Dimeric ligands define a role for transcriptional activation domains in reinitiation

A novel genetic system to detect protein–protein interactions

1989 • 6,022 citations

Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes

1991 • 4,043 citations

The retinoblastoma protein associates with the protein phosphatase type 1 catalytic subunit.

1993 • 1,459 citations

SRα Promoter: an Efficient and Versatile Mammalian cDNA Expression System Composed of the Simian Virus 40 Early Promoter and the R-U5 Segment of Human T-Cell Leukemia Virus Type 1 Long Terminal Repeat

1988 • 1,351 citations

Transcriptional activation: A complex puzzle with few easy pieces

1994 • 1,112 citations

X-ray structure of calcineurin inhibited by the immunophilin-immunosuppressant FKBP12-FK506 complex

1995 • 821 citations

Controlling Signal Transduction with Synthetic Ligands

1993 • 815 citations

Two distinct signal transmission pathways in T lymphocytes are inhibited by complexes formed between an immunophilin and either FK506 or rapamycin.

1990 • 699 citations

A eukaryotic transcriptional activator bearing the DNA specificity of a prokaryotic repressor

1985 • 686 citations

SR alpha promoter: an efficient and versatile mammalian cDNA expression system composed of the simian virus 40 early promoter and the R-U5 segment of human T-cell leukemia virus type 1 long terminal repeat.

1988 • 638 citations

Separation of DNA Binding from the Transcription-Activating Function of a Eukaryotic Regulatory Protein

1986 • 626 citations

Direct and selective binding of an acidic transcriptional activation domain to the TATA-box factor TFIID

1990 • 620 citations

Mechanism of action of an acidic transcriptional activator in vitro

1991 • 557 citations

Identification of an 11-kDa FKBP12-rapamycin-binding domain within the 289-kDa FKBP12-rapamycin-associated protein and characterization of a critical serine residue.

1995 • 547 citations

Transcription factor ATF interacts with the TATA factor to facilitate establishment of a preinitiation complex

1988 • 488 citations

COMMON THEMES IN ASSEMBLY AND FUNCTION OF EUKARYOTIC TRANSCRIPTION COMPLEXES

1995 • 434 citations

Binding of general transcription factor TFIIB to an acidic activating region

1991 • 377 citations

Characterization of the nuclear and cytoplasmic components of the lymphoid-specific nuclear factor of activated T cells (NF-AT) complex.

1993 • 344 citations

Recycling of the general transcription factors during RNA polymerase II transcription.

1995 • 309 citations

Dominant Missense Mutations in a Novel Yeast Protein related to Mammalian Phosphatidylinositol 3-Kinase and VPS34 Abrogate Rapamycin Cytotoxicity

1993 • 271 citations

Multiple mechanisms provide rapid and stringent glucose repression of GAL gene expression in Saccharomyces cerevisiae.

1994 • 247 citations

Functional steps in transcription initiation and reinitiation from the major late promoter in a HeLa nuclear extract.

1987 • 228 citations

Dominant missense mutations in a novel yeast protein related to mammalian phosphatidylinositol 3-kinase and VPS34 abrogate rapamycin cytotoxicity.

1993 • 202 citations

Connecting a promoter-bound protein to TBP bypasses the need for a transcriptional activation domain

1995 • 188 citations

Analysis of the role of the transcription factor ATF in the assembly of a functional preinitiation complex

1988 • 180 citations

Stimulation of RNA polymerase II transcription initiation by recruitment of TBP in vivo

1995 • 161 citations

The acidic transcriptional activator GAL-VP16 acts on preformed template-committed complexes.

1992 • 125 citations

Molecular analysis of the interaction of calcineurin with drug-immunophilin complexes

1994 • 116 citations

Increased Recruitment of TATA-Binding Protein to the Promoter by Transcriptional Activation Domains in Vivo

1994 • 114 citations

A role for activator-mediated TFIIB recruitment in diverse aspects of transcriptional regulation

1995 • 56 citations

Uncoupling of Initiation and Reinitiation Rates During HeLa RNA Polymerase II Transcription In Vitro

1993 • 45 citations

Uncoupling of initiation and reinitiation rates during HeLa RNA polymerase II transcription in vitro.

1993 • 23 citations

Synthesis of reinitiated transcripts by mammalian RNA polymerase II is controlled by elongation factor SII.

1993 • 15 citations