Overexpressing Cu/Zn superoxide dismutase enhances survival of transplanted neurons in a rat model of Parkinson's disease

Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide.

1990 • 7,068 citations

Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis

1993 • 6,762 citations

Estimation of nuclear population from microtome sections

1946 • 4,378 citations

Motor Neuron Degeneration in Mice that Express a Human Cu,Zn Superoxide Dismutase Mutation

1994 • 3,959 citations

Oxidative Stress, Glutamate, and Neurodegenerative Disorders

1993 • 3,746 citations

Cell Death During Development of the Nervous System

1991 • 3,033 citations

A redox-based mechanism for the neuroprotective and neurodestructive effects of nitric oxide and related nitroso-compounds

1993 • 2,423 citations

Quantitative recording of rotational behavior in rats after 6-hydroxy-dopamine lesions of the nigrostriatal dopamine system

1970 • 1,980 citations

Effects of Cerebral Ischemia in Mice Deficient in Neuronal Nitric Oxide Synthase

1994 • 1,578 citations

Basal Lipid Peroxidation in Substantia Nigra Is Increased in Parkinson's Disease

1989 • 1,369 citations

Transition Metals, Ferritin, Glutathione, and Ascorbic Acid in Parkinsonian Brains

1989 • 1,367 citations

Alterations in glutathione levels in Parkinson's disease and other neurodegenerative disorders affecting basal ganglia

1994 • 1,120 citations

Increased Nigral Iron Content and Alterations in Other Metal Ions Occurring in Brain in Parkinson's Disease

1989 • 1,117 citations

A radical hypothesis for neurodegeneration

1993 • 727 citations

Attenuation of focal cerebral ischemic injury in transgenic mice overexpressing CuZn superoxide dismutase.

1991 • 591 citations

Central nervous system trauma and strokeII. Physiological and pharmacological evidence for involvement of oxygen radicals and lipid peroxidation

1989 • 580 citations

Free Radicals and Brain Damage

1993 • 527 citations

Selective Increase of Iron in Substantia Nigra Zona Compacta of Parkinsonian Brains

1991 • 516 citations

Transgenic mice with increased Cu/Zn-superoxide dismutase activity: animal model of dosage effects in Down syndrome.

1987 • 461 citations

Transgenic mice with increased Cu/Zn-superoxide dismutase activity are resistant to N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity

1992 • 457 citations

Functional neural transplantation

1995 • 278 citations

Human fetal dopamine neurons grafted in a rat model of Parkinson's disease: immunological aspects, spontaneous and drug-induced behaviour, and dopamine release

1988 • 277 citations

Monitoring of cell viability in suspensions of embryonic CNS tissue and its use as a criterion for intracerebral graft survival

1985 • 271 citations

Rapid Communication: Attenuation of Methamphetamine‐Induced Neurotoxicity in Copper/Zinc Superoxide Dismutase Transgenic Mice

1994 • 265 citations

Lazaroids improve the survival of grafted rat embryonic dopamine neurons.

1994 • 225 citations

Intracerebral grafting of neuronal cell suspensions. III. Activity of intrastriatal nigral suspension implants as assessed by measurements of dopamine synthesis and metabolism.

1983 • 199 citations

Mesencephalic dopamine cell deficit involves areas A8, A9 and A10 in weaver mutant mice

1988 • 173 citations

Temporal pattern of host responses against intrastriatal grafts of syngeneic, allogeneic or xenogeneic embryonic neuronal tissue in rats

1995 • 136 citations

Protective actions of human recombinant basic fibroblast growth factor on MPTP-lesioned nigrostriatal dopamine neurons after intraventricular infusion

1993 • 133 citations

Genetic control of number of midbrain dopaminergic neurons in inbred strains of mice: relationship to size and neuronal density of the striatum.

1980 • 126 citations

Effects of cool storage on survival and function of intrastriatal ventral mesencephalic grafts

1991 • 120 citations

Programmed Cell Death in Developing Grafts of Fetal Substantia Nigra

1994 • 120 citations

Three-dimensional computer reconstruction of midbrain dopaminergic neuronal populations: From mouse to man

1983 • 112 citations

Superoxide Dismutase, Catalase, and Glutathione Peroxidase Activities in Copper/Zinc‐Superoxide Dismutase Transgenic Mice

1992 • 105 citations

Human cytoplasmic superoxide dismutase cDNA clone: a probe for studying the molecular biology of Down syndrome.

1982 • 95 citations

Human embryonic dopamine neurons xenografted to the rat: effects of cryopreservation and varying regional source of donor cells on transplant survival, morphology and function

1994 • 79 citations

Nigral dopaminergic cell loss in vitamin E deficient rats

1994 • 46 citations

Nigrostriatal function in vitamin E deficiency: Clinical, experimental, and positron emission tomographic studies

1994 • 38 citations