Characterization of cytokine LD78 gene promoters: positive and negative transcriptional factors bind to a negative regulatory element common to LD78, interleukin-3, and granulocyte-macrophage colony-stimulating factor gene promoters.

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

[57] Sequencing end-labeled DNA with base-specific chemical cleavages

1980 • 15,302 citations

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

1983 • 11,902 citations

Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells.

1982 • 8,069 citations

A conserved AU sequence from the 3′ untranslated region of GM-CSF mRNA mediates selective mRNA degradation

1986 • 4,200 citations

Recombinant Genomes Which Express Chloramphenicol Acetyltransferase in Mammalian Cells

1982 • 3,106 citations

Firefly luciferase gene: structure and expression in mammalian cells.

1987 • 3,088 citations

Equilibria and kinetics of lac repressor-operator interactions by polyacrylamide gel electrophoresis

1981 • 2,828 citations

DNAase footprinting a simple method for the detection of protein-DNA binding specificity

1978 • 2,092 citations

Properties of the Novel Proinflammatory Supergene "Intercrine" Cytokine Family

1991 • 1,864 citations

CAT constructions with multiple unique restriction sites for the functional analysis of eukaryotic promoters and regulatory elements

1987 • 1,792 citations

Identification of a common nucleotide sequence in the 3'-untranslated region of mRNA molecules specifying inflammatory mediators.

1986 • 1,591 citations

A nuclear factor that binds to a conserved sequence motif in transcriptional control elements of immunoglobulin genes

1986 • 1,150 citations

The macrophage and B cell-specific transcription factor PU.1 is related to the ets oncogene

1990 • 993 citations

Firefly Luciferase Gene: Structure and Expression in Mammalian Cells

1987 • 924 citations

Two distinct transcription factors bind to the HSV thymidine kinase promoter in vitro

1985 • 805 citations

High efficiency polyoma DNA transfection of chloroquine treated cells

1983 • 711 citations

Biology of the rantes/sis cytokine family

1991 • 688 citations

A protein binds to a satellite DNA repeat at three specific sites that would be brought into mutual proximity by DNA folding in the nucleosome

1984 • 674 citations

Regulation of Interleukin-2 Gene Enhancer Activity by the T Cell Accessory Molecule CD28

1991 • 660 citations

Interleukin 3-dependent and -independent mast cells stimulated with IgE and antigen express multiple cytokines.

1989 • 557 citations

Identification and characterization of an inhibitor of haemopoietic stem cell proliferation

1990 • 470 citations

cDNA sequences of two inducible T-cell genes.

1989 • 392 citations

Macrophage inflammatory protein 1 modulates macrophage function.

1992 • 321 citations

Negative regulation of human c-fos expression by thes retinoblastoma gene product

1990 • 298 citations

Cloning and characterization of a cDNA for murine macrophage inflammatory protein (MIP), a novel monokine with inflammatory and chemokinetic properties.

1988 • 285 citations

Structure of the chromosomal gene for granulocyte-macrophage colony stimulating factor: comparison of the mouse and human genes.

1985 • 257 citations

Cooperativity and hierarchical levels of functional organization in the SV40 enhancer

1988 • 238 citations

Enhancing and suppressing effects of recombinant murine macrophage inflammatory proteins on colony formation in vitro by bone marrow myeloid progenitor cells

1990 • 236 citations

Sequence-Specific Binding of Human Ets-1 to the T Cell Receptor α Gene Enhancer

1990 • 229 citations

Demonstration of stem cell inhibition and myeloprotective effects of SCI/rhMIP1 alpha in vivo

1992 • 178 citations

Acute-phase reaction induces a specific complex between hepatic nuclear proteins and the interleukin 6 response element of the rat alpha 2-macroglobulin gene.

1990 • 177 citations

Constitutive and IL-6-induced nuclear factors that interact with the human C-reactive protein promoter.

1990 • 176 citations

Mitogenic activation of human T cells induces two closely related genes which share structural similarities with a new family of secreted factors.

1989 • 152 citations

Two genetically defined trans-acting loci coordinately regulate overlapping sets of liver-specific genes

1990 • 149 citations

Myeloid and megakaryocytic properties of K-562 cell lines.

1983 • 146 citations

Properties Of The Novel Proinflammatory Supergene Intercrine Cytokine Family

1991 • 136 citations

A cDNA Clone Used to Study mRNA Inducible in Human Tonsillar Lymphocytes by a Tumor Promoter1

1986 • 122 citations

Regulatory elements responsible for inducible expression of the granulocyte colony-stimulating factor gene in macrophages.

1990 • 122 citations

[18] Oligonucleotide-directed construction of mutations via gapped duplex DNA

1987 • 119 citations

Two inflammatory mediator cytokine genes are closely linked and variably amplified on chromosome 17q

1990 • 119 citations

Structures of human genes coding for cytokine LD78 and their expression.

1990 • 118 citations

Effects of hematopoietic growth factors on the survival of primitive stem cells in liquid suspension culture

1991 • 117 citations

Macrophage-inflammatory protein protects multipotent hematopoietic cells from the cytotoxic effects of hydroxyurea in vivo

1992 • 114 citations

A novel polypeptide secreted by activated human T lymphocytes.

1989 • 112 citations

Cloning of a cellular factor, interleukin binding factor, that binds to NFAT-like motifs in the human immunodeficiency virus long terminal repeat.

1991 • 108 citations

Differential regulation of lnterleukin-6, macrophage inflammatory protein-1, and JE/MCP-1 cytokine expression in macrophage cell lines

1991 • 96 citations

A 58-base-pair region of the human C3 gene confers synergistic inducibility by interleukin-1 and interleukin-6.

1990 • 93 citations

Macrophage-inflammatory protein protects multipotent hematopoietic cells from the cytotoxic effects of hydroxyurea in vivo

1992 • 92 citations

Characterization of the mouse granulocyte-macrophage colony-stimulating factor (GM-CSF) gene promoter: nuclear factors that interact with an element shared by three lymphokine genes--those for GM-CSF, interleukin-4 (IL-4), and IL-5.

1991 • 87 citations

A Negative Regulatory Element with Properties Similar to Those of Enhancers Is Contained within an Alu Sequence

1989 • 87 citations

Positive and negative elements regulate human interleukin 3 expression.

1990 • 87 citations

Transcriptional regulation of interleukin 3 gene expression in T lymphocytes.

1990 • 87 citations

An 11-base-pair DNA sequence motif apparently unique to the human interleukin 4 gene confers responsiveness to T-cell activation signals.

1992 • 83 citations

Characterization of the human granulocyte-macrophage colony-stimulating factor promoter region by genetic analysis: correlation with DNase I footprinting.

1988 • 69 citations

Nuclear factors interacting with an interleukin-6 responsive element of rat α₂-macroglobulin gene

1989 • 68 citations

A novel tumor necrosis factor-responsive transcription factor which recognizes a regulatory element in hemopoietic growth factor genes.

1990 • 67 citations

Transcription and replication silencer element is present within conserved region of human Alu repeats interacting with nuclear protein

1990 • 66 citations

[18] DNA contacts probed by modification protection and interference studies

1991 • 65 citations

Uncoupling of cytokine mRNA expression and protein secretion during the induction phase of T cell anergy.

1992 • 56 citations

Synthesis of a novel cytokine and its gene (LD78) expressions in hematopoietic fresh tumor cells and cell lines.

1989 • 54 citations

Three Human Homologs of a Murine Gene Encoding an Inhibitor of Stem Cell Proliferation

1990 • 53 citations

A negative regulatory element with properties similar to those of enhancers is contained within an Alu sequence.

1989 • 51 citations

The repeated sequence CATT(A/T) is required for granulocyte-macrophage colony-stimulating factor promoter activity.

1990 • 49 citations

Genomic structure of murine macrophage inflammatory protein-1 alpha and conservation of potential regulatory sequences with a human homolog, LD78.

1991 • 48 citations

A high proportion of early response genes are constitutively activated in T cells by HTLV-I.

1992 • 44 citations

Regulatory Elements Responsible for Inducible Expression of the Granulocyte Colony-Stimulating Factor Gene in Macrophages

1990 • 37 citations

: A potent stem cell inhibitor with potential roles in development

1992 • 35 citations

Nucleotide sequence of the third cytokine LD78 gene and mapping of all three LD78 gene loci to human chromosome 17

1992 • 31 citations

A 58-Base-Pair Region of the Human C3 Gene Confers Synergistic Inducibility by Interleukin-1 and Interleukin-6

1990 • 29 citations

Recombinant LD78 protein, a member of the small cytokine family, enhances osteoclast differentiation in rat bone marrow culture system

1992 • 26 citations

Enhancing and suppressing effects of recombinant murine macrophage inflammatory proteins on colony formation in vitro by bone marrow myeloid progenitor cells

1990 • 24 citations

T-Cell Chemotactic Activity of Cytokine LD78: A Comparative Study with lnterleukin-8, a Chemotactic Factor for the T-Cell CD45RA+ Phenotype

1993 • 21 citations

Characterization of the Mouse Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF) Gene Promoter: Nuclear Factors That Interact with an Element Shared by Three Lymphokine Genes—Those for GM-CSF, Interleukin-4 (IL-4), and IL-5

1991 • 21 citations

A Novel Tumor Necrosis Factor-Responsive Transcription Factor Which Recognizes a Regulatory Element in Hemopoietic Growth Factor Genes

1990 • 19 citations

Characterization of the Human Granulocyte-Macrophage Colony-Stimulating Factor Promoter Region by Genetic Analysis: Correlation with DNase I Footprinting

1988 • 15 citations

The Repeated Sequence CATT(A/T) Is Required for Granulocyte-Macrophage Colony-Stimulating Factor Promoter Activity

1990 • 13 citations

Effects of hematopoietic growth factors on the survival of primitive stem cells in liquid suspension culture

1991 • 13 citations

Structures of Human Genes Coding for Cytokine LD78 and Their Expression

1990 • 11 citations

Suppressive Effect of LD78 on the Proliferation of Human Hemopoietic Progenitors

1992 • 5 citations

T-cell chemotactic activity of cytokine LD78 : a comparative study with interleukin-8, a chemotactic factor for the T-cell CD45RA+ phenotype

1993 • 2 citations