Positron Emission Tomographic Evidence of Similarity Between Obesity and Drug Addiction

Central nervous system control of food intake

2000 • 6,305 citations

Environmental Contributions to the Obesity Epidemic

1998 • 2,243 citations

Cellular and Molecular Mechanisms of Drug Dependence

1988 • 2,094 citations

Brain dopamine and obesity

2001 • 1,817 citations

The Reward Deficiency Syndrome: A Biogenetic Model for the Diagnosis and Treatment of Impulsive, Addictive and Compulsive Behaviors

2000 • 929 citations

Decreased dopamine D₂ receptor availability is associated with reduced frontal metabolism in cocaine abusers

1993 • 906 citations

Low Level of Brain Dopamine D₂ Receptors in Methamphetamine Abusers: Association With Metabolism in the Orbitofrontal Cortex

2001 • 901 citations

Stress-induced eating.

1994 • 847 citations

Allelic Association of the D2 Dopamine Receptor Gene With Receptor-Binding Characteristics in Alcoholism or Gene ism

1991 • 656 citations

Decreases in Dopamine Receptors but not in Dopamine Transporters in Alcoholics

1996 • 603 citations

Prevalence of Attempting Weight Loss and Strategies for Controlling Weight

1999 • 539 citations

“Nonhedonic” food motivation in humans involves dopamine in the dorsal striatum and methylphenidate amplifies this effect

2002 • 447 citations

Medicinal strategies in the treatment of obesity

2000 • 436 citations

Absence of opiate rewarding effects in mice lacking dopamine D2 receptors

1997 • 435 citations

Prediction of Reinforcing Responses to Psychostimulants in Humans by Brain Dopamine D₂ Receptor Levels

1999 • 406 citations

Reinforcing effects of psychostimulants in humans are associated with increases in brain dopamine and occupancy of D(2) receptors.

1999 • 403 citations

Imaging endogenous dopamine competition with [¹¹C]raclopride in the human brain

1994 • 378 citations

Dopamine Production in the Caudate Putamen Restores Feeding in Dopamine-Deficient Mice

2001 • 345 citations

Model for the regulation of energy balance and adiposity by the central nervous system

1999 • 339 citations

Overexpression of dopamine D2 receptors reduces alcohol self‐administration

2001 • 318 citations

Dopamine D2 Receptor Availability in Opiate-Dependent Subjects before and after Naloxone-Precipitated Withdrawal

1997 • 286 citations

Modulation of feeding‐induced activation of mesolimbic dopamine transmission by appetitive stimuli and its relation to motivational state

1999 • 276 citations

Palatability and the Micro-structure of Feeding in Humans: the Appetizer Effect

1996 • 235 citations

Mesolimbic dopaminergic system activity as a function of food reward: A microdialysis study

1996 • 228 citations

Impact of moods and social context on eating behavior

2001 • 222 citations

Low Serotonin and Dopamine Metabolite Concentrations in Cerebrospinal Fluid From Bulimic Patients With Frequent Binge Episodes

1992 • 217 citations

Alcohol preference and sensitivity are markedly reduced in mice lacking dopamine D2 receptors

1998 • 214 citations

Acute tolerance development to the cardiovascular and subjective effects of cocaine.

1985 • 213 citations

Haloperidol antagonism of cue-elicited cocaine craving

1996 • 205 citations

D2 dopamine receptor gene and obesity

1994 • 195 citations

The Role of Serotonin in Eating Disorders

1990 • 172 citations

Strategies and Potential Molecular Targets for Obesity Treatment

1998 • 161 citations

Effects of Naltrexone on Food Intake and Changes in Subjective Appetite During Eating: Evidence for Opioid Involvement in the Appetizer Effect

1997 • 160 citations

D2 receptors binding potential is not affected by Taq1 polymorphism at the D2 receptor gene

1998 • 156 citations

Genetic variants of the human obesity (OB) gene: association with body mass index in young women, psychiatric symptoms, and interaction with the dopamine D2 receptor (DRD2) gene.

1996 • 134 citations

Effect of cocaine self-administration on dopamine D2 receptors in rhesus monkeys

1998 • 128 citations

Enhanced resting activity of the oral somatosensory cortex in obese subjects

2002 • 121 citations

CSF monoamine levels in normal-weight bulimia: evidence for abnormal noradrenergic activity

1990 • 97 citations

Acute and Chronic Dopamine Dynamics in a Nonhuman Primate Model of Recreational Cocaine Use

2000 • 95 citations

Endurance training effects on striatal D2 dopamine receptor binding and striatal dopamine metabolite levels

1987 • 93 citations

The advantage of using positron emission tomography in drug research

1996 • 93 citations

Biochemical mechanisms responsible for the attenuation of diabetic and obese conditions in ob/ob mice treated with dopaminergic agonists

1999 • 88 citations

Relationships between Mesolimbic Dopamine Function and Eating Behaviora

1988 • 75 citations

Behavioral and Cardiovascular Effects of Intravenous Methylphenidate in Normal Subjects and Cocaine Abusers

1997 • 70 citations

Intense sweeteners and energy density of foods: implications for weight control

1999 • 65 citations

Extracellular dopamine in the nucleus accumbens of the rat during treadmill running

1995 • 55 citations

Antagonism of behavioral effects of cocaine by selective dopamine receptor blockers

1990 • 55 citations

Effects of phentermine on striatal dopamine and serotonin release in conscious rats:In vivo microdialysis study

1998 • 50 citations

Cortical tongue area studied by chronically implanted subdural electrodes—with special reference to parietal motor and frontal sensory responses

1994 • 47 citations

Neuropsychiatric disorders: Investigation of schizophrenia and substance abuse

1992 • 43 citations

Behavioural microanalysis of the role of dopamine in amphetamine anorexia

1988 • 38 citations

β-Carbolines characterized as benzodiazepine receptor agonists and inverse agonists produce bi-directional changes in palatable food consumption

1986 • 24 citations

Physical activity, total energy expenditure, and food intake in grossly obese and normal weight women

1995 • 23 citations

The effects of cocaine on food intake of baboons before, during, and after a period of repeated desipramine

1990 • 20 citations