Inhibition of Nucleolar Function and Morphological Change by Adriamycin Associated with Heat Shock Protein 70 Accumulation

Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease

1979 • 22,482 citations

THE HEAT-SHOCK PROTEINS

1988 • 5,214 citations

Biology of disease: free radicals and tissue injury.

1982 • 3,078 citations

DNA TOPOISOMERASE POISONS AS ANTITUMOR DRUGS

1989 • 1,799 citations

DNA TOPOISOMERASES

1985 • 1,524 citations

Formation of 8-hydroxyguanine moiety in cellular DNA by agents producing oxygen radicals and evidence for its repair

1986 • 933 citations

Differential induction of transcriptionally active p53 following UV or lonizing radiation: Defects in chromosome instability syndromes?

1993 • 799 citations

The Anthracycline Antineoplastic Drugs

1981 • 794 citations

Induction of nuclear accumulation of the tumor-suppressor protein p53 by DNA-damaging agents.

1993 • 770 citations

Nuclear and nucleolar localization of the 72,000-dalton heat shock protein in heat-shocked mammalian cells.

1984 • 522 citations

Cellular and biochemical events in mammalian cells during and after recovery from physiological stress.

1986 • 513 citations

Morphological study of the mammalian stress response: characterization of changes in cytoplasmic organelles, cytoskeleton, and nucleoli, and appearance of intranuclear actin filaments in rat fibroblasts after heat-shock treatment.

1985 • 428 citations

Biochemical and pharmacological properties of p170 and p180 forms of topoisomerase II

1989 • 409 citations

Involvement of ATP in the nuclear and nucleolar functions of the 70 kd heat shock protein.

1985 • 327 citations

Endogenous oxidative damage of deoxycytidine in DNA.

1992 • 280 citations

Increased formation of oxidative DNA damage, 8-hydroxydeoxyguanosine, in human livers with chronic hepatitis.

1994 • 277 citations

Effect of antineoplastic agents on the DNA cleavage/religation reaction of eukaryotic topoisomerase II: inhibition of DNA religation by etoposide

1989 • 228 citations

The dynamic state of heat shock proteins in chicken embryo fibroblasts.

1986 • 227 citations

Heat-shock proteins protect cells from monocyte cytotoxicity: possible mechanism of self-protection.

1993 • 223 citations

Hydrogen peroxide or heat shock induces resistance to hydrogen peroxide in Chinese hamster fibroblasts

1987 • 217 citations

Characterization of the thermotolerant cell. II. Effects on the intracellular distribution of heat-shock protein 70, intermediate filaments, and small nuclear ribonucleoprotein complexes.

1988 • 195 citations

Oxidative destruction of DNA by the adriamycin-iron complex

1984 • 173 citations

Use of salicylate with high pressure liquid chromatography and electrochemical detection (LCE) as a sensitive measure of hydroxyl free radicals in adriamycin treated rats

1986 • 164 citations

Enhancement of reactive oxygen-dependent mitochondrial membrane lipid peroxidation by the anticancer drug adriamycin

1985 • 154 citations

Hydroxyl radical production and DNA damage induced by anthracycline‐iron complex

1984 • 149 citations

The role of heat-shock proteins as molecular chaperones

1991 • 143 citations

DNA topoisomerase II: A primer on the enzyme and its unique role as a multidrug target in cancer chemotherapy

1987 • 139 citations

Human ribosomal RNA gene: nucleotide sequence of the transcription initiation region and comparison of three mammalian genes.

1982 • 139 citations

Rapid isolation of nucleoli from detergent purified nuclei of various tumor and tissue culture cells

1974 • 103 citations

The 180-kDa isoform of topoisomerase II is localized in the nucleolus and belongs to the structural elements of the nucleolar remnant

1992 • 98 citations

Elevated Level of 8‐Hydroxydeoxyguanosine in DNA of Liver, Kidneys, and Brain of Long‐Evans Cinnamon Rats

1993 • 85 citations

HSP70 Overexpression Mediates the Escape of a Doxorubicin-Induced G2 Cell Cycle Arrest

1996 • 75 citations

Differential Expression of hsp70 Stress Proteins in Human Endothelial Cells Exposed to Heat Shock and Hydrogen Peroxide

1991 • 73 citations

Thiol-dependent DNA damage produced by anthracycline-iron complexes. The structure-activity relationships and molecular mechanisms.

1985 • 52 citations

Heat stress induces hsc70/nuclear topoisomerase Icomplex formation in vivo: evidence for hsc70-mediated, ATP-independentreactivation in vitro.

1994 • 51 citations

Possible Correlation between DNA Damage Induced by Hydrogen Peroxide and Translocation of Heat Shock 70 Protein into the Nucleus

1995 • 46 citations

Thermotolerance and nuclear protein aggregation: Protection against initial damage or better recovery?

1995 • 39 citations

Segmental dynamics of the cytoplasmic domain oferythrocyte band 3 determined by time-resolved fluorescence anisotropy:sensitivity to pH and ligand binding.

1994 • 38 citations

Comparative ultrastructural studies of nucleoli of tumor cells treated with adriamycin and the newer anthracyclines, carminomycin and marcellomycin.

1978 • 37 citations

Induction of heat shock 70 mRNA by cadmium is mediated by glutathione suppressive and non-suppressive triggers

1994 • 36 citations

Detection of free radicals during the cellular metabolism of adriamycin

1990 • 16 citations

Nature of the so-called fibrillar component in the segregated nucleolus after treatment of actinomycin D.

1972 • 12 citations

Nature of the So-called Fibrillar Component in the Segregated Nucleolus after Treatment of Actinomycin D

1972 • 5 citations