Age-dependent changes in the immunoreactivity for neurofilaments in rabbit hippocampus

“Western Blotting”: Electrophoretic transfer of proteins from sodium dodecyl sulfate-polyacrylamide gels to unmodified nitrocellulose and radiographic detection with antibody and radioiodinated protein A

1981 • 8,657 citations

Monoclonal antibodies distinguish phosphorylated and nonphosphorylated forms of neurofilaments in situ.

1983 • 1,162 citations

Intracellular transport in neurons.

1980 • 1,011 citations

The slow component of axonal transport. Identification of major structural polypeptides of the axon and their generality among mammalian neurons.

1975 • 937 citations

Intermediate filaments in nervous tissues

1978 • 502 citations

Monoclonal antibodies distinguish several differentially phosphorylated states of the two largest rat neurofilament subunits (NF-H and NF-M) and demonstrate their existence in the normal nervous system of adult rats

1987 • 490 citations

New roles for glia

1991 • 464 citations

Site-specific phosphorylation induces disassembly of vimentin filaments in vitro

1987 • 442 citations

Normal aging: regionally specific changes in hippocampal synaptic transmission

1994 • 332 citations

The structure, biochemical properties, and immunogenicity of neurofilament peripheral regions are determined by phosphorylation state.

1985 • 325 citations

Neurofilament phosphorylation: a new look at regulation and function

1991 • 309 citations

An immunofluorescence microscopical study of the neurofilament triplet proteins, vimentin and glial fibrillary acidic protein within the adult rat brain.

1981 • 304 citations

Nimodipine increases excitability of rabbit CA1 pyramidal neurons in an age- and concentration-dependent manner

1992 • 293 citations

Induction of long-term potentiation is associated with an increase in the number of axospinous synapses with segmented postsynaptic densities

1991 • 272 citations

Lewy Bodies of Parkinson's Disease Contain Neurofilament Antigens

1983 • 256 citations

Neurofilament proteins of rat peripheral nerve and spinal cord.

1978 • 219 citations

Immunohistochemical distribution of pro-somatostatin-related peptides in cerebral cortex

1983 • 216 citations

Expression of neurofilament subunits in neurons of the central and peripheral nervous system: an immunohistochemical study with monoclonal antibodies

1986 • 206 citations

Immunoaffinity Purification of Human Choline Acetyltransferase: Comparison of the Brain and Placental Enzymes

1985 • 204 citations

Purification of individual components of the neurofilament triplet: filament assembly from the 70000-dalton subunit

1982 • 201 citations

Phosphorylation protects neurofilaments against proteolysis

1987 • 199 citations

Chapter 32 Hippocampal formation: anatomy and the patterns of pathology in Alzheimer's disease

1990 • 196 citations

‘Increased calcium-current’ hypothesis of brain aging

1987 • 192 citations

Axonal transport in neurological disease

1988 • 183 citations

Atlas of the Rabbit Brain and Spinal Cord

1985 • 181 citations

Hippocampus-dependent learning facilitated by a monoclonal antibody or D-cycloserine

1992 • 180 citations

Reactivity of a panel of neurofilament antibodies on phosphorylated and dephosphorylated neurofilaments.

1986 • 179 citations

A monoclonal antibody to non-phosphorylated neurofilament protein marks the vulnerable cortical neurons in Alzheimer's disease

1987 • 161 citations

The concentration of glial fibrillary acidic protein increases with age in the mouse and rat brain

1991 • 146 citations

The Calcium Rationale in Aging and Alzheimer's Disease

1994 • 142 citations

Alterations in neurofilament protein immunoreactivity in human hippocampal neurons related to normal aging and Alzheimer's disease

1994 • 133 citations

Monoclonal antibodies recognize individual neurofilament triplet proteins.

1982 • 121 citations

Intermediate Filaments in Nervous Tissue

1985 • 116 citations

Effects of phosphorylation of the neurofilament L protein on filamentous structures.

1990 • 109 citations

Trace eyeblink conditioning in rabbits demonstrates heterogeneity of learning ability both between and within age groups

1996 • 108 citations

Nimodipine decreases calcium action potentials in rabbit hippocampal CA1 neurons in an age‐dependent and concentration‐dependent manner

1994 • 97 citations

Progressive transformation of the cytoskeleton associated with normal aging and Alzheimer's disease

1992 • 96 citations

The neurofilament triplet is present in distinct subpopulations of neurons in the central nervous system of the guinea-pig

1992 • 91 citations

The immunological relatedness of neurofilament proteins of higher vertebrates.

1984 • 91 citations

Expression of microtubule-associated protein 2 by reactive astrocytes.

1990 • 84 citations

Effect of phosphorylation on 68 KDa neurofilament subunit protein assembly by the cyclic AMP dependent protein kinase in vitro

1990 • 73 citations

S0MAT0STATIN-28tl-12)-LIKE IMMUNOREACTIVITY IN THE RAT

1982 • 71 citations

Analysis of epitopes shared by Hirano bodies and neurofilament proteins in normal and Alzheimer's disease hippocampus.

1989 • 67 citations

Age-related loss of calcium binding proteins in rabbit hippocampus

1996 • 67 citations

Effects of social deprivation in prepubescent rhesus monkeys: immunohistochemical analysis of the neurofilament protein triplet in the hippocampal formation

1993 • 66 citations

Aging and classical conditioning: Parallel studies in rabbits and humans

1988 • 62 citations

Studies on the biosynthesis of neurofilament proteins.

1980 • 61 citations

The neuronal cytoskeleton and its role in axonal and dendritic plasticity

1993 • 61 citations

Muscarinic acetylcholine receptor‐expression in astrocytes in the cortex of young and aged rats

1993 • 60 citations

Age-related disruption of classical conditioning: A model systems approach to memory disorders

1988 • 57 citations

Diminished calcium currents in aged hippocampal dentate gyrus granule neurones

1989 • 57 citations

Aging-Related Increases in Voltage-Sensitive, Inactivating Calcium Currents in Rat Hippocampus Implications for Mechanisms of Brain Aging and Alzheimer's Disease

1989 • 57 citations

Dietary nimodipine improves associative learning in aging rabbits

1990 • 55 citations

The older rabbit as an animal model: Implications for Alzheimer's disease

1996 • 55 citations

Differential distribution of 68 Kd and 200 Kd neurofilament proteins in the gerbil hippocampus and their early distributional changes following transient forebrain ischemia

1992 • 55 citations

The effects of age on eyeblink conditioning in the freely moving Fischer-344 rat

1991 • 52 citations

Cholinergic fiber aberrations in nucleus basalis lesioned rat and Alzheimer's disease

1992 • 47 citations

Immunohistochemical demonstration of neuron-specific enolase and microtubule-associated protein 2 in reactive astrocytes after injury in the adult forebrain

1994 • 45 citations

Neurofilament Distribution is Altered in the Mnd (Motor Neuron Degeneration) Mouse

1991 • 45 citations

Persistent degenerative state of non-pyramidal neurons in the ca1 region of the gerbil hippocampus following transient forebrain ischemia

1993 • 38 citations

Characterization of a panel of neurofilament antibodies recognizing N‐terminal epitopes

1991 • 33 citations

Cholinoceptive cells in rat cerebral cortex: Somatodendritic immunoreactivity for muscarinic receptor and cytoskeletal proteins

1993 • 30 citations

Classical conditioning: The rosetta stone for brain substrates of age-related deficits in learning and memory?

1988 • 28 citations

Age-related neurofilament phosphorylation in normal human brains

1989 • 27 citations

Proteolysis of filament proteins in glial and neuronal cells afterIn vivo stimulation of hippocampal NMDA receptors

1992 • 20 citations

Vulnerability of the Neuronal Cytoskeleton in Aging and Alzheimer Disease: Widespread Involvement of All Three Major Filament Systems

1991 • 18 citations

Staining with monoclonal antibodies to neurofilaments distinguishes between subpopulations of neurofibrillary tangles, between groups of axons and between groups of dendrites

1987 • 17 citations

Immunomagnetic removal of neurons from developing chick optic tectum results in glial phenotypic instability

1992 • 12 citations

Myenteric plexus neurons have developmentally acquired differences in the medium molecular weight subunit of neurofilament protein

1993 • 10 citations

Effect of treatment with the dihydropyridine-type calcium antagonist darodipine (PY 108-068) on the expression of neurofilament protein immunoreactivity in the cerebellar cortex of aged rats

1994 • 10 citations

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