The Ubiquitin-like Protein FAT10 Forms Covalent Conjugates and Induces Apoptosis

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

The biochemistry of apoptosis

2000 • 7,314 citations

An endotoxin-induced serum factor that causes necrosis of tumors.

1975 • 4,522 citations

The TNF and TNF Receptor Superfamilies

2001 • 3,533 citations

Suppression of TNF-α-Induced Apoptosis by NF-κB

1996 • 2,623 citations

The 26S Proteasome: A Molecular Machine Designed for Controlled Proteolysis

1999 • 1,872 citations

CD95's deadly mission in the immune system

2000 • 1,714 citations

Induction of apoptosis in mature T cells by tumour necrosis factor

1995 • 1,139 citations

Apoptotic DNA Fragmentation

2000 • 885 citations

Noncanonical MMS2-Encoded Ubiquitin-Conjugating Enzyme Functions in Assembly of Novel Polyubiquitin Chains for DNA Repair

1999 • 814 citations

Conjugation with the ubiquitin-related modifier SUMO-1 regulates the partitioning of PML within the nucleus

1998 • 676 citations

Rad6-Dependent Ubiquitination of Histone H2B in Yeast

2000 • 662 citations

The ubiquitin system

2000 • 627 citations

Evolution and function of ubiquitin-like protein-conjugation systems

2000 • 394 citations

A modified tetracycline-regulated system provides autoregulatory, inducible gene expression in cultured cells and transgenic mice.

1995 • 383 citations

A Giant Protease with Potential to Substitute for Some Functions of the Proteasome

1999 • 377 citations

Prevention of diabetes in nonobese diabetic mice by tumor necrosis factor (TNF): similarities between TNF-alpha and interleukin 1.

1990 • 356 citations

Ubiquitination and Endocytosis of Plasma Membrane Proteins: Role of Nedd4/Rsp5p Family of Ubiquitin-Protein Ligases

2000 • 356 citations

A role for the proteasome regulator PA28α in antigen presentation

1996 • 341 citations

Ubiquitin and its kin: how close are the family ties?

2000 • 316 citations

Ubiquitin‐dependent internalization and down‐regulation of plasma membrane proteins

1997 • 270 citations

Tumor necrosis factor enhances HLA-A,B,C and HLA-DR gene expression in human tumor cells.

1987 • 248 citations

The Interferon-γ-inducible 11 S Regulator (PA28) and the LMP2/LMP7 Subunits Govern the Peptide Production by the 20 S Proteasome in Vitro

1995 • 233 citations

A third interferon‐γ‐induced subunit exchange in the 20S proteasome

1996 • 168 citations

How an Inhibitor of the HIV-I Protease Modulates Proteasome Activity

1999 • 164 citations

A MHC-encoded ubiquitin-like protein (FAT10) binds noncovalently to the spindle assembly checkpoint protein MAD2

1999 • 158 citations

Overexpression of the Proteasome Subunits LMP2, LMP7, and MECL-1, But Not PA28α/β, Enhances the Presentation of an Immunodominant Lymphocytic Choriomeningitis Virus T Cell Epitope

2000 • 121 citations

Identification of seven new humanMHC class I region genes around theHLA-F locus

1996 • 120 citations

MHC Class I Antigen Processing of an Adenovirus CTL Epitope Is Linked to the Levels of Immunoproteasomes in Infected Cells

2000 • 117 citations

Lactacystin, a Specific Inhibitor of the Proteasome, Inhibits Human Platelet Lysosomal Cathepsin A-like Enzyme

1997 • 116 citations

A ubiquitin-like protein which is synergistically inducible by interferon-γ and tumor necrosis factor-α

1999 • 116 citations

The Selective Proteasome Inhibitors Lactacystin and Epoxomicin Can Be Used to Either Up- or Down-Regulate Antigen Presentation at Nontoxic Doses

2000 • 106 citations

Identification and analysis of a novel member of the ubiquitin family expressed in dendritic cells and mature B cells

1997 • 99 citations

The Ligation Systems for Ubiquitin and Ubiquitin-like Proteins

1998 • 97 citations

The proteasome regulator PA28α/β can enhance antigen presentation without affecting 20S proteasome subunit composition

2000 • 68 citations