Role of reactive oxygen metabolites in experimental glomerular disease

Superoxide Dismutase

1969 • 12,578 citations

Oxygen-Derived Free Radicals in Postischemic Tissue Injury

1985 • 5,488 citations

Biology of disease: free radicals and tissue injury.

1982 • 3,078 citations

Biological Defense Mechanisms. THE PRODUCTION BY LEUKOCYTES OF SUPEROXIDE, A POTENTIAL BACTERICIDAL AGENT

1973 • 2,955 citations

Oxygen-Dependent Microbial Killing by Phagocytes

1978 • 2,519 citations

Oxygen free radicals and iron in relation to biology and medicine: Some problems and concepts

1986 • 2,052 citations

Oxygen Radicals and Human Disease

1987 • 1,854 citations

Role of oxygen-derived free radicals and metabolites in leukocyte-dependent inflammatory reactions.

1982 • 1,241 citations

The Biochemical Basis of Phagocytosis

1959 • 1,240 citations

Role of metals in oxygen radical reactions

1985 • 1,149 citations

Oxygen free radicals in ischemic acute renal failure in the rat.

1984 • 1,041 citations

Evidence for the generation of an electronic excitation state(s) in human polymorphonuclear leukocytes and its participation in bactericidal activity

1972 • 966 citations

Oxygen Metabolism and the Toxic Properties of Phagocytes

1980 • 886 citations

Superoxide and Superoxide Dismutases

1978 • 754 citations

Complement and immunoglobulins stimulate superoxide production by human leukocytes independently of phagocytosis.

1975 • 749 citations

Enzymatic Defenses of the Mouse Heart Against Reactive Oxygen Metabolites

1980 • 711 citations

Tissue injury in inflammation. Oxidants, proteinases, and cationic proteins.

1987 • 699 citations

Ischemia-reperfusion injury: role of oxygen-derived free radicals.

1986 • 680 citations

A Mechanism for the Production of Ethylene from Methional

1970 • 668 citations

Release of Inflammatory Mediators from Stimulated Neutrophils

1980 • 649 citations

Xanthine oxidase: biochemistry, distribution and physiology.

1986 • 635 citations

Effect of anthracycline antibiotics on oxygen radical formation in rat heart.

1983 • 634 citations

Free radicals and inflammation: superoxide-dependent activation of a neutrophil chemotactic factor in plasma.

1980 • 628 citations

Measurement of endothelial cell free radical generation: evidence for a central mechanism of free radical injury in postischemic tissues.

1988 • 610 citations

Redox cycling of anthracyclines by cardiac mitochondria. I. Anthracycline radical formation by NADH dehydrogenase.

1986 • 608 citations

H2O2 Release from Human Granulocytes during Phagocytosis

1977 • 586 citations

Generation of free radicals and lipid peroxidation by redox cycling of adriamycin and daunomycin

1977 • 545 citations

Redox cycling of anthracyclines by cardiac mitochondria. II. Formation of superoxide anion, hydrogen peroxide, and hydroxyl radical.

1986 • 525 citations

Oxidative Autoactivation of Latent Collagenase by Human Neutrophils

1985 • 466 citations

Phagocyte-generated oxygen metabolites and cellular injury.

1982 • 457 citations

Oxygen-Dependent Microbial Killing by Phagocytes

1978 • 448 citations

The Biology and Pathology of Oxygen Radicals

1978 • 437 citations

Oxygen Free Radicals Linked to Many Diseases

1987 • 399 citations

Long-Lived Oxidants Generated by Human Neutrophils: Characterization and Bioactivity

1983 • 396 citations

Adriamycin-induced nephrotic syndrome in rats: sequence of pathologic events.

1982 • 367 citations

Brominating Oxidants Generated by Human Eosinophils

1986 • 364 citations

Fragmentation of proteins by free radicals and its effect on their susceptibility to enzymic hydrolysis

1986 • 345 citations

Evidence for role of hydroxyl radical in complement and neutrophil-dependent tissue injury.

1983 • 338 citations

Glutathione redox cycle protects cultured endothelial cells against lysis by extracellularly generated hydrogen peroxide.

1984 • 334 citations

Prevention of granulocyte-mediated oxidant lung injury in rats by a hydroxyl radical scavenger, dimethylthiourea.

1984 • 322 citations

Oxygen, ischemia and inflammation.

1986 • 313 citations

A new role for complement in experimental membranous nephropathy in rats.

1980 • 303 citations

Evidence suggesting a role for hydroxyl radical in gentamicin-induced acute renal failure in rats.

1988 • 297 citations

In vitro suppression of serum elastase-inhibitory capacity by reactive oxygen species generated by phagocytosing polymorphonuclear leukocytes.

1979 • 293 citations

The origin of the chemiluminescence of phagocytosing granulocytes.

1976 • 283 citations

Activation of the endogenous metalloproteinase, gelatinase, by triggered human neutrophils.

1986 • 267 citations

Reactive oxygen species: production and role in the kidney

1986 • 267 citations

Abrogation of Macrophage-dependent Injury in Experimental Glomerulonephritis in the Rabbit

1981 • 263 citations

Potential Mediator of Inflammation

1980 • 255 citations

Neutrophils degrade subendothelial matrices in the presence of alpha-1-proteinase inhibitor. Cooperative use of lysosomal proteinases and oxygen metabolites.

1984 • 253 citations

A role for oxygen free radicals in aminonucleoside nephrosis

1986 • 247 citations

Systemic complement activation, lung injury, and products of lipid peroxidation.

1985 • 237 citations

New mechanism for glomerular injury. Myeloperoxidase-hydrogen peroxide-halide system.

1987 • 235 citations

Glomerular prostaglandin and thromboxane synthesis in rat nephrotoxic serum nephritis. Effects on renal hemodynamics.

1983 • 234 citations

Complement membrane attack complex stimulates production of reactive oxygen metabolites by cultured rat mesangial cells.

1986 • 230 citations

Myeloperoxidase-catalyzed inactivation of alpha 1-protease inhibitor by human neutrophils.

1981 • 222 citations

Oxygen-radical-mediated permeability edema and vasoconstriction in isolated perfused rabbit lungs.

1982 • 222 citations

[39] The generation of chemiluminescence (CL) by phagocytic cells

1978 • 215 citations

Evidence for the role of oxygen radicals in acute nephrotoxic nephritis.

1984 • 212 citations

Mechanism of adriamycin cardiotoxicity: Evidence for oxidative stress

1981 • 210 citations

Antioxidant Defenses in the Lung

1986 • 210 citations

Prostaglandins and other arachidonic acid metabolites in the kidney

1986 • 206 citations

Antioxidant defense mechanisms of endothelial cells: glutathione redox cycle versus catalase

1986 • 199 citations

Hydrogen Peroxide Production by Rat Brain In Vivo

1980 • 197 citations

Endogenous defenses against the cytotoxicity of hydrogen peroxide in cultured rat hepatocytes.

1985 • 196 citations

Lipid peroxidation and acute lung injury after thermal trauma to skin. Evidence of a role for hydroxyl radical.

1985 • 188 citations

Enhancement of platelet function by superoxide anion.

1977 • 186 citations

In vitro evaluation of opsonic and cellular granulocyte function by luminol-dependent chemiluminescence: utility in patients with severe neutropenia and cellular deficiency states

1978 • 183 citations

Reactive oxygen production by cultured rat glomerular mesangial cells during phagocytosis is associated with stimulation of lipoxygenase activity.

1983 • 180 citations

Hormonal modulation of glomerular function

1983 • 172 citations

Do human neutrophils make hydroxyl radical? Determination of free radicals generated by human neutrophils activated with a soluble or particulate stimulus using electron paramagnetic resonance spectrometry.

1986 • 171 citations

Experimental Membranous Glomerulonephritis in Rats

1980 • 171 citations

The specificity of thiourea, dimethylthiourea and dimethyl sulphoxide as scavengers of hydroxyl radicals. Their protection of α1-antiproteinase against inactivation by hypochlorous acid

1987 • 170 citations

Complement-induced glomerular epithelial cell injury. Role of the membrane attack complex in rat membranous nephropathy.

1986 • 166 citations

Complement and the direct mediation of immune glomerular injury: A new perspective

1985 • 165 citations

Glutathione cycle activity and pyridine nucleotide levels in oxidant-induced injury of cells.

1985 • 162 citations

Prostaglandin synthesis in isolated rat kidney glomeruli.

1979 • 158 citations

Increased glomerular thromboxane synthesis as a possible cause of proteinuria in experimental nephrosis.

1985 • 158 citations

Reactions of ferrioxamine and desferrioxamine with the hydroxyl radical

1982 • 151 citations

Nuclear catalyzed antibiotic free radical formation.

1982 • 149 citations

Degradation of human glomerular basement membrane by stimulated neutrophils. Activation of a metalloproteinase(s) by reactive oxygen metabolites.

1987 • 147 citations

Evidence that proteases are involved in superoxide production by human polymorphonuclear leukocytes and monocytes.

1980 • 146 citations

Glomerular basement membrane damage in immunological glomerulonephritis.

1968 • 145 citations

The detection of monocytes in human glomerulonephritis

1985 • 129 citations

Evidence suggesting a role for hydroxyl radical in puromycin aminonucleoside-induced proteinuria

1988 • 127 citations

Recombinant tumor necrosis factor/cachectin and interleukin 1 pretreatment decreases lung oxidized glutathione accumulation, lung injury, and mortality in rats exposed to hyperoxia.

1987 • 122 citations

Inhibition of Phagocytosis-Associated Chemiluminescence by Superoxide Dismutase

1974 • 119 citations

Protein degradation following treatment with hydrogen peroxide.

1984 • 116 citations

The Degradation of Human Glomerular Basement Membrane with Purified Lysosomal Proteinases: Evidence for the Pathogenic Role of the Polymorphonuclear Leucocyte in Glomerulonephritis

1978 • 115 citations

Impaired Chemiluminescence During Phagocytosis of Opsonized Bacteria

1973 • 113 citations

Lipoxygenase activity in rat kidney glomeruli, glomerular epithelial cells, and cortical tubules.

1982 • 106 citations

Evidence suggesting a role for hydroxyl radical in passive Heymann nephritis in rats

1988 • 106 citations

Immune complex induced generation of oxygen metabolites by human neutrophils.

1982 • 101 citations

Immune complexes bind to cultured rat glomerular mesangial cells to stimulate superoxide release. Evidence for an Fc receptor.

1987 • 100 citations

Stimulation by oxygen radicals of prostaglandin production by rat renal glomeruli

1981 • 100 citations

Neutrophil-platelet interaction mediated by myeloperoxidase and hydrogen peroxide.

1980 • 100 citations

Role of oxygen radicals in phorbol myristate acetate-induced glomerular injury

1985 • 97 citations

Platelet enhancement of O2-. responses in stimulated human neutrophils. Identification of platelet factor as adenine nucleotide.

1988 • 94 citations

Defective Initiation of Oxidative Metabolism in Polymorphonuclear Leukocytes

1979 • 89 citations

Hydroxyl radical mediation of immune renal injury by desferrioxamine

1986 • 84 citations

Degradation of soluble collagen by ozone or hydroxyl radicals

1984 • 81 citations

Enhanced glomerular prostaglandin formation in experimental membranous nephropathy

1987 • 78 citations

Participation of the myeloperoxidase-H2O2-halide system in immune complex nephritis

1987 • 74 citations

Morphologic correlates of glomerular oxidant injury induced by the myeloperoxidase-hydrogen peroxide-halide system of the neutrophil.

1988 • 72 citations

Superoxide and inflammation: a mechanism for the anti-inflammatory activity of superoxide dismutase.

1980 • 72 citations

The chlorinating potential of the human monocyte

1983 • 71 citations

The role of superoxide anion and hydrogen peroxide in glomerular injury induced by puromycin aminonucleoside in rats

1987 • 64 citations

Neutrophil-endothelial cell interaction. Evidence for and mechanisms of the self-protection of bovine microvascular endothelial cells from hydrogen peroxide-induced oxidative stress.

1986 • 64 citations

Free-radical-mediated postischemic reperfusion injury in the kidney

1986 • 64 citations

Platelets in Glomerular Disease

1984 • 63 citations

Mediation of IgA induced lung injury in the rat. Role of macrophages and reactive oxygen products.

1986 • 63 citations

The effect of a single intravenous injection of aminonucleoside of Puromycin on the rat kidney: A light‐ and electron‐microscope study

1962 • 62 citations

Degradation of glomerular basement membrane by human neutrophils in vitro

1984 • 62 citations

Superoxide dismutase: Rationale for use in reperfusion injury and inflammation

1986 • 61 citations

Generation of chemiluminescence by a particulate fraction isolated from human neutrophils. Analysis of molecular events.

1979 • 61 citations

Free radical production from normal and adriamycin-treated rat cardiac sarcosomes

1985 • 61 citations

Glutathione modulates toxic oxygen metabolite injury of canine chief cell monolayers in primary culture

1988 • 59 citations

Myeloperoxidase-Mediated Platelet Release Reaction

1979 • 56 citations

Activation of human neutrophil gelatinase by endogenous serine proteinases

1988 • 54 citations

The effect of oxidants on neutrophil-mediated degradation of glomerular basement membrane collagen

1986 • 52 citations

Anti-GBM antibody-induced proteinuria in isolated perfused rat kidney

1985 • 51 citations

Light emission by isolated rat glomeruli in response to phorbol myristate acetate.

1981 • 51 citations

Effect of enzymatically generated reactive oxygen metabolites on the cyclic nucleotide content in isolated rat glomeruli.

1984 • 50 citations

A role for thromboxane in complement-mediated glomerular injury.

1987 • 49 citations

Nephritogenic Antibody Mechanisms Involving Antigens within the Glomerulus

1981 • 49 citations

Glomerular injury and proteinuria in rats after intrarenal injection of cobra venom factor. Evidence for the role of neutrophil-derived oxygen free radicals.

1986 • 47 citations

Priming of macrophages for enhanced oxidative metabolism by exposure to proteolytic enzymes.

1981 • 46 citations

Effects of diphenyl-phenylenediamine on gentamicin-induced lipid peroxidation and toxicity in rat renal cortex.

1986 • 41 citations

DMSO Does Not Protect Against Hydroxyl Radical Induced Peroxidation in Model Membranes

1981 • 39 citations

Dexamethasone and hydrogen peroxide production by mesangial cells during phagocytosis

1986 • 38 citations

Daunorubicin-stimulated reactive oxygen metabolism in cardiac sarcosomes

1981 • 38 citations

Immune complex effects on glomerular eicosanoid production and renal hemodynamics

1987 • 35 citations

Accumulation of Lung Tissue Oxidized Glutathione (GSSG) as a Marker of Oxidant Induced Lung Injury

1986 • 35 citations

Hydroxyl radical scavengers ameliorate proteinuria in rat immune complex glomerulonephritis.

1988 • 33 citations

Biphasic effect of oxygen radicals on prostaglandin production by rat mesangial cells

1987 • 32 citations

Superoxide Anion Production from Guinea Pig Macrophages Stimulated with Immune Complexes of Different IgG Subclasses1

1980 • 25 citations

Potential role of cyclic nucleotides in glomerular pathophysiology.

1980 • 22 citations

Generation of Chemiluminescence by a Particulate Fraction Isolated from Human Neutrophils

1979 • 21 citations

Trypsin- and chymotrypsin-induced chemiluminescence by isolated rat glomeruli

1987 • 15 citations

Effect of stimulated neutrophils on cyclic nucleotide content in isolated rat glomeruli

1987 • 13 citations

Evidence against a role for superoxide ions in the injury of nephrotoxic nephritis in rats

1985 • 10 citations

Generation of a biologically active lipid from arachidonic acid by exposure to a superoxide-generating system.

1980 • 6 citations