The human gut microbiome: Implications for future health care

An obesity-associated gut microbiome with increased capacity for energy harvest

2006 • 11,120 citations

Prevalence of Overweight and Obesity in the United States, 1999-2004

2006 • 8,878 citations

Human gut microbes associated with obesity

2006 • 7,995 citations

Dietary Modulation of the Human Colonic Microbiota: Introducing the Concept of Prebiotics

1995 • 7,436 citations

Diversity of the Human Intestinal Microbial Flora

2005 • 7,395 citations

Obesity alters gut microbial ecology

2005 • 5,818 citations

The gut microbiota as an environmental factor that regulates fat storage

2004 • 5,730 citations

The Human Microbiome Project

2007 • 5,410 citations

Metagenomic Analysis of the Human Distal Gut Microbiome

2006 • 4,423 citations

'Metabonomics': understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data

1999 • 3,649 citations

Mechanisms underlying the resistance to diet-induced obesity in germ-free mice

2007 • 2,435 citations

Metabonomics: a platform for studying drug toxicity and gene function

2002 • 1,871 citations

An ecological and evolutionary perspective on human–microbe mutualism and disease

2007 • 1,542 citations

Mucosal flora in inflammatory bowel disease

2002 • 1,344 citations

The fundamental basis of inflammatory bowel disease

2007 • 1,277 citations

A Genomic View of the Human- Bacteroides thetaiotaomicron Symbiosis

2003 • 1,265 citations

Symbiotic gut microbes modulate human metabolic phenotypes

2008 • 1,103 citations

Association between insertion mutation in NOD2 gene and Crohn's disease in German and British populations

2001 • 1,096 citations

Metabolic profiling reveals a contribution of gut microbiota to fatty liver phenotype in insulin-resistant mice

2006 • 1,019 citations

Human metabolic phenotype diversity and its association with diet and blood pressure

2008 • 1,012 citations

Commensal anaerobic gut bacteria attenuate inflammation by regulating nuclear-cytoplasmic shuttling of PPAR-γ and RelA

2003 • 983 citations

The Fecal Microbiota of Irritable Bowel Syndrome Patients Differs Significantly From That of Healthy Subjects

2007 • 976 citations

Gut microorganisms, mammalian metabolism and personalized health care

2005 • 917 citations

Human disease classification in the postgenomic era: A complex systems approach to human pathobiology

2007 • 586 citations

Rapid and Noninvasive Metabonomic Characterization of Inflammatory Bowel Disease

2007 • 586 citations

Infectious History

2000 • 491 citations

Intestinal floras of populations that have a high risk of colon cancer

1995 • 484 citations

A top‐down systems biology view of microbiome‐mammalian metabolic interactions in a mouse model

2007 • 459 citations

The Effect of a Nonabsorbed Oral Antibiotic (Rifaximin) on the Symptoms of the Irritable Bowel Syndrome

2006 • 457 citations

Gut microbiota: a potential new territory for drug targeting

2008 • 449 citations

Changes in predominant bacterial populations in human faeces with age and with Clostridium difficile infection

2002 • 443 citations

Phylogenetic Analysis of the Human Gut Microbiota Using 16S rDNA Clone Libraries and Strictly Anaerobic Culture‐Based Methods

2002 • 426 citations

Probiotic impact on microbial flora, inflammation and tumour development in IL-10 knockout mice

2001 • 291 citations

INTERMAP: background, aims, design, methods, and descriptive statistics (nondietary)

2003 • 283 citations

Immune responses that adapt the intestinal mucosa to commensal intestinal bacteria

2005 • 267 citations

Commensal Bacteria, Redox Stress, and Colorectal Cancer: Mechanisms and Models

2004 • 241 citations

Dose-dependent effect of dietary meat on endogenous colonic N-nitrosation

2001 • 227 citations

Role of infection in irritable bowel syndrome

2007 • 187 citations

Autoantibodies against appetite-regulating peptide hormones and neuropeptides: Putative modulation by gut microflora

2008 • 171 citations

Inter-species transplantation of gut microbiota from human to pigs

2007 • 168 citations

Prevalence and temporal stability of selected clostridial groups in irritable bowel syndrome in relation to predominant faecal bacteria

2006 • 158 citations

Phylometabonomic Patterns of Adaptation to High Fat Diet Feeding in Inbred Mice

2008 • 104 citations

Deoxycholic acid formation in gnotobiotic mice associated with human intestinal bacteria

2006 • 93 citations

Dietary Modification of the Intestinal Microbiota

2004 • 87 citations

Bioecologic Control of the Gastrointestinal Tract: The Role of Flora and Supplemented Probiotics and Synbiotics

2005 • 80 citations

Probiotics modulate inflammatory cytokine secretion from inflamed mucosa in active ulcerative colitis

2006 • 70 citations

Effects of intestinal bacteria on the development of colonic neoplasm: an experimental study

1999 • 50 citations

Dysbiosis and pouchitis

2006 • 35 citations

Dietary Modification of the Intestinal Microbiota

2004 • 32 citations

Global systems biology and personalized healthcare solutions.

2006 • 24 citations

Intestinal secretory and absorptive function in Trichinella spiralis mouse model of postinfective gut dysfunction: role of bile acids

2007 • 21 citations

Effects of intestinal bacteria on the development of colonic neoplasm II. Changes in the immunological environment

1999 • 19 citations

Authors' reply: Dysbiosis and pouchitis (Br J Surg 2006; 93: 1325–1334)

2007 • 3 citations