Factors in the Pathophysiology of the Liver Ischemia-Reperfusion Injury

NF-κB AND REL PROTEINS: Evolutionarily Conserved Mediators of Immune Responses

1998 • 5,178 citations

Nuclear factor-κB in cancer development and progression

2006 • 3,334 citations

NF-κB: Ten Years After

1996 • 3,008 citations

Nitric oxide synthases in mammals

1994 • 2,762 citations

A human intercellular adhesion molecule (ICAM-1) distinct from LFA-1.

1986 • 1,428 citations

Oxidative stress and gene regulation

2000 • 1,298 citations

Strategies for Safer Liver Surgery and Partial Liver Transplantation

2007 • 966 citations

Molecular mechanisms of hepatic ischemia-reperfusion injury and preconditioning

2003 • 826 citations

Platelet-Derived Serotonin Mediates Liver Regeneration

2006 • 758 citations

Neutrophils contribute to ischemia/reperfusion injury in rat liver in vivo

1990 • 739 citations

Prophylactic Treatment with Cerium Oxide Nanoparticles Attenuate Hepatic Ischemia Reperfusion Injury in Sprague Dawley Rats

2017 • 696 citations

Apoptosis and Necrosis in the Liver: A Tale of Two Deaths?

2006 • 677 citations

Neutrophil and Kupffer cell-induced oxidant stress and ischemia-reperfusion injury in rat liver

1991 • 663 citations

Warner-Lambert/Parke-Davis award lecture. Cytokine-mediated activation of vascular endothelium. Physiology and pathology.

1988 • 597 citations

Hepatic ischemia-reperfusion injury

2001 • 538 citations

Protective strategies against ischemic injury of the liver

2003 • 531 citations

A Prospective Randomized Study in 100 Consecutive Patients Undergoing Major Liver Resection With Versus Without Ischemic Preconditioning

2003 • 496 citations

Role of tumor necrosis factor-α in disease states and inflammation

1993 • 415 citations

The contraction of hepatic stellate (Ito) cells stimulated with vasoactive substances

1993 • 391 citations

Oxygen-derived radicals: a link between reperfusion injury and inflammation.

1987 • 389 citations

V. Necrapoptosis and the mitochondrial permeability transition: shared pathways to necrosis and apoptosis

1999 • 379 citations

Mechanism of cell death during warm hepatic ischemia-reperfusion in rats: Apoptosis or necrosis?

2001 • 377 citations

Hepatic microcirculatory perfusion failure is a determinant of liver dysfunction in warm ischemia-reperfusion.

1994 • 374 citations

Vascular Occlusions for Liver Resections

1989 • 350 citations

THE ROLE OF THE COMPLEMENT SYSTEM IN ISCHEMIA-REPERFUSION INJURY

2004 • 328 citations

Ischemia/Reperfusion Injury

2002 • 322 citations

The role of cytokine networks in the local liver injury following hepatic ischemia/reperfusion in the rat

1996 • 312 citations

Mechanisms of ischemic injury are different in the steatotic and normal rat liver

2000 • 286 citations

Adenosine A2A receptor activation reduces hepatic ischemia reperfusion injury by inhibiting CD1d-dependent NKT cell activation

2006 • 286 citations

Ischemia-Reperfusion Injury: Processes in Pathogenetic Networks: A Review

2007 • 265 citations

Complement activates Kupffer cells and neutrophils during reperfusion after hepatic ischemia

1993 • 252 citations

The biologic characteristics of cytokines and their implication in surgical injury.

1990 • 252 citations

Intercellular adhesion molecule 1 (ICAM-1) expression and its role in neutrophil-induced ischemia-reperfusion injury in rat liver

1995 • 251 citations

APOPTOSIS OF SINUSOIDAL ENDOTHELIAL CELLS OCCURS DURING LIVER PRESERVATION INJURY BY A CASPASE-DEPENDENT MECHANISM1

1999 • 238 citations

Therapeutic approaches for ischemia/reperfusion injury in the liver

1999 • 234 citations

Tumor necrosis factor α, but not Fas, mediates hepatocellular apoptosis in the murine ischemic liver

2002 • 231 citations

A caspase inhibitor fully protects rats against lethal normothermic liver ischemia by inhibition of liver apoptosis

1999 • 224 citations

Platelets induce sinusoidal endothelial cell apoptosis upon reperfusion of the cold ischemic rat liver

2000 • 218 citations

A Prospective, Randomized, Controlled Trial Comparing Intermittent Portal Triad Clamping Versus Ischemic Preconditioning With Continuous Clamping for Major Liver Resection

2006 • 212 citations

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1990 • 211 citations

Hepatic Tumor Necrosis Factor Signaling and Nuclear Factor-κB: Effects on Liver Homeostasis and Beyond

2007 • 209 citations

Past and future approaches to ischemia-reperfusion lesion associated with liver transplantation

2006 • 203 citations

Leukocytes contribute to hepatic ischemia/reperfusion injury via intercellular adhesion molecule-1-mediated venular adherence

1995 • 192 citations

Nitric oxide in liver injury

1999 • 191 citations

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2006 • 181 citations

Centrilobular Injury Following Hypoxia in Isolated, Perfused Rat Liver

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Platelets and platelet-derived serotonin promote tissue repair after normothermic hepatic ischemia in mice

2007 • 162 citations

Technique of hepatic vascular exclusion for extensive liver resection

1992 • 161 citations

Microvascular dysfunction induced by reperfusion injury and protective effect of ischemic preconditioning

2002 • 155 citations

INTERLEUKIN 1 RECEPTOR BLOCKADE REDUCES TUMOR NECROSIS FACTOR PRODUCTION, TISSUE INJURY, AND MORTALITY AFTER HEPATIC ISCHEMIA-REPERFUSION IN THE RAT1

1997 • 148 citations

Neutrophil CD18-dependent arrest on intercellular adhesion molecule 1 (ICAM-1) in shear flow can be activated through L-selectin.

1997 • 147 citations

Formation and release of purine catabolites during hypoperfusion, anoxia, and ischemia

1987 • 143 citations

Reduction of Ischemia-Reperfusion Injury of the Liver by In Vivo Adenovirus-Mediated Gene Transfer of the Antiapoptotic Bcl-2 Gene

1999 • 142 citations

Beneficial effect of allopurinol in liver ischemia.

1985 • 142 citations

Impact of leukocyte-endothelial cell interaction in hepatic ischemia-reperfusion injury

1994 • 142 citations

Role of platelets in hepatic allograft preservation injury in the rat.

1993 • 142 citations

Complement activation following oxidative stress

1999 • 141 citations

Physiology and pathophysiology of nitric oxide.

1996 • 141 citations

Calpain Cleavage of Focal Adhesion Proteins Regulates the Cytoskeletal Attachment of Integrin αIIbβ3 (Platelet Glycoprotein IIb/IIIa) and the Cellular Retraction of Fibrin Clots

1997 • 137 citations

Hepatic Ischemia/Reperfusion in Rats Induces iNOS Gene Transcription by Activation of NF-κB

1999 • 133 citations

Dexamethasone: Benefit and Prejudice for Patients Undergoing On-Pump Coronary Artery Bypass Grafting

2005 • 131 citations

Changes in the levels of endogenous coenzyme Q homologs, α-tocopherol, and glutathione in rat liver after hepatic ischemia and reperfusion, and the effect of pretreatment with coenzyme Q10

1984 • 130 citations

Role of platelets in hepatic allograft preservation injury in the rat

1993 • 124 citations

MOLECULAR MECHANISMS OF HEPATIC ISCHEMIAREPERFUSION INJURY AND PRECONDITIONING

2003 • 119 citations

The response of the hepatocyte to ischemia

2007 • 116 citations

Endogenous adenosine inhibits platelet aggregation during myocardial ischemia in dogs.

1991 • 114 citations

Nuclear Factor-κB Is Activated by Hyperoxia but Does Not Protect from Cell Death

1997 • 106 citations

Response of plasma and tissue endothelin-1 to liver ischemia and its implication in ischemia-reperfusion injury

1995 • 104 citations

Role of Cytokines and Cytokine-Producing Cells in Reperfusion Injury to the Liver

1999 • 101 citations

L-selectin and ICAM-1 mediate reperfusion injury and neutrophil adhesion in the warm ischemic mouse liver

1998 • 100 citations

Specific Role of Interleukin-1 in Hepatic Neutrophil Recruitment after Ischemia/Reperfusion

2002 • 96 citations

Protection of the liver during hepatic surgery

2004 • 94 citations

Regulatory effects of adenosine and adenine nucleotides on oxygen radical responses of neutrophils.

1988 • 91 citations

Physiology and Pathology

1978 • 88 citations

The Role of Calcium Ions and Calcium Channel Entry Blockers in Experimental Ischemia–Reperfusion-induced Liver Injury

1991 • 86 citations

Nitric oxide and peroxynitrite-mediated pulmonary cell death

1998 • 84 citations

Blockade of the ?-arginine/NO synthase pathway worsens hepatic apoptosis and liver transplant preservation injury

2002 • 82 citations

Inflammatory Modulation of Hepatocyte Apoptosis by Nitric Oxide: In Vivo, In Vitro, and In Silico Studies

2004 • 80 citations

Redox Regulation of Cytokine Expression in Kupffer Cells

2002 • 79 citations

Protective effect of a human C5a receptor antagonist against hepatic ischaemia-reperfusion injury in rats

2004 • 79 citations

Lymphocyte function during hepatic ischemia/reperfusion injury

2007 • 78 citations

Up-Regulation Of Oxygen-Derived Free Radicals By Interleukin-1 In Hepatic Ischemia/Reperfusion Injury1

1997 • 77 citations

Molecular signaling pathways in ischemia/reperfusion.

2004 • 77 citations

Modulation of ischemia-reperfusion-induced hepatic injury by kupffer cells

1994 • 77 citations

REGULATION OF THE COMPLEMENT CASCADE BY SOLUBLE COMPLEMENT RECEPTOR TYPE 1

1995 • 76 citations

IMPACT OF N-ACETYLCYSTEINE ON THE HEPATIC MICROCIRCULATION AFTER ORTHOTOPIC LIVER TRANSPLANTATION1

1996 • 75 citations

Role of NF-κB on liver cold ischemia-reperfusion injury

2002 • 74 citations

REMODELING OF HEPATIC MICROVASCULAR RESPONSIVENESS AFTER ISCHEMIA/REPERFUSION

1997 • 72 citations

Tumor necrosis factor-induced, superoxide-mediated neutrophil accumulation in cold ischemic/reperfused rat liver

1997 • 69 citations

Role of Exogenousl-Arginine in Hepatic Ischemia–Reperfusion Injury

1997 • 67 citations

Tumor necrosis factor-induced, superoxide-mediated neutrophil accumulation in cold ischemic/reperfused rat liver

1997 • 66 citations

Efficacy of intraportal injection of anti-ICAM-1 monoclonal antibody against liver cell injury following warm ischemia in the rat

1995 • 66 citations

NF-κB in transplantation: friend or foe?

2001 • 66 citations

Leukocyte stasis in hepatic sinusoids

1996 • 65 citations

Liver transplantation and rejection: an overview.

1999 • 65 citations

Ischemic preconditioning and intermittent clamping improve murine hepatic microcirculation and Kupffer cell function after ischemic injury

2004 • 61 citations

Inosine released after hypoxia activates hepatic glucose liberation through A₃adenosine receptors

2005 • 58 citations

PATHOGENIC ROLE OF KUPFFER CELL ACTIVATION IN THE REPERFUSION INJURY OF COLD-PRESERVED LIVER

1994 • 53 citations

The involvement of reactive oxygen species in hypoxic injury to rat liver.

1988 • 52 citations

Biochemical aspects of cellular oxidative stress.

1988 • 52 citations

Regulation of hepatic blood flow during resuscitation from hemorrhagic shock: role of NO and endothelins

1997 • 51 citations

PATHOGENIC ROLE OF KUPFFER CELL ACTIVATION IN THE REPERFUSION INJURY OF COLD-PRESERVED LIVER

1994 • 44 citations

Preventive Effects of Superoxide Dismutase Derivatives Modified with Monosaccharides on Reperfusion Injury in Rat Liver Transplantation

1997 • 43 citations

Changes in creatine phosphate, inorganic phosphate, and the purine pattern in dog hearts with time of coronary artery occlusion and effect thereon of mioflazine, a nucleoside transport inhibitor

1986 • 42 citations

Donor graft adenoviral iNOS gene transfer ameliorates rat liver transplant preservation injury and improves survival

2006 • 40 citations

BACKGROUND AND PROGNOSTIC IMPLICATIONS OF PERIREPERFUSION TISSUE INJURIES IN HUMAN LIVER TRANSPLANTS

1998 • 39 citations

Modulation of mitochondrial calcium management attenuates hepatic warm ischemia-reperfusion injury

2005 • 39 citations

Reperfusion injury of the liver.

1991 • 39 citations

Expression of cytokine-dependent adhesion molecules in postreperfusion biopsy specimens of liver allografts

1994 • 37 citations

Factors during donor care that may affect liver transplantation outcome

2004 • 36 citations

Involvement of endothelin/ nitric oxide balance in hepatic ischemia/ reperfusion injury

1999 • 33 citations

Protective effect of a human C5a receptor antagonist against hepatic ischaemia-reperfusion injury in rats

2004 • 28 citations

Mecanismos moleculares en el daño por isquemia-reperfusión hepática y en el preacondicionamiento isquémico

2005 • 26 citations

Factors during Donor Care That May Affect Liver Transplantation Outcome

2004 • 25 citations

Allopurinol Effects in Rat Liver Transplantation on Recovery of Energy Metabolism and Free Radical-Induced Damage

1995 • 25 citations

Nitric oxide mediates the blood flow response to intravenous adenosine in the rabbit.

1994 • 21 citations

Ischaemic preconditioning modulates the activity of Kupffer cells during in vivo reperfusion injury of rat liver

2003 • 17 citations

Protective effects of free radical scavenger and antioxidant administration on ischemic liver cell injury.

1987 • 17 citations

Improvement of Normothermic Rat Liver Ischemia/Reperfusion by Muramyl Dipeptide

1998 • 14 citations

Osteogenic Protein-1 Induces Bone Formation in the Presence of Bacterial Infection in a Rat Intramuscular Osteoinduction Model

2004 • 12 citations