Identification of the Critical Features of a Small Peptide Inhibitor of JNK Activity

Signal Transduction by the JNK Group of MAP Kinases

2000 • 4,096 citations

PD 098059 Is a Specific Inhibitor of the Activation of Mitogen-activated Protein Kinase Kinase in Vitro and in Vivo

1995 • 3,456 citations

A protein kinase involved in the regulation of inflammatory cytokine biosynthesis

1994 • 3,285 citations

JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain

1994 • 3,219 citations

The stress-activated protein kinase subfamily of c-Jun kinases

1994 • 2,616 citations

SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase

2001 • 2,488 citations

Signal Transduction through MAP Kinase Cascades

1998 • 1,762 citations

Selective interaction of JNK protein kinase isoforms with transcription factors.

1996 • 1,333 citations

Organization and regulation of mitogen-activated protein kinase signaling pathways

1999 • 1,288 citations

Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene

1997 • 1,229 citations

Regulation of JNK signaling by GSTp

1999 • 1,102 citations

Cell-penetrating peptides

2000 • 767 citations

A Cytoplasmic Inhibitor of the JNK Signal Transduction Pathway

1997 • 678 citations

A Mammalian Scaffold Complex That Selectively Mediates MAP Kinase Activation

1998 • 653 citations

JNK2 contains a specificity-determining region responsible for efficient c-Jun binding and phosphorylation.

1994 • 639 citations

Cell-Permeable Peptide Inhibitors of JNK

2001 • 581 citations

Protein transduction: unrestricted delivery into all cells?

2000 • 560 citations

The search for physiological substrates of MAP and SAP kinases in mammalian cells

1997 • 544 citations

ATF-2 contains a phosphorylation-dependent transcriptional activation domain.

1995 • 504 citations

Scaffold proteins may biphasically affect the levels of mitogen-activated protein kinase signaling and reduce its threshold properties

2000 • 494 citations

The JIP Group of Mitogen-Activated Protein Kinase Scaffold Proteins

1999 • 454 citations

Phosphotyrosyl Peptides Block Stat3-mediated DNA Binding Activity, Gene Regulation, and Cell Transformation

2001 • 436 citations

Glutathione S-transferase P1–1 (GSTP1–1) Inhibits c-Jun N-terminal Kinase (JNK1) Signaling through Interaction with the C Terminus

2001 • 304 citations

Differential targeting of MAP kinases to the ETS-domain transcription factor Elk-1

1998 • 302 citations

Interaction of a Mitogen-Activated Protein Kinase Signaling Module with the Neuronal Protein JIP3

2000 • 278 citations

Measurement of the binding of tyrosyl phosphopeptides to SH2 domains: a reappraisal.

1995 • 253 citations

Acquisition of Sensitivity of Stress-activated Protein Kinases to the p38 Inhibitor, SB 203580, by Alteration of One or More Amino Acids within the ATP Binding Pocket

1998 • 232 citations

CEP-1347 (KT7515), a Semisynthetic Inhibitor of the Mixed Lineage Kinase Family

2001 • 203 citations

CEP‐1347 (KT7515), an Inhibitor of JNK Activation, Rescues Sympathetic Neurons and Neuronally Differentiated PC12 Cells from Death Evoked by three Distinct Insults

1999 • 192 citations

A Conserved Docking Site in MEKs Mediates High-affinity Binding to MAP Kinases and Cooperates with a Scaffold Protein to Enhance Signal Transmission

2001 • 179 citations

IB1 Reduces Cytokine-induced Apoptosis of Insulin-secreting Cells

2000 • 123 citations

Inhibition of JNK by Overexpression of the JNK Binding Domain of JIP-1 Prevents Apoptosis in Sympathetic Neurons

2001 • 112 citations

Mixed lineage kinase-dependent JNK activation is governed by interactions of scaffold protein JIP with MAPK module components

2001 • 107 citations

Activation of the JNK pathway is important for cardiomyocyte death in response to simulated ischemia

1999 • 97 citations

Direct inhibition of c‐Jun N‐terminal kinase in sympathetic neurones preventsc‐junpromoter activation and NGF withdrawal‐induced death

2001 • 95 citations

A Role for the Extracellular Signal-regulated Kinase and p38 Mitogen-activated Protein Kinases in Interleukin-1β-stimulated Delayed Signal Tranducer and Activator of Transcription 3 Activation, Atrial Natriuretic Factor Expression, and Cardiac Myocyte Morphology

2001 • 73 citations

Binding Affinities of Tyrosine-phosphorylated Peptides to the COOH-terminal SH2 and NH2-terminal Phosphotyrosine Binding Domains of Shc

1995 • 59 citations

Human c-Jun N-terminal kinase expression and activation in the nervous system

1999 • 44 citations

CEP-1347/KT7515, a JNK pathway inhibitor, supports the in vitro survival of chick embryonic neurons

1998 • 44 citations

Biosensor-Based Estimation of Kinetic and Equilibrium Constants

2001 • 42 citations

MAP Kinases in Plant Signal Transduction: How Many, and What For?

2000 • 38 citations

Identification of a Glutathione-S-Transferase Effector Domain for Inhibition of jun Kinase, by Molecular Dynamics

1999 • 36 citations

Transactivation of Naturally Occurring HIV-1 Long Terminal Repeats by the JNK Signaling Pathway

2000 • 19 citations