Immunolesioning of basal forebrain cholinergic neurons facilitates hippocampal kindling and perturbs neurotrophin messenger RNA regulation

Modification of seizure activity by electrical stimulation: II. Motor seizure

1972 • 6,939 citations

A permanent change in brain function resulting from daily electrical stimulation

1969 • 3,056 citations

Long-lasting neurotrophin-induced enhancement of synaptic transmission in the adult hippocampus

1995 • 1,354 citations

Limbic seizures produced by pilocarpine in rats: Behavioural, electroencephalographic and neuropathological study

1983 • 1,082 citations

Mice lacking brain-derived neurotrophic factor develop with sensory deficits

1994 • 1,066 citations

Targeted disruption of the BDNF gene perturbs brain and sensory neuron development but not motor neuron development

1994 • 1,046 citations

BDNF mRNA is decreased in the hippocampus of individuals with Alzheimer's disease

1991 • 887 citations

Multiple promoters direct tissue-specific expression of the rat BDNF gene

1993 • 851 citations

trkB, a neural receptor protein-tyrosine kinase: evidence for a full-length and two truncated receptors.

1991 • 785 citations

Differential expression of mRNAs for neurotrophins and their receptors after axotomy of the sciatic nerve.

1993 • 685 citations

Targeted disruption of the trkB neurotrophin receptor gene results in nervous system lesions and neonatal death

1993 • 670 citations

Increased levels of messenger RNAs for neurotrophic factors in the brain during kindling epileptogenesis

1991 • 636 citations

Neurotrophins and brain insults

1994 • 564 citations

A modified histochemical technique to visualize acetylcholinesterase-containing axons.

1985 • 441 citations

A crucial epileptogenic site in the deep prepiriform cortex

1985 • 425 citations

Immunolesioning: selective destruction of neurons using immunotoxin to rat NGF receptor

1991 • 422 citations

Complete and selective cholinergic denervation of rat neocortex and hippocampus but not amygdala by an immunotoxin against the p75 NGF receptor

1994 • 406 citations

BDNF, and NT-4/5 enhance glutamatergic synaptic transmission in cultured hippocampal neurones

1994 • 402 citations

Increased production of the TrkB protein tyrosine kinase receptor after brain insults

1993 • 344 citations

Positive Feedback between Acetylcholine and the Neurotrophins Nerve Growth Factor and Brain‐derived Neurotrophic Factor in the Rat Hippocampus

1994 • 301 citations

Cholinergic excitation of GABAergic interneurons in the rat hippocampal slice.

1992 • 291 citations

Persistent Seizure Susceptibility and Recurrent Spontaneous Seizures in Kindled Cats

1974 • 289 citations

Suppressed Epileptogenesis in BDNF Mutant Mice

1995 • 272 citations

Spontaneous Recurrent Seizures in Rats: Amino Acid and Monoamine Determination in the Hippocampus

1994 • 263 citations

Neuronal colocalization of mRNAs for neurotrophins and their receptors in the developing central nervous system suggests a potential for autocrine interactions.

1993 • 261 citations

Differential usage of multiple brain-derived neurotrophic factor promoters in the rat brain following neuronal activation.

1993 • 248 citations

Effects of atropine, reserpine, 6-hydroxydopamine, and handling on seizure development in the rat

1973 • 240 citations

Spatial learning impairments in rats with selective immunolesion of the forebrain cholinergic system

1992 • 204 citations

Cholinergic regulation of brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) but not neurotrophin-3 (NT-3) mRNA levels in the developing rat hippocampus

1993 • 204 citations

Regulation of neurotrophin and traka, trkb and trkc tyrosine kinase receptor messenger RNA expression in kindling

1993 • 199 citations

The kindling model of epilepsy

1983 • 197 citations

Epilepsy

1993 • 190 citations

Cholinergic denervation of the rat hippocampus by fimbrial transection leads to a transient accumulation of nerve growth factor (NGF) without change in mRNANGF content

1986 • 188 citations

Excitatory amino acid analogues: Neurotoxicity and seizures

1982 • 188 citations

Neural lesioning with ribosome-inactivating proteins: suicide transport and immunolesioning

1992 • 183 citations

Selective Lesioning of the Basal Forebrain Cholinergic System by Intraventricular 192 IgG–saporin: Behavioural, Biochemical and Stereological Studies in the Rat

1995 • 179 citations

Kindling mechanisms: Current progress on an experimental epilepsy model

1986 • 179 citations

192 immunoglobulin G-saporin produces graded behavioral and biochemical changes accompanying the loss of cholinergic neurons of the basal forebrain and cerebellar Purkinje cells

1995 • 175 citations

Targeted disruption of the trkB neurotrophin receptor gene results in nervous system lesions and neonatal death

1993 • 164 citations

Cholinergic seizure kindling in the rat: Comparison of caudate, amygdala and hippocampus

1975 • 145 citations

Electrophysiology of Epilepsy

1984 • 136 citations

Increased beta-nerve growth factor messenger RNA and protein levels in neonatal rat hippocampus following specific cholinergic lesions

1987 • 132 citations

Septal cholinergic afferents regulate expression of brain-derived neurotrophic factor andβ-nerve growth factor mRNA in rat hippocampus

1992 • 122 citations

Neuronal activity in the subcortically denervated hippocampus: A chronic model for epilepsy

1989 • 119 citations

Brain Insults in Rats Induce Increased Expression of the BDNF Gene through Differential Use of Multiple Promoters

1994 • 113 citations

Retardation of amygdala kindling by antagonism of NMD-aspartate and muscarinic cholinergic receptors: Evidence for the summation of excitatory mechanisms in kindling

1988 • 111 citations

Time course of cholinergic and monoaminergic changes in rat brain after immunolesioning with 192 IgG-saporin

1994 • 104 citations

Epilepsy: models, mechanisms and concepts

1994 • 95 citations

Expression of neurotrophin and trk receptor genes in adult rats with fimbria transections: Effect of intraventricular nerve growth factor and brain-derived neurotrophic factor administration

1994 • 95 citations

Widespread increase of nerve growth factor protein in the rat forebrain after kindling-induced seizures

1992 • 90 citations

Cholinergic regulation of hippocampal brain-derived neurotrophic factor mRNA expression: Evidence from lesion and chronic cholinergic drug treatment studies

1993 • 83 citations

Neuronal Supersensitivity to Acetylcholine Induced by Kindling in the Rat Hippocampus

1979 • 82 citations

Electrophysiology of GABA-mediated synaptic transmission and possible roles in epilepsy

1991 • 79 citations

Muscarinic cholinergic receptors participate in the kindling model of epilepsy

1978 • 77 citations

Chemical kindling by muscarinic amygdaloid stimulation in the rat

1983 • 75 citations

Amygdala kindling induces muscarinic cholinergic receptor declines in a highly specific distribution within the limbic system

1980 • 73 citations

Bidirectional transfer of electrical and carbachol kindling

1983 • 70 citations

Antagonism of central but not peripheral cholinergic receptors retards amygdala kindling in rats

1987 • 69 citations

Intraventricular injection of antiserum to nerve growth factor delays the development of amygdaloid kindling

1988 • 57 citations

Role of GABA in the genesis of chemoconvulsant seizures

1992 • 52 citations

Excitatory neurotransmitters in kindling: Excitatory amino acid, cholinergic, and opiate mechanisms

1989 • 45 citations

Role of noradrenergic ascending system in extinction of epileptic phenomena.

1986 • 45 citations

Anticonvulsant effects of ipsilateral but not contralateral microinjections of the dopamine D2 agonist LY 171555 into the nucleus accumbens of amygdala-kindled rats

1991 • 43 citations

Effect of atropine sulfate on amygdaloid kindling in the rat

1979 • 42 citations

Serotonergic mechanisms in amygdaloid-kindled seizures in the rat

1982 • 38 citations

Entorhinal cortex regulation of multiple brain-derived neurotrophic factor promoters in the rat hippocampus

1993 • 37 citations

Failure of atropine to retard amygdaloid kindling

1976 • 35 citations

Participation of muscarinic cholinergic receptors may be an important requirement of the kindling process

1980 • 27 citations

Cholinergic denervation of the rat hippocampus by 192-lgG-saporin

1994 • 24 citations

Combined treatment with muscarinic and nicotinic cholinergic antagonists slows development of kindled seizures

1985 • 21 citations

Serotonin and Kindling Development

1987 • 21 citations

Muscarinic cholinergic regulation of epileptic spiking in kindling

1979 • 18 citations

Anticonvulsant activity of the noradrenergic locus coeruleus system: Role of beta mediation

1994 • 15 citations

Electrical kindling is associated with increases in amygdala acetylcholine levels: an in vivo microdialysis study

1994 • 13 citations

The Effects of Atropine and Reserpine on Cortical Kindling in the Rat

1979 • 12 citations

Effects of scopolamine on the rewarding and seizure-inducing properties of amygdaloid stimulation

1993 • 11 citations

Atropine slows olfactory bulb kindling while diminished cholinergic innervation does not

1988 • 10 citations

Rapidly recurring seizures and status epilepticus: ictal density as a factor in epileptogenesis

1993 • 6 citations