Pathobionts of the gastrointestinal microbiota and inflammatory disease

Cancer-related inflammation

2008 • 10,288 citations

Changes of Intestinal Functions in Liver Cirrhosis

2016 • 6,567 citations

Host-Bacterial Mutualism in the Human Intestine

2005 • 4,852 citations

The gut microbiota shapes intestinal immune responses during health and disease

2009 • 4,497 citations

Molecular-phylogenetic characterization of microbial community imbalances in human inflammatory bowel diseases

2007 • 4,230 citations

Induction of Intestinal Th17 Cells by Segmented Filamentous Bacteria

2009 • 4,117 citations

Induction of Colonic Regulatory T Cells by Indigenous Clostridium Species

2010 • 3,305 citations

Ecological and Evolutionary Forces Shaping Microbial Diversity in the Human Intestine

2006 • 3,102 citations

Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease

2008 • 2,577 citations

Interleukin-1 polymorphisms associated with increased risk of gastric cancer

2000 • 2,355 citations

A microbial symbiosis factor prevents intestinal inflammatory disease

2008 • 2,187 citations

Inducible Foxp3 ⁺ regulatory T-cell development by a commensal bacterium of the intestinal microbiota

2010 • 1,973 citations

The NIH Human Microbiome Project

2009 • 1,879 citations

NLRP6 Inflammasome Regulates Colonic Microbial Ecology and Risk for Colitis

2011 • 1,849 citations

Specific Microbiota Direct the Differentiation of IL-17-Producing T-Helper Cells in the Mucosa of the Small Intestine

2008 • 1,653 citations

Gut-Residing Segmented Filamentous Bacteria Drive Autoimmune Arthritis via T Helper 17 Cells

2010 • 1,474 citations

The Key Role of Segmented Filamentous Bacteria in the Coordinated Maturation of Gut Helper T Cell Responses

2009 • 1,340 citations

Translocation of Helicobacter pylori CagA into Gastric Epithelial Cells by Type IV Secretion

2000 • 1,261 citations

Proinflammatory T-cell responses to gut microbiota promote experimental autoimmune encephalomyelitis

2010 • 1,213 citations

Enteric defensins are essential regulators of intestinal microbial ecology

2009 • 1,076 citations

Has the Microbiota Played a Critical Role in the Evolution of the Adaptive Immune System?

2010 • 1,069 citations

Therapeutic manipulation of the enteric microflora in inflammatory bowel diseases: antibiotics, probiotics, and prebiotics

2004 • 1,052 citations

ATP drives lamina propria TH17 cell differentiation

2008 • 1,035 citations

Helicobacter pylori: gastric cancer and beyond

2010 • 1,017 citations

Communicable Ulcerative Colitis Induced by T-bet Deficiency in the Innate Immune System

2007 • 880 citations

Vancomycin-resistant Enterococcus domination of intestinal microbiota is enabled by antibiotic treatment in mice and precedes bloodstream invasion in humans

2010 • 852 citations

Interleukin-23 drives innate and T cell–mediated intestinal inflammation

2006 • 814 citations

CD4+CD25+ TR Cells Suppress Innate Immune Pathology Through Cytokine-dependent Mechanisms

2003 • 748 citations

Enterobacteriaceae Act in Concert with the Gut Microbiota to Induce Spontaneous and Maternally Transmitted Colitis

2010 • 747 citations

Enhanced Escherichia coli adherence and invasion in Crohn’s disease and colon cancer 1 1The authors thank Professor T. K. Korhonen (Division of General Microbiology, University of Helsinki, Finland), who kindly donated Escherichia coli IH11165; Professor J.-F. Colombel (Laboratoire de Recherche sur les Maladies Inflammatoire de l’Intestine, Centre Hospitalier Universitaire, Lille, France) and Professor A. Darfeuille-Michaud (Faculte de Pharmacie, Clermont-Ferrand, France), who kindly donated …

2004 • 685 citations

Vancomycin-resistant enterococci exploit antibiotic-induced innate immune deficits

2008 • 589 citations

An inverse relation between cagA+ strains of Helicobacter pylori infection and risk of esophageal and gastric cardia adenocarcinoma.

1998 • 534 citations

Helicobacter hepaticusTriggers Colitis in Specific-Pathogen-Free Interleukin-10 (IL-10)-Deficient Mice through an IL-12- and Gamma Interferon-Dependent Mechanism

1998 • 449 citations

Mucosal antibodies in inflammatory bowel disease are directed against intestinal bacteria.

1996 • 437 citations

Modulation of the Intestinal Microbiota Alters Colitis-Associated Colorectal Cancer Susceptibility

2009 • 415 citations

Chronic Active Hepatitis and Associated Liver Tumors in Mice Caused by a Presistent Bacterial Infection With a Novel Helicobacter Species

1994 • 388 citations

The impact of the microbiota on the pathogenesis of IBD: lessons from mouse infection models

2010 • 376 citations

Segmented Filamentous Bacteria Are Potent Stimuli of a Physiologically Normal State of the Murine Gut Mucosal Immune System

1999 • 370 citations

Helicobacter pyloriColonization Is Inversely Associated with Childhood Asthma

2008 • 353 citations

Emergence of DiverseHelicobacterSpecies in the Pathogenesis of Gastric and Enterohepatic Diseases

2001 • 349 citations

Bacteria-triggered CD4+ T Regulatory Cells Suppress Helicobacter hepaticus–induced Colitis

2002 • 324 citations

Inflammatory bowel disease: an immunity-mediated condition triggered by bacterial infection with Helicobacter hepaticus

1997 • 318 citations

Culture-Independent Analyses of Temporal Variation of the Dominant Fecal Microbiota and Targeted Bacterial Subgroups in Crohn's Disease

2006 • 300 citations

CD4+ CD25+ Regulatory T Lymphocytes Inhibit Microbially Induced Colon Cancer in Rag2-Deficient Mice

2003 • 300 citations

Association between intraepithelial Escherichia coli and colorectal cancer

1998 • 281 citations

A Pathobiont of the Microbiota Balances Host Colonization and Intestinal Inflammation

2010 • 274 citations

Gain and Loss of Multiple Genes During the Evolution of Helicobacter pylori

2005 • 230 citations

A National Study of Helicobactor pylori Infection in Gastric Biopsy Specimens

2010 • 206 citations

Elimination of colon cancer in germ-free transforming growth factor beta 1-deficient mice.

2002 • 195 citations

Inflammatory large bowel disease in immunodeficient mice naturally infected with Helicobacter hepaticus.

1996 • 184 citations

Commensal Gut Flora Drives the Expansion of Proinflammatory CD4 T Cells in the Colonic Lamina Propria under Normal and Inflammatory Conditions

2008 • 184 citations

Segmented filamentous bacteria in a defined bacterial cocktail induce intestinal inflammation in SCID mice reconstituted with CD45RBhigh CD4+ T cells

2007 • 181 citations

Nitric oxide and TNF-α trigger colonic inflammation and carcinogenesis in Helicobacter hepaticus -infected, Rag2 -deficient mice

2009 • 176 citations

Helicobacter hepaticus infection in mice: models for understanding lower bowel inflammation and cancer

2010 • 175 citations

Intestinal microflora are necessary for development of spontaneous adenocarcinoma of the large intestine in T-cell receptor beta chain and p53 double-knockout mice.

2001 • 151 citations

Colitis-Associated Colorectal Cancer Driven by T-bet Deficiency in Dendritic Cells

2009 • 149 citations

The human gut microbiome: Implications for future health care

2008 • 138 citations

Overview of the epidemiology of colorectal cancer

1997 • 128 citations

Helicobacter pylori's Unconventional Role in Health and Disease

2009 • 114 citations

Pathogenic and Protective Roles of MyD88 in Leukocytes and Epithelial Cells in Mouse Models of Inflammatory Bowel Disease

2010 • 101 citations

Enterohepatic Helicobacter Species Are Prevalent in Mice from Commercial and Academic Institutions in Asia, Europe, and North America

2007 • 99 citations

SCID/NCr Mice Naturally Infected with Helicobacter hepaticus Develop Progressive Hepatitis, Proliferative Typhlitis, and Colitis

1998 • 93 citations

Induction of colitis by a CD4⁺T cell clone specific for a bacterial epitope

2003 • 87 citations

The role of inflammation in the pathogenesis of colorectal cancer

2009 • 78 citations

Toll-Like Receptor 4-Mediated Regulation of Spontaneous Helicobacter-Dependent Colitis in IL-10–Deficient Mice

2009 • 64 citations

Inhibition of Helicobacter hepaticus-Induced Colitis by IL-10 Requires the p50/p105 Subunit of NF-κB

2006 • 41 citations

Inhibitory Effect of Enterohepatic Helicobacter hepaticus on Innate Immune Responses of Mouse Intestinal Epithelial Cells

2007 • 40 citations

Fecal matters

2011 • 20 citations

A tough controversy to stomach

2009 • 4 citations