Axonal transport in neurological disease

Identification of a novel force-generating protein, kinesin, involved in microtubule-based motility

1985 • 1,930 citations

The slow component of axonal transport. Identification of major structural polypeptides of the axon and their generality among mammalian neurons.

1975 • 937 citations

Experiments on the mechanism of nerve growth

1948 • 829 citations

Neurofilament gene expression: a major determinant of axonal caliber.

1987 • 705 citations

Cross-linker system between neurofilaments, microtubules and membranous organelles in frog axons revealed by the quick-freeze, deep-etching method

1982 • 672 citations

Peripheral Neuropathy

1984 • 654 citations

The retrograde axonal transport of nerve growth factor

1974 • 598 citations

Axon caliber related to neurofilaments and microtubules in sciatic nerve fibers of rats and mice

1970 • 525 citations

Different axoplasmic proteins generate movement in opposite directions along microtubules in vitro

1985 • 463 citations

Control of axonal caliber by neurofilament transport.

1984 • 439 citations

Experimental and Clinical Neurotoxicology

1981 • 432 citations

ULTRASTRUCTURAL STUDIES OF THE DYING-BACK PROCESS

1974 • 367 citations

Single microtubules from squid axoplasm support bidirectional movement of organelles

1985 • 363 citations

Proximal axonal enlargement in motor neuron disease

1968 • 359 citations

The movement of membranous organelles in axons. Electron microscopic identification of anterogradely and retrogradely transported organelles.

1980 • 349 citations

Slow Axonal Transport of Neurofilament Proteins: Impairment of β,β′-Iminodipropionitrile Administration

1978 • 340 citations

Ultrastructural Studies of the Dying-Back Process

1977 • 273 citations

Axonal lesions and waltzing syndrome after IDPN administration in rats

1964 • 259 citations

The Enlarging View of Hexacarbon Neurotoxicity

1980 • 242 citations

Selective retrograde transsynaptic transfer of a protein, tetanus toxin, subsequent to its retrograde axonal transport

1979 • 229 citations

Cytoplasmic structure in rapid-frozen axons.

1982 • 229 citations

Management of peripheral nerve problems

1980 • 227 citations

Tetanus Toxin: Direct Evidence for Retrograde Intraaxonal Transport

1975 • 224 citations

Does a defect of energy metabolism in the nerve fiber underlie axonal degeneration in polyneuropathies?

1979 • 222 citations

Giant axonal neuropathy ? A unique case with segmental neurofilamentous masses

1972 • 205 citations

Spread of herpes simplex virus in peripheral nerves

1971 • 186 citations

THE AXONAL PATHOLOGY IN CHRONIC IDPN INTOXICATION

1980 • 185 citations

Correlation of axonal regeneration and slow component B in two branches of a single axon

1983 • 178 citations

Aluminum effect on slow axonal transport: a novel impairment of neurofilament transport

1984 • 151 citations

Electron microscopy of focal neuroaxonal lesions produced by ?-??-iminodipropionitrile (IDPN) in rats

1965 • 149 citations

Pathology of motor neurons in accelerated hereditary canine spinal muscular atrophy.

1982 • 144 citations

REVERSAL OF AXONAL TRANSPORT AT A NERVE CRUSH¹

1977 • 138 citations

Optic Disc Edema in Raised Intracranial Pressure

1977 • 136 citations

Blockade of Rapid Axonal Transport

1979 • 135 citations

Evidence for the glia-neuron protein transfer hypothesis from intracellular perfusion studies of squid giant axons.

1977 • 132 citations

Experimental diabetic neuropathy: impairment of slow transport with changes in axon cross-sectional area.

1985 • 127 citations

Slowing of the axonal transport of neurofilament proteins during development

1983 • 127 citations

EVIDENCE FOR AN INTRAAXONAL TRANSPORT OF FIXED AND STREET RABIES VIRUS

1979 • 122 citations

Incorporation of axonally transported glycoproteins into axolemma during nerve regeneration

1981 • 114 citations

Aluminum intoxication: a disorder of neurofilament transport in motor neurons

1985 • 103 citations

Slow axonal transport in acrylamide neuropathy: different abnormalities produced by single-dose and continuous administration

1985 • 97 citations

THE PATHOLOGY OF PAPILLOEDEMA: A HISTOLOGICAL STUDY OF SIXTY EYES

1911 • 94 citations

Pathogenesis of Human Poliovirus Infection in Mice

1980 • 94 citations

Giant Axonal Neuropathy—A Generalized Disorder of Cytoplasmic Microfilament Formation

1976 • 93 citations

Axoplasmic transport and its relation to other nerve functions

1983 • 92 citations

Microtubule-neurofilament segregation produced by beta, beta'- iminodipropionitrile: evidence for the association of fast axonal transport with microtubules

1983 • 92 citations

Giant axonal neuropathy: acceleration of neurofilament transport in optic axons.

1985 • 91 citations

Axoplasmic transport and its relation to other nerve functions

1982 • 90 citations

Changes in fast axonal transport during experimental nerve compression at low pressures

1984 • 89 citations

Early and Dose‐Dependent Decrease of Retrograde Axonal Transport in Acrylamide‐Intoxicated Rats

1983 • 79 citations

Cytoskeletal disorganization induced by local application of β,β′‐iminodipropionitrile and 2,5‐hexanedione

1983 • 77 citations

The neurotoxins 2,5‐hexanedione and acrylamide promote aggregation of intermediate filaments in cultured fibroblasts

1983 • 76 citations

The cytoskeleton in myelinated axons: A freeze-etch replica study

1982 • 75 citations

‘Acrylamide-induced‘ neuropathy and impairment of axonal transport of proteins. II. Abnormal accumulations of smooth endoplasmic reticulum as sites of focal retention of fast transported proteins. Electron microscope radioautographic study

1981 • 74 citations

Acrylamide and 2,5-hexanedione neuropathies: abnormal bidirectional transport rate in distal axons

1981 • 72 citations

Demyelination in experimental beta, beta'-iminodipropionitrile and hexacarbon neuropathies. Evidence for an axonal influence.

1981 • 67 citations

The Neurotoxicity of the Rat Poison Vacor

1980 • 64 citations

The Spatio-Temporal Pattern of the Axonopathy Associated with the Neurotoxicity of 3,4-Dimethyl-2,5-Hexanedione in the Rat

1983 • 60 citations

THE PATTERN OF RECOVERY OF AXONS IN THE NERVOUS SYSTEM OF RATS FOLLOWING 2,5‐HEXANEDIOL INTOXICATION: A QUESTION OF RHEOLOGY?

1982 • 59 citations

Axonal growth during regeneration: a quantitative autoradiographic study.

1980 • 59 citations

Pathogenesis of Human Poliovirus Infection in Mice

1980 • 57 citations

Redistribution of proteins of fast axonal transport following administration of beta,beta'-iminodipropionitrile: a quantitative autoradiographic study.

1982 • 56 citations

Altered retrograde axonal transport of nerve growth factor after single and repeated doses of acrylamide in the rat

1983 • 55 citations

3,4-Dimethyl-2,5-hexanedione impairs the axonal transport of neurofilament proteins

1984 • 53 citations

The axoplasmic reticulum within myelinated axons is not transported rapidly

1983 • 51 citations

Giant axonal neuropathy: An inborn error of organization of intermediate filaments

1982 • 44 citations

Giant axonal neuropathy: a conditional mutation affecting cytoskeletal organization.

1985 • 38 citations

Effect of changes in neurofilament content on caliber of small axons: the beta,beta'-iminodipropionitrile model

1987 • 30 citations

New Method for the Study of the Nervous System

1852 • 28 citations

FAST AXONAL TRANSPORT THROUGH GIANT AXONAL SWELLINGS IN HEXACARBON NEUROPATHY

1977 • 28 citations

Rapid reorganization of the axonal cytoskeleton induced by a gamma diketone

1983 • 25 citations

Recovery of distal changes after nerve constriction by a ligature

1983 • 24 citations

ULTRASTRUCTUAL CHANGES IN AXONS CAUSED BY ACRYLAMIDE ABOVE A NERVE LIGATURE

1981 • 21 citations

Changes in Microtubules and Neurofilaments in Constricted, Hypoplastic Nerve Fibers

1971 • 20 citations

Experimental neurotoxic disorders of motor neurons: neurofibrillary pathology.

1982 • 19 citations

Vacor Neuropathy: Ultrastructural and Axonal Transport Studies

1987 • 19 citations

Some effects of prolonged constriction on nerve regeneration in the rabbit

1985 • 16 citations

Intoxication with beta, beta' -iminodipropionitrile: a model of optic disc swelling.

1982 • 15 citations

Axonal transport of cytoskeletal proteins in aluminum toxicity

1983 • 14 citations

DIABETIC NEUROPATHY

1985 • 5 citations