Co-expression of Prostaglandin Receptors with Opposite Effects

Analysis of numerical methods for computer simulation of kinetic processes: Development of KINSIM—A flexible, portable system

1983 • 597 citations

D1 and D2 dopamine receptor mRNA in rat brain.

1991 • 483 citations

G protein—coupled receptor kinases

1993 • 434 citations

Cloning and expression of a cDNA for the human prostanoid FP receptor.

1994 • 386 citations

Cloning of a novel human prostaglandin receptor with characteristics of the pharmacologically defined EP2 subtype.

1994 • 384 citations

Alternative splicing produces a divergent cytoplasmic tail in the human endothelial thromboxane A2 receptor.

1994 • 357 citations

Molecular Cloning and Characterization of the Human Prostanoid DP Receptor

1995 • 332 citations

Cloning and expression of a cDNA for the human prostaglandin E receptor EP1 subtype.

1993 • 305 citations

Two thromboxane A2 receptor isoforms in human platelets. Opposite coupling to adenylyl cyclase with different sensitivity to Arg60 to Leu mutation.

1996 • 298 citations

Expression of platelet membrane glycoproteins and alpha-granule proteins by a human erythroleukemia cell line (HEL).

1984 • 242 citations

Drug efficacy at guanine nucleotide-binding regulatory protein-linked receptors: thermodynamic interpretation of negative antagonism and of receptor activity in the absence of ligand.

1992 • 232 citations

Link between D1 and D2 dopamine receptors is reduced in schizophrenia and Huntington diseased brain.

1989 • 197 citations

Two Gs-coupled prostaglandin E receptor subtypes, EP2 and EP4, differ in desensitization and sensitivity to the metabolic inactivation of the agonist.

1996 • 188 citations

Cloning and expression of a cDNA for the human prostanoid IP receptor.

1994 • 187 citations

Prostaglandin E2 receptors of the EP2 and EP4 subtypes regulate activation and differentiation of mouse B lymphocytes to IgE-secreting cells.

1996 • 155 citations

Relationship of cAMP and calcium messenger systems in prostaglandin-stimulated UMR-106 cells.

1988 • 150 citations

Cloning and Expression of the EP2 Subtype of Human Receptors for Prostaglandin E2

1993 • 144 citations

Regulation of blood platelet function by cyclic nucleotides.

1978 • 141 citations

Characterization and chromosomal mapping of the human thromboxane A2 receptor gene.

1993 • 140 citations

Distinct cellular localization of mRNAs for three subtypes of prostaglandin E receptor in kidney

1994 • 137 citations

Regulation of cyclic AMP metabolism in rabbit cortical collecting tubule cells by prostaglandins.

1988 • 132 citations

Molecular cloning and expression of multiple isoforms of human prostaglandin E receptor EP3 subtype generated by alternative messenger RNA splicing: multiple second messenger systems and tissue-specific distributions.

1995 • 129 citations

Isoforms of the EP3 Subtype of Human Prostaglandin E2 Receptor Transduce Both Intracellular Calcium and cAMP Signals

1994 • 122 citations

Prostaglandin E receptor subtypes in mouse osteoblastic cell line.

1996 • 117 citations

Splice Variants of the Human EP3 Receptor for Prostaglandin E2

1995 • 111 citations

Differential localization of prostaglandin E receptor subtypes in human kidney

1996 • 107 citations

Two Isoforms of the Prostaglandin E Receptor EP3 Subtype Different in Agonist-independent Constitutive Activity

1996 • 106 citations

Cloning and expression of a cDNA for the human prostacyclin receptor

1994 • 106 citations

Molecular cloning and expression of human EP₃ receptors: evidence of three variants with differing carboxyl termini

1994 • 100 citations

Constitutive Activation of Opsin: Interaction of Mutants with Rhodopsin Kinase and Arrestin

1995 • 98 citations

Splice Variants of the Human EP3 Receptor for Prostaglandin E2

1995 • 89 citations

Cloning and Expression of the EP3-Subtype of Human Receptors for Prostaglandin E2

1994 • 75 citations

Lower efficacy: interaction with an inhibitory receptor or partial agonism?

1994 • 71 citations

Cloning and expression of a prostaglandin E receptor EP3 subtype from human erythroleukaemia cells

1994 • 65 citations

Prostaglandin E receptor EP3γ isoform, with mostly full constitutive Gi activity and agonist‐dependent Gs activity

1996 • 58 citations

Silencing of the Constitutive Activity of the Dopamine D1B Receptor

1996 • 57 citations

Constitutive activity of human prostaglandin E receptor EP₃ isoforms

1997 • 57 citations

Coexpression of 5-HT2A and 5-HT4 receptors coupled to distinct signaling pathways in human intestinal muscle cells

1995 • 55 citations

Constitutive Activation of the Thyrotropin Receptor by Deletion of a Portion of the Extracellular Domain

1995 • 52 citations

The Long Cytoplasmic Carboxyl Terminus of the Prostaglandin E₂Receptor EP₄Subtype Is Essential for Agonist-Induced Desensitization

1997 • 44 citations

Model of prostaglandin-regulated cyclic AMP metabolism in intact platelets: examination of time-dependent effects on adenylate cyclase and phosphodiesterase activities.

1989 • 36 citations

Central Neural Mechanisms of Touch and Proprioception

1994 • 31 citations

Novel mechanism of heterologous desensitization of adenylate cyclase: prostaglandins bind with different affinities to both stimulatory and inhibitory receptors on platelets.

1990 • 30 citations

(5Z)‐carbacyclin discriminates between prostacyclin‐receptors coupled to adenylate cyclase in vascular smooth muscle and platelets

1987 • 30 citations

Multiple Adrenergic Receptor Subtypes Controlling Cyclic AMP Formation: Comparison of Brain Slices and Primary Neuronal and Glial Cultures

1991 • 29 citations

Expression of thromboxane A2 receptor in cultured human erythroleukemia cells and its induction by 12-O-tetradecanoylphorbol-13-acetate

1989 • 26 citations

Comparison of Iloprost, Cicaprost and prostacyclin effects on cyclic AMP metabolism in intact platelets

1992 • 20 citations

A model of desensitization in intact cells.

1978 • 20 citations

Prostaglandin E2 both stimulates and inhibits adenyl cyclase on platelets: Comparison of effects on cloned EP4 and EP3 prostaglandin receptor subtypes

1996 • 18 citations

Kinetic evidence indicating separate stimulatory and inhibitory prostaglandin receptors on platelet membranes.

1986 • 17 citations

Induction of prostacyclin receptor expression in human erythroleukemia cells

1989 • 16 citations

Preferential desensitization of beta- versus alpha 2-adrenergic receptors accelerates loss of response to norepinephrine in primary glial cultures.

1992 • 15 citations

Prostaglandin-concentration-dependent desensitization of adenylate cyclase in human erythroleukaemia (HEL) cells is abolished by pertussis toxin and enhanced by induction by dimethyl sulphoxide

1991 • 10 citations