Controlling CD4 gene expression during T cell lineage commitment

A Novel Transcription Factor, T-bet, Directs Th1 Lineage Commitment

2000 • 3,456 citations

Transcriptional Regulation in Mammalian Cells by Sequence-Specific DNA Binding Proteins

1989 • 3,219 citations

Distinct Effects of T-bet in T _H 1 Lineage Commitment and IFN-γ Production in CD4 and CD8 T Cells

2002 • 1,169 citations

Development of Spontaneous Airway Changes Consistent with Human Asthma in Mice Lacking T-bet

2002 • 633 citations

LIN-12/Notch signaling: lessons from worms and flies

1998 • 545 citations

An Activated Form of Notch Influences the Choice between CD4 and CD8 T Cell Lineages

1996 • 488 citations

Molecular and Cellular Events of T Cell Development

1989 • 466 citations

A lineage-specific transcriptional silencer regulates CD4 gene expression during T lymphocyte development

1994 • 418 citations

Effector differentiation is not prerequisite for generation of memory cytotoxic T lymphocytes

2001 • 407 citations

Selective requirement for MAP kinase activation in thymocyte differentiation

1995 • 398 citations

Silencers, silencing, and heritable transcriptional states

1992 • 296 citations

DIFFERENTIAL SIGNALING BY LYMPHOCYTE ANTIGEN RECEPTORS

1997 • 273 citations

Differential Roles of ERK and p38 MAP Kinase Pathways in Positive and Negative Selection of T Lymphocytes

1998 • 217 citations

Asymmetric signaling requirements for thymocyte commitment to the CD4+ versus CD8+ T cell lineages: A new perspective on thymic commitment and selection

1995 • 207 citations

Unexpectedly Complex Regulation of CD4/CD8 Coreceptor Expression Supports a Revised Model for CD4+CD8+ Thymocyte Differentiation

1996 • 199 citations

Lck Activity Controls CD4/CD8 T Cell Lineage Commitment

2000 • 194 citations

TOX: an HMG box protein implicated in the regulation of thymocyte selection

2002 • 176 citations

Epigenetic silencing of CD4 in T cells committed to the cytotoxic lineage

2001 • 172 citations

T-cell selection

1998 • 168 citations

A transcriptional silencer controls the developmental expression of the CD4 gene.

1994 • 156 citations

New perspectives on a developmental dilemma: the kinetic signaling model and the importance of signal duration for the CD4/CD8 lineage decision

2002 • 154 citations

c-Myb is essential for early T cell development

1999 • 153 citations

Inducible Expression of a p56Lck Transgene Reveals a Central Role for Lck in the Differentiation of CD4 SP Thymocytes

2000 • 143 citations

Signal strength in thymic selection and lineage commitment

2001 • 132 citations

Intermediate steps in positive selection: differentiation of CD4+8int TCRint thymocytes into CD4-8+TCRhi thymocytes.

1995 • 129 citations

Expression of the CD4 gene requires a Myb transcription factor.

1992 • 127 citations

Identification and characterization of a T-cell-specific enhancer adjacent to the murine CD4 gene.

1991 • 116 citations

Characterization of the human CD4 gene promoter: transcription from the CD4 gene core promoter is tissue-specific and is activated by Ets proteins.

1993 • 111 citations

Transcriptional silencing of homeotic genes in drosophila

1995 • 100 citations

A gene-rich cluster between the CD4 and triosephosphate isomerase genes at human chromosome 12p13.

1996 • 98 citations

Regulation of Lineage Commitment Distinct from Positive Selection

1999 • 98 citations

A transgenic mouse model to analyze CD8⁺effector T cell differentiationin vivo

1999 • 97 citations

Elf-1 binds to a critical element in a second CD4 enhancer.

1994 • 92 citations

Regulation of expression of the human lymphocyte activation gene-3 ( LAG-3 ) molecule, a ligand for MHC class II

1998 • 90 citations

Activation of the Extracellular Signal-Related Kinase/Mitogen-Activated Protein Kinase Pathway Discriminates CD4 Versus CD8 Lineage Commitment in the Thymus

1999 • 86 citations

Post-Transcriptional Regulation of Early T Cell Development by T Cell Receptor Signals

1992 • 83 citations

The Notch Pathway Intermediate HES-1 Silences CD4 Gene Expression

1998 • 83 citations

Locus control regions and epigenetic chromatin modifiers

2000 • 79 citations

Notch1 and T-cell development: insights from conditional knockout mice

2001 • 79 citations

A Myc-Associated Zinc Finger Protein Binding Site Is One of Four Important Functional Regions in the CD4 Promoter

1995 • 69 citations

Deletion of the CD4 silencer element supports a stochastic mechanism of thymocyte lineage commitment

2001 • 67 citations

Identification and characterization of a human CD4 silencer

1996 • 64 citations

Negative Regulation of CD4 Gene Expression by a HES-1–c-Myb Complex

2001 • 59 citations

Notch signaling in lymphocyte development

2001 • 55 citations

Genomic organization of the human LAG-3/CD4 locus

1997 • 46 citations

Characterization of an intronless CD4 minigene expressed in mature CD4 and CD8 T cells, but not expressed in immature thymocytes.

1996 • 46 citations

The CD4/CD8 lineage decision: integration of signalling pathways

2000 • 45 citations

Asymmetric Redundancy in CD4 Silencer Function

1996 • 42 citations

Positive selection induces CD4 promoter and enhancer function

1997 • 37 citations

Slow Accumulation of Active Mitogen-Activated Protein Kinase During Thymocyte Differentiation Regulates the Temporal Pattern of Transcription Factor Gene Expression

1999 • 34 citations

Activated p56lck Directs Maturation of Both CD4 and CD8 Single-Positive Thymocytes

2001 • 32 citations

A Potential Role for Elf-1 in CD4 Promoter Function

1999 • 31 citations

Thymocytes control the CD4 gene differently from mature T lymphocytes

1997 • 22 citations

Subclass-Specific Nuclear Localization of a Novel Cd4 Silencer Binding Factor

1999 • 22 citations

Binding of c-Myb to the core sequence of the CD4 promoter

1993 • 22 citations

Precise arrangement of factor-binding sites is required for murine CD4 promoter function

2000 • 12 citations

In Vivo Dissection of Lymphocyte Signaling Pathways

1993 • 6 citations