A role for activator-mediated TFIIB recruitment in diverse aspects of transcriptional regulation

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

1983 • 11,902 citations

Nuclear protein CBP is a coactivator for the transcription factor CREB

1994 • 1,447 citations

Analysis of Sp1 in vivo reveals mutiple transcriptional domains, including a novel glutamine-rich activation motif

1988 • 1,403 citations

Transcriptional activation: A complex puzzle with few easy pieces

1994 • 1,112 citations

An RNA polymerase II holoenzyme responsive to activators

1994 • 586 citations

Mechanism of action of an acidic transcriptional activator in vitro

1991 • 557 citations

A glutamine-rich hydrophobic patch in transcription factor Sp1 contacts the dTAFII110 component of the Drosophila TFIID complex and mediates transcriptional activation.

1994 • 531 citations

Factors involved in specific transcription by mammalian RNA polymerase II: purification, genetic specificity, and TATA box-promoter interactions of TFIID.

1988 • 477 citations

Critical Structural Elements of the VP16 Transcriptional Activation Domain

1991 • 461 citations

The basics of basal transcription by RNA polymerase II

1994 • 409 citations

Initiation of Transcription by RNA Polymerase II: A Multi-step Process

1993 • 390 citations

Cloning of an Intrinsic Human TFIID Subunit That Interacts with Multiple Transcriptional Activators

1995 • 385 citations

Binding of general transcription factor TFIIB to an acidic activating region

1991 • 377 citations

DNA topology and a minimal set of basal factors for transcription by RNA polymerase II

1993 • 374 citations

Different activation domains stimulate transcription from remote (‘enhancer’) and proximal (‘promoter’) positions.

1992 • 359 citations

Factors involved in specific transcription in mammalian RNA polymerase II. Functional analysis of initiation factors IIA and IID and identification of a new factor operating at sequences downstream of the initiation site.

1987 • 355 citations

Interaction of human thyroid hormone receptor beta with transcription factor TFIIB may mediate target gene derepression and activation by thyroid hormone.

1993 • 328 citations

Physical Analysis of Transcription Preinitiation Complex Assembly on a Class II Gene Promoter

1988 • 320 citations

Eukaryotic activators function during multiple steps of preinitiation complex assembly

1993 • 311 citations

TATA-binding protein-independent initiation: YY1, TFIIB, and RNA polymerase II direct basal transcription on supercoiled template DNA

1994 • 275 citations

Pattern of aromatic and hydrophobic amino acids critical for one of two subdomains of the VP16 transcriptional activator.

1993 • 261 citations

How different eukaryotic transcriptional activators can cooperate promiscuously

1990 • 261 citations

TBP-TAF complexes: selectivity factors for eukaryotic transcription

1994 • 250 citations

Multiple functional domains of human transcription factor IIB: distinct interactions with two general transcription factors and RNA polymerase II.

1993 • 229 citations

Interaction between an acidic activator and transcription factor TFIIB is required for transcriptional activation

1993 • 225 citations

Activator-induced conformational change in general transcription factor TFIIB

1994 • 177 citations

Identification of a minimal set of proteins that is sufficient for accurate initiation of transcription by RNA polymerase II.

1993 • 148 citations

転写因子TF II Bとヒト甲状腺ホルモン受容体βとの結合は標的遺伝子の発現と甲状腺ホルモンによる活性化を仲介する

1993 • 135 citations

Promoter specificity of basal transcription factors

1992 • 131 citations

Proline-rich activator CTF1 targets the TFIIB assembly step during transcriptional activation.

1994 • 114 citations

Effects of activation-defective TBP mutations on transcription initiation in yeast

1994 • 110 citations

The role of activators in assembly of RNA polymerase II transcription complexes

1994 • 86 citations

Transcriptional Activation by the Acidic Domain of Vmw65 Requires the Integrity of the Domain and Involves Additional Determinants Distinct from Those Necessary for TFIIB Binding

1993 • 65 citations

Overproduction and single-step purification of GAL4 fusion proteins from Escherichia coli

1993 • 49 citations

Modeling eukaryotic transcriptional activation

1994 • 47 citations

Activation of RNA polymerase II transcription by the specific DNA-binding protein LSF. Increased rate of binding of the basal promoter factor TFIIB.

1992 • 46 citations

Identification of functional targets of the Zta transcriptional activator by formation of stable preinitiation complex intermediates.

1994 • 34 citations

Defective transcriptional activation by diverse VP16 mutants associated with a common inability to form open promoter complexes.

1994 • 28 citations

Transcriptional activation by the acidic domain of Vmw65 requires the integrity of the domain and involves additional determinants distinct from those necessary for TFIIB binding.

1993 • 28 citations

Transcriptional Activation: Tuning-up transcription

1995 • 26 citations