrane domain adenylyl cyclase in Dictyostelium

1997 • 128 citations

Ras-mediated activation of the TORC2–PKB pathway is critical for chemotaxis

2010 • 127 citations

Neutrophil microtubules suppress polarity and enhance directional migration

2005 • 126 citations

Cloning, Chromosomal Mapping, and Regulatory Properties of the Human Type 9 Adenylyl Cyclase (ADCY9)

1998 • 108 citations

A Novel Ras-interacting Protein Required for Chemotaxis and Cyclic Adenosine Monophosphate Signal Relay inDictyostelium

1999 • 101 citations

Rapamycin inhibits GM‐CSF‐induced neutrophil migration

2003 • 92 citations

The mDial Formin Is Required for Neutrophil Polarization, Migration, and Activation of the LARG/RhoA/ROCK Signaling Axis during Chemotaxis

2009 • 88 citations

The ADMA/DDAH pathway is a critical regulator of endothelial cell motility

2007 • 88 citations

The role of cyclic nucleotides in neutrophil migration

1996 • 82 citations

PDZRhoGEF and myosin II localize RhoA activity to the back of polarizing neutrophil-like cells

2007 • 81 citations

Involvement of mTORC1 and mTORC2 in regulation of glioblastoma multiforme growth and motility

2009 • 78 citations

Flotillins Interact with PSGL-1 in Neutrophils and, upon Stimulation, Rapidly Organize into Membrane Domains Subsequently Accumulating in the Uropod

2009 • 73 citations

Chemotaxis: moving forward and holding on to the past

2005 • 72 citations

Modulation of Rho Guanine Exchange Factor Lfc Activity by Protein Kinase A-Mediated Phosphorylation

2009 • 66 citations

The PI3K-Mediated Activation of CRAC Independently Regulates Adenylyl Cyclase Activation and Chemotaxis

2005 • 63 citations

Differential Regulation of Formyl Peptide and Platelet-activating Factor Receptors

1998 • 62 citations

Quantitative analysis of eosinophil chemotaxis tracked using a novel optical device — TAXIScan

2007 • 60 citations

Effect of Cyclic AMP Level Reduction on Human Neutrophil Responses to Formylated Peptides

1996 • 44 citations

A Chemoattractant-mediated G_i-coupled Pathway Activates Adenylyl Cyclase in Human Neutrophils

2006 • 42 citations

Signal relay during chemotaxis

2008 • 41 citations

AKAP-Lbc: A molecular scaffold for the integration of cyclic AMP and Rho transduction pathways

2006 • 37 citations

Correlation of conformation and phosphorylation and dephosphorylation of smooth muscle myosin.

1988 • 36 citations

Intracellular Role of Adenylyl Cyclase in Regulation of Lateral Pseudopod Formation duringDictyosteliumChemotaxis

2005 • 35 citations

Asymmetrical protein kinase A activity establishes neutrophil cytoskeletal polarity and enables chemotaxis

2005 • 29 citations

Real-time measurements of cAMP production in liveDictyosteliumcells

2009 • 28 citations

Involvement of the βγ subunits of inhibitory GTP-binding protein in chemoattractant receptor-mediated potentiation of cyclic AMP formation in guinea pig neutrophils

1996 • 14 citations