Chemical and biological studies of the major DNA adduct of cis-diamminedichloroplatinum(II), cis[Pt(NH3)2{d(GpG)}], built into a specific site in a viral genome

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

[2] New M13 vectors for cloning

1983 • 5,402 citations

Adducts of the antitumor drug cis-diamminedichloroplatinum(II) with DNA: formation, identification, and quantitation

1985 • 994 citations

Some current perspectives on chemical carcinogenesis in humans and experimental animals: Presidential Address.

1978 • 938 citations

Structural aspects of platinum anticancer drug interactions with DNA

1987 • 927 citations

DNA fragments differing by single base-pair substitutions are separated in denaturing gradient gels: correspondence with melting theory.

1983 • 895 citations

Sites and thermodynamic quantities associated with proton and metal ion interaction with ribonucleic acid, deoxyribonucleic acid, and their constituent bases, nucleosides, and and nucleotides

1971 • 748 citations

A novel repair enzyme: UVRABC excision nuclease of Escherichia coli cuts a DNA strand on both sides of the damaged region

1983 • 618 citations

Binding of the antitumor drug cis-diamminedichloroplatinum(II) (cisplatin) to DNA

1985 • 436 citations

X-Ray Structure of the Major Adduct of the Anticancer Drug Cisplatin with DNA: cis -[Pt(NH ₃ ) ₂ {d(pGpG)}]

1985 • 403 citations

cis-Diamminedichloroplatinum(II)-induced DNA adducts in peripheral leukocytes from seven cancer patients: quantitative immunochemical detection of the adduct induction and removal after a single dose of cis-diamminedichloroplatinum(II).

1987 • 266 citations

Mutagenicity of cancer chemotherapeutic agents in the Salmonella/microsome test.

1977 • 263 citations

Binding of cis - and trans -Dichlorodiammineplatinum(II) to DNA: Evidence for Unwinding and Shortening of the Double Helix

1979 • 254 citations

Sequence-dependent termination of in vitro DNA synthesis by cis- and trans-diamminedichloroplatinum (II).

1985 • 219 citations

Platinum-DNA adducts in leukocyte DNA correlate with disease response in ovarian cancer patients receiving platinum-based chemotherapy.

1987 • 216 citations

Sequence-Determined DNA Separations

1984 • 210 citations

Depurination causes mutations in SOS-induced cells.

1981 • 186 citations

Use of exonuclease III to determine the site of stable lesions in defined sequences of DNA: the cyclobutane pyrimidine dimer and cis and trans dichlorodiammine platinum II examples

1981 • 144 citations

Inhibition of the BamHI cleavage and unwinding of pBR322 deoxyribonucleic acid by the antitumor drug cis-dichlorodiammineplatinum(II)

1981 • 138 citations

Effect of cis -Platinum(II)Diamminodichloride on Wild Type and Deoxyribonucleic Acid Repair-Deficient Mutants of Escherichia coli

1973 • 137 citations

Base-pair substitution hotspots in GAG and GCG nucleotide sequences in Escherichia coli K-12 induced by cis-diamminedichloroplatinum (II).

1981 • 125 citations

The antitumor drug cis-dichlorodiammineplatinum forms an intrastrand d(GpG) crosslink upon reaction with [d(ApGpGpCpCpT)]2

1982 • 107 citations

Reactions of the UVRABC excision nuclease with DNA damaged by diamminedichloroplatinum(II)

1985 • 105 citations

Heavy metal nucleotide interactions. 11. Stereochemical and electronic effects in the electrophilic attack of cis- and trans-diammineplatinum(II) on 5'-guanosine monophosphate and polyguanylate in aqueous solution

1978 • 100 citations

Thiourea Reverses Cross-Links and Restores Biological Activity in DNA Treated with Dichlorodiaminoplatinum(II)

1979 • 96 citations

Carcinogenicity of antitumor cis-platinum(II) coordination complexes in the mouse and rat.

1979 • 94 citations

Mutagenic properties of CIS-Platinum(II)diammino-dichloride in Escherichia coli

1975 • 90 citations

The quantitative detection of various Pt-DNA-adducts in Chinese hamster ovary cells treated with cisplatin: application of immunochemical techniques

1985 • 88 citations

cis-Diamminedichloroplatinum(II) induced distortion in a double-helical DNA fragment

1984 • 86 citations

Mutagenicity, cytotoxicity, and DNA binding of platinum(II)-chloroammines in Chinese hamster ovary cells.

1980 • 76 citations

Spectrum of cisplatin-induced mutations in Escherichia coli.

1987 • 76 citations

Specific strand loss in N-2-acetylaminofluorene-modified DNA

1987 • 66 citations

Mutagenicity of platinum coordination complexes in Salmonella typhimurium

1980 • 61 citations

A ¹H and ³¹P NMR study of cis‐Pt(NH₃)₂ [d(CpGpG)‐N7 (2),N7 (3)] The influence of a 5′‐terminal cytosine, on the structure of the cis‐Pt(NH₃)₂ [d(GpG)‐N7,N7] instrastrand cross‐link

1985 • 58 citations

Construction and characterization of extrachromosomal probes for mutagenesis by carcinogens: site-specific incorporation of O6-methylguanine into viral and plasmid genomes.

1984 • 57 citations

A d(GpG)-platinated oligonucleotide can form a duplex with a complementary strand

1984 • 51 citations

Synthesis and characterization of [d(ApGpGpCpCpT)]2 and its adduct with the anticancer drug cis-diamminedichloroplatinum(II)

1988 • 44 citations

Reaction of the antitumor drug cis-diamminedichloroplatinum(II) with the trinucleotide d(GpApG): identification of the two main products and kinetic aspects of their formation

1986 • 42 citations

Complex of cis-(NH3)2PtCl2 with guanylyl(3′-5′)-cytidine

1979 • 37 citations

Binding of cis- and trans-diamminedichloroplatinum(II) to deoxyribonucleic acid exposes nucleosides as measured immunochemically with anti-nucleoside antibodies

1986 • 35 citations

DNA fragment conformations. A 1H-NMR conformational analysis of the d(G-G)-chelated platinum-oligonucleotide d(A-T-G-G)cisPt

1984 • 33 citations

Acute lymphocytic leukemia developing in a male with germ cell carcinoma: A case report

1980 • 29 citations

A probe for the mutagenic activity of the carcinogen 4-aminobiphenyl: synthesis and characterization of an M13mp10 genome containing the major carcinogen-DNA adduct at a unique site

1987 • 29 citations

Deoxyhexanucleotide containing a vinyl chloride induced DNA lesion, 1,N6-ethenoadenine: synthesis, physical characterization, and incorporation into a duplex bacteriophage M13 genome as part of an amber codon

1987 • 28 citations

Site-specifically platinated DNA, a new probe of the biological activity of platinum anticancer drugs

1986 • 27 citations

Influence of chromosome integrity on Escherichia coli cell division

1980 • 11 citations