Protein kinase C in beta-cells: expression of multiple isoforms and involvement in cholinergic stimulation of insulin secretion

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

Current Protocols in Molecular Biology

2001 • 2,451 citations

Activation of the zeta isozyme of protein kinase C by phosphatidylinositol 3,4,5-trisphosphate.

1993 • 966 citations

Protein kinase C - a question of specificity

1994 • 958 citations

Protein kinase C

1991 • 914 citations

PKCu is a novel, atypical member of the protein kinase C family.

1994 • 519 citations

Tissue and cellular distribution of the extended family of protein kinase C isoenzymes

1992 • 441 citations

Molecular cloning and characterization of PKC iota, an atypical isoform of protein kinase C derived from insulin-secreting cells.

1993 • 352 citations

A new member of the third class in the protein kinase C family, PKC lambda, expressed dominantly in an undifferentiated mouse embryonal carcinoma cell line and also in many tissues and cells.

1994 • 236 citations

Nutrient regulation of insulin secretion

1993 • 149 citations

Nutrient regulation of insulin secretion

1992 • 120 citations

Diacylglycerol Production, Ca²⁺Influx, and ProteinKinase C Activation in Sustained Cellular Responses*

1995 • 111 citations

Identification of functional ionotropic glutamate receptor proteins in pancreatic β‐cells and in islets of Langerhans

1995 • 104 citations

Calcium‐activated, phospholipid‐dependent protein kinase in rat pancreas islets of langerhans

1982 • 99 citations

Effects of protein kinase C activation on the regulation of the stimulus-secretion coupling in pancreatic β-cells

1989 • 84 citations

Is Protein Kinase C Required for Physiologic Insulin Release?

1988 • 81 citations

Immunocytochemical localization of alpha-protein kinase C in rat pancreatic beta-cells during glucose-induced insulin secretion.

1992 • 78 citations

The role of protein kinase C in cholinergic stimulation of insulin secretion from rat islets of Langerhans

1989 • 74 citations

Use of a PCR-based method to characterize protein kinase C isoform expression in cardiac cells

1993 • 70 citations

Protein phosphorylation and beta-cell function

1994 • 61 citations

Diacylglycerol production, Ca2+ influx, and protein kinase C activation in sustained cellular responses

1995 • 59 citations

Glucose-induced phosphorylation of myristoylated alanine-rich C kinase substrate (MARCKS) in isolated rat pancreatic islets.

1992 • 58 citations

Identification and subcellular characterization of protein kinase-C isoforms in insulinoma beta-cells and whole islets.

1994 • 55 citations

Identification and characterization of Ca2+-phospholipid-dependent protein kinase in rat islets and hamster β-cells

1984 • 54 citations

The effects of glucose, N-acetylglucosamine, glyceraldehyde and other sugars on insulin release in vivo

1975 • 51 citations

Effects of insulin secretagogues on protein kinase C-catalyzed phosphorylation of an endogenous substrate in isolated pancreatic islets.

1990 • 49 citations

Perspectives in diabetes. Is protein kinase C required for physiologic insulin release?

1988 • 47 citations

Different Expression of Protein Kinase C Isozymes in Pancreatic Islet Cells*

1990 • 44 citations

Endogenous substrate proteins for Ca2+-calmodulin-dependent, Ca2+-phospholipid-dependent and cyclic AMP-dependent protein kinases in mouse pancreatic islets

1984 • 39 citations

The role of cytosolic free Ca2+ and protein kinase C in acetylcholine-induced insulin release in the clonal β-cell line, HIT-T15

1990 • 38 citations

Differential down-regulation of insulin-sensitive protein kinase-C isoforms by 12-O-tetradecanoylphorbol-13-acetate in rat adipocytes and BC3H-1 myocytes.

1993 • 37 citations

The role of protein kinase-C in signal transduction through vasopressin and acetylcholine receptors in pancreatic B-cells from normal mouse.

1994 • 36 citations

Involvement of protein kinase C in the phosphorylation of an insulin-granule membrane protein

1984 • 34 citations

Effects of a phorbol ester and clomiphene on protein phosphorylation and insulin secretion in rat pancreatic islets

1988 • 32 citations

Glucose-induced phospholipid-dependent protein phosphorylation in neonatal rat islets

1986 • 31 citations

Age-Dependent Expression of Protein Kinase C Isoforms in Rat Islets

1991 • 30 citations

Stimulation of insulin release by vasopressin in the clonal β-cell line, HIT-T15: the role of protein kinase C

1992 • 29 citations

Localization of βII Subspecies of Protein Kinase C in β-Cells

1989 • 29 citations

Localization of beta II subspecies of protein kinase C in beta-cells

1989 • 20 citations

Protein kinase C and the regulation of insulin secretion

1990 • 7 citations