Multiphoton microscopy and fluorescence lifetime imaging microscopy (FLIM) to monitor metastasis and the tumor microenvironment

Two-Photon Laser Scanning Fluorescence Microscopy

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Untangling the ErbB signalling network

2001 • 6,623 citations

Cancer Metastasis: Building a Framework

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Deep tissue two-photon microscopy

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Stromal Fibroblasts Present in Invasive Human Breast Carcinomas Promote Tumor Growth and Angiogenesis through Elevated SDF-1/CXCL12 Secretion

2005 • 3,543 citations

Handbook Of Biological Confocal Microscopy

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Macrophages: Obligate Partners for Tumor Cell Migration, Invasion, and Metastasis

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Molecular imaging in living subjects: seeing fundamental biological processes in a new light

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Shedding light onto live molecular targets

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Handbook of Biological Confocal Microscopy

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Live tissue intrinsic emission microscopy using multiphoton-excited native fluorescence and second harmonic generation

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Collagen reorganization at the tumor-stromal interface facilitates local invasion

2006 • 1,626 citations

Molecular imaging of cancer with positron emission tomography

2002 • 1,599 citations

Fibroblast-led collective invasion of carcinoma cells with differing roles for RhoGTPases in leading and following cells

2007 • 1,446 citations

Compensation mechanism in tumor cell migration

2003 • 1,360 citations

Collagen density promotes mammary tumor initiation and progression

2008 • 1,293 citations

Second-harmonic imaging microscopy for visualizing biomolecular arrays in cells, tissues and organisms

2003 • 1,243 citations

In vivo multiphoton microscopy of NADH and FAD redox states, fluorescence lifetimes, and cellular morphology in precancerous epithelia

2007 • 915 citations

Intravital imaging of cell movement in tumours

2003 • 908 citations

Three-Dimensional High-Resolution Second-Harmonic Generation Imaging of Endogenous Structural Proteins in Biological Tissues

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Human breast cancer cells generated by oncogenic transformation of primary mammary epithelial cells

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An evaluation of confocal versus conventional imaging of biological structures by fluorescence light microscopy.

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THE METABOLISM OF TUMORS

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Dynamic imaging of collagen and its modulation in tumors in vivo using second-harmonic generation

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Imaging cells and extracellular matrix in vivo by using second-harmonic generation and two-photon excited fluorescence

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Interpreting Second-Harmonic Generation Images of Collagen I Fibrils

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Acid-Mediated Tumor Invasion: a Multidisciplinary Study

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Two-Photon Fluorescence Spectroscopy and Microscopy of NAD(P)H and Flavoprotein

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Fiber-optic fluorescence imaging

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A microenvironmental model of carcinogenesis

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Two-photon imaging to a depth of 1000 µm in living brains by use of a Ti:Al_2O_3 regenerative amplifier

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In vivo measurement of gene expression, angiogenesis and physiological function in tumors using multiphoton laser scanning microscopy

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Dissecting tumour pathophysiology using intravital microscopy

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Illuminating the metastatic process

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Long-term two-photon fluorescence imaging of mammalian embryos without compromising viability

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Optical imaging of Renilla luciferase reporter gene expression in living mice

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Fluorescence lifetime imaging by time‐correlated single‐photon counting

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In Vivo Multiphoton Microscopy of Deep Brain Tissue

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Multiphoton Excitation Provides Optical Sections from Deeper within Scattering Specimens than Confocal Imaging

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Identification and Testing of a Gene Expression Signature of Invasive Carcinoma Cells within Primary Mammary Tumors

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2-Deoxy-D-glucose reduces epilepsy progression by NRSF-CtBP–dependent metabolic regulation of chromatin structure

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Characterization of the Myosin-Based Source for Second-Harmonic Generation from Muscle Sarcomeres

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Fluorescence lifetime imaging

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Single cell behavior in metastatic primary mammary tumors correlated with gene expression patterns revealed by molecular profiling.

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3-Dimensional imaging of collagen using second harmonic generation

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THE GREAT ESCAPE: When Cancer Cells Hijack the Genes for Chemotaxis and Motility

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Metabolic Mapping of MCF10A Human Breast Cells via Multiphoton Fluorescence Lifetime Imaging of the Coenzyme NADH

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In vivo multiphoton fluorescence lifetime imaging of protein-bound and free nicotinamide adenine dinucleotide in normal and precancerous epithelia

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Quantitative Imaging of Lateral ErbB1 Receptor Signal Propagation in the Plasma Membrane

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Glycolysis in cancer: A potential target for therapy

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The Warburg effect and its cancer therapeutic implications

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In vivo quantitation of rare circulating tumor cells by multiphoton intravital flow cytometry

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Application of the Stretched Exponential Function to Fluorescence Lifetime Imaging

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Fluorescence Lifetime Imaging Microscopy (FLIM)

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The activity status of cofilin is directly related to invasion, intravasation, and metastasis of mammary tumors

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Multiphoton endoscopy

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Three-dimensional chromatin distribution in neuroblastoma nuclei shown by confocal scanning laser microscopy

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Imaging in Systems Biology

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Second harmonic generation imaging of endogenous structural proteins

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Regulatable Expression of p21-activated Kinase-1 Promotes Anchorage-independent Growth and Abnormal Organization of Mitotic Spindles in Human Epithelial Breast Cancer Cells

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Hypoxia, glucose metabolism and the Warburg’s effect

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Polarization-dependent optical second-harmonic imaging of a rat-tail tendon

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Practical implementation of adaptive optics in multiphoton microscopy

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Second-harmonic microscopy of biological tissue

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Multiphoton Microscopy of Endogenous Fluorescence Differentiates Normal, Precancerous, and Cancerous Squamous Epithelial Tissues

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Imaging FRET between spectrally similar GFP molecules in single cells

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Multiphoton-FLIM Quantification of the EGFP-mRFP1 FRET Pair for Localization of Membrane Receptor-Kinase Interactions

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Practical limits of resolution in confocal and non‐linear microscopy

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Coordinated Regulation of Pathways for Enhanced Cell Motility and Chemotaxis Is Conserved in Rat and Mouse Mammary Tumors

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Host microenvironment in breast cancer development: Extracellular matrix–stromal cell contribution to neoplastic phenotype of epithelial cells in the breast

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Steady state and time-resolved fluorescence properties of metastatic and non-metastatic malignant cells from different species

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New developments in multiphoton microscopy

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Endogenous Optical Biomarkers of Ovarian Cancer Evaluated with Multiphoton Microscopy

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Simultaneous imaging of GFP, CFP and collagen in tumors in vivousing multiphoton microscopy

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Fluorescence lifetime imaging of unstained tissues: early results in human breast cancer

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Two-photon fluorescence endoscopy with a micro-optic scanning head

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Optical second‐harmonic scattering in rat‐tail tendon

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Rapid acquisition, analysis, and display of fluorescence lifetime-resolved images for real-time applications

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Studying biological tissue with fluorescence lifetime imaging: microscopy, endoscopy, and complex decay profiles

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Simultaneous two-photon spectral and lifetime fluorescence microscopy

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Two‐photon fluorescence lifetime imaging microscopy of macrophage‐mediated antigen processing

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Imaging Phosphorylation Dynamics of the Epidermal Growth Factor Receptor

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Imaging molecular interactions by multiphoton FLIM

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Autofluorescence Spectroscopy of Normal and Malignant Human Breast Cell Lines¶

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Spatially Distinct Binding of Cdc42 to PAK1 and N-WASP in Breast Carcinoma Cells

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On the Fluorescence of NAD(P)H in Whole‐Cell Preparations of Tumours and Normal Tissues

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Quantification of integrin receptor agonism by fluorescence lifetime imaging

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Activated Ezrin Promotes Cell Migration through Recruitment of the GEF Dbl to Lipid Rafts and Preferential Downstream Activation of Cdc42

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Confocal and two-photon microscopy

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The potential role of transformation-induced metabolic changes in tumor-host interaction.

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Endogenous fluorescence spectroscopy of cell suspensions for chemopreventive drug monitoring.

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Rac regulates the interaction of fascin with protein kinase C in cell migration

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Autofluorescence characteristics of immortalized and carcinogen-transformed human bronchial epithelial cells

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Imaging in situ protein–DNA interactions in the cell nucleus using FRET–FLIM

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Nonlinear Optical Imaging of Cellular Processes in Breast Cancer

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Endogenous Fluorescence Spectroscopy of Cell Suspensions for Chemopreventive Drug Monitoring¶

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<title>Multiwavelength TCSPC lifetime imaging</title>

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SLIM: A new method for molecular imaging

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Metabolic imaging of tumors using intrinsic and extrinsic fluorescent markers

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Fibre‐optic two‐photon scanning fluorescence microscopy

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Applications of Combined Spectral Lifetime Microscopy for Biology

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Practical Fluorescence Resonance Energy Transfer or Molecular Nanobioscopy of Living Cells

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Time-resolved DNA-microarray reading by an intensified CCD for ultimate sensitivity

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Resolution improvement in two-photon fluorescence microscopy with a single-mode fiber

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An active Src kinase-β-actin association is linked to actin dynamics at the periphery of colon cancer cells

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Noninvasive Native Fluorescence Imaging of Head and Neck Tumors

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Two-Photon Excitation Fluorescence Microscopy

2007 • 14 citations