Functional antagonism of the Polycomb-Group genes eed and Bmi1 in hemopoietic cell proliferation

The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus

1999 • 1,549 citations

The long-term repopulating subset of hematopoietic stem cells is deterministic and isolatable by phenotype

1994 • 1,109 citations

Posterior transformation, neurological abnormalities, and severe hematopoietic defects in mice with a targeted deletion of the bmi-1 proto-oncogene.

1994 • 775 citations

Hoxa9 transforms primary bone marrow cells through specific collaboration with Meis1a but not Pbx1b

1998 • 643 citations

Long-term culture of B lymphocytes and their precursors from murine bone marrow.

1982 • 612 citations

Differential expression of homeobox genes in functionally distinct CD34+ subpopulations of human bone marrow cells.

1994 • 529 citations

Overexpression of HOXA10 in Murine Hematopoietic Cells Perturbs both Myeloid and Lymphoid Differentiation and Leads to Acute Myeloid Leukemia

1997 • 336 citations

p16INK4a Gene Inactivation by Deletions, Mutations, and Hypermethylation Is Associated With Transformed and Aggressive Variants of Non-Hodgkin's Lymphomas

1998 • 300 citations

The eed mutation disrupts anterior mesoderm production in mice

1995 • 284 citations

Altered cellular proliferation and mesoderm patterning in Polycomb-M33-deficient mice

1997 • 266 citations

A role for mel-18, a Polycomb group-related vertebrate gene, during the anteroposterior specification of the axial skeleton

1996 • 256 citations

Identification of Bmi1-interacting proteins as constituents of a multimeric mammalian polycomb complex.

1997 • 240 citations

Characterization of Interactions between the Mammalian Polycomb-Group Proteins Enx1/EZH2 and EED Suggests the Existence of Different Mammalian Polycomb-Group Protein Complexes

1998 • 219 citations

Functions of mammalian Polycomb group and trithorax group related genes

1997 • 199 citations

Targeted disruption of the mouse homologue of the Drosophila polyhomeotic gene leads to altered anteroposterior patterning and neural crest defects

1997 • 196 citations

The polyhomeotic gene of Drosophila encodes a chromatin protein that shares polytene chromosome-binding sites with Polycomb.

1992 • 193 citations

RING1 Is Associated with the Polycomb Group Protein Complex and Acts as a Transcriptional Repressor

1997 • 189 citations

Overexpression of HOXB3 in Hematopoietic Cells Causes Defective Lymphoid Development and Progressive Myeloproliferation

1997 • 187 citations

Representative in Vitro cDNA Amplification From Individual Hemopoietic Cells and Colonies

1990 • 185 citations

Stage-Specific Expression of Polycomb Group Genes in Human Bone Marrow Cells

1998 • 165 citations

Murine Polycomb- and trithorax-group genes regulate homeotic pathways and beyond.

1997 • 163 citations

Identification and Characterization of Interactions between the Vertebrate Polycomb-Group Protein BMI1 and Human Homologs of Polyhomeotic

1997 • 159 citations

The Polycomb Group Protein Complex of Drosophila melanogaster Has Different Compositions at Different Target Genes

1997 • 147 citations

Murine Polycomb- and trithorax-group genes regulate homeotic pathways and beyond

1997 • 140 citations

Interaction of Mouse Polycomb-Group (Pc-G) Proteins Enx1 and Enx2 with Eed: Indication for Separate Pc-G Complexes

1998 • 123 citations

RING1 Interacts with Multiple Polycomb-Group Proteins and Displays Tumorigenic Activity

1999 • 122 citations

The Additional sex combs gene of Drosophila encodes a chromatin protein that binds to shared and unique Polycomb group sites on polytene chromosomes

1998 • 114 citations

Comparison of germline mosaics of genes in the Polycomb group of Drosophila melanogaster.

1995 • 112 citations

Point Mutations in the WD40 Domain of Eed Block Its Interaction with Ezh2

1998 • 95 citations

Genetic interactions and dosage effects of Polycomb group genes in mice

1998 • 84 citations

Functional analysis of mouse Polycomb group genes

1998 • 81 citations

Acquisition of p16INK4Aandp15INK4BGene Abnormalities Between Initial Diagnosis and Relapse in Children With Acute Lymphoblastic Leukemia

1999 • 80 citations

Genetic interactions and dosage effects of Polycomb group genes of Drosophila

1995 • 67 citations

Defective development of thymocytes overexpressing the costimulatory molecule, heat-stable antigen.

1994 • 48 citations

The MurinePolycomb-Group Geneeedand Its Human Orthologue: Functional Implications of Evolutionary Conservation

1998 • 36 citations

Reduction of early B lymphocyte precursors in transgenic mice overexpressing the murine heat-stable antigen.

1996 • 36 citations

Identification of properties that can distinguish primitive populations of stromal-cell-responsive lympho-myeloid cells from cells that are stromal-cell-responsive but lymphoid-restricted and cells that have lympho-myeloid potential but are also capable of competitively repopulating myeloablated recipients

1996 • 30 citations

Identification of properties that can distinguish primitive populations of stromal-cell-responsive lympho-myeloid cells from cells that are stromal-cell-responsive but lymphoid-restricted and cells that have lympho-myeloid potential but are also capable of competitively repopulating myeloablated recipients

1996 • 25 citations

Short Communication Mammalian Polycomb group genes are categorized as a new type of early response gene induced by B-cell receptor cross-linking

1998 • 16 citations

Acquisition of p16INK4Aandp15INK4BGene Abnormalities Between Initial Diagnosis and Relapse in Children With Acute Lymphoblastic Leukemia

1999 • 7 citations