Afferent and spinal mechanisms of joint pain

The Excitatory Amino Acid Receptors: Their Classes, Pharmacology, and Distinct Properties in the Function of the Central Nervous System

1989 • 2,203 citations

Evidence for a central component of post-injury pain hypersensitivity

1983 • 2,103 citations

Induction of c-fos-like protein in spinal cord neurons following sensory stimulation

1987 • 1,975 citations

The Biochemical Basis of Neuropharmacology.

1974 • 1,911 citations

NMDA-receptor activation increases cytoplasmic calcium concentration in cultured spinal cord neurones

1986 • 1,842 citations

The physiology of excitatory amino acids in the vertebrate central nervous system

1987 • 1,718 citations

Local effector functions of capsaicin-sensitive sensory nerve endings: Involvement of tachykinins, calcitonin gene-related peptide and other neuropeptides

1988 • 1,673 citations

The cytoarchitectonic organization of the spinal cord in the cat

1952 • 1,595 citations

Diffuse noxious inhibitory controls (DNIC). I. Effects on dorsal horn convergent neurones in the rat

1979 • 1,325 citations

Peripheral and spinal mechanisms of nociception.

1987 • 1,025 citations

Response of cutaneous sensory units with unmyelinated fibers to noxious stimuli.

1969 • 1,011 citations

Expression of C‐fos‐like protein as a marker for neuronal activity following noxious stimulation in the rat

1990 • 1,009 citations

Stimulus-transcription coupling in neurons: role of cellular immediate-early genes

1989 • 973 citations

Activity-dependent neuronal plasticity following tissue injury and inflammation

1992 • 933 citations

The neuropharmacology of capsaicin: review of some recent observations.

1986 • 833 citations

Brainstem Control of Spinal Pain-Transmission Neurons

1978 • 820 citations

Kinesthetic sensibility.

1978 • 796 citations

Diffuse noxious inhibitory controls (DNIC). II. Lack of effect on non-convergent neurones, supraspinal involvement and theoretical implications

1979 • 765 citations

Hyperalgesia Mediated by Spinal Glutamate or Substance P Receptor Blocked by Spinal Cyclooxygenase Inhibition

1992 • 725 citations

Dynamic receptive field plasticity in rat spinal cord dorsal horn following C-primary afferent input

1987 • 667 citations

Evidence for involvement ofN-methylaspartate receptors in ‘wind-up’ of class 2 neurones in the dorsal horn of the rat

1987 • 666 citations

Antinociceptive actions of spinal nonsteroidal anti-inflammatory agents on the formalin test in the rat.

1992 • 651 citations

Neurogenic hyperalgesia: central neural correlates in responses of spinothalamic tract neurons

1991 • 616 citations

Analgesic Effect of Intraarticular Morphine after Arthroscopic Knee Surgery

1991 • 595 citations

Spinal and Trigeminal Mechanisms of Nociception

1983 • 593 citations

Opioids from immunocytes interact with receptors on sensory nerves to inhibit nociception in inflammation.

1990 • 593 citations

Relative effectiveness of C primary afferent fibers of different origins in evoking a prolonged facilitation of the flexor reflex in the rat

1986 • 561 citations

Capsaicin-induced ion fluxes in dorsal root ganglion cells in culture

1988 • 558 citations

Production of collagenase and prostaglandins by isolated adherent rheumatoid synovial cells.

1976 • 555 citations

Pain Sensations and Reactions

1953 • 553 citations

Tachykinins

1988 • 542 citations

Activation of unmyelinated afferent fibres by mechanical stimuli and inflammation of the urinary bladder in the cat.

1990 • 522 citations

Intraneuronal Substance P Contributes to the Severity of Experimental Arthritis

1984 • 521 citations

Peripheral opioid receptors mediating antinociception in inflammation. Evidence for involvement of mu, delta and kappa receptors.

1989 • 520 citations

Evidence for spinal N-methyl-d-aspartate receptor involvement in prolonged chemical nociception in the rat

2016 • 516 citations

Expression of c‐fos protein in interneurons and projection neurons of the rat spinal cord in response to noxious somatic, articular, and visceral stimulation

1989 • 500 citations

Synaptic actions in motoneurones by afferents in which may evoke the flexion reflex

1959 • 494 citations

The innervation of the knee joint. An anatomical and histological study in the cat.

1967 • 468 citations

Arthritis induced by a T-lymphocyte clone that responds to Mycobacterium tuberculosis and to cartilage proteoglycans.

1985 • 463 citations

The rubrospinal tract. II. Facilitation of interneuronal transmission in reflex paths to motoneurones

1969 • 462 citations

Evidence for spinalN-methyl-d-aspartate receptor involvement in prolonged chemical nociception in the rat

1990 • 458 citations

Substance P Activation of Rheumatoid Synoviocytes: Neural Pathway in Pathogenesis of Arthritis

1987 • 450 citations

Extracellular Potassium in the Mammalian Central Nervous System

1979 • 445 citations

Enhancement of dynorphin gene expression in spinal cord following experimental inflammation: stimulus specificity, behavioral parameters and opioid receptor binding

1988 • 435 citations

Primary afferent units from the hairy skin of the rat hind limb

1982 • 418 citations

Expansion of receptive fields of spinal lamina I projection neurons in rats with unilateral adjuvant-induced inflammation: the contribution of dorsal horn mechanisms

1989 • 395 citations

Effects of an experimental arthritis on the sensory properties of fine articular afferent units

1985 • 371 citations

Excitatory amino acids and synaptic transmission: the evidence for a physiological function

1990 • 370 citations

The hyperalgesic effects of prostacyclin and prostaglandin E2

1978 • 359 citations

Anatomical and physiological studies of knee joint innervation in the cat.

1956 • 352 citations

Lipoxygenation of arachidonic acid as a source of polymorphonuclear leukocyte chemotactic factors in synovial fluid and tissue in rheumatoid arthritis and spondyloarthritis.

1980 • 350 citations

Proceedings of the Vth World Congress on Pain

1988 • 349 citations

Contribution of sensory afferents and sympathetic efferents to joint injury in experimental arthritis

1986 • 348 citations

Time course of mechanosensitivity changes in articular afferents during a developing experimental arthritis

1988 • 336 citations

Characteristics of knee joint receptors in the cat

1969 • 329 citations

Composition of Peripheral Nerves

1969 • 322 citations

II - Prostaglandin hyperalgesia: The peripheral analgesic activity of morphine, enkephalins and opioid antagonists

1979 • 317 citations

Supraspinal control of interneurones mediating spinal reflexes

1959 • 317 citations

The pain system. The neural basis of nociceptive transmission in the mammalian nervous system.

1985 • 315 citations

Synovial Fluid Changes in Joint Disease.

1953 • 314 citations

Differential effects of excitatory amino acid antagonists on dorsal horn nociceptive neurones in the rat

1990 • 310 citations

The reflex sympathetic dystrophy syndrome

1976 • 307 citations

A monoclonal antibody against neurofilament protein specifically labels a subpopulation of rat sensory neurones

1984 • 306 citations

Substance P regulates the vasodilator activity of calcitonin gene-related peptide

1988 • 306 citations

A limited arthritic model for chronic pain studies in the rat

1992 • 304 citations

Receptors in the knee joint ligaments and their role in the biomechanics of the joint.

1991 • 304 citations

Treatment of arthritis with topical capsaicin: a double-blind trial.

1991 • 299 citations

Actions on gamma‐motoneurones elicited by electrical stimulation of group I muscle afferent fibres in the hind limb of the cat.

1983 • 299 citations

In situ hybridization histochemistry and immunocytochemistry reveal an increase in spinal dynorphin biosynthesis in a rat model of peripheral inflammation and hyperalgesia.

1988 • 292 citations

Agonist- and voltage-gated calcium entry in cultured mouse spinal cord neurons under voltage clamp measured using arsenazo III

1987 • 288 citations

Extracellular K+ accumulation in the central nervous system

1983 • 282 citations

Dissociation Between the Antinociceptive and Anti-Inflammatory Effects of the Nonsteroidal Anti-Inflammatory Drugs

1991 • 275 citations

Sources of input to interneurones mediating group I non‐reciprocal inhibition of motoneurones in the cat.

1985 • 271 citations

Activity‐Dependent Changes in Rat Ventral Horn Neurons in vitro; Summation of Prolonged Afferent Evoked Postsynaptic Depolarizations Produce a D‐2‐Amino‐5‐Phosphonovaleric Acid Sensitive Windup

1990 • 270 citations

EXPERIMENTAL EVIDENCE ON THE NATURE OF CUTANEOUS HYPERALGESIA

1950 • 268 citations

Differential activation of spinal cord dynorphin and enkephalin neurons during hyperalgesia: evidence using cDNA hybridization

1988 • 268 citations

Signaling of Kinesthetic Information by Peripheral Sensory Receptors

1982 • 265 citations

ACUTE ARTHRITIS IN MAN AND DOG AFTER INTRASYNOVIAL INJECTION OF SODIUM URATE CRYSTALS

1962 • 265 citations

Excitatory amino acid receptors and nociceptive neurotransmission in rat spinal cord

1990 • 259 citations

Responsiveness and functional attributes of electrically localized terminals of cutaneous C-fibers in vivo and in vitro

1992 • 259 citations

Substance P release from knee joint afferent terminals: modulation by opioids

1988 • 254 citations

Differential supraspinal control of synaptic actions evoked by volleys in the flexion reflex afferents in alpha motoneurones.

1961 • 252 citations

Prostaglandins and related substances

1983 • 244 citations

Chemical activation of nociceptive peripheral neurones

1991 • 241 citations

Slowly adapting receptors in cat knee joint: can they signal joint angle?

1975 • 240 citations

A critical review of the afferent pathways and the potential chemical mediators involved in cardiac pain

1992 • 234 citations

Excitation and sensitization of fine articular afferents from cat's knee joint by prostaglandin E2.

1988 • 233 citations

Peripheral patterns of calcitonin‐gene‐related peptide general somatic sensory innervation: Cutaneous and deep terminations

1989 • 229 citations

Tachykinins and calcitonin gene-related peptide enhance release of endogenous glutamate and aspartate from the rat spinal dorsal horn slice

1990 • 229 citations

Opioid analgesia at peripheral sites: a target for opioids released during stress and inflammation?

1987 • 228 citations

Intrinsic mechanisms of antinociception in inflammation: local opioid receptors and beta-endorphin

1990 • 228 citations

Leukotriene and prostaglandin sensitization of cutaneous high-threshold C- and A-delta mechanonociceptors in the hairy skin of rat hindlimbs

1987 • 226 citations

Identification of prostaglandin E2 and leukotriene B4 in the synovial fluid of painful, dysfunctional temporomandibular joints

1990 • 225 citations

Mechanical sensitivity of group III and IV afferents from posterior articular nerve in normal and inflamed cat knee

1986 • 222 citations

PROSTAGLANDIN SYNTHETASE INHIBITORS

1979 • 220 citations

Release of immunoreactive substance P in the spinal cord during development of acute arthritis in the knee joint of the cat: a study with antibody microprobes

1990 • 220 citations

Enhanced responses of spinothalamic tract neurons to excitatory amino acids accompany capsaicin-induced sensitization in the monkey

1992 • 220 citations

Mechanically insensitive afferents (MIAs) in cutaneous nerves of monkey

1991 • 219 citations

Effects of capsaicin on inflammation and on the substance P content of nervous tissues in rats with adjuvant arthritis

1983 • 216 citations

Evidence for a central component in the sensitization of spinal neurons with joint input during development of acute arthritis in cat's knee

1990 • 213 citations

Release, spread and persistence of immunoreactive neurokinin A in the dorsal horn of the cat following noxious cutaneous stimulation. Studies with antibody microprobes

1990 • 213 citations

Organization of the lumbar sympathetic outflow to skeletal muscle and skin of the cat hindlimb and tail

1985 • 212 citations

Comparison of primary afferent and glutamate excitation of neurons in the mammalian spinal dorsal horn

1988 • 210 citations

Spinal opioid analgesic effects are enhanced in a model of unilateral inflammation/hyperalgesia: possible involvement of noradrenergic mechanisms

1991 • 208 citations

Chapter 11 Neurochemistry and neural circuitry in the dorsal horn

1986 • 206 citations

Proprioceptive discharges from stretch‐receptors in the knee‐joint of the cat

1953 • 205 citations

Responses of fine medial articular nerve afferents to passive movements of knee joints

1983 • 204 citations

Evidence that adjuvant arthritis in the rat is associated with chronic pain

1987 • 203 citations

Inhibition of prostaglandin biosynthesis as the mechanism of analgesia of aspirin-like drugs in the dog knee joint

1975 • 196 citations

Substance P-, calcitonin gene-related peptide-and C-flanking peptide of neuropeptide Y-immunoreactive fibres are present in normal synovium but depleted in patients with rheumatoid arthritis

1990 • 195 citations

Processing of Sensory Information in the Superficial Dorsal Horn of the Spinal Cord

1989 • 195 citations

Inflammation of the hind limb as a model of unilateral, localized pain: influence on multiple opioid systems in the spinal cord of the rat

1988 • 195 citations

Increase of substance P in primary afferent nerves during chronic pain

1981 • 194 citations

LEUKOTRIENE B4, AN INFLAMMATORY MEDIATOR IN GOUT

1982 • 193 citations

Neural control of vascular permeability: interactions between primary afferents, mast cells, and sympathetic efferents

1989 • 193 citations

Enhancement of the responses of ascending tract cells in the cat spinal cord by acute inflammation of the knee joint

1987 • 192 citations

A noxious stimulus induces the preprotachykinin-A gene expression in the rat dorsal root ganglion: a quantitative study using in situ hybridization histochemistry

1988 • 191 citations

Composition of Peripheral Nerves

1969 • 190 citations

Opioid Analgesia at Peripheral Sites

1987 • 189 citations

Leukotriene B4, a mediator of inflammation present in synovial fluid in rheumatoid arthritis.

1983 • 174 citations

Articular reflexes at the ankle joint: An electromyogrphic study of normal and abnormal influences of ankle-joint mechanoreceptors upon reflex activity in the leg muscles

1967 • 171 citations

Chapter 1 Anatomy and physiology of descending control of nociceptive responses of dorsal horn neurons: comprehensive review

1988 • 171 citations

Substance p and arthritis: analysis of plasma and synovial fluid levels

1990 • 171 citations

Activation of groups III and IV sensory units in medial articular nerve by local mechanical stimulation of knee joint.

1983 • 170 citations

Differences in the chemical expression of rat primary afferent neurons which innervate skin, muscle or joint

1989 • 170 citations

Response of primate joint afferent neurons to mechanical stimulation of knee joint

1977 • 167 citations

The adequacy of stretch receptors in the cat knee joint for signalling joint angle throughout a full range of movement.

1980 • 166 citations

Preproenkephalin mrna in spinal dorsal horn neurons is induced by peripheral inflammation and is co-localized with Fos and Fos-related proteins

1992 • 165 citations

Changes in tonic descending inhibition of spinal neurons with articular input during the development of acute arthritis in the cat

1991 • 165 citations

c-fos Expression in rat lumbar spinal cord during the development of adjuvant-induced arthritis

1992 • 161 citations

Neural changes in acute arthritis in monkeys. I. Parallel enhancement of responses of spinothalamic tract neurons to mechanical stimulation and excitatory amino acids

1992 • 161 citations

Unresponsive afferent nerve fibres in the sural nerve of the rat.

1991 • 159 citations

Release of substance P from the spinal dorsal horn is enhanced in polyarthritic rats

1987 • 158 citations

The biochemical basis of neuropharmacology

1987 • 158 citations

The presence of a kinin in inflammatory synovial effusion from arthritides of varying etiologies

1967 • 158 citations

Electrophysiological characteristics of dorsal horn cells in rats with cutaneous inflammation resulting from chronic arthritis

1982 • 156 citations

The analgesic effects of morphine, but not those of the enkephalinase inhibitor thiorphan, are enhanced in arthritic rats

1983 • 155 citations

Experimental joint disease

1963 • 154 citations

Neural changes in acute arthritis in monkeys. IV. Time-course of amino acid release into the lumbar dorsal horn

1992 • 154 citations

Glucocorticoids suppress levels of immunoreactive bradykinin in inflamed tissue as evaluated by microdialysis probes

1990 • 154 citations

Aspirin-like drugs may block pain independently of prostaglandin synthesis inhibition

1991 • 154 citations

Actions on gamma‐motoneurones elicited by electrical stimulation of joint afferent fibres in the hind limb of the cat.

1986 • 152 citations

A model of chronic pain in the rat: response of multiple opioid systems to adjuvant-induced arthritis

1986 • 150 citations

Somatosensory properties of spinoreticular neurons in the cat

1977 • 150 citations

Dose-dependent analgesic and hyperalgesic effects of systemic naloxone in arthritic rats

1981 • 149 citations

Discharge characteristics of fine medial articular afferents at rest and during passive movements of inflamed knee joints

1983 • 148 citations

Intra-articular pressure in rheumatoid arthritis of the knee. 3. Pressure changes during joint use.

1970 • 147 citations

Role of joint afferents in motor control exemplified by effects on reflex pathways from Ib afferents.

1978 • 145 citations

Prostaglandins inhibit endogenous pain control mechanisms by blocking transmission at spinal noradrenergic synapses

1988 • 145 citations

Opiates inhibit the discharges of fine afferent units from inflamed knee joint of the cat

1987 • 144 citations

Contribution of the Nervous System to the Pathophysiology of Rheumatoid Arthritis and Other Polyarthritides

1987 • 136 citations

The role of substance P and calcitonin gene-related peptide in neurogenic plasma extravasation and vasodilatation in the rat

1989 • 134 citations

Ankle joint urate arthritis (AJUA) in rats: an alternative animal model of arthritis to that produced by Freundʼs adjuvant

1987 • 134 citations

Neuropeptides in synovium of patients with rheumatoid arthritis and osteoarthritis.

1988 • 131 citations

Levels of Prostaglandins F₂α and E₂and Thromboxane B₂In Joint Fluid in Rheumatoid Arthritis

1977 • 131 citations

Met-enkephalin levels and opiate receptors in the spinal cord of chronic suffering rats

1980 • 131 citations

Peripheral effect of fentanyl upon nociception in inflamed tissue of the rat

1988 • 130 citations

Depression by morphine and the non-opioid analgesic agents, metamizol (dipyrone), lysine acetylsalicylate, and paracetamol, of activity in rat thalamus neurones evoked by electrical stimulation of nociceptive afferents

1988 • 127 citations

Mechanical factors influencing response of joint afferent neurons from cat knee

1975 • 126 citations

The projection of the medial and posterior articular nerves of the cat's knee to the spinal cord

1988 • 125 citations

THE SYNOVIAL PROSTAGLANDIN SYSTEM IN CHRONIC INFLAMMATORY ARTHRITIS: DIFFERENTIAL EFFECTS OF STEROIDAL AND NONSTEROIDAL ANTI‐INFLAMMATORY DRUGS

1981 • 124 citations

Different RNA Fractions during Cell Growth and Synchronous Division in Mass Cultures of Tetrahymena Pyriformis

1962 • 123 citations

Prodynorphin gene expression is enhanced in the spinal cord of chronic arthritic rats

1987 • 122 citations

Joint receptors and kinaesthesia

1988 • 121 citations

Spinal afferent processing

1987 • 121 citations

Response properties and descending control of rat dorsal horn neurons with deep receptive fields

1990 • 119 citations

Sensitization of articular afferents to mechanical stimuli by bradykinin

1989 • 118 citations

The Effects of NMDA Antagonists on Neuronal Activity in Cat Spinal Cord Evoked by Acute Inflammation in the Knee Joint

1991 • 117 citations

A model of chronic pain in the rat: functional correlates of alterations in the activity of opioid systems

1987 • 116 citations

On the Reflex Effects from the Knee Joint of the Cat

1960 • 116 citations

Increase in substance P and CGRP, but not somatostatin content of innervating dorsal root ganglia in adjuvant monoarthritis in the rat

1992 • 115 citations

Sensory receptors in ankle joint capsules of normal and arthritic rats

1985 • 115 citations

THE SENSITIVITY AND INNERVATION OF THE ARTICULAR CAPSULE

1950 • 114 citations

Tonic descending inhibition of spinal cord neurones driven by joint afferents in normal cats and in cats with an inflamed knee joint

1991 • 114 citations

Intra-articular pressure in rheumatoid arthritis of the knee. I. Pressure changes during passive joint distension.

1970 • 114 citations

Peptide containing nerves in human synovium: immunohistochemical evidence for decreased innervation in rheumatoid arthritis.

1990 • 113 citations

Sensory innervation of the anterior cruciate ligament. An electrophysiological study of the response properties of single identified mechanoreceptors in the cat.

1992 • 113 citations

Adrenal medullary implants in the rat spinal cord reduce nociception in a chronic pain model

1990 • 113 citations

Inhibition of carrageenan induced inflammation in the rat knee joint by substance P antagonist.

1989 • 113 citations

Convergent inputs from articular, cutaneous and muscle receptors onto ascending tract cells in the cat spinal cord

1987 • 112 citations

Effects of prostaglandins and other putative chemical intermediaries on the activity of canine testicular polymodal receptors studied in vitro

1987 • 110 citations

Enhancement of preprotachykinin A gene expression by adjuvant-induced inflammation in the rat spinal cord: possible involvement of substance P-containing spinal neurons in nociception

1989 • 109 citations

Freund's adjuvants: relationship of arthritogenicity and adjuvanticity in rats to vehicle composition.

1974 • 108 citations

The distribution and termination of nerves in the knee joint of the cat

1944 • 108 citations

Calcitonin gene-related peptide increases in the dorsal root ganglia of adjuvant arthritic rat

1989 • 108 citations

The effect of kinin agonists and antagonists on the pain response of the human blister base

1987 • 107 citations

Activation of fine articular afferent units by bradykinin

1985 • 106 citations

Effects of temporomandibular joint stimulation on nociceptive and nonnociceptive neurons of the cat's trigeminal subnucleus caudalis (medullary dorsal horn)

1988 • 104 citations

The role of N‐methylaspartate receptors in mediating responses of rat and cat spinal neurones to defined sensory stimuli.

1987 • 104 citations

Induction of the gene encoding pro-dynorphin by experimentally induced arthritis enhances staining for dynorphin in the spinal cord of rats

1989 • 103 citations

Dynamic changes in the receptive field properties of spinal cord neurons with ankle input in rats with chronic unilateral inflammation in the ankle region

1993 • 103 citations

Afferent and efferent axons in the medial and posterior articular nerves of the cat

1983 • 102 citations

Ultrastructural three‐dimensional reconstruction of group III and group IV sensory nerve endings (“free nerve endings”) in the knee joint capsule of the cat: Evidenence for multiple receptive sites

1990 • 102 citations

The effects of locally applied capsaicin on conduction in cutaneous nerves in four mammalian species

1986 • 101 citations

Potent antinociceptive effects of Kelatorphan (a highly efficient inhibitor of multiple enkephalin-degrading enzymes) systemically administered in normal and arthritic rats

1989 • 100 citations

Calcitonin Gene‐related Peptide Causes Intraspinal Spreading of Substance P Released by Peripheral Stimulation

1992 • 99 citations

Peripheral inflammation is associated with increased dynorphin immunoreactivity in both projection and local circuit neurons in the superficial dorsal horn of the rat lumbar spinal cord

1989 • 99 citations

PGI2-induced activation and sensitization of articular mechanonociceptors

1991 • 99 citations

The role of PGE2 in the sensitization of mechanoreceptors in normal and inflamed ankle joints of the rat

1991 • 99 citations

Sensory neuropeptide interactions in the production of plasma extravasation in the rat

1992 • 99 citations

Afferent fibers mediate the increase of met-enkephalin elicited in rat spinal cord by localized pain

1984 • 99 citations

Clinical response to regional intravenous guanethidine in patients with rheumatoid arthritis.

1986 • 98 citations

Species differences in biotransformation and excretion of salicylate.

1972 • 97 citations

Neural changes in acute arthritis in monkeys. III. Changes in substance P, calcitonin gene-related peptide and glutamate in the dorsal horn of the spinal cord

1992 • 97 citations

Bradykinin is increased during acute and chronic inflammation: Therapeutic implications

1988 • 94 citations

Chapter 20 Electrophysiological evidence for the activation of descending inhibitory controls by nociceptive afferent pathways

1988 • 93 citations

Effects of naproxen on connective tissue changes in the adjuvant arthritic rat

1979 • 93 citations

Differential effects of various doses of morphine and naloxone on two nociceptive test thresholds in arthritic and normal rats

1990 • 92 citations

Cat spinoreticular neurons: Locations, responses and changes in responses during repetitive stimulation

1978 • 92 citations

Information signaled by sensory fibers in medial articular nerve

1975 • 91 citations

Contributions of arachidonic acid derivatives and substance P to the sensitization of cutaneous nociceptors

1990 • 91 citations

Is prostacyclin the major pro-inflammatory prostanoid in joint fluid?

1980 • 89 citations

Neural changes in acute arthritis in monkeys. II. Increased glutamate immunoreactivity in the medial articular nerve

1992 • 89 citations

Characteristics of hip joint mechanoreceptors in the cat.

1982 • 88 citations

IMMUNOHISTOCHEMICAL DEMONSTRATION OF NOCICEPTORS IN THE CAPSULE AND SYNOVIAL FOLDS OF HUMAN ZYGAPOPHYSEAL JOINTS

1987 • 88 citations

Purinergic regulation of bradykinin-induced plasma extravasation and adjuvant-induced arthritis in the rat.

1991 • 87 citations

The effect of knee joint afferent discharge on transmission in flexion reflex pathways in decerebrate cats.

1981 • 86 citations

An investigation into the validity of subatmospheric pressure recordings from synovial fluid and their dependence on joint angle.

1979 • 84 citations

Production of Hyperalgesic Prostaglandins by Sympathetic Postganglionic Neurons

1989 • 83 citations

Basic and Regulatory Mechanisms of In Vitro Release of Met‐Enkephalin from the Dorsal Zone of the Rat Spinal Cord

1984 • 83 citations

Release and spread of immunoreactive neurokinin A in the cat spinal cord in a model of acute arthritis

1990 • 83 citations

Anatomy of the rat knee joint and fibre composition of a major articular nerve

1991 • 82 citations

Changes in brain and spinal tryptophan and 5-hydroxy-indoleacetic acid levels follwing acute morphine administration in normal and arthritic rats

1979 • 81 citations

Possible relationships between extracellular potassium activity and presynaptic inhibition in the spinal cord of the cat

1974 • 80 citations

Sample handling techniques when analyzing regulatory peptides

1987 • 80 citations

Study of Somatic Pain

1938 • 80 citations

Intrathecal injection of acetylsalicylic acid, salicylic acid and indometacin depresses C fibre-evoked activity in the rat thalamus and spinal cord

1992 • 79 citations

The sensory innervation of the medial ligament of the knee joint

1954 • 79 citations

Inflammatory mediators and nociception in the joint: Excitation and sensitization of slowly conducting afferent fibers of cat's knee by prostaglandin I2

1992 • 79 citations

Epinephrine exacerbates arthritis by an action at presynaptic b2-adrenoceptors

1990 • 79 citations

Modulatory Effects of Descending Systems on Spinal Dorsal Horn Neurons

1986 • 79 citations

Pain and Inflammatory Mediators

1978 • 79 citations

The arthritic rat as a model of clinical pain?

1990 • 79 citations

Silver Impregnation and Immnunohistochemical Study of Nerves in Lumbar Facet Joint Plical Tissue

1991 • 78 citations

THE ORIGIN AND NATURE OF NORMAL HUMAN SYNOVIAL FLUID 12

1940 • 77 citations

Origin of sympathetic and sensory innervation of the temporo-mandibular joint. A retrograde axonal tracing study in the rat

1990 • 76 citations

Acute and Chronic Phases of Unilateral Inflammation in Rat's Ankle are Associated with an Increase in the Proportion of Calcitonin Gene‐related Peptide‐immunoreactive Dorsal Root Ganglion Cells

1993 • 74 citations

Prostaglandins and anti-inflammatory drugs in the dog knee joint

1972 • 74 citations

Substance P- and calcitonin gene-related peptide immunoreactivity in primary afferent neurons of the cat's knee joint

1991 • 73 citations

Dorsal horn (convergent) neurones in the intact anaesthetized arthritic rat. I. Segmental excitatory influences

1987 • 73 citations

Opioid receptor types and antinociceptive activity in chronic inflammation: bothe κ- and μ-opiate agonistic effects are enhanced in arthritic rats

1986 • 72 citations

Peripheral opioid receptors mediating antinociception in inflammation. Activation by endogenous opioids and role of the pituitary-adrenal axis

1990 • 71 citations

THE ROLE OF PROSTAGLANDINS IN RABBIT MONOARTICULAR ARTHRITIS

1974 • 71 citations

The Deployment of Sensory Nerve Endings at the Knee Joint of the Cat.

1953 • 69 citations

Spinal cord dynorphin may modulate nociception via a ℵ-opioid receptor in chronic arthritic rats

1985 • 69 citations

First-order nociceptive synapses in rat dorsal horn are blocked by an amino acid antagonist

1986 • 69 citations

Specific neurokinin receptors mediate plasma extravasation in the rat knee joint

1991 • 68 citations

Motivational effects of opioids in an animal model of prolonged inflammatory pain: alteration in the effects of κ-but not of μ-receptor agonists

1988 • 68 citations

Acute inflammation of the knee joint in the cat alters responses of flexor motoneurons to leg movements

1988 • 67 citations

Joint afferent fibres responding to muscle stretch, vibration and contraction

1973 • 67 citations

Paradoxical hyperalgesic effect of exceedingly low doses of systemic morphine in an animal model of persistent pain (Freund's adjuvant-induced arthritic rats)

1987 • 67 citations

Joint Fluid Pressure in Chronic Knee Effusions

1963 • 67 citations

Characteristics of wrist joint receptors in the cat

1979 • 66 citations

Changes in extracellular potassium concentration in cat spinal cord in response to innocuous and noxious stimulation of legs with healthy and inflamed knee joints

1990 • 66 citations

Suppression of carrageenan-induced hyperalgesia, hyperthermia and edema by a bradykinin antagonist

1989 • 66 citations

Response of joint afferent neurons in cat medial articular nerve to active and passive movements of the knee

1976 • 65 citations

Joint Receptors and Kinaesthesis

1973 • 64 citations

The autonomic and somatic innervation of the articular capsule

1952 • 64 citations

Effects of acetylsalicylic acid and indomethacin on single groups III and IV sensory units from acutely inflamed joints

1986 • 63 citations

Response and receptive-field properties of spinomesencephalic tract cells in the cat

1986 • 63 citations

Neurogenic and non-neurogenic inflammation in the rat paw following chemical sympathectomy

1991 • 63 citations

Capsaicin-induced release of calcitonin gene-related peptide from dorsal horn slices is enhanced in adjuvant arthritic rats

1989 • 62 citations

Facilitation from Ipsilateral Primary Afferents of Interneuronal Transmission in the Ia Inhibitory Pathway to Motoneurones

1972 • 61 citations

Activation of normal and inflamed fine articular afferent units by serotonin

1992 • 61 citations

Nerves in inflammatory synovium: immunohistochemical observations on the adjuvant arthritis rat model.

1990 • 61 citations

Localization of substance P and neurofilament immunoreactive fibers in the lumbar facet joint capsule and supraspinous ligament of the rabbit

1988 • 61 citations

Capsaicin suppresses substance P-induced joint inflammation in the rat

1989 • 60 citations

Concentrations of prostaglandins D2, E2, F2 alpha, 6-keto-F1 alpha and thromboxane B2 in synovial fluid from patients with inflammatory joint disorders and osteoarthritis.

1984 • 60 citations

Responses of spinal cord neurones to stimulation of articular afferent fibres in the cat.

1986 • 59 citations

N-methyl-d-aspartate receptors mediate responses of rat dorsal horn neurones to hindlimb ischemia

1990 • 58 citations

Angiotensin-converting enzyme in discrete forebrain areas of spontaneously hypertensive rats

1984 • 58 citations

Immunoreactive tachykinins, calcitonin gene-related peptide and neuropeptide Y in human synovial fluid from inflamed knee joints

1989 • 57 citations

Effect of peptidase inhibition on the pattern of intraspinally released immunoreactive substance P detected with antibody microprobes

1992 • 57 citations

Peptidergic innervation of the temporomandibular disk in the rat

1989 • 57 citations

The pharmacology of segmental transmission in the spinal cord

1989 • 57 citations

Localization and Central Projections of Primary Afferent Neurons That Innervate the Temporomandibular Joint in Cats

1987 • 56 citations

15-Hydroxy-eicosatetraenoic acid (15-Hete) inhibits carragheenan-induced experimental arthritis and reduces synovial fluid leukotriene B4 (LTB4)

1989 • 55 citations

Sensory inputs to neurones in Clarke's column from muscle, cutaneous and joint receptors

1973 • 55 citations

Modifications of serotonin-, substance P- and calcitonin gene-related peptide-like immunoreactivities in the dorsal horn of the spinal cord of arthritic rats: a quantitative immunocytochemical study

1991 • 55 citations

Peripheral and spinal components of the sensitization of spinal neurons during an acute experimental arthritis

1988 • 55 citations

Regional distribution of mast cells and peptide containing nerves in normal and adjuvant arthritic rat synovium.

1991 • 55 citations

Inhibitory effects of indomethacin, aspirin and certain other drugs on inflammations induced in rat and dog by carrageenan, sodium urate and ellagic acid.

1970 • 54 citations

Synthesis of arachidonate cyclo-oxygenase products by rheumatoid and nonrheumatoid synovial lining in nonproliferative organ culture

1983 • 54 citations

Time-dependent changes in the activity of opioid systems in the spinal cord of monoarthritic rats—A release and in situ hybridization study

1992 • 53 citations

Arthritis induced in cat by sodium urate: a possible animal model for tonic pain

1984 • 53 citations

Vasopressin and oxytocin in the rat spinal cord: analysis of their role in the control of nociception

1984 • 51 citations

The effect of lysine acetylsalicylate on joint capsule mechanoreceptors in rats with polyarthritis

1985 • 51 citations

Increased norepinephrine and uric acid levels in the spinal cord of arthritic rats

1986 • 50 citations

Changes in synovial PO2 and blood flow in the rabbit knee joint due to stimulation of the posterior articular nerve.

1992 • 49 citations

Fiber Size Distribution of Myelinated and Unmyelinated Axons in the Medial and Posterior Articular Nerves of the Cat's Knee Joint

1988 • 48 citations

Opioid systems in the response to inflammatory pain: Sustained blockade suggests role of κ- but not μ-opioid receptors in the modulation of nociception, behaviour and pathology

1991 • 48 citations

Analgesic drugs in the cat.

1968 • 48 citations

Electrophysiological evidence for a tonic activity of the spinal cord intrinsic opioid systems in a chronic pain model

1989 • 47 citations

Leukocytes and prostaglandins in acute inflammation

1974 • 47 citations

Prostaglandin production in arthritis.

1978 • 47 citations

The responses to somatic stimuli of deep spinothalamic tract cells in the lumbar spinal cord of the cat

1982 • 47 citations

THE EFFECT OF ACUTE JOINT INFLAMMATION ON FLEXION REFLEX EXCITABILITY IN THE DECEREBRATE, LOW‐SPINAL CAT

1988 • 46 citations

The mycobacterial 65 kD heat-shock protein and autoimmune arthritis

1989 • 46 citations

Complex temporal changes in 5-hydroxytryptamine synthesis in the central nervous system induced by experimental polyarthritis in the rat

1987 • 45 citations

Urate crystal induced inflammation in dog joints: sequence of synovial changes.

1974 • 45 citations

Slowly adapting receptors in cat hip joint

1979 • 44 citations

Effect of Anti-Inflammatory Agents on Acute Experimental Synovitis In Dogs

1966 • 44 citations

Histochemical changes of substance P, FRAP, serotonin and succinic dehydrogenase in the spinal cord of rats with adjuvant arthritis

1985 • 43 citations

Segmental reflexes mediated by joint afferent neurons in cat knee

1978 • 43 citations

Structure and function of temporomandibular joint innervation.

1971 • 42 citations

REFLEX MUSCULAR RESPONSES TO STIMULATION OF ARTICULAR NERVES IN THE CAT

1950 • 42 citations

Co-localization of proenkephalin- and prodynorphin-derived opioid peptides in laminae IV/V spinal neurons revealed in arthritic rats

1988 • 42 citations

Catecholamine secretion and adrenal nerve activity in response to movements of normal and inflamed knee joints in cats.

1986 • 42 citations

Increase in extracellular potassium level in rat spinal dorsal horn induced by noxious stimulation and peripheral injury

1988 • 42 citations

The effects of 5‐HT on articular sensory receptors in normal and arthritic rats

1990 • 41 citations

Flexion-extension sensitivity of elbow joint afferents in cat

1975 • 41 citations

Static and dynamic responses of slowly adapting joint receptors

1974 • 41 citations

Dorsal horn (convergent) neurones in the intact anaesthetized arthritic rat. II. Heterotopic inhibitory influences

1987 • 40 citations

Trigeminal nerve and temporomandibular joint of the cat: A horseradish peroxidase study

1979 • 40 citations

Changes in blood pressure and heart rate induced by movements of normal and inflamed knee joints

1984 • 40 citations

Noradrenergic and peptidergic nerves in the synovial membrane of the sprague‐dawley rat

1990 • 39 citations

Spontaneous and evoked release of met-enkephalin-like material from the spinal cord of arthritic rats in vivo

1988 • 38 citations

Mediators of substance P-induced inflammation in the rat knee joint

1990 • 38 citations

The interrelation of neural discharge, intra‐articular pressure, and joint angle in the knee of the dog.

1986 • 37 citations

High-dose epinephrine acts at α2-adrenoceptors to suppress experimental arthritis

1991 • 37 citations

Peptides and Nociception

1984 • 37 citations

Analgesia produced by low doses of the opiate antagonist naloxone in arthritic rats is reduced in morphine-tolerant animals

1986 • 37 citations

CAPSULAR COMPLIANCE AND PRESSURE-VOLUME RELATIONSHIPS IN NORMAL AND ARTHRITIC KNEES

1972 • 37 citations

EXPERIMENTAL EVALUATION OF THE HYPOTHESIS OF LIGAMENTO‐MUSCULAR PROTECTIVE REFLEXES: II. A study in cat using the medial collateral ligament of the knee joint

1959 • 37 citations

The nervous control of joint blood vessels

1956 • 36 citations

Distribution of substance P‐like immunoreactive nerve fibers in temporomandibular joint soft tissues of monkey

1986 • 36 citations

Change of prostaglandin E level in joint fluids after treatment with flurbiprofen in patients with rheumatoid arthritis and osteoarthritis.

1981 • 36 citations

Capsaicin and nociception.

1987 • 36 citations

Arthrokinetic Reflex of the Knee

1956 • 36 citations

Central projection of sensory fibers from the cat knee joint

1972 • 36 citations

Ultrastructure of sensory nerve endings in monkey (Macaca fascicularis) knee joint capsule

1984 • 35 citations

Lack of significant changes in μ, δ opioid binding sites and neutral endopeptidase EC 3.4.24.11 in the brain and spinal cord of arthritic rats

1989 • 34 citations

Can tolerance to morphine be induced in arthritic rats?

1985 • 34 citations

An intracellular study of descending and non‐cutaneous afferent input to spinocervical tract neurones in the cat.

1984 • 34 citations

Capsaicin inhibits responses of fine afferents from the knee joint of the cat to mechanical and chemical stimuli

1990 • 33 citations

Extracellular potassium accumulation in the frog spinal cord induced by stimulation of the skin and ventrolateral columns

1981 • 32 citations

Responses of bone and joint blood vessels in cats and rabbits to electrical stimulation of nerves supplying the knee.

1990 • 32 citations

Response Properties of Thick Myelinated Group II Afferents in the Medial Articular Nerve of Normal and Inflamed Knee Joints of the Cat

1991 • 31 citations

Repeated low doses of morphine induce a rapid tolerance in arthritic rats but a potentiation of opiate analgesia in normal animals

1986 • 31 citations

Somatostatin is increased in the dorsal root ganglia of adjuvant-inflamed rat

1990 • 30 citations

Inflammation—histamine and 5-hydroxytryptamine

1987 • 29 citations

Antinociceptive effects of neonatal capsaicin in rats with adjuvant arthritis

1984 • 29 citations

STUDIES ON THE RELATIVE EFFECTS OF PROSTAGLANDINS, BRADYKININ, 5‐HYDROXYTRYPTAMINE AND HISTAMINE ON THE SYNOVIAL MICROCIRCULATION IN DOGS

1976 • 29 citations

Innervation of the synovial membrane of the cats joint capsule

1976 • 28 citations

Reactions of cardiac postganglionic sympathetic neurons to movements of normal and inflamed knee joints

1985 • 28 citations

[Prostaglandins E2 and F2 alpha concentrations in the synovial fluid in rheumatoid and traumatic knee joint diseases].

1980 • 28 citations

Further observations on animal hypnosis

1959 • 28 citations

Responses of quadriceps motor units to mechanical stimulation of knee joint receptors in the decerebrate cat

1988 • 28 citations

Monosynaptic excitation of dorsal spinocerebellar tract neurones from low threshold joint afferents.

1972 • 28 citations

Gastrointestinal peptides in serum and synovial fluid from patients with inflammatory joint disease.

1986 • 27 citations

CENTRAL CONNECTIONS FOR AFFERENT FIBERS FROM THE KNEE JOINT OF THE CAT

1949 • 27 citations

Neuromodulation of synovitis: capsaicin effect on severity of experimental arthritis

1989 • 26 citations

The avian microcrystal arthritis I. Simultaneous recording of nociception and temperature effect in the inflamed joint

1974 • 26 citations

Origin of sympathetic and sensory innervation of the elbow joint in the rat: A retrograde axonal tracing study with wheat germ agglutinin conjugated horseradish peroxidase

1988 • 26 citations

Neurogenic acceleration of osteoarthritis

1998 • 26 citations

Role of joint afferents in relation to the initiation of forelimb stepping in thalamic cats

1984 • 25 citations

Effects of synthetic substance P on unit-discharges of testicular nociceptors of dogs

1979 • 25 citations

Cyclic AMP and prostaglandin E in perfusates of rat hind paws during the development of adjuvant arthritis

1978 • 25 citations

Synovial Fluid Changes in Joint Disease

1953 • 24 citations

Neutrophils contribute to sympathetic nerve terminal-dependent plasma extravasation in the knee joint of the rat

1991 • 24 citations

Strong heat stimulation sensitizes the heat response as well as the bradykinin response of visceral polymodal receptors

1992 • 24 citations

Persistence of immunoreactive neurokinins in the dorsal horn of barbiturate anaesthetized and spinal cats, following release by tibial nerve stimulation

1990 • 24 citations

Discharge characteristics of sympathetic efferents to the knee joint of the cat

1987 • 24 citations

Carrageenin-induced arthritis: V. A morphologic study of the development of inflammation in acute arthritis

1983 • 24 citations

EARLY EFFECTS OF PARTIAL SENSORY DENERVATION OF THE HIP FOR RELIEF OF PAIN IN CHRONIC ARTHRITIS

1949 • 23 citations

CONDUCTION RATES AND DORSAL ROOT INFLOW OF SENSORY FIBERS FROM THE KNEE JOINT OF THE CAT

1948 • 23 citations

Substance P-, somatostatin-, vasoactive intestinal peptide- and cholecystokinin-like levels in the spinal cord of polyarthritic rats

1985 • 23 citations

Somatotopical arrangement of rat spinal dorsal horn cells processing input from deep tissues

1990 • 22 citations

Total and free serum tryptophan levels and brain 5-hydroxytryptamine metabolism in arthritic rats

1980 • 22 citations

The effect of mechanical stimulation of knee joint afferents on quadriceps motor unit activity in the decerebrate cat

1987 • 21 citations

Viscosity of Normal Human Synovial Fluid

1946 • 21 citations

Origin of sympathetic innervation of the knee joint in the cat: A retrograde tracing study with horseradish peroxidase

1990 • 20 citations

Changes in lipoxygenase products from synovial fluid in carragheenan induced arthritis in dogs

1988 • 20 citations

Properties of rheumatoid and normal synovial tissue in vitro and cells derived from them

1982 • 20 citations

Measurement of sulfidopeptide leukotrienes and their metabolism in human synovial fluid of patients with rheumatoid arthritis.

1988 • 19 citations

Potassium accumulation in the frog spinal cord induced by nociceptive stimulation of the skin

1980 • 19 citations

The neurotoxic effect of gold sodium thiomalate on the peripheral nerves of the rat: Insights into the antiinflammatory actions of gold therapy

1986 • 19 citations

The response to viscero-peritoneal nociceptive stimuli is reduced in experimental arthritic rats

1986 • 17 citations

Fibers in monkey posterior articular nerves

1977 • 17 citations

15-HETE inhibits leukotriene B4 formation and synovial cell proliferation in experimental arthritis

1990 • 17 citations

Articular reflexes at the knee joint: an electromyographic study

1972 • 16 citations

Responses of blood vessels in the rabbit knee to electrical stimulation of the joint capsule.

1990 • 16 citations

Negative Pressures in Knee Joints

1966 • 16 citations

FLUID COMPARTMENTATION AND ARTICULAR MECHANORECEPTOR DISCHARGE IN THE CAT KNEE JOINT

1985 • 16 citations

Plasma extravasation in the cat knee-joint induced by antidromic articular nerve stimulation

1985 • 15 citations

Expression of myelin basic protein mRNA and polypeptides in mouse oligodendrocytes in culture: differential regulation by genetic and epigenetic factors

1988 • 14 citations

Adrenoceptor profile of blood vessels in the knee joint of the rabbit.

1989 • 14 citations

The effect of elbow joint afferent discharge on transmission in forelimb flexion reflex pathways to biceps and triceps brachii in decerebrate cats

1982 • 13 citations

The effect of gold, an antirheumatic therapy, on substance P levels in rat peripheral nerve

1988 • 13 citations

Neurokinin A-like immunoreactivity in articular afferents of the cat

1992 • 12 citations

Responses of blood vessels in the rabbit knee to acute joint inflammation.

1990 • 12 citations

An anatomical study of the origin of sympathetic and sensory innervation of the elbow and knee joint in the monkey

1991 • 12 citations

The Morphology and Distribution of Nerve Fibers and Endings Associated with the Mandibular Joint of the Mouse

1966 • 12 citations

THE RESPONSE OF SLOWLY ADAPTING MECHANORECEPTORS IN THE CAT KNEE JOINT TO TETANIC CONTRACTION OF HIND LIMB MUSCLES

1985 • 11 citations

Simultaneous measurements of tryptophan and its metabolites, kynurenine and serotonin, in the superficial layers of the spinal dorsal horn. A study in normal and arthritic rats

1990 • 11 citations

Projection of Afferent Fibers From the Knee Joint to the Cerebellum of the Cat

1953 • 11 citations

The composition of the medial articular nerve to the knee in the dog.

1982 • 10 citations

The effects of direction and acceleration of movement of the knee joint of the dog on medial articular nerve discharge.

1987 • 9 citations

Questionable role of leukotriene B4 in monosodium urate (MSU)-induced synovitis in the dog

1986 • 9 citations

Macrophages from adjuvant arthritic rats preferentially synthetize prostacyclin

1980 • 9 citations

Effects of diclofenac, indomethacin, tolfenamic acid and hydrocortisone on prostanoid production in healthy and rheumatic synovial cells

1989 • 8 citations

The projection of the posterior knee joint nerve to the cerebellar cortex

1974 • 7 citations

Inflammation--mediators and mechanisms.

1987 • 7 citations

Inhibitory effect of acemetacin, a prodrug of indomethacin, on prostaglandin E2 release from inflamed synovial tissue.

1984 • 4 citations

Special Topic: Neurophysiology

1979 • 3 citations

Release of prostaglandin-like substance from inflamed synovial tissue of rat

1978 • 3 citations

Sensory nerve endings in joint capsules of domestic and wild rabbit.

1965 • 2 citations

Deleted Work

1955 • 0 citations