Glycation of glucagon-like peptide-1(7-36)amide: characterization and impaired action on rat insulin secreting cells

Degradation of glucose-dependent insulinotropic polypeptide and truncated glucagon-like peptide 1 in vitro and in vivo by dipeptidyl peptidase IV.

1995 • 1,064 citations

Antidiabetogenic Effect of Glucagon-like Peptide-1 (7–36)amide in Normal Subjects and Patients with Diabetes Mellitus

1992 • 858 citations

Glucagon-like peptide I stimulates insulin gene expression and increases cyclic AMP levels in a rat islet cell line.

1987 • 830 citations

Degradation of glucagon-like peptide-1 by human plasma in vitro yields an N-terminally truncated peptide that is a major endogenous metabolite in vivo.

1995 • 741 citations

Pancreatic beta-cells are rendered glucose-competent by the insulinotropic hormone glucagon-like peptide-1(7-37)

1993 • 576 citations

Cloning and Functional Expression of the Human Islet GLP-1 Receptor: Demonstration That Exendin-4 Is an Agonist and Exendin-(9–39) an Antagonist of the Receptor

1993 • 533 citations

Cell and Molecular Biology of the Incretin Hormones Glucagon-Like Peptide-I and Glucose-Dependent Insulin Releasing Polypeptide

1995 • 519 citations

Abnormal plasma glucose and insulin responses in heterozygous lean (ob/+) mice

1981 • 401 citations

Characterization of a Novel Glucose-Responsive Insulin-Secreting Cell Line, BRIN-BD11, Produced by Electrofusion

1996 • 345 citations

Degradation of glucose-dependent insulinotropic polypeptide and truncated glucagon-like peptide 1 in vitro and in vivo by dipeptidyl peptidase IV

1995 • 283 citations

Dipeptidyl peptidase IV resistant analogues of glucagon-like peptide-1 which have extended metabolic stability and improved biological activity

1998 • 279 citations

New developments in the incretin concept

1985 • 275 citations

Structure-activity studies of glucagon-like peptide-1.

1994 • 272 citations

Glucagonlike Peptide I (7–37) Actions on Endocrine Pancreas

1989 • 254 citations

Glucagonostatic and Insulinotropic Action of Glucagonlike Peptide I-(7–36)-Amide

1989 • 222 citations

Functional expression of the rat glucagon-like peptide-I receptor, evidence for coupling to both adenylyl cyclase and phospholipase-C.

1993 • 214 citations

Effect of glucagon-like peptide-1 (proglucagon 78-107amide) on hepatic glucose production in healthy man

1994 • 187 citations

Receptors for glucagon-like peptide-1(7–36) amide on rat insulinoma-derived cells

1988 • 153 citations

The role of the free cytosolic calcium level in beta-cell signal transduction by gastric inhibitory polypeptide and glucagon-like peptide I(7-37).

1993 • 146 citations

Glucagon-like peptide 1 (GLP-1) as a new therapeutic approach for Type 2-diabetes

2009 • 142 citations

Potent glycogenic effect of GLP-1(7?36)amide in rat skeletal muscle

1994 • 133 citations

Glucagon-Like Peptide I Increases Cytoplasmic Calcium in Insulin-Secreting βTC3-Cells by Enhancement of Intracellular Calcium Mobilization

1995 • 128 citations

Cloning and functional expression of the human islet GLP-1 receptor. Demonstration that exendin-4 is an agonist and exendin-(9-39) an antagonist of the receptor

1993 • 121 citations

Normalization of Insulin Responses to Glucose by Overnight Infusion of Glucagon-Like Peptide 1 (7–36) Amide in Patients With NIDDM

1996 • 115 citations

Comparison of the Effects of Various C-Terminal and NTerminal Fragment Peptides of Glucagon-Like Peptide-1 on Insulin and Glucagon Release from the Isolated Perfused Rat Pancreas*

1989 • 109 citations

Glucagon-Like Peptide-I Analogs: Effects on Insulin Secretion and Adenosine 3′,5′-Monophosphate Formation*

1990 • 106 citations

Modulation of Glucose-Induced Insulin Secretion from a Rat Clonal β-Cell Line*

1990 • 88 citations

Characterization of a novel glucose-responsive insulin-secreting cell line, BRIN-BD11, produced by electrofusion

1996 • 86 citations

Comparison of the Effects of Glucagon-Like Peptide-1-( 1-3 7) and -(7-37) and Glucagon on Islet Hormone Release from Isolated Perfused Canine and Rat Pancreases*

1989 • 85 citations

Glycation of Insulin in the Islets of Langerhans of Normal and Diabetic Animals

1996 • 82 citations

Homologous Desensitization of the Insulinotropic Glucagon-Like Peptide-I(7–37) Receptor on Insulinoma (HIT-T15) Cells*

1991 • 74 citations

Effect of glucagon-like peptide-1 on insulin secretion

1988 • 70 citations

Identification of the site of glycation of human insulin

1996 • 68 citations

Failure of GLP-l(7–36)amide to affect glycogenesis in rat skeletal muscle

1995 • 57 citations

Signal transmission after GLP-1(7-36)amide binding in RINm5F cells

1989 • 56 citations

Isolation, structural characterization and pharmacological activity of dog neuromedin U

1991 • 55 citations

Glucagonlike Peptide-I-(7–36)-Amide Receptors Only in Islets of Langerhans: Autoradiographic Survey of Extracerebral Tissues in Rats

1991 • 45 citations

Characterization of insulin glycation in insulin-secreting cells maintained in tissue culture

1997 • 41 citations

Cognitive function testing in studies of acute hypoglycaemia: rights and wrongs?

1998 • 40 citations

Effects of Non-Glycated and Glycated Glucagon-Like Peptide-1(7-36) Amide on Glucose Metabolism in Isolated Mouse Abdominal Muscle

1997 • 36 citations

Therapeutic potential of glucagon-like peptide 1 in type 2 diabetes.

1996 • 32 citations

Pancreatic B-cell dysfunction and glucose toxicity in non-insulin-dependent diabetes

1997 • 32 citations

Structural requirements for biological activity of glucagon‐like peptide‐I

1992 • 31 citations

Detection of the Human Glucagon-Like Peptide 1(7-36) Amide Receptor on Insulinoma-Derived Cell Membranes

1994 • 22 citations

Is GLP-1 amide an endogenous antagonist at GLP-1 receptors?

1994 • 21 citations

252-Californium Plasma Desorption Time-of-Flight Mass Spectrometry of Peptides and Proteins

2003 • 19 citations

Glucagonostatic and Insulinotropic Action of Glucagonlike Peptide 1－（7－36）－Amide

1990 • 13 citations

Physiology and Pathophysiology of GLP-1

1996 • 5 citations