Neurotrophin signalling in health and disease

The capsaicin receptor: a heat-activated ion channel in the pain pathway

1997 • 8,634 citations

Neurotrophins: Roles in Neuronal Development and Function

2001 • 4,134 citations

The BDNF val66met Polymorphism Affects Activity-Dependent Secretion of BDNF and Human Memory and Hippocampal Function

2003 • 3,746 citations

The Nerve Growth Factor 35 Years Later

1987 • 3,107 citations

Trk Receptors: Roles in Neuronal Signal Transduction

2003 • 2,410 citations

Neurotrophins and their receptors: A convergence point for many signalling pathways

2003 • 2,173 citations

Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells

1994 • 1,999 citations

Neurotrophin signal transduction in the nervous system

2000 • 1,910 citations

Neurotrophins as synaptic modulators

2001 • 1,773 citations

Regulation of Cell Survival by Secreted Proneurotrophins

2001 • 1,618 citations

Hippocampal long-term potentiation is impaired in mice lacking brain-derived neurotrophic factor.

1995 • 1,416 citations

Bradykinin and nerve growth factor release the capsaicin receptor from PtdIns(4,5)P2-mediated inhibition

2001 • 1,240 citations

High-affinity NGF binding requires coexpression of the trk proto-oncogene and the low-affinity NGF receptor

1991 • 1,232 citations

Recombinant BDNF Rescues Deficits in Basal Synaptic Transmission and Hippocampal LTP in BDNF Knockout Mice

1996 • 1,219 citations

Continuous infusion of nerve growth factor prevents basal forebrain neuronal death after fimbria fornix transection.

1986 • 1,063 citations

A phase 1 clinical trial of nerve growth factor gene therapy for Alzheimer disease

2005 • 1,021 citations

Sortilin is essential for proNGF-induced neuronal cell death

2004 • 926 citations

Rap1 mediates sustained MAP kinase activation induced by nerve growth factor

1998 • 868 citations

Variant Brain-Derived Neurotrophic Factor (BDNF) (Met66) Alters the Intracellular Trafficking and Activity-Dependent Secretion of Wild-Type BDNF in Neurosecretory Cells and Cortical Neurons

2004 • 862 citations

p75 and Trk: A two-receptor system

1995 • 861 citations

The nerve growth factor: thirty-five years later.

1987 • 720 citations

Neurotrophin signaling through the p75 neurotrophin receptor

2002 • 686 citations

Mutations in the TRKA/NGF receptor gene in patients with congenital insensitivity to pain with anhidrosis

1996 • 622 citations

The Brain-Derived Neurotrophic Factor Gene Confers Susceptibility to Bipolar Disorder: Evidence from a Family-Based Association Study

2002 • 604 citations

A de novo mutation affecting human TrkB associated with severe obesity and developmental delay

2004 • 584 citations

Family-based association study of 76 candidate genes in bipolar disorder: BDNF is a potential risk locus

2002 • 570 citations

Nerve growth factor and nociception

1993 • 530 citations

PC12 cell neuronal differentiation is associated with prolonged p21ras activity and consequent prolonged ERK activity

1992 • 480 citations

Activation of Trk neurotrophin receptors in the absence of neurotrophins

2001 • 474 citations

Intracerebroventricular Infusion of Nerve Growth Factor in Three Patients with Alzheimer’s Disease

1998 • 458 citations

The biological effects of endogenous nerve growth factor on adult sensory neurons revealed by a trkA-IgG fusion molecule

1995 • 427 citations

The effect of systemically administered recombinant human nerve growth factor in healthy human subjects

1994 • 394 citations

Identification of the Mechanisms Regulating the Differential Activation of the MAPK Cascade by Epidermal Growth Factor and Nerve Growth Factor in PC12 Cells

2001 • 371 citations

A BDNF Coding Variant is Associated with the NEO Personality Inventory Domain Neuroticism, a Risk Factor for Depression

2002 • 329 citations

Neurotrophins: from enthusiastic expectations through sobering experiences to rational therapeutic approaches

2002 • 326 citations

The many faces of p75NTR

2002 • 309 citations

Neurotrophins

2002 • 272 citations

Neurotrophins and hyperalgesia

1999 • 270 citations

Nerve Growth Factor Activates Persistent Rap1 Signaling in Endosomes

2001 • 242 citations

Disruption of a Single Allele of the Nerve Growth Factor Gene Results in Atrophy of Basal Forebrain Cholinergic Neurons and Memory Deficits

1997 • 232 citations

Association of BDNF with anorexia, bulimia and age of onset of weight loss in six European populations

2004 • 228 citations

Met66 in the brain-derived neurotrophic factor (BDNF) precursor is associated with anorexia nervosa restrictive type

2003 • 202 citations

Association studies of multiple candidate genes for Parkinson's disease using single nucleotide polymorphisms

2001 • 198 citations

BDNF Regulates the Intrinsic Excitability of Cortical Neurons

1999 • 197 citations

The uniqueness of being a neurotrophin receptor

2001 • 194 citations

Does Rap1 deserve a bad Rap?

2003 • 194 citations

Activation of Trk Neurotrophin Receptor Signaling by Pituitary Adenylate Cyclase-activating Polypeptides

2002 • 194 citations

Immunohistochemical Evidence of Seizure-Induced Activation of trk Receptors in the Mossy Fiber Pathway of Adult Rat Hippocampus

1999 • 189 citations

Two conserved domains in the NGF propeptide are necessary and sufficient for the biosynthesis of correctly processed and biologically active NGF.

1991 • 148 citations

A unique pathway for sustained neurotrophin signaling through an ankyrin-rich membrane-spanning protein

2004 • 136 citations

Mutation and polymorphism analysis of the TRKA (NTRK1) gene encoding a high-affinity receptor for nerve growth factor in congenital insensitivity to pain with anhidrosis (CIPA) families

2000 • 88 citations

Neuronal life and death decisions: functional antagonism between the Trk and p75 neurotrophin receptors

1999 • 65 citations

A missense polymorphism (S205L) of the low‐affinity neurotrophin receptor p75^NTR gene is associated with depressive disorder and attempted suicide

2004 • 56 citations

p75 Neurotrophin receptor signaling

2000 • 54 citations

The Gly571arg mutation, associated with the autonomic and sensory disorder congenital insensitivity to pain with anhidrosis, causes the inactivation of the NTRK1/nerve growth factor receptor

2000 • 39 citations

Mutation and polymorphism analysis of the TRKA (NTRK1) gene encoding a high-affinity receptor for nerve growth factor in congenital insensitivity to pain with anhidrosis (CIPA) families

2000 • 26 citations

Brief Research Communication A Missense Polymorphism (S205L) of the Low-Affinity Neurotrophin Receptor p75 NTR Gene Is Associated With Depressive Disorder and Attempted Suicide

2004 • 1 citations