Behavioral screening for cognition enhancers: from indiscriminate to valid testing: Part I

The Cholinergic Hypothesis of Geriatric Memory Dysfunction

1982 • 5,422 citations

Selective impairment of learning and blockade of long-term potentiation by an N-methyl-D-aspartate receptor antagonist, AP5

1986 • 3,586 citations

Fundamentals of Human Neuropsychology

1995 • 2,015 citations

The neuropsychology of schizophrenia

1991 • 1,376 citations

The validity of animal models of depression

1984 • 1,365 citations

Conditioning and Associative Learning

1984 • 1,327 citations

Oral Tetrahydroaminoacridine in Long-Term Treatment of Senile Dementia, Alzheimer Type

1986 • 1,148 citations

Fundamentals of human neuropsychology

1982 • 1,041 citations

Neural mechanisms of learning and memory

1977 • 864 citations

Animal Model of Depression

1969 • 705 citations

A COMPARATIVE STUDY OF VISUOSPATIAL MEMORY AND LEARNING IN ALZHEIMER-TYPE DEMENTIA AND PARKINSON'S DISEASE

1988 • 654 citations

Cholinergic function and intellectual decline in Alzheimer's disease

1986 • 605 citations

The Neuropsychology of Human Memory

1982 • 573 citations

Involvement of Hormonal and Neuromodulatory Systems in the Regulation of Memory Storage

1989 • 565 citations

THE CHOLINERGIC HYPOTHESIS—TEN YEARS ON

1986 • 563 citations

α ₂ -Adrenergic Mechanisms in Prefrontal Cortex Associated with Cognitive Decline in Aged Nonhuman Primates

1985 • 544 citations

Attenuation of scopolamine-induced impairment of spontaneous alternation behaviour by antagonist but not inverse agonist and agonist ?-carbolines

1988 • 502 citations

Benzodiazepine impairs and β-carboline enhances performance in learning and memory tasks

1986 • 500 citations

The Effects of Nicotine on Attention, Information Processing, and Short-Term Memory in Patients with Dementia of the Alzheimer Type

1989 • 491 citations

The retroactive effect of electroshock on learning.

1949 • 420 citations

The alpha-2 adrenergic agonist guanfacine improves memory in aged monkeys without sedative or hypotensive side effects: evidence for alpha-2 receptor subtypes

1988 • 386 citations

Facilitation of time-dependent memory processes with posttrial epinephrine injections

1975 • 376 citations

Physostigmine and Arecoline: Effects of Intravenous Infusions in Alzheimer Presenile Dementia

1981 • 362 citations

Behavioural, biochemical and histochemical effects of different neurotoxic amino acids injected into nucleus basalis magnocellularis of rats

1987 • 352 citations

Validation criteria for animal models of human mental disorders: Learned helplessness as a paradigm case

1986 • 333 citations

Comparative effects of ibotenic acid- and quisqualic acid-induced lesions of the substantia innominata on attentional function in the rat: further implications for the role of the cholinergic neurons of the nucleus basalis in cognitive processes

1989 • 325 citations

Retrograde Amnesia: Temporal Gradient in Very Long Term Memory Following Electroconvulsive Therapy

1975 • 321 citations

Conditioning in amnesic patients

1979 • 317 citations

Intravenous nicotine in Alzheimer's disease: a pilot study

1988 • 312 citations

Nimodipine Facilitates Associative Learning in Aging Rabbits

1989 • 305 citations

Learning and memory deficits after lesions of the nucleus basalis magnocellularis: Reversal by physostigmine

1985 • 305 citations

Effects of the NMDA antagonists CPP and MK-801 on radial arm maze performance in rats

1990 • 274 citations

CHOLINERGIC ‘BLOCKADE’ AS A MODEL FOR CHOLINERGIC DEPLETION

1988 • 258 citations

D-cycloserine, a positive modulator of the N-methyl-D-aspartate receptor, enhances performance of learning tasks in rats

1989 • 253 citations

Patterns of memory failure after scopolamine treatment: Implications for cholinergic hypotheses of dementia

1986 • 241 citations

Age-related alterations in the rodent brain cholinergic system and behavior

1980 • 237 citations

Effects of the novel compound aniracetam (Ro 13-5057) upon impaired learning and memory in rodents

1982 • 232 citations

Dehydroepiandrosterone and its sulfate enhance memory retention in mice

1988 • 232 citations

The effects of physostigmine and scopolamine on recognition memory in monkeys

1986 • 224 citations

Modulation of memory processing by neuropeptide Y

1987 • 222 citations

The role of cholinergic projections from the nucleus basalis in memory

1991 • 213 citations

Presynaptic Serotonergic Dysfunction in Patients with Alzheimer's Disease

1987 • 213 citations

Dissociating learning and performance: Drug and hormone enhancement of memory storage

1989 • 211 citations

The Cholinergic Hypothesis of Memory: A Review of Animal Experiments

1988 • 210 citations

Scopolamine effects on memory retention in mice: A model of dementia?

1986 • 209 citations

Tetrahydroaminoacridine–Lecithin Combination Treatment in Patients with Intermediate-Stage Alzheimer's Disease

1990 • 207 citations

Physostigmine and Recent Memory: Effects in Young and Aged Nonhuman Primates

1979 • 205 citations

Cortical cholinergic fibers in aging and Alzheimer's disease: A morphometric study

1989 • 198 citations

Treatment Development Strategies for Alzheimer’s Disease

1987 • 198 citations

Learning impairment following lesion of the basal nucleus of Meynert in the marmoset: Modification by cholinergic drugs

1986 • 197 citations

Mechanisms of cholinesterase inhibition in senile dementia of the alzheimer type: Clinical, pharmacological, and therapeutic aspects

1988 • 196 citations

Memory facilitating and anti-amnesic effects of corticosteroids

1978 • 196 citations

The effects of ondansetron, a 5-HT3 receptor antagonist, on cognition in rodents and primates

1990 • 190 citations

Use of THA in treatment of Alzheimer-like dementia: pilot study in twelve patients.

1981 • 186 citations

NMDA receptor antagonists can enhance or impair learning performance in animals

1989 • 184 citations

Evidence for a direct cholinergic involvement in the scopolamine-induced amnesia in monkeys: Effects of concurrent administration of physostigmine and methylphenidate with scopolamine

1978 • 179 citations

The mnemon and its juices: neuromodulation of memory processes

1983 • 178 citations

Pharmacological investigations of neurotransmitter involvement in passive avoidance responding: A review and some new results

1982 • 174 citations

NMDA antagonist MK-801 impairs acquisition but not performance of spatial working and reference memory

1990 • 170 citations

Tacrine (tetrahydroaminoacridine; THA) and lecithin in senile dementia of the Alzheimer type: a multicentre trial. Groupe Francais d'Etude de la Tetrahydroaminoacridine.

1990 • 170 citations

The use of avoidance training in studies of modulation of memory storage

1986 • 169 citations

Facilitation of maze learning with posttrial injections of picrotoxin.

1961 • 168 citations

Cholinergic modulation of memory in rats

1985 • 166 citations

Different forms of post-training memory processing

1989 • 162 citations

Activating the damaged basal forebrain cholinergic system: tonic stimulation versus signal amplification

1990 • 162 citations

Intraseptal administration of muscimol produces dose-dependent memory impairments in the rat

1989 • 154 citations

Memory facilitation produced by dopamine agonists: Role of receptor subtype and mnemonic requirements

1989 • 151 citations

Modulation of memory processing by neuropeptide Y varies with brain injection site

1989 • 150 citations

A critique of the vasopressin-memory hypothesis

1984 • 146 citations

Nicotine enhances delayed matching-to-sample performance by primates

1988 • 144 citations

Behavioral effects of nimodipine in animals.

1982 • 140 citations

Dissociating performance and learning deficits on spatial navigation tasks in rats subjected to cholinergic muscarinic blockade

1989 • 140 citations

Effect of atropine on learning, extinction, retention and retrieval in rats

1964 • 140 citations

Post-training administration of GABAergic antagonists enhances retention of aversively motivated tasks

1988 • 139 citations

Pilocarpine and physostigmine attenuate spatial memory impairments produced by lesions of the nucleus basalis magnocellularis.

1986 • 138 citations

Topographical distribution of neurochemical changes in Alzheimer's disease

1988 • 137 citations

Cognitive deficits in olivopontocerebellar atrophy: Implications for the cholinergic hypothesis of Alzheimer's dementia

1988 • 137 citations

Quantitative histochemistry of brain acetylcholinesterase and learning rate in the aged rat

1986 • 136 citations

Preservation of musical memory in Alzheimer's disease.

1989 • 134 citations

Pharmacology of nootropics and metabolically active compounds in relation to their use in dementia

1990 • 132 citations

Cerebral Protein Synthesis Inhibitors Block Long-Term Memory

1970 • 132 citations

Catecholaminergic neurones assessed ante-mortem in Alzheimer's disease

1987 • 131 citations

Nootropic drugs: Animal models for studying effects on cognition

1984 • 128 citations

Effect of age and punishment condition on long-term retention by the rat of active- and passive-avoidance learning.

1970 • 127 citations

Some effects of scopolamine on a passive avoidance response in rats

1965 • 125 citations

Pilocarpine and physostigmine attenuate spatial memory impairments produced by lesions of the nucleus basalis magnocellularis.

1986 • 122 citations

Proactive interference effects on short-term memory in rats: I. Basic parameters and drug effects.

1990 • 122 citations

Basal forebrain lesions and memory: Alterations in neurotensin, not acetylcholine, may cause amnesia.

1989 • 120 citations

Idazoxan, an α-2 antagonist, facilitates memory retrieval in the rat

1989 • 120 citations

Low dose scopolamine affects discriminability but not rate of forgetting in delayed conditional discrimination

1988 • 119 citations

Scopolamine and the control of attention in humans

1986 • 118 citations

Interactions between oxiracetam, aniracetam and scopolamine on behavior and brain acetylcholine

1987 • 118 citations

Pharmacological alleviation of cholinergic lesion induced memory deficits in rats

1985 • 117 citations

Noradrenergic Modulation of Selective Attention: Its Role in Memory Retrieval

1985 • 117 citations

Galanin antagonizes acetylcholine on a memory task in basal forebrain-lesioned rats.

1988 • 115 citations

Memory facilitation with posttrial injection of oxotremorine and physostigmine in mice

1979 • 112 citations

Modulation of memory processing by glutamic acid receptor agonists and antagonists

1990 • 111 citations

An evaluation of the mechanism of scopolamine-induced impairment in two passive avoidance protocols

1988 • 107 citations

Effects of bombesin and gastrin-releasing peptide on memory processing

1988 • 105 citations

Plasma catecholamines: Effects of footshock level and hormonal modulators of memory storage*1

1981 • 105 citations

Antibiotics and memory.

1976 • 104 citations

Bidirectional effects of β-carbolines and benzodiazepines on cognitive processes

1987 • 104 citations

Basal Forebrain Cholinergic Neurons and Alzheimer’s Disease

1988 • 104 citations

Memory enhancement: Supra-additive effect of subcutaneous cholinergic drug combinations in mice

1985 • 103 citations

Effects of anticholinergic drugs on learning and memory

1983 • 103 citations

Scopolamine disrupts maintenance of attention rather than memory processes

1981 • 102 citations

Animal Memory and Learning

1990 • 102 citations

Permanence of Retrograde Amnesia Produced by Electroconvulsive Shock

1967 • 102 citations

A Pilot Study of Haloperidol Treatment of Psychosis and Behavioral Disturbance in Alzheimer's Disease

1989 • 102 citations

Multiple-Dose Arecoline Infusions in Alzheimer's Disease

1988 • 99 citations

Effects of ibotenic acid lesions of the basal forebrain on serial reversal learning in marmosets

1985 • 95 citations

The effect of pre- and post-trial amphetamine injections on avoidance responses of rats

1971 • 95 citations

Central cholinergic involvement in working memory: Effects of scopolamine on continuous nonmatching and discrimination performance in the rat.

1985 • 94 citations

ANIMAL BEHAVIOR AND DRUG ACTION

1965 • 94 citations

Scopolamine degrades spatial working memory but spares spatial reference memory: Dissimilarity of anticholinergic effect and restriction of distal visual cues

1985 • 94 citations

Induction of depression with oxotremorine in patients with Alzheimer's disease

1987 • 94 citations

Scopolamine effects on memory, language, visuospatial praxis and psychomotor speed

1990 • 93 citations

Antibiotics and memory.

1976 • 91 citations

Attenuation of scopolamine-induced amnesia in mice

1988 • 91 citations

Lack of Efficacy of Hydergine in Patients with Alzheimer's Disease

1990 • 90 citations

Milacemide, a glycine prodrug, enhances performance of learning tasks in normal and amnestic rodents

1989 • 90 citations

What is the importance of vasopressin in memory processes?

1983 • 89 citations

Vinpocetine: Nootropic effects on scopolamine-induced and hypoxia-induced retrieval deficits of a step-through passive avoidance response in rats

1986 • 88 citations

Physostigmine improves water maze performance following nucleus basalis magnocellularis lesions in rats

1988 • 88 citations

Effects of Nucleus Basalis Magnocellularis Lesions in Rats on Delayed Matching and Non‐Matching to Position Tasks

1989 • 87 citations

RS 86 in the treatment of alzheimer's disease: Cognitive and biological effects

1987 • 87 citations

Cognition activators

1988 • 87 citations

Drugs as Research Tools in Psychology: Cholinergic Drugs and Information Processing

1984 • 86 citations

Muscarinic Agonist Therapy of Alzheimer's Disease

1986 • 86 citations

Enhancement of learning and memory in mice by a benzodiazepine antagonist

1988 • 84 citations

Effects of pentylenetetrazol on memory storage in mice

1968 • 84 citations

Treatment development strategies for Alzheimer's disease

1986 • 84 citations

Restoration of cholinomimetic activity by clonidine in cholinergic plus noradrenergic lesioned rats

1990 • 83 citations

A long-acting cholinesterase inhibitor reverses spatial memory deficits in mice

1988 • 81 citations

Radial-arm maze deficits produced by colchicine administered into the area of the nucleus basalis are ameliorated by cholinergic agents

1988 • 81 citations

No response to high‐dose muscarinic agonist therapy in Alzheimer's disease

1988 • 80 citations

Effects of different doses of galanthamine, a long-acting acetylcholinesterase inhibitor, on memory in mice

1990 • 79 citations

TRH attenuates scopolamine-induced memory impairment in humans

1990 • 77 citations

Scopolamine impairs both working and reference memory in rats: a replication and extension

1989 • 77 citations

Attenuation of experimentally-induced amnesia

1981 • 76 citations

Post-training injection of the acetylcholine M2 receptor antagonist AF-DX 116 improves memory

1990 • 75 citations

Antagonism of endogenous opioids modulates memory processing

1987 • 73 citations

Brain cyclic AMP and memory in mice

1982 • 73 citations

(±)-cis-2-Methyl-spiro(1,3-oxathiolane-5,3′) quinuclidine (AF102B): A new M1 agonist attenuates cognitive dysfunctions in AF64A-treated rats

1989 • 72 citations

Comparison of the effects of four cholinomimetic agents on cognition in primates following disruption by scopolamine or by lists of objects

1989 • 71 citations

Treatment of Alzheimer's disease with short- and long-term oral THA and lecithin: a double-blind study

1990 • 71 citations

Clinical trials with the cholinergic drug RS 86 in Alzheimer's disease (AD) and senile dementia of the Alzheimer type (SDAT)

1984 • 71 citations

Effects of continuous infusion of cholinergic drugs on memory impairment in rats with basal forebrain lesions.

1989 • 71 citations

4-Aminopyridine in the treatment of alzheimer's disease

1988 • 70 citations

Effects of opiate antagonists on spatial memory in young and aged rats

1985 • 69 citations

The effects of scopolamine hydrobromide on one-way and two-way avoidance learning in rats

1968 • 69 citations

Reversal of scopolamine-induced amnesia and alterations in energy metabolism by the nootropic piracetam: implications regarding identification of brain structures involved in consolidation of memory traces

1987 • 68 citations

Effects of the NMDA antagonists CPP and MK-801 on delayed conditional discrimination

1989 • 67 citations

Effect of physostigmine on memory consolidation and retrieval processes in intact and nucleus basalis-lesioned rats

1989 • 64 citations

Opiate antagonists enhance the working memory of rats in the radial maze

1990 • 64 citations

Effects of quisqualic acid nucleus basalis lesioning on cortical EEG, passive avoidance and water maze performance

1990 • 64 citations

Human studies on the benzodiazepine receptor antagonist ?-carboline ZK 93 426: preliminary observations on psychotropic activity

1987 • 64 citations

Cholinergic—dopaminergic interactions in radial-arm maze performance

1988 • 64 citations

Evidence for a possible functional interaction between serotonergic and cholinergic mechanisms in memory retrieval

1987 • 64 citations

Memory retrieval enhanced by amphetamine after a long retention interval

1982 • 63 citations

Behavioral methods for measuring effects of drugs on learning and memory in animals

1984 • 63 citations

Tetrahydroaminoacridine, 3,4 diaminopyridine and physostigmine: Direct comparison of effects on memory in aged primates

1988 • 62 citations

Visuospatial learning impairment following lesion of the cholinergic projection to the hippocampus

1988 • 62 citations

Effect of opiate receptor blockade on pain sensitivity in the rat

1977 • 59 citations

(.+-.)-9-Amino-1,2,3,4-tetrahydroacridin-1-ol. A potential Alzheimer's disease therapeutic of low toxicity

1988 • 59 citations

Effects of DM-9384 in a model of amnesia based on animals with GABAergic neuronal dysfunctions

1990 • 58 citations

Effects of DM-9384, a cyclic derivative of GABA, on amnesia and decreases in GABAA and muscarinic receptors induced by cycloheximide.

1991 • 57 citations

Effects of post-training d-amphetamine on acquisition of an appetitive autoshaped lever press response in rats

1988 • 57 citations

Effects of aniracetam on delayed matching-to-sample performance of monkeys and pigeons

1985 • 57 citations

Effects of scopolamine on avoidance conditioning and habituation of mice

1968 • 57 citations

A mnemonic role for vasopressin: The evidence for and against

1985 • 56 citations

Piracetam combined with lecithin in the treatment of Alzheimer's disease

1986 • 55 citations

Contrasting effects of vasopressin, desglycinamide-vasopressin and amphetamine on a delayed matching to position task in rats

1987 • 53 citations

Piracetam in elderly psychiatric patients with mild diffuse cerebral impairment

1983 • 53 citations

Central effects of guanfacine and clonidine during wakefulness and sleep in healthy subjects.

1980 • 53 citations

Benzodiazepine receptor ligand influences on acquisition: Suggestion of an endogenous modulatory mechanism mediated by benzodiazepine receptors

1990 • 52 citations

Hemicholinium-3 impairs spatial learning and the deficit is reversed by cholinomimetics

1989 • 52 citations

Effects of cholinergic drugs on poor performance of rats in a shuttle-box

1968 • 51 citations

Retrograde Amnesia: Production of Skeletal but Not Cardiac Response Gradient by Electroconvulsive Shock

1970 • 50 citations

The effect of NMDA antagonists in the radial arm maze task with an interposed delay

1990 • 50 citations

Effect of cholinesterase inhibitors on Morris water task behavior following lesions of the nucleus basalis magnocellularis.

1988 • 50 citations

Effects of cholinergic drugs on learning impairment in ventral globus pallidus-lesioned rats

1989 • 49 citations

Do piracetam-like compounds act centrally via peripheral mechanisms?

1987 • 48 citations

The effects of THA on medial septal lesion-induced memory defects

1990 • 48 citations

Opiate antagonist facilitation of time-dependent memory processes: Dependence upon intact norepinephrine function

1985 • 47 citations

Oral Administration of Chronic Physostigmine does not Improve Cognitive or Mnesic Performances in Alzheimer's Presenile Dementia

1982 • 46 citations

Intracerebroventricular bethanechol chloride infusion in Alzheimer's disease

1989 • 46 citations

Behavioral microanalysis of spatial delayed alternation performance: rehearsal through overt behavior, and effects of scopolamine and chlordiazepoxide

1992 • 46 citations

Cholinergic modulation of memory for step-down type passive avoidance task in mice

1986 • 46 citations

Behavioural effects of etiracetam in rats

1981 • 46 citations

Cholinergic drug effects on visual discriminations: A signal detection analysis

1981 • 46 citations

Effect of cholinesterase inhibitors on Morris water task behavior following lesions of the nucleus basalis magnocellularis.

1988 • 46 citations

Nucleus basalis magnocellularis lesions: Lack of biochemical and immunocytochemical recovery and effect of cholinesterase inhibitors on passive avoidance.

1988 • 45 citations

Behavioral Models of Aging in Nonhuman Primates

1988 • 45 citations

Modulation of memory retention by neuropeptide K

1990 • 45 citations

Clonidine Treatment of Alzheimer's Disease

1989 • 45 citations

GABAergic modulation of memory with regard to passive avoidance and conditioned suppression tasks in mice

1988 • 45 citations

Failure of cholinergic agonist RS‐86 to improve cognition and movement in PSP despite effects on sleep

1989 • 44 citations

Cholinergic drugs reverse AF64A-induced impairment of passive avoidance learning in rats

1991 • 44 citations

Permanent facilitation of avoidance behavior by d-amphetamine and scopolamine

1972 • 44 citations

Drug Effects and Learning and Memory Processes

1971 • 44 citations

Animal Models of Alzheimer's Disease: Behavior, Pharmacology, Transplants

1986 • 44 citations

Reversal of scopolamine-induced amnesia of passive avoidance by pre- and post-training naloxone

1986 • 44 citations

Tetrahydroaminoacridine improves the spatial acquisition deficit produced by nucleus basalis lesions in rats

1990 • 44 citations

Effects of the novel compound NIK-247 on impairment of passive avoidance response in mice

1988 • 43 citations

Naloxone and ?-endorphin alter the effects of post-training epinephrine on memory

1987 • 43 citations

Effect of 4-(o-benzylphenoxy)-N-methylbutylamine hydrochloride (MCI-2016) on the scopolamine-induced deficit of spontaneous alternation behavior in rats.

1983 • 42 citations

Spontaneous exploration of a 6-arm radial tunnel maze by basal forebrain lesioned rats: effects of the benzodiazepine receptor antagonist ?-carboline ZK 93 426

1989 • 41 citations

Low dose tetrahydroaminoacridine (THA) improves cognitive function but does not affect brain acetylcholine in rats

1990 • 41 citations

Retrieval of well-learned propositional rules: Insensitive to changes in activity of individual neurotransmitter systems?

1990 • 41 citations

Do passive-avoidance tasks permit assessment of retrograde amnesia in rats?

1970 • 40 citations

Clinical Experience with and Side-effects of Tacrine Hydrochloride in Alzheimer's Disease: A Pilot Study

1989 • 40 citations

Brain acetylcholinesterase activity is markedly reduced in dominantly-inherited olivopontocerebellar atrophy.

1988 • 40 citations

Scopolamine interactions with D1 and D2 antagonists on radial-arm maze performance in rats

1988 • 39 citations

Opposing effects of vasopressin on matching versus non-matching to position: further evidence for response, not memory, modulation

1990 • 38 citations

Non‐Alzheimer‐type pattern of brain cholineacetyltransferase reduction in dominantly inherited olivopontocerebellar atrophy

1989 • 38 citations

Interactions of scopolamine and physostigmine with ECS and one trial learning

1971 • 37 citations

Memory deficits following nucleus basalis magnocellularis lesions may be mediated through limbic, but not neocortical, targets

1990 • 37 citations

Evidence against a specific effect of cholinergic drugs on spatial memory in primates

1991 • 36 citations

Effects of naloxone on Morris water maze learning in the rat: Enhanced acquisition with pretraining but not posttraining administration

1989 • 35 citations

Effects of systemic pancreastatin on memory retention

1988 • 35 citations

Effects of a new TRH analogue, YM-14673 on a passive avoidance test as a possible criterion of improvement in cognitive disturbance in rodents

1988 • 35 citations

Dissociative effects of ibotenic and quisqualic acid-induced basal forebrain lesions on cortical acetylcholinesterase-positive fiber density and cytochrome oxidase activity

1991 • 34 citations

CGS 8216, a benzodiazepine receptor antagonist, enhances learning and memory in mice

1988 • 33 citations

Differences in psychic performance with guanfacine and clonidine in normotensive subjects.

1980 • 33 citations

Assessment of working memory in rats using spatial alternation behavior with variable retention intervals: effects of fixed-ratio size and scopolamine

1990 • 32 citations

Desglycinamide-9-arginine-8-vasopressin (DGAVP, Organon 5667) in patients with dementia

1985 • 32 citations

FACILITATION OF MEMORY CONSOLIDATION

1983 • 32 citations

The effect of pramiracetam (CI-879) on the acquisition of a radial arm maze task

1986 • 32 citations

Flumazenil improves active avoidance performance in aging NZB/B1NJ and C57BL/6NNia mice

1990 • 32 citations

Scopolamine differentially disrupts the behavior of male and female Wistar rats in a delayed nonmatching to position procedure

1990 • 32 citations

Bidirectional Nature of Benzodiazepine Receptor Ligands Extends to Effects on Vigilance

1988 • 31 citations

The need for common perspectives in the development and use of animal models for age-related cognitive and neurodegenerative disorders

1988 • 31 citations

Effects of DM-9384, a pyrrolidone derivative, on alcohol- and chlordiazepoxide-induced amnesia in mice

1990 • 29 citations

Nootropic drugs in Alzheimer's disease

1991 • 29 citations

Involvement of a steroidal component in the mechanism of action of piracetam-like nootropics

1990 • 29 citations

Facilitation of retrieval by d-amphetamine following anisomycin-induced amnesia

1982 • 29 citations

Greater task difficulty amplifies the facilitatory effect of des-glycinamide arginine vasopressin on appetitively motivated learning.

1985 • 29 citations

Beneficial effects of FKS-508 (AF102B), a selective M1 agonist, on the impaired working memory in AF64A-treated rats.

1989 • 29 citations

Behavioral effects of angiotensin II and angiotensin II-(4-8)-pentapeptide in rats

1988 • 28 citations

Enhancing effects of Hoe 175 on memory in mice

1985 • 28 citations

β-Carbolines as Tools in Memory Research: Animal Data and Speculations

1988 • 28 citations

The delayed reaction in animals and children

1913 • 28 citations

Parallel modifications of spatial memory performances, exploration patterns, and hippocampal theta rhythms in fornix-damaged rats: Reversal of oxotremorine.

1988 • 27 citations

Cognitive functions affected by scopolamine in alzheimer's disease and normal aging

1988 • 26 citations

Post-trial hormonal treatment effects: memory modulation or perceptual distortion?

1987 • 26 citations

Quaternary naloxone enhances acquisition of a discriminated Y-maze escape and a one-way active avoidance task in mice

1985 • 26 citations

Multicenter trial of naloxone in alzheimer's disease

1989 • 26 citations

Enhancement by secoverine and physostigmine of retention of passive avoidance response in mice

1987 • 25 citations

R 58 735: A new antihypoxic drug with anticonvulsant properties and possible effects on cognitive functions

1986 • 25 citations

Does DGAVP influence memory, attention and mood in young healthy men?

1987 • 25 citations

Effects of arecoline and pilocarpine on learning ability in marmosets pretreated with hemicholinium-3

1987 • 25 citations

Memory retrieval deficits: Alleviation by etiracetam, a nootropic drug

1980 • 25 citations

Oxiracetam prevents mecamylamine-induced impairment of active, but not passive, avoidance learning in mice

1990 • 24 citations

Memory facilitation by post-training intraperitoneal, intracerebroventricular and intra-amygdala injection of Ro 5-4864

1991 • 24 citations

Tetrahydroaminoacridine facilitates passive avoidance learning in rats with nucleus basalts magnocellularis lesions

1989 • 24 citations

Effects of cycloheximide, a protein synthesis inhibitor, on mouse brain catecholamine biochemistry

1982 • 24 citations

Is it possible to model psychotic states in animals?

1987 • 22 citations

Central muscarinic activities of an M1-selective agonist: preferential effect on reversal of amnesia

1990 • 22 citations

Parallel modifications of spatial memory performances, exploration patterns, and hippocampal theta rhythms in fornix-damaged rats: Reversal of oxotremorine.

1988 • 21 citations

Effects of atropine on avoidance condition: Interaction with nicotine and comparison with N-methyl-atropine

1972 • 21 citations

Lack of efficacy of clonidine on memory in aged cebus monkeys

1988 • 20 citations

Naloxone and [Met5]enkephalin effects on retention: attenuation by adrenal denervation

1987 • 20 citations

Clonidine disrupts aged‐monkey delayed response performance

1988 • 20 citations

Piracetam facilitates retrieval but does not impair extinction of bar-pressing in rats

1979 • 20 citations

Frontal cortex as the site of action of physostigmine in nbM-lesioned rats

1990 • 20 citations

Tetrahydroaminoacridine (THA) in Alzheimer's disease.

1989 • 20 citations

Phosphodiesterase inhibitors facilitate memory for passive avoidance conditioning

1981 • 19 citations

Elevation of brain tyrosine by inhibitors of protein synthesis is not responsible for their amnesic effect

1978 • 18 citations

Retention impairment by posttraining epinephrine: Role of state dependency and of endogenous opioid mechanisms.

1987 • 18 citations

β-Carbolines as Tools in Memory Research: Human Data with the β-Carboline ZK 93426

1988 • 18 citations

The silent epidemic: the search for treatment of age-related memory impairment

1989 • 18 citations

Memory retention test performance in mice: Improvement by chronic oral cholinergic drug treatment

1984 • 18 citations

Chronic stress and memory: Implication of the central cholinergic system

1990 • 17 citations

Acute effects of oral pyridostigmine on memory and cognitive function in SDAT

1989 • 17 citations

Orotate improves memory and enhances synaptic long-term potentiation in active avoidance behaviour in rats with perforant path stimulation as the conditioned stimulus

1988 • 17 citations

Acquisition and retention of avoidance behaviors following septal lesions or scopolamine injections in rats

1973 • 17 citations

Pharmacological Approaches in the Treatment of Senile Dementia

1989 • 17 citations

Memory consolidation: not a useful hypothesis in the search for memory-enhancing drugs

1986 • 17 citations

A vasopressin metabolite produces qualitatively different effects on memory retrieval depending on the accessibility of the memory

1990 • 16 citations

DGAVP (Org 5667) in early Alzheimer's disease patients

1990 • 16 citations

Improved recognition memory in monkeys following naloxone administration

1988 • 16 citations

Arginine vasopressin facilitates reversal and impairs retention of a brightness discrimination in albino rats

1987 • 16 citations

Effects of DGAVP on verbal memory

1988 • 16 citations

Effects of the novel compound, Hoe 065, upon impaired learning and memory in rodents

1989 • 15 citations

Progress Report on the Canadian Multicentre Trial of Tetrahydroaminoacridine with Lecithin in Alzheimer's Disease

1989 • 15 citations

The Use of Differences and Similarities in Comparative Psychopathology

1976 • 15 citations

Effect of a Novel CNS-Selective Cholinesterase Inhibitor, SM-10888, on Habituation and Passive Avoidance Responses in Mice

1990 • 15 citations

Methods for Determining the Effects of Drugs on Learning

2003 • 15 citations

Tetrahydroaminoacridine in Alzheimer's disease

1990 • 15 citations

Reduced haloperidol plasma concentration and clinical response in acute exacerbations of schizophrenia

1990 • 15 citations

Effect of DM-9384, a New Pyrrolidone Derivative, on Passive Avoidance and Cerebral Choline Acetyltransferase Activity in Rats

1990 • 14 citations

Haloperidol facilitates memory retrieval in the rat

1986 • 14 citations

Intracerebroventricular apomorphine alleviates spontaneous forgetting and increases cortical noradrenaline

1984 • 14 citations

Two-drug combinations of memory enhancers: Effect of dose ratio upon potency and therapeutic window, in mice

1988 • 14 citations

Disinhibitory properties of β-carboline antagonists of benzodiazepine receptors: a possible therapeutic approach for senile dementia?

1989 • 13 citations

Influences of peripheral adrenocorticotropin 1–39 (ACTH) and human corticotropin releasing hormone (h-CRH) on human auditory evoked potentials (AEP)

1990 • 13 citations

Therapeutic effect of THA on hemicholinium-3-induced learning impairment is independent of serotonergic and noradrenergic systems

1990 • 13 citations

New Pharmacological Perspectives on Nootropic Drugs

1988 • 12 citations

Scopolamine’s effect on passive avoidance

1970 • 12 citations

Arresting memory decline

1988 • 12 citations

Failure of chronic physostigmine to ameliorate working memory deficits after medial septal lesions

1987 • 11 citations

Memory for discriminated escape learning: Pharmacologic enhancement and disruption

1987 • 10 citations

Role of β-Endorphin and Other Mechanisms in the Simultaneous and Consecutive Processing of New and Old Memories

1986 • 10 citations

Effect of BMY 21502 on acquisition of shape discrimination and memory retention in monkey

1990 • 10 citations

Memory enhancement in mice: Role of drug dose and training-testing interval

1988 • 9 citations

The Effects of Vasopressin on Memory in Healthy Young Adult Volunteers

1990 • 9 citations

Effect of V-9-M, a peptide fragment derived from procholecystokinin, on memory processes in the rat

1989 • 7 citations

Effects of antihypertensive drugs on cognitive function in adolescents.

1984 • 7 citations

Attenuation of benzodiazepine-induced passive avoidance deficit by post-training administration of muscimol: interaction with the cholinergic neuronal system

1990 • 6 citations

Treatment of alcohol organic mental disorder with piracetam

1987 • 5 citations

Effect of lysine-8-vasopressin on retention and retrieval of a discrimination reward task in the rat.

1988 • 4 citations

Enkephalins are Hormonal Modulator of Learning and Memory

1986 • 2 citations