Generation of peroxynitrite contributes to ischemia-reperfusion injury in isolated rat hearts

Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide.

1990 • 7,068 citations

The L-Arginine-Nitric Oxide Pathway

1993 • 6,737 citations

Nitric oxide: an endogenous modulator of leukocyte adhesion.

1991 • 3,079 citations

The mitochondrial generation of hydrogen peroxide. General properties and effect of hyperbaric oxygen

1973 • 2,608 citations

Characterization of three inhibitors of endothelial nitric oxide synthase in vitro and in vivo

1990 • 1,869 citations

Endothelial nitric oxide synthase: molecular cloning and characterization of a distinct constitutive enzyme isoform.

1992 • 1,004 citations

Mechanism of myocardial "stunning".

1990 • 995 citations

Nitric oxide protects against cellular damage and cytotoxicity from reactive oxygen species.

1993 • 785 citations

Enzyme-independent formation of nitric oxide in biological tissues

1995 • 783 citations

Control of coronary vascular tone by nitric oxide.

1990 • 713 citations

Demonstration of free radical generation in "stunned" myocardium of intact dogs with the use of the spin trap alpha-phenyl N-tert-butyl nitrone.

1988 • 691 citations

Control of cardiac muscle cell function by an endogenous nitric oxide signaling system.

1993 • 656 citations

Direct detection of free radicals in the reperfused rat heart using electron spin resonance spectroscopy.

1987 • 628 citations

Induction and potential biological relevance of a Ca²⁺‐independent nitric oxide synthase in the myocardium

1992 • 623 citations

NG-nitro L-arginine methyl ester and other alkyl esters of arginine are muscarinic receptor antagonists.

1993 • 521 citations

Dityrosine, a specific marker of oxidation, is synthesized by the myeloperoxidase-hydrogen peroxide system of human neutrophils and macrophages.

1993 • 486 citations

Inhibition of nitric oxide synthesis in septic shock: how much is beneficial?

1991 • 409 citations

Nitric oxide attenuates cardiac myocyte contraction

1993 • 405 citations

Stable Mn(III) porphyrins mimic superoxide dismutase in vitro and substitute for it in vivo.

1994 • 403 citations

Nitric Oxide-dependent Parasympathetic Signaling Is Due to Activation of Constitutive Endothelial (Type III) Nitric Oxide Synthase in Cardiac Myocytes

1995 • 381 citations

Aromatic hydroxylation and nitration of phenylalanine and tyrosine by peroxynitrite

1994 • 377 citations

Tyrosine Modification by Reactive Nitrogen Species: A Closer Look

1995 • 371 citations

Paradoxical fate and biological action of peroxynitrite on human platelets.

1994 • 364 citations

The role of L-arginine in ameliorating reperfusion injury after myocardial ischemia in the cat.

1992 • 323 citations

Role of L-arginine-nitric oxide pathway in myocardial reoxygenation injury

1992 • 312 citations

Peroxynitrite induces both vasodilatation and impaired vascular relaxation in the isolated perfused rat heart.

1994 • 300 citations

Mitochondrial Nitric Oxide Synthase: A Ubiquitous Regulator of Oxidative Phosphorylation?

1996 • 244 citations

Nitric Oxide Regulation of Superoxide and Peroxynitrite-dependent Lipid Peroxidation

1994 • 244 citations

Direct Measurement of Nitric Oxide Generation in the Ischemic Heart Using Electron Paramagnetic Resonance Spectroscopy

1995 • 243 citations

Cardioprotection and attenuation of endothelial dysfunction by organic nitric oxide donors in myocardial ischemia-reperfusion.

1992 • 234 citations

Peroxynitrite, a product of superoxide and nitric oxide, produces coronary vasorelaxation in dogs.

1994 • 232 citations

The role of nitric oxide in cardiac depression induced by interleukin‐1β and tumour necrosis factor‐α

1995 • 226 citations

Dityrosine and tyrosine oxidation products are endogenous markers for the selective proteolysis of oxidatively modified red blood cell hemoglobin by (the 19 S) proteasome.

1993 • 197 citations

Inhibition of nitric oxide synthesis protects the isolated working rabbit heart from ischaemia-reperfusion injury

1995 • 176 citations

Myocardial stunning and hibernation. The physiology behind the colloquialisms.

1991 • 171 citations

Inhibition of Nitric Oxide Limits Infarct Size in the in Situ Rabbit Heart

1993 • 160 citations

Inhibition of Nitric Oxide Synthesis Reduces Infarct Size by an Adenosine-Dependent Mechanism

1995 • 154 citations

Inhibitory action of cyclic GMP on secretion, polyphosphoinositide hydrolysis and calcium mobilization in thrombin-stimulated human platelets

1986 • 136 citations

Protection Against Ischemic Injury by Nonvasoactive Concentrations of Nitric Oxide Synthase Inhibitors in the Perfused Rabbit Heart

1995 • 135 citations

Peroxynitrite impairs cardiac contractile function by decreasing cardiac efficiency

1997 • 103 citations

Sustain inhibition of nitric oxide by NG-nitro-l-arginine improves myocardial function following ischemia/reperfusion in isolated perfused rat heart

1995 • 98 citations

Plasma Nitric Oxide End Products Are Increased in the Ischemic Canine Heart

1995 • 66 citations

Superoxide Dismutase: Pharmacological Developments and Applications

1992 • 64 citations

Cyclic GMP in the perfused rat heart Effect of ischaemia, anoxia and nitric oxide synthase inhibitor

1994 • 52 citations

Modulation of myocardial contraction by endocardial and coronary vascular endothelium

1993 • 50 citations

A Potential Role for Nitric Oxide in Myocardial Stunning

1994 • 31 citations