The nuclear localization signal (NLS) of PDX‐1 is part of the homeodomain and represents a novel type of NLS

A new DNA binding and dimerization motif in immunoglobulin enhancer binding, daughterless, MyoD, and myc proteins

1989 • 2,706 citations

Nuclear targeting sequences — a consensus?

1991 • 1,908 citations

Insulin-promoter-factor 1 is required for pancreas development in mice

1994 • 1,789 citations

PDX-1 is required for pancreatic outgrowth and differentiation of the rostral duodenum

1996 • 1,505 citations

Two interdependent basic domains in nucleoplasmin nuclear targeting sequence: Identification of a class of bipartite nuclear targeting sequence

1991 • 1,501 citations

Conversion of Xenopus Ectoderm into Neurons by NeuroD, a Basic Helix-Loop-Helix Protein

1995 • 1,028 citations

IPF1, a homeodomain-containing transactivator of the insulin gene.

1993 • 882 citations

HOMEODOMAIN PROTEINS

1994 • 828 citations

Short protocols in molecular biology

1990 • 720 citations

Cell-Specific Expression of the Rat Insulin Gene: Evidence for Role of Two Distinct 5′ Flanking Elements

1985 • 698 citations

Insulin gene enhancer binding protein Isl-1 is a member of a novel class of proteins containing both a homeo-and a Cys–His domain

1990 • 684 citations

Cell-specific expression controlled by the 5′-flanking region of insulin and chymotrypsin genes

1983 • 659 citations

Tissue-specific regulation of the insulin gene by a novel basic helix-loop-helix transcription factor.

1995 • 601 citations

Expression of murine STF-1, a putative insulin gene transcription factor, in β cells of pancreas, duodenal epithelium and pancreatic exocrine and endocrine progenitors during ontogeny

1995 • 562 citations

IDX-1: a new homeodomain transcription factor expressed in rat pancreatic islets and duodenum that transactivates the somatostatin gene.

1994 • 427 citations

Synergistic activation of the insulin gene by a LIM-homeo domain protein and a basic helix-loop-helix protein: building a functional insulin minienhancer complex.

1992 • 396 citations

Characterization of somatostatin transactivating factor-1, a novel homeobox factor that stimulates somatostatin expression in pancreatic islet cells.

1993 • 332 citations

HEB, a helix-loop-helix protein related to E2A and ITF2 that can modulate the DNA-binding ability of myogenic regulatory factors.

1992 • 312 citations

Nuclear protein import

1997 • 296 citations

Transcriptional "silencer" element in rat repetitive sequences associated with the rat insulin 1 gene locus.

1986 • 257 citations

RNA-Mediated Gene Duplication: the Rat Preproinsulin I Gene Is a Functional Retroposon

1985 • 256 citations

A mutational analysis of the insulin gene transcription control region: expression in beta cells is dependent on two related sequences within the enhancer.

1987 • 242 citations

Short protocols in molecular biology, 2nd Edn

1992 • 225 citations

Transcriptional regulation of the human insulin gene is dependent on the homeodomain protein STF1/IPF1 acting through the CT boxes.

1994 • 207 citations

Insulin expression in pancreatic islet cells relies on cooperative interactions between the helix loop helix factor E47 and the homeobox factor STF-1.

1994 • 205 citations

Characterization of somatostatin transactivating factor-1, a novel homeobox factor that stimulates somatostatin expression in pancreatic islet cells

1993 • 183 citations

The p38/Reactivating Kinase Mitogen-activated Protein Kinase Cascade Mediates the Activation of the Transcription Factor Insulin Upstream Factor 1 and Insulin Gene Transcription by High Glucose in Pancreatic β-Cells

1997 • 176 citations

XIHbox 8: a novel Xenopus homeo protein restricted to a narrow band of endoderm

1989 • 162 citations

Pancreatic beta cells express a diverse set of homeobox genes.

1994 • 156 citations

RNA-mediated gene duplication: the rat preproinsulin I gene is a functional retroposon.

1985 • 153 citations

The Pancreatic Islet Factor STF-1 Binds Cooperatively with Pbx to a Regulatory Element in the Somatostatin Promoter: Importance of the FPWMK Motif and of the Homeodomain

1995 • 152 citations

Two Related Helix-Loop-Helix Proteins Participate in Separate Cell-Specific Complexes That Bind the Insulin Enhancer

1991 • 150 citations

The Insulin Gene Contains Multiple Transcriptional Elements That Respond to Glucose

1994 • 145 citations

Hepatocyte nuclear factor 1 alpha is expressed in a hamster insulinoma line and transactivates the rat insulin I gene.

1992 • 139 citations

Glucose modulates the binding activity of the β-cell transcription factor IUF1 in a phosphorylation-dependent manner

1994 • 134 citations

Cell-specific and ubiquitous factors are responsible for the enhancer activity of the rat insulin II gene.

1991 • 130 citations

Novel Insulin Promoter- and Enhancer-Binding Proteins That Discriminate between Pancreatic α- and β-Cells

1991 • 116 citations

The human poly(ADP-ribose) polymerase nuclear localization signal is a bipartite element functionally separate from DNA binding and catalytic activity.

1992 • 107 citations

Functional Characterization of the Transactivation Properties of the PDX-1 Homeodomain Protein

1997 • 96 citations

Homeodomain of yeast repressor alpha 2 contains a nuclear localization signal.

1990 • 87 citations

Insulin expression in pancreatic islet cells relies on cooperative interactions between the helix loop helix factor E47 and the homeobox factor STF-1

1994 • 84 citations

The insulin gene contains multiple transcriptional elements that respond to glucose.

1994 • 83 citations

Identification of the Nuclear Localization Signal of the POU Domain Protein Tst-1/Oct6

1996 • 71 citations

The helix-loop-helix transcription factor USF (upstream stimulating factor) binds to a regulatory sequence of the human insulin gene enhancer

1993 • 69 citations

Functional regions of the homeodomain protein IDX-1 required for transactivation of the rat somatostatin gene.

1996 • 59 citations

Two nuclear localization signals present in the basic-helix 1 domains of MyoD promote its active nuclear translocation and can function independently.

1995 • 56 citations

The conserved ELK-homeodomain of KNOTTED-1 contains two regions that signal nuclear localization

1996 • 54 citations

Two distinct class A helix-loop-helix transcription factors, E2A and BETA1, form separate DNA binding complexes on the insulin gene E box.

1994 • 52 citations

Nuclear localization signals, DNA binding, and transactivation properties of quail Pax-6 (Pax-QNR) isoforms.

1995 • 51 citations

Determination of Functional Domains of the Human Transcription Factor PAX8 Responsible for its Nuclear Localization and Transactivating Potential

1997 • 51 citations

Effect of 5′-Flanking Sequence Deletions on Expression of the Human Insulin Gene in Transgenic Mice

1990 • 50 citations

NOTES/Insulin Gene Expression in Nonexpressing Cells Appears To Be Regulated by Multiple Distinct Negative-Acting Control Elements

1991 • 29 citations

Functional regions of the homeodomain protein IDX-1 required for transactivation of the rat somatostatin gene

1996 • 24 citations

Insulin gene expression in nonexpressing cells appears to be regulated by multiple distinct negative-acting control elements.

1991 • 19 citations

Functional analysis of a newly identified TAAT‐box of the rat insulin‐II gene promoter

1995 • 6 citations