A genetic analysis of processes regulating cytochrome P4501A1 expression

The myoD Gene Family: Nodal Point During Specification of the Muscle Cell Lineage

1991 • 1,564 citations

Stereospecific, high affinity binding of 2,3,7,8-tetrachlorodibenzo-p-dioxin by hepatic cytosol. Evidence that the binding species is receptor for induction of aryl hydrocarbon hydroxylase.

1976 • 1,343 citations

Cloning of a Factor Required for Activity of the Ah (Dioxin) Receptor

1991 • 963 citations

Cloning of the Ah-receptor cDNA reveals a distinctive ligand-activated transcription factor.

1992 • 830 citations

Identification of the Ah Receptor Nuclear Translocator Protein (Arnt) as a Component of the DNA Binding Form of the Ah Receptor

1992 • 769 citations

Enzyme induction in the cytochrome P-450 system

1990 • 631 citations

Association of the Ah receptor with the 90-kDa heat shock protein.

1988 • 511 citations

Microsomes, Drug Oxidations and Chemical Carcinogenesis

1980 • 498 citations

Genetic and Molecular Aspects of 2,3,7,8-Tetra-Chlorodibenzo-P-Dioxin Action

1990 • 446 citations

cDNA cloning and structure of mouse putative Ah receptor

1992 • 406 citations

The mouse glucocorticoid receptor: mapping of functional domains by cloning, sequencing and expression of wild-type and mutant receptor proteins.

1986 • 392 citations

Association of the dioxin receptor with the Mr 90,000 heat shock protein: A structural kinship with the glucocorticoid receptor

1988 • 234 citations

Role of the aryl hydrocarbon receptor nuclear translocator protein in aryl hydrocarbon (dioxin) receptor action.

1993 • 207 citations

Genetic Approaches to Steroid Hormone Action

1976 • 203 citations

Biochemical and genetic analysis of variant mouse hepatoma cells defective in the induction of benzo(a)pyrene-metabolizing enzyme activity.

1983 • 200 citations

Single-step selection of clones of a mouse hepatoma line deficient in aryl hydrocarbon hydroxylase.

1979 • 191 citations

The Ah Locus and the Metabolism of Chemical Carcinogens and Other Foreign Compounds

1977 • 188 citations

Structure and function of the Ah receptor for 2,3,7,8-tetrachlorodibenzo-p-dioxin. Species difference in molecular properties of the receptors from mouse and rat hepatic cytosols.

1986 • 168 citations

Regulatory gene product of the Ah locus. Characterization of receptor mutants among mouse hepatoma clones.

1982 • 160 citations

ENZYMATIC HYDROXYLATION OF BENZOPYRENE AND ITS RELATIONSHIP TO CYTOTOXICITY

1969 • 136 citations

Mutations affecting the regulation of transcription of the cytochrome P1-450 gene in the mouse Hepa-1 cell line.

1985 • 124 citations

Dominant and recessive aryl hydrocarbon hydroxylase-deficient mutants of mouse hepatoma line, Hepa-1, and assignment of recessive mutants to three complementation groups

1983 • 124 citations

The receptor for 2,3,7,8-tetrachlorodibenzo-p-dioxin in the mouse hepatoma cell line Hepa 1c1c7. A comparison with the glucocorticoid receptor and the mouse and rat hepatic dioxin receptors.

1987 • 79 citations

Microsomes and drug oxidations

1989 • 76 citations

Analysis of two benzo[a]pyrene-resistant mutants of the mouse hepatoma Hepa-1 P(1)450 gene via cDNA expression in yeast.

1987 • 68 citations

Chemical cross-linking of the cytosolic and nuclear forms of the Ah receptor in hepatoma cell line 1c1c7

1992 • 66 citations

Aryl hydrocarbon hydroxylase induction in mammalian liver cell culture—IV. Stimulation of the enzyme activity in established cell lines derived from rat or mouse hepatoma and from normal rat liver

1973 • 62 citations

Metabolism of polycyclic hydrocarbons in mammalian cell cultures

1971 • 59 citations

Hepatic Ah receptor for 2,3,7,8-tetrachlorodibenzo-p-dioxin. Partial stabilization by molybdate.

1986 • 54 citations

Mechanism of Action of a Repressor of Dioxin-Dependent Induction of Cyplal Gene Transcription

1992 • 54 citations

Evidence that benzo(a)pyrene-resistant, aryl hydrocarbon hydroxylase-deficient variants of mouse hepatoma line, Hepa-1, are mutational in origin

1981 • 52 citations

Novel variants in benzo(a)pyrene metabolism. Isolation by fluorescence-activated cell sorting.

1981 • 42 citations

Mechanism of action of a repressor of dioxin-dependent induction of Cyp1a1 gene transcription.

1992 • 36 citations

Analysis of steroid resistance in lymphoid cell hybrids

1980 • 34 citations

A third genetic locus affecting the Ah (dioxin) receptor.

1988 • 30 citations

Variation in aryl hydrocarbon (benzo(a)pyrene) hydroxylase activity in heteroploid and predominantly diploid rat liver cells in culture.

1976 • 26 citations

Single-step phototoxic selection procedure for isolating cells that possess aryl hydrocarbon hydroxylase.

1983 • 23 citations

Transfection by Genomic DNA of Cytochrome P₁-450 Enzymatic Activity and Inducibility

1985 • 22 citations

Isolation and Characterization of Revertants from Four Different Classes of Aryl Hydrocarbon Hydroxylase-Deficient Hepa-1 Mutants

1984 • 21 citations

Heterogeneity in the Rate of Benzo[a]pyrene Metabolism in Single Cells: Quantitation Using Flow Cytometry

1982 • 19 citations

Unstable aryl hydrocarbon hydroxylase-deficient variants of a rat hepatoma line

1980 • 15 citations

The Ah Receptor Nuclear Translocator Gene (ARNT) Is Located on q21 of Human Chromosome 1 and on Mouse Chromosome 3 near Cf-3

1993 • 15 citations

Transfection by genomic DNA of cytochrome P1-450 enzymatic activity and inducibility.

1985 • 14 citations

Regulation of cytochrome P-450c in differentiated and dedifferentiated rat hepatoma cells: Role of theAh receptor

1987 • 14 citations

Isolation and characterization of revertants from four different classes of aryl hydrocarbon hydroxylase-deficient hepa-1 mutants.

1984 • 13 citations

DNA transfection of a gene repressing aryl hydrocarbon hydroxylase induction

1988 • 10 citations

An Mspl RFLP in the human ARNT gene, encoding a subunit of the nuclear form of the Ah (dioxin) receptor

1992 • 7 citations

MUTANTS OF CULTURED HEPATOMA CELLS DEFICIENT IN ARYL HYDROCARBON HYDROXYLASE

1980 • 3 citations