Construction of a vector for site-specific frameshift mutagenesis containing the mutable hotspot of Salmonella typhimurium TA98 on an M13 bacteriophage

Molecular Cloning: A Laboratory Manual

2001 • 133,517 citations

Improved M13 phage cloning vectors and host strains: nucleotide sequences of the M13mpl8 and pUC19 vectors

1985 • 15,222 citations

Rapid and efficient site-specific mutagenesis without phenotypic selection.

1985 • 7,573 citations

[19] Rapid and efficient site-specific mutagenesis without phenotypic selection

1987 • 5,413 citations

[2] New M13 vectors for cloning

1983 • 5,402 citations

Rapid bacteriophage sedimentation in the presence of polyethylene glycol and its application to large-scale virus purification

1970 • 1,556 citations

Frameshift Mutations and the Genetic Code

1966 • 1,400 citations

On the formation of spontaneous deletions: The importance of short sequence homologies in the generation of large deletions

1982 • 690 citations

Mechanistic studies of ionizing radiation and oxidative mutagenesis: genetic effects of a single 8-hydroxyguanine (7-hydro-8-oxoguanine) residue inserted at a unique site in a viral genome

1990 • 687 citations

Identifying Environmental Chemicals Causing Mutations and Cancer

1979 • 575 citations

Genetic studies of the lac repressor

1978 • 517 citations

Misalignment-mediated DNA synthesis errors

1990 • 306 citations

Mechanisms of spontaneous mutagenesis: An analysis of the spectrum of spontaneous mutation in the Escherichia coli lacI gene

1986 • 305 citations

The base substitution fidelity of eucaryotic DNA polymerases. Mispairing frequencies, site preferences, insertion preferences, and base substitution by dislocation.

1986 • 301 citations

MECHANISMS OF SPONTANEOUS AND INDUCED FRAMESHIFT MUTATION IN BACTERIOPHAGE T4

1985 • 292 citations

Method for determining whether a gene of Escherichia coli is essential: application to the polA gene

1984 • 256 citations

Structural intermediates of deletion mutagenesis: a role for palindromic DNA.

1984 • 251 citations

Rapid and Efficient Site-Specific Mutagenesis without Phenotypic Selection

1989 • 233 citations

Stabilization of Z DNA in Vivo by Localized Supercoiling

1989 • 220 citations

Mutation frequency and spectrum resulting from a single abasic site in a single-stranded vector

1990 • 200 citations

Frequency and spectrum of mutations produced by a single cis-syn thymine-thymine cyclobutane dimer in a single-stranded vector.

1988 • 189 citations

Carcinogen-induced mutation spectrum in wild-type, uvrA and umuC strains of Escherichia coli

1984 • 183 citations

Frameshift mutagenesis by eucaryotic DNA polymerases in vitro.

1986 • 177 citations

Site-specifically modified oligodeoxynucleotides as probes for the structural and biological effects of DNA-damaging agents

1988 • 177 citations

Chemical Carcinogens as Frameshift Mutagens: Salmonella DNA Sequence Sensitive to Mutagenesis by Polycyclic Carcinogens

1974 • 169 citations

Ff coliphages: structural and functional relationships

1986 • 156 citations

Site-specific mutagenesis: retrospective and prospective

1991 • 149 citations

Site-specific mutagenesis in vivo by single methylated or deaminated purine bases

1986 • 118 citations

The vinyl chloride DNA derivative N2,3-ethenoguanine produces G----A transitions in Escherichia coli.

1991 • 118 citations

Carcinogen-induced frameshift mutagenesis in repetitive sequences.

1992 • 107 citations

Demonstration of the production of frameshift and base-substitution mutations by quasipalindromic DNA sequences.

1984 • 105 citations

Genetic studies with heteroduplex DNA of bacteriophage f1. Asymmetric segregation, base correction and implications for the mechanism of genetic recombination

1975 • 99 citations

SOS-dependent replication past a single trans-syn T-T cyclobutane dimer gives a different mutation spectrum and increased error rate compared with replication past this lesion in uninduced cells

1990 • 98 citations

Z-DNA-forming sequences are spontaneous deletion hot spots.

1989 • 87 citations

DNA replication of single-stranded Escherichia coli DNA phages

1985 • 85 citations

Local DNA Sequence Control of Deletion Formation in Escherichia coli Plasmid pBR322

1987 • 84 citations

Transient generation of displaced single-stranded DNA during nick translation

1982 • 80 citations

Deletion formation in bacteriophage T4

1988 • 75 citations

Construction of plasmids containing a unique acetylaminofluorene adduct located within a mutation hot spot

1989 • 74 citations

Multiregulatory element of filamentous bacteriophages

1985 • 72 citations

Hotspot sites for acridine-induced frameshift mutations in bacteriophage T4 correspond to sites of action of the T4 type II topoisomerase

1988 • 68 citations

Specific strand loss in N-2-acetylaminofluorene-modified DNA

1987 • 66 citations

Mechanisms of mutagenesis by exocyclic DNA adducts. Transfection of M13 viral DNA bearing a site-specific adduct shows that ethenocytosine is a highly efficient RecA-independent mutagenic noninstructional lesion

1991 • 63 citations

Mutagenic properties of a unique abasic site in mammalian cells

1990 • 62 citations

Construction and characterization of extrachromosomal probes for mutagenesis by carcinogens: site-specific incorporation of O6-methylguanine into viral and plasmid genomes.

1984 • 57 citations

Site-specific frameshift mutagenesis by a propanodeoxyguanosine adduct positioned in the (CpG)4 hot-spot of Salmonella typhimurium hisD3052 carried on an M13 vector.

1992 • 55 citations

Site-specifically alkylated oligodeoxynucleotides: Probes for mutagenesis, DNA repair and the structural effects of DNA damage

1990 • 54 citations

Single d(ApG)/cis-diamminedichloroplatinum(II) adduct-induced mutagenesis in Escherichia coli.

1990 • 53 citations

Spectrum of spontaneous frameshift mutations

1986 • 51 citations

Base-change analysis of revertants of the hisD3052 allele in Salmonella typhimurium

1988 • 46 citations

Chemical and biological studies of the major DNA adduct of cis-diamminedichloroplatinum(II), cis[Pt(NH3)2{d(GpG)}], built into a specific site in a viral genome

1988 • 44 citations

Tetracycline promoter mutations decrease non-B DNA structural transitions, negative linking differences and deletions in recombinant plasmids in Escherichia coli

1989 • 44 citations

DNA sequence analysis of spontaneous mutation in a PolA1 strain of Escherichia coli indicates sequence-specific effects

1987 • 42 citations

Mutagenesis by site-specific arylamine adducts in plasmid DNA: enhancing replication of the adducted strand alters mutation frequency

1990 • 39 citations

Molecular analysis of mutations induced by the intercalating agent ellipticine at the hisd3052 allele of salmonella typhimurium TA98

1992 • 33 citations

Deoxyhexanucleotide containing a vinyl chloride induced DNA lesion, 1,N6-ethenoadenine: synthesis, physical characterization, and incorporation into a duplex bacteriophage M13 genome as part of an amber codon

1987 • 28 citations

Defect in excision repair alters the mutational specificity of PUVA treatment in the lacI gene of Escherichia coli

1987 • 28 citations

DNA sequence analysis of spontaneous and β-methoxy-acrolein-induced mutations in Salmonella typhimurium hisD 3052

1991 • 27 citations

Mechanism of mutation by thymine starvation in Escherichia coli: clues from mutagenic specificity

1985 • 26 citations

Overlapping direct repeats stimulate deletions iin specially designed derivatives of plasmid pBR325 in Escherichia coli

1989 • 25 citations

Preparation and characterization of a viral DNA molecule containing a site-specific 2-aminofluorene adduct: A new probe for mutagenesis by carcinogens

1986 • 22 citations

In vivo effect of DNA repair on the transition frequency produced from a single O6-methyl-or O6-n-butyl-guanine in a T:G base pair

1988 • 19 citations

Mutagenesis by aflatoxin in M13 DNA: Base-substitution mechanisms and the origin of strand bias

1989 • 18 citations

Study of mutational specificity in the lacl gene of escherichia coli as a window on the mechanisms of mutation

1990 • 18 citations

Construction of a human shuttle vector containing a single nitrogen mustard interstrand, DNA-DNA cross-link at a unique plasmid location.

1991 • 16 citations

Sequence analysis of Salmonella typhimurium revertants.

1990 • 14 citations

High-frequency spontaneous deletion of DNA sequences flanked by direct DNA repeats which also contain an internal palindrome

1987 • 1 citations