Alcohol preference and sensitivity are markedly reduced in mice lacking dopamine D2 receptors

A psychomotor stimulant theory of addiction.

1987 • 2,704 citations

Cellular and Molecular Mechanisms of Drug Dependence

1988 • 2,094 citations

Low level of response to alcohol as a predictor of future alcoholism

1994 • 828 citations

Parkinsonian-like locomotor impairment in mice lacking dopamine D2 receptors

1995 • 649 citations

Molecular Mechanisms of Drug Reinforcement and Addiction

1995 • 573 citations

Voluntary consumption of ethanol in 15 inbred mouse strains

1993 • 564 citations

Differences in Alcohol Preference among Inbred Strains of Mice

1959 • 453 citations

Locomotor Activity in D2 Dopamine Receptor-Deficient Mice Is Determined by Gene Dosage, Genetic Background, and Developmental Adaptations

1998 • 448 citations

Pituitary Lactotroph Hyperplasia and Chronic Hyperprolactinemia in Dopamine D2 Receptor-Deficient Mice

1997 • 423 citations

Elevated alcohol consumption in null mutant mice lacking 5–HT1B serotonin receptors

1996 • 356 citations

Localization of Genes Affecting Alcohol Drinking in Mice

1994 • 298 citations

Ethanol preferentially stimulates dopamine release in the nucleus accumbens of freely moving rats

1985 • 279 citations

The A1 Allele at the D2 Dopamine Receptor Gene and Alcoholism

1993 • 274 citations

Genetic differences in the rewarding and activating effects of morphine and ethanol

1992 • 271 citations

Identifying genes for alcohol and drug sensitivity: recent progress and future directions

1999 • 259 citations

Oral ethanol self-administration in rats is reduced by the administration of dopamine and glutamate receptor antagonists into the nucleus accumbens

1992 • 257 citations

Effects of Acute and Repeated Ethanol Exposures on the Locomotor Activity of BXD Recombinant Inbred Mice

1995 • 221 citations

Pharmacological Effects of Ethanol on the Nervous System

1997 • 214 citations

Neurochemical Bases of Locomotion and Ethanol Stimulant Effects

1996 • 209 citations

Identification of sex–specific quantitative trait loci controlling alcohol preference in C57BL/6 mice

1996 • 188 citations

Densities of dopamine D2 receptors are reduced in CNS regions of alcohol-preferring P rats

1993 • 166 citations

Effects of D1 and D2 dopamine receptor agents on ethanol consumption in the high-alcohol-drinking (HAD) line of rats

1993 • 151 citations

Differences in response to the aversive properties of ethanol in rats selectively bred for oral ethanol preference

1988 • 138 citations

Alcohol Acceptance, Preference, and Sensitivity in Mice. II. Quantitative Trait Loci Mapping Analysis Using BXD Recombinant Inbred Strains

1995 • 137 citations

D2 Dopamine Receptor Gene Is Associated but Not Linked With Alcoholism

1991 • 133 citations

Review of the putative association of dopamine D2 receptor and alcoholism: A meta‐analysis

1993 • 131 citations

Confirmation of Quantitative Trait Loci for Alcohol Preference in Mice

1998 • 129 citations

Lack of association between an RFLP near the D2 dopamine receptor gene and severe alcoholism

1992 • 126 citations

Linkage Disequilibria at the D2 Dopamine Receptor Locus (DRD2) in Alcoholics and Controls

1994 • 108 citations

Localization of Genes Mediating Acute and Sensitized Locomotor Responses to Cocaine in BXD/Ty Recombinant Inbred Mice

1998 • 101 citations

Genetic Analyses of the Biphasic Nature of the Alcohol Dose‐Response Curve

1991 • 94 citations

Genotypic differences in brain dopamine receptor function in the DBA/2J and C57BL/6J inbred mouse strains

1994 • 86 citations

Indexing Withdrawal in Mice: Matching Genotypes for Exposure in Studies Using Ethanol Vapor Inhalation

1994 • 79 citations

Dopamine receptor agonist reduces ethanol self-administration in the ethanol-preferring C57BL/6J inbred mouse

1994 • 79 citations

Distinctions among sedative, disinhibitory, and ataxic properties of ethanol in inbred and selectively bred mice

1990 • 77 citations

Dopamine D₂ Receptor Gene Expression in Rat Lines Selected for Differences in Voluntary Alcohol Consumption

1994 • 36 citations

Pharmacogenetics of cocaine: II. Mesocorticolimbic and striatal dopamine and cocaine receptors in C57BL and DBA mice

1993 • 29 citations

Genetic influences on locomotor activating effects of ethanol and sodium pentobarbital

1994 • 20 citations

Reduction of voluntary alcohol intake in the rat by modulation of the dopaminergic mesolimbic system: Transplantation of ventral mesencephalic cell suspensions

1994 • 19 citations

Differences in Free‐Choice Ethanol Acceptance between Taste Aversion‐Prone and Taste Aversion‐Resistant Rats

1997 • 19 citations

Single genes and complex phenotypes

1998 • 9 citations