Concise Review: Epigenetic Mechanisms Contribute to Pluripotency and Cell Lineage Determination of Embryonic Stem Cells

Translating the Histone Code

2001 • 9,488 citations

Crystal structure of the nucleosome core particle at 2.8 Å resolution

1997 • 8,906 citations

Establishment in culture of pluripotential cells from mouse embryos

1981 • 8,424 citations

A Bivalent Chromatin Structure Marks Key Developmental Genes in Embryonic Stem Cells

2006 • 5,132 citations

Core Transcriptional Regulatory Circuitry in Human Embryonic Stem Cells

2005 • 4,388 citations

Quantitative expression of Oct-3/4 defines differentiation, dedifferentiation or self-renewal of ES cells

2000 • 3,564 citations

Formation of Pluripotent Stem Cells in the Mammalian Embryo Depends on the POU Transcription Factor Oct4

1998 • 3,360 citations

Functional Expression Cloning of Nanog, a Pluripotency Sustaining Factor in Embryonic Stem Cells

2003 • 3,230 citations

The Homeoprotein Nanog Is Required for Maintenance of Pluripotency in Mouse Epiblast and ES Cells

2003 • 3,179 citations

Epigenetic Reprogramming in Mammalian Development

2001 • 2,978 citations

Polycomb complexes repress developmental regulators in murine embryonic stem cells

2006 • 2,473 citations

The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells

2006 • 2,414 citations

Full-term development of mice from enucleated oocytes injected with cumulus cell nuclei

1998 • 2,257 citations

Control of Developmental Regulators by Polycomb in Human Embryonic Stem Cells

2006 • 2,241 citations

BMP Induction of Id Proteins Suppresses Differentiation and Sustains Embryonic Stem Cell Self-Renewal in Collaboration with STAT3

2003 • 2,079 citations

Active genes are tri-methylated at K4 of histone H3

2002 • 2,064 citations

Chromatin modification and epigenetic reprogramming in mammalian development

2002 • 1,870 citations

Methylation-Induced Repression— Belts, Braces, and Chromatin

1999 • 1,823 citations

Histone acetylation and transcriptional regulatory mechanisms

1998 • 1,793 citations

Histone H4-K16 Acetylation Controls Chromatin Structure and Protein Interactions

2006 • 1,777 citations

Role of Histone H3 Lysine 9 Methylation in Epigenetic Control of Heterochromatin Assembly

2001 • 1,685 citations

Formation of germ-line chimaeras from embryo-derived teratocarcinoma cell lines

1984 • 1,518 citations

Cooperation between Complexes that Regulate Chromatin Structure and Transcription

2002 • 1,474 citations

Chromatin signatures of pluripotent cell lines

2006 • 1,288 citations

Embryo-Derived Stem Cells: Of Mice and Men

2001 • 1,274 citations

Role of Histone H3 Lysine 27 Methylation in X Inactivation

2003 • 1,175 citations

Hyperdynamic Plasticity of Chromatin Proteins in Pluripotent Embryonic Stem Cells

2006 • 973 citations

In vitro differentiation of embryonic stem cells

1995 • 965 citations

Molecular basis for the discrimination of repressive methyl-lysine marks in histone H3 by Polycomb and HP1 chromodomains

2003 • 961 citations

REST and Its Corepressors Mediate Plasticity of Neuronal Gene Chromatin throughout Neurogenesis

2005 • 900 citations

Establishment and Maintenance of a Heterochromatin Domain

2002 • 895 citations

Early Lineage Segregation between Epiblast and Primitive Endoderm in Mouse Blastocysts through the Grb2-MAPK Pathway

2006 • 877 citations

Epigenetic Codes for Heterochromatin Formation and Silencing

2002 • 858 citations

The Glucocorticoid Receptor: Rapid Exchange with Regulatory Sites in Living Cells

2000 • 791 citations

The histone modification pattern of active genes revealed through genome-wide chromatin analysis of a higher eukaryote

2004 • 788 citations

The key to development: interpreting the histone code?

2005 • 729 citations

ATP-dependent remodeling and acetylation as regulators of chromatin fluidity

1999 • 705 citations

Regulatory networks in embryo-derived pluripotent stem cells

2005 • 658 citations

Myogenic Regulatory Factors and the Specification of Muscle Progenitors in Vertebrate Embryos

2002 • 566 citations

Chd1 chromodomain links histone H3 methylation with SAGA- and SLIK-dependent acetylation

2005 • 504 citations

Global Nature of Dynamic Protein-Chromatin Interactions In Vivo: Three-Dimensional Genome Scanning and Dynamic Interaction Networks of Chromatin Proteins

2004 • 454 citations

Morphogens, their identification and regulation

2004 • 437 citations

Spatial Distribution of Di- and Tri-methyl Lysine 36 of Histone H3 at Active Genes

2005 • 431 citations

Epigenetic Control of Mouse Oct-4 Gene Expression in Embryonic Stem Cells and Trophoblast Stem Cells

2004 • 400 citations

An improved single-cell cDNA amplification method for efficient high-density oligonucleotide microarray analysis

2006 • 385 citations

CpG-binding Protein (CXXC Finger Protein 1) Is a Component of the Mammalian Set1 Histone H3-Lys4 Methyltransferase Complex, the Analogue of the Yeast Set1/COMPASS Complex

2005 • 320 citations

Histone H3 variants specify modes of chromatin assembly

2002 • 320 citations

New POU dimer configuration mediates antagonistic control of an osteopontin preimplantation enhancer by Oct-4 and Sox-2

1998 • 313 citations

Neural induction promotes large-scale chromatin reorganisation of theMash1locus

2005 • 281 citations

Control of SRF binding to CArG box chromatin regulates smooth muscle gene expression in vivo

2005 • 269 citations

Physiological rationale for responsiveness of mouse embryonic stem cells to gp130 cytokines

2001 • 264 citations

Epigenetic characterization of the early embryo with a chromatin immunoprecipitation protocol applicable to small cell populations

2006 • 263 citations

Stabilization of Xist RNA Mediates Initiation of X Chromosome Inactivation

1997 • 247 citations

Epigenetic Inheritance of Active Chromatin After Removal of the Main Transactivator

1999 • 239 citations

The Expression of Endothelial Nitric-oxide Synthase Is Controlled by a Cell-specific Histone Code

2005 • 227 citations

Histone Code Modifications on Pluripotential Nuclei of Reprogrammed Somatic Cells

2004 • 204 citations

PR-Set7-dependent methylation of histone H4 Lys 20 functions in repression of gene expression and is essential for mitosis

2005 • 194 citations

EZH2 and Histone 3 Trimethyl Lysine 27 Associated with Il4 and Il13 Gene Silencing in TH1 Cells

2005 • 153 citations

Covalent Histone Modifications Underlie the Developmental Regulation of Insulin Gene Transcription in Pancreatic β Cells

2003 • 141 citations

Polycomb group protein complexes exchange rapidly in livingDrosophila

2005 • 133 citations

Formation of an Active Tissue-Specific Chromatin Domain Initiated by Epigenetic Marking at the Embryonic Stem Cell Stage

2005 • 130 citations

Monitoring dynamic protein interactions with photoquenching FRET

2006 • 91 citations

IN VIVO METHYLATION AND TURNOVER OF RAT BRAIN HISTONES

1974 • 79 citations

Quantitative Imaging of Protein Interactions in the Cell Nucleus

2005 • 78 citations

Chromatin Modification and the Endothelial-specific Activation of the E-selectin Gene

2005 • 72 citations

Genome-wide analysis of DNA methylation status of CpG islands in embryoid bodies, teratomas, and fetuses

2003 • 65 citations

Lineage Promiscuity and Plasticity in Hematopoietic Development

2005 • 40 citations

Histone modification in constitutive heterochromatin versus unexpressed euchromatin in human cells

2004 • 25 citations