The Core Promoter Region of the Tumor Necrosis Factor α Gene Confers Phorbol Ester Responsiveness to Upstream Transcriptional Activators

Molecular Cloning. A Laboratory Manual

1983 • 27,328 citations

The role of protein kinase C in cell surface signal transduction and tumour promotion

1984 • 7,521 citations

Inositol trisphosphate and diacylglycerol as second messengers

1984 • 3,535 citations

Phorbol ester-inducible genes contain a common cis element recognized by a TPA-modulated trans-acting factor

1987 • 3,057 citations

Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133

1989 • 2,486 citations

An inducible transcription factor activates expression of human immunodeficiency virus in T cells

1987 • 2,149 citations

Purified transcription factor AP-1 interacts with TPA-inducible enhancer elements

1987 • 2,107 citations

Fos and jun: The AP-1 connection

1988 • 1,597 citations

Transcriptional interference between c-Jun and the glucocorticoid receptor: Mutual inhibition of DNA binding due to direct protein-protein interaction

1990 • 1,583 citations

The promoter-specific transcription factor Sp1 binds to upstream sequences in the SV40 early promoter

1983 • 1,471 citations

Transcription factor AP-2 mediates induction by two different signal-transduction pathways: Protein kinase C and cAMP

1987 • 1,391 citations

GAL4-VP16 is an unusually potent transcriptional activator

1988 • 1,379 citations

Binding of a nuclear protein to the cyclic-AMP response element of the somatostatin gene

1987 • 1,364 citations

Activation of protein kinase C decreases phosphorylation of c-Jun at sites that negatively regulate its DNA-binding activity

1991 • 1,071 citations

Transcription factor ATF cDNA clones: an extensive family of leucine zipper proteins able to selectively form DNA-binding heterodimers.

1989 • 1,046 citations

Five intermediate complexes in transcription initiation by RNA polymerase II

1989 • 1,033 citations

Mechanism of transcriptional activation by Sp1: Evidence for coactivators

1990 • 1,029 citations

Prolonged activation of jun and collagenase genes by tumour necrosis factor-α

1989 • 726 citations

Human CCAAT-binding proteins have heterologous subunits

1988 • 712 citations

GC box binding induces phosphorylation of Sp1 by a DNA-dependent protein kinase

1990 • 677 citations

Transcription activation by the adenovirus E1a protein

1989 • 667 citations

Human Lymphotoxin and tumor necrosis factor genes: structure, homology and chromosomal localization

1985 • 509 citations

fos-associated cellular p39 is related to nuclear transcription factor AP-1

1988 • 508 citations

MINIREVIEW: Cyclic AMP Response Element Binding Proteins: A Cornucopia of Transcription Factors

1990 • 394 citations

Tumor necrosis factor stimulates interleukin-1 and prostaglandin E2 production in resting macrophages

1986 • 344 citations

Commitment and activation at pol II promoters: A tail of protein-protein interactions

1990 • 332 citations

Tumor necrosis factor provokes superoxide anion generation from neutrophils

1986 • 307 citations

Functional heterogeneity of mammalian TATA-box sequences revealed by interaction with a cell-specific enhancer

1990 • 193 citations

Tumors Producing Human Tumor Necrosis Factor Induce Hypercalcemia and Osteoclastic Bone Resorption in Nude Mice*

1989 • 154 citations

Distinct Adenosine 3′,5′-Monophosphate and Phorbol Ester-Responsive Signal Transduction Pathways Converge at the Level of Transcriptional Activation by the Interactions of DNA-Binding Proteins

1989 • 151 citations

The history, properties, and biological effects of cachectin

1988 • 143 citations

Genetic analysis of the human tumor necrosis factor alpha/cachectin promoter region in a macrophage cell line.

1989 • 122 citations

Identification of a tumor necrosis factor-responsive element in the tumor necrosis factor alpha gene

1991 • 86 citations

E1A-dependent trans-activation of the c-fos promoter requires the TATAA sequence.

1990 • 55 citations