INTERLEUKIN 1 RECEPTOR BLOCKADE REDUCES TUMOR NECROSIS FACTOR PRODUCTION, TISSUE INJURY, AND MORTALITY AFTER HEPATIC ISCHEMIA-REPERFUSION IN THE RAT1

Experimental pathology of the liver

1931 • 3,113 citations

Shock and Tissue Injury Induced by Recombinant Human Cachectin

1986 • 2,587 citations

Interleukin-1 and interleukin-1 antagonism

1991 • 2,276 citations

Neutrophil-activating peptide-1/interleukin 8, a novel cytokine that activates neutrophils.

1989 • 1,993 citations

Tumor necrosis factor (cachectin) is an endogenous pyrogen and induces production of interleukin 1.

1986 • 1,501 citations

Interleukin-1 receptor antagonist activity of a human interleukin-1 inhibitor

1990 • 1,143 citations

Primary structure and functional expression from complementary DNA of a human interleukin-1 receptor antagonist

1990 • 1,095 citations

Interleukin 1 induces a shock-like state in rabbits. Synergism with tumor necrosis factor and the effect of cyclooxygenase inhibition.

1988 • 990 citations

Interleukin-1 receptor antagonist reduces mortality from endotoxin shock

1990 • 865 citations

Role of tumor necrosis factor-alpha in the pathophysiologic alterations after hepatic ischemia/reperfusion injury in the rat.

1990 • 828 citations

NEUTROPHIL INFILTRATION AS AN IMPORTANT FACTOR IN LIVER ISCHEMIA AND REPERFUSION INJURY

1993 • 799 citations

Biological properties of recombinant human monocyte-derived interleukin 1 receptor antagonist.

1990 • 569 citations

Prevention of lung reperfusion injury in rabbits by a monoclonal antibody against interleukin-8

1993 • 529 citations

A specific receptor antagonist for interleukin 1 prevents Escherichia coli ‐induced shock in rabbits

1991 • 435 citations

Extended Preservation of Human Liver Grafts With UW Solution

1989 • 405 citations

Hypoxia-mediated induction of endothelial cell interleukin-1 alpha. An autocrine mechanism promoting expression of leukocyte adhesion molecules on the vessel surface.

1992 • 341 citations

Interleukin-1 receptor blockade improves survival and hemodynamic performance in Escherichia coli septic shock, but fails to alter host responses to sublethal endotoxemia.

1992 • 338 citations

Interleukin 1 (IL-1) gene expression, synthesis, and effect of specific IL-1 receptor blockade in rabbit immune complex colitis.

1990 • 333 citations

Molecular Cloning and Expression of Rat Interleukin-1α cDNA

1989 • 332 citations

Effects of immune complexes on production by human monocytes of interleukin 1 or an interleukin 1 inhibitor.

1985 • 325 citations

Interleukin 1 beta induces the formation of nitric oxide by beta-cells purified from rodent islets of Langerhans. Evidence for the beta-cell as a source and site of action of nitric oxide.

1992 • 283 citations

Staphylococcus epidermidis induces complement activation, tumor necrosis factor and interleukin-1, a shock-like state and tissue injury in rabbits without endotoxemia. Comparison to Escherichia coli.

1991 • 248 citations

THE PRODUCTION OF TUMOR NECROSIS FACTOR ALPHA AND THE DEVELOPMENT OF A PULMONARY CAPILLARY INJURY FOLLOWING HEPATIC ISCHEMIA/REPERFUSION

1990 • 193 citations

Interleukin 1 and Tumor Necrosis Factor Production as the Initial Stimulants of Liver Ischemia and Reperfusion Injury

1994 • 153 citations

A urine inhibitor of interleukin 1 activity affects both interleukin 1 alpha and 1 beta but not tumor necrosis factor alpha.

1987 • 142 citations

Induction by Toxic-Shock-Syndrome Toxin-1 of a Circulating Tumor Necrosis Factor-Like Substance in Rabbits and of Immunoreactive Tumor Necrosis Factor and Interleukin-1 from Human Mononuclear Cells

1988 • 99 citations

Effect of interleukin-1 (IL-1) blockade on cytokine synthesis: II. IL-1 receptor antagonist inhibits lipopolysaccharide-induced cytokine synthesis by human monocytes

1992 • 96 citations

Priming and Stimulation of Bovine Neutrophils by Recombinant Human interleukin-1 Alpha and Tumor Necrosis Factor Alpha

1991 • 91 citations

Synthesis and release of interleukin 1 by reoxygenated human mononuclear phagocytes.

1992 • 88 citations

Detection of interleukin 1 alpha and 1 beta in rabbit tissues during endotoxemia using sensitive radioimmunoassays

1991 • 78 citations

Neutrophils, cytokines, and adhesion molecules in hepatic ischemia and reperfusion injury.

1994 • 76 citations

THE BENEFICIAL EFFECT OF CYCLOSPORINE ON LIVER ISCHEMIA IN RATS

1989 • 60 citations

Hepatic ischemia models for determining the effects of ATP-MgCl2 treatment

1986 • 50 citations

Liver Procurement for Orthotopic Transplantation: An Analysis of the Pittsburgh Experience

1984 • 31 citations

The Effect of Hypothermia on Liver Adenosine Triphosphate (ATP) Recovery Following Combined Shock and Ischemia

1992 • 22 citations