Polarized secretion of lysosomal enzymes: co-distribution of cation-independent mannose-6-phosphate receptors and lysosomal enzymes along the osteoclast exocytic pathway.

PERIODATE-LYSINE-PARAFORMALDEHYDE FIXATIVE A NEW FIXATIVE FOR IMMUNOELECTRON MICROSCOPY

1974 • 3,882 citations

The trans Golgi Network: Sorting at the Exit Site of the Golgi Complex

1986 • 1,175 citations

Pathways of Protein Secretion in Eukaryotes

1985 • 1,050 citations

BIOSYNTHETIC PROTEIN TRANSPORT AND SORTING BY THE ENDOPLASMIC RETICULUM AND GOLGI

1987 • 985 citations

LYSOSOMAL ENZYMES AND THEIR RECEPTORS

1986 • 915 citations

Intracellular site of asialoglycoprotein receptor-ligand uncoupling: Double-label immunoelectron microscopy during receptor-mediated endocytosis

1983 • 816 citations

Chloroquine inhibits lysosomal enzyme pinocytosis and enhances lysosomal enzyme secretion by impairing receptor recycling.

1980 • 743 citations

Cell-mediated extracellular acidification and bone resorption: evidence for a low pH in resorbing lacunae and localization of a 100-kD lysosomal membrane protein at the osteoclast ruffled border.

1985 • 738 citations

Progress in Unraveling Pathways of Golgi Traffic

1985 • 615 citations

Demonstration of an extensive trans-tubular network continuous with the Golgi apparatus stack that may function in glycosylation

1985 • 448 citations

Trafficking of lysosomal enzymes in normal and disease states.

1986 • 445 citations

ON THE MECHANISMS OF BONE RESORPTION

1968 • 331 citations

Glycoproteins of the lysosomal membrane.

1985 • 294 citations

The mannose-6-phosphate receptor for lysosomal enzymes is concentrated in cis Golgi cisternae

1984 • 291 citations

Mannose-6-phosphate receptors for lysosomal enzymes cycle between the Golgi complex and endosomes.

1986 • 270 citations

Evidence for extensive subcellular organization of asparagine-linked oligosaccharide processing and lysosomal enzyme phosphorylation.

1983 • 270 citations

Purification of a Gal beta 1 to 4GlcNAc alpha 2 to 6 sialyltransferase and a Gal beta 1 to 3(4)GlcNAc alpha 2 to 3 sialyltransferase to homogeneity from rat liver.

1982 • 248 citations

Biosynthesis of lysosomal hydrolases: their synthesis in bound polysomes and the role of co- and post-translational processing in determining their subcellular distribution

1982 • 246 citations

Phosphomannosyl-enzyme receptors in rat liver. Subcellular distribution and role in intracellular transport of lysosomal enzymes.

1980 • 231 citations

New Observations on the Substrate Specificity of Cathepsin C (Dipeptidyl Aminopeptidase I)

1969 • 225 citations

Dependence on pH of polarized sorting of secreted proteins

1987 • 212 citations

Purification and characterization of a cation-dependent mannose 6-phosphate receptor from murine P388D1 macrophages and bovine liver.

1985 • 193 citations

Lysosomal membrane dynamics: structure and interorganellar movement of a major lysosomal membrane glycoprotein.

1986 • 193 citations

Identification and characterization of cells deficient in the mannose 6-phosphate receptor: evidence for an alternate pathway for lysosomal enzyme targeting.

1983 • 186 citations

THE CYTOCHEMICAL DEMONSTRATION OF LYSOSOMAL ARYL SULFATASE ACTIVITY BY LIGHT AND ELECTRON MICROSCOPY

1965 • 185 citations

Protein sorting by selective retention in the endoplasmic reticulum and Golgi stack

1987 • 179 citations

Biosynthesis and turnover of the mannose 6-phosphate receptor in cultured Chinese hamster ovary cells.

1983 • 169 citations

Ultrastructural localization of the mannose 6-phosphate receptor in rat liver.

1984 • 162 citations

46 kd mannose 6-phosphate receptor: Cloning, expression, and homology to the 215 kd mannose 6-phosphate receptor

1987 • 150 citations

Cloning of the bovine 215-kDa cation-independent mannose 6-phosphate receptor.

1987 • 132 citations

Is movement of mannose 6-phosphate-specific receptor triggered by binding of lysosomal enzymes?

1987 • 123 citations

Redistribution of mannose-6-phosphate receptors induced by tunicamycin and chloroquine.

1984 • 114 citations

The interaction of phosphorylated oligosaccharides and lysosomal enzymes with bovine liver cation-dependent mannose 6-phosphate receptor.

1987 • 106 citations

Synthesis of phosphorylated recognition marker in lysosomal enzymes is located in the cis part of Golgi apparatus.

1982 • 106 citations

Antibodies against lysosomal membranes reveal a 100,000-mol-wt protein that cross-reacts with purified H+,K+ ATPase from gastric mucosa.

1984 • 96 citations

Cloning of a cDNA encoding the human cation-dependent mannose 6-phosphate-specific receptor.

1987 • 95 citations

The mannose 6-phosphate receptor of Chinese Hamster ovary cells. Isolation of mutants with altered receptors.

1981 • 77 citations

Accumulation of coated vesicles bearing mannose 6-phosphate receptors for lysosomal enzymes in the Golgi region of I-cell fibroblasts.

1984 • 65 citations

Ultrastructural immunocytochemical localization of the phosphomannosyl receptor in Chinese hamster ovary (CHO) cells.

1983 • 61 citations

Synthesis and transport of lysosomal acid phosphatase in normal and I-cell fibroblasts.

1985 • 60 citations

The endosomal concentration of a mannose 6-phosphate receptor is unchanged in the absence of ligand synthesis.

1987 • 59 citations

β-Glucuronidase of Rat Preputial Gland1

1975 • 57 citations

The distribution of 215-kilodalton mannose 6-phosphate receptors within cis (heavy) and trans (light) Golgi subfractions varies in different cell types.

1987 • 52 citations

Cytochemical localization of arylsulfatase B in rat basophils and mast cells.

1980 • 34 citations

Synthesis, transport and processing of cathepsin C in Morris hepatoma 7777 cells and rat hepatocytes

1985 • 30 citations

Lysosomal enzyme trafficking in mannose 6-phosphate receptor-positive mouse L-cells: demonstration of a steady state accumulation of phosphorylated acid hydrolases.

1986 • 24 citations