BMI1 is a target gene of E2F-1 and is strongly expressed in primary neuroblastomas

DAVID: Database for Annotation, Visualization, and Integrated Discovery

2003 • 8,668 citations

Transcriptional Regulatory Networks in Saccharomyces cerevisiae

2002 • 2,967 citations

Neuroblastoma: biological insights into a clinical enigma

2003 • 2,087 citations

Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells

2003 • 1,851 citations

The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus

1999 • 1,549 citations

Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells

2003 • 1,435 citations

Bmi-1 dependence distinguishes neural stem cell self-renewal from progenitor proliferation

2003 • 1,303 citations

Sibling rivalry in the E2F family

2002 • 1,158 citations

EZH2 is downstream of the pRB-E2F pathway, essential for proliferation and amplified in cancer

2003 • 1,147 citations

E2F integrates cell cycle progression with DNA repair, replication, and G₂/M checkpoints

2002 • 1,102 citations

Bmi-1 collaborates with c-Myc in tumorigenesis by inhibiting c-Myc-induced apoptosis via INK4a/ARF

1999 • 1,068 citations

Chromatin Association of Human Origin Recognition Complex, Cdc6, and Minichromosome Maintenance Proteins during the Cell Cycle: Assembly of Prereplication Complexes in Late Mitosis

2000 • 912 citations

Microarray analysis identifies a death-from-cancer signature predicting therapy failure in patients with multiple types of cancer

2005 • 912 citations

Stabilization of Chromatin Structure by PRC1, a Polycomb Complex

1999 • 794 citations

Identification of cooperating oncogenes in Eμ-myc transgenic mice by provirus tagging

1991 • 765 citations

E2Fs regulate the expression of genes involved in differentiation, development, proliferation, and apoptosis

2001 • 747 citations

Stem Cells and Cancer

2004 • 739 citations

Analysis of promoter binding by the E2F and pRB families in vivo: distinct E2F proteins mediate activation and repression

2000 • 619 citations

Role for E2F in Control of Both DNA Replication and Mitotic Functions as Revealed from DNA Microarray Analysis

2001 • 587 citations

E2F target genes: unraveling the biology

2004 • 557 citations

Rb inactivation promotes genomic instability by uncoupling cell cycle progression from mitotic control

2004 • 552 citations

Bmi1 is essential for cerebellar development and is overexpressed in human medulloblastomas

2004 • 532 citations

Novel zinc finger gene implicated as myc collaborator by retrovirally accelerated lymphomagenesis in Eμ-myc transgenic mice

1991 • 516 citations

Phenotypic diversification in human neuroblastoma cells: expression of distinct neural crest lineages.

1989 • 466 citations

Use of Chromatin Immunoprecipitation To Clone Novel E2F Target Promoters

2001 • 387 citations

The Core of the Polycomb Repressive Complex Is Compositionally and Functionally Conserved in Flies and Humans

2002 • 385 citations

Reconstitution of a Functional Core Polycomb Repressive Complex

2001 • 367 citations

Polycomb, Epigenomes, and Control of Cell Identity

2003 • 343 citations

Emerging roles for E2F: Beyond the G1/S transition and DNA replication

2003 • 334 citations

A Common Set of Gene Regulatory Networks Links Metabolism and Growth Inhibition

2004 • 317 citations

E2Fs Regulate Adipocyte Differentiation

2002 • 310 citations

Conditional expression of N-myc in human neuroblastoma cells increases expression of alpha-prothymosin and ornithine decarboxylase and accelerates progression into S-phase early after mitogenic stimulation of quiescent cells.

1996 • 307 citations

Polycomb complexes and silencing mechanisms

2004 • 305 citations

The genetics of the E2F family of transcription factors: shared functions and unique roles

2002 • 301 citations

The bmi-1 oncoprotein is differentially expressed in non-small cell lung cancer and correlates with INK4A-ARF locus expression

2001 • 299 citations

BMI-1 gene amplification and overexpression in hematological malignancies occur mainly in mantle cell lymphomas.

2001 • 284 citations

Myc Requires Distinct E2F Activities to Induce S Phase and Apoptosis

2001 • 253 citations

The E2F6 transcription factor is a component of the mammalian Bmi1-containing polycomb complex

2001 • 248 citations

The Bmi-1 oncoprotein is overexpressed in human colorectal cancer and correlates with the reduced p16INK4a/p14ARF proteins

2004 • 247 citations

Cell cycle-dependent and cell cycle-independent control of transcription by the Drosophila E2F/RB pathway

2003 • 242 citations

Functional antagonism of the Polycomb-Group genes eed and Bmi1 in hemopoietic cell proliferation

1999 • 219 citations

RYBP, a new repressor protein that interacts with components of the mammalian Polycomb complex, and with the transcription factor YY1

1999 • 219 citations

E2F-Dependent Histone Acetylation and Recruitment of the Tip60 Acetyltransferase Complex to Chromatin in Late G₁

2004 • 207 citations

Interaction of YY1 with E2Fs, mediated by RYBP, provides a mechanism for specificity of E2F function

2002 • 196 citations

Linking the Rb and Polycomb Pathways

2001 • 188 citations

Gene expression changes in response to E2F1 activation

2002 • 184 citations

Mice doubly deficient for the Polycomb Group genes Mel18 and Bmi1 reveal synergy and requirement for maintenance but not initiation of Hox gene expression

2001 • 183 citations

Repression of the Arf tumor suppressor by E2F3 is required for normal cell cycle kinetics

2004 • 174 citations

Gene repression by Polycomb group protein complexes: a distinct complex for every occasion?

2003 • 172 citations

Comparison of gene expression profiling between malignant and normal plasma cells with oligonucleotide arrays

2002 • 172 citations

Mining for regulatory programs in the cancer transcriptome

2005 • 170 citations

Stage-Specific Expression of Polycomb Group Genes in Human Bone Marrow Cells

1998 • 165 citations

Human neuroblastoma I-type cells are malignant neural crest stem cells.

1995 • 164 citations

MYCN in neuronal tumours

2003 • 144 citations

Loss of a FYN-regulated differentiation and growth arrest pathway in advanced stage neuroblastoma

2002 • 138 citations

MycN sensitizes neuroblastoma cells for drug-induced apoptosis

1999 • 129 citations

Enrichment for Histone H3 Lysine 9 Methylation at Alu Repeats in Human Cells

2003 • 122 citations

Pocket Protein Complexes Are Recruited to Distinct Targets in Quiescent and Proliferating Cells

2005 • 117 citations

Induction of cyclin E-cdk2 kinase activity, E2F-dependent transcription and cell growth by Myc are genetically separable events

2000 • 110 citations

TRIP-Br: a novel family of PHD zinc finger- and bromodomain-interacting proteins that regulate the transcriptional activity of E2F-1/DP-1

2001 • 104 citations

Polycomb group gene mel-18 modulates the self-renewal activity and cell cycle status of hematopoietic stem cells

2004 • 99 citations

MycN and IFNγ cooperate in apoptosis of human neuroblastoma cells

1998 • 98 citations

Bmi-1 Regulation of INK4A-ARF Is a Downstream Requirement for Transformation of Hematopoietic Progenitors by E2a-Pbx1

2003 • 88 citations

E2F Proteins Regulate MYCN Expression in Neuroblastomas

2003 • 68 citations

Xenopus Embryonic E2F Is Required for the Formation of Ventral and Posterior Cell Fates during Early Embryogenesis

2000 • 52 citations

E2F and Sp1/Sp3 Synergize but Are Not Sufficient to Activate the MYCN Gene in Neuroblastomas

2004 • 49 citations

Position-effect variegation in Drosophila depends on the dose of the gene encoding the E2F transcriptional activator and cell cycle regulator

1996 • 48 citations

NUB-7: a stable I-type human neuroblastoma cell line inducible along N- and S-type cell lineages.

1994 • 32 citations

Expression of P27KIP1 is prognostic and independent ofMYCN amplification in human neuroblastoma

2001 • 22 citations