Insulin Inhibits Angiotensinogen Gene Expression via the Mitogen-Activated Protein Kinase Pathway in Rat Kidney Proximal Tubular Cells1

The Effect of Intensive Treatment of Diabetes on the Development and Progression of Long-Term Complications in Insulin-Dependent Diabetes Mellitus

1993 • 23,535 citations

Protein kinase C isoenzymes: divergence in signal transduction?

1993 • 1,237 citations

The Effect of Long-Term Intensified Insulin Treatment on the Development of Microvascular Complications of Diabetes Mellitus

1993 • 1,215 citations

The nucleotide sequence of the rat cytoplasmic β–actin gene

1983 • 1,059 citations

Inhibition of MAP Kinase Kinase Blocks the Differentiation of PC-12 Cells Induced by Nerve Growth Factor

1995 • 906 citations

Angiotensinogen gene is expressed and differentially regulated in multiple tissues of the rat.

1986 • 484 citations

Efficacy of captopril in postponing nephropathy in normotensive insulin dependent diabetic patients with microalbuminuria.

1991 • 478 citations

Long-term renoprotective effect of angiotensin-converting enzyme inhibition in non-insulin-dependent diabetes mellitus. A 7-year follow-up study

1996 • 443 citations

Angiotensin II-induced hypertrophy of cultured murine proximal tubular cells is mediated by endogenous transforming growth factor-beta.

1993 • 381 citations

Identification of a Sequence in the PEPCK Gene That Mediates a Negative Effect of Insulin on Transcription

1990 • 369 citations

In situ hybridization evidence for angiotensinogen messenger RNA in the rat proximal tubule. An hypothesis for the intrarenal renin angiotensin system.

1990 • 325 citations

Renal renin-angiotensin system in diabetes: functional, immunohistochemical, and molecular biological correlations

1993 • 307 citations

Long-term Renoprotective Effect of Angiotensin-converting Enzyme Inhibition in Non—insulin-dependent Diabetes Mellitus

1996 • 297 citations

Elevated glucose stimulates TGF-β gene expression and bioactivity in proximal tubule

1992 • 264 citations

Cloning and sequence analysis of cDNA for rat angiotensinogen.

1983 • 237 citations

Angiotensin II induces cellular hypertrophy in cultured murine proximal tubular cells

1990 • 211 citations

High glucose induces cell hypertrophy and stimulates collagen gene transcription in proximal tubule

1990 • 196 citations

An insulin response element in the glyceraldehyde-3-phosphate dehydrogenase gene binds a nuclear protein induced by insulin in cultured cells and by nutritional manipulations in vivo.

1990 • 150 citations

Wortmannin, a specific inhibitor of phosphatidylinositol‐3 kinase, blocks osteoclastic bone resorption

1995 • 148 citations

Multiple protein kinase A-regulated events are required for transcriptional induction by cAMP.

1995 • 148 citations

Insulin regulation of the glucagon gene is mediated by an insulin-responsive DNA element.

1991 • 136 citations

ECM gene expression and its modulation by insulin in diabetic rats

1992 • 123 citations

Control of growth hormone synthesis in cultured GH1 cells by 3,5,3'-triiodo-L-thyronine and glucocorticoid agonists and antagonists: studies on the independent and synergistic regulation of the growth hormone response

1979 • 121 citations

Molecular mechanisms of glucose action on angiotensinogen gene expression in rat proximal tubular cells

1999 • 117 citations

Angiotensin converting enzyme gene polymorphism and ACE inhibition in diabetic nephropathy

1998 • 106 citations

Diabetes-induced glomerular dysfunction: Links to a more reduced cytosolic ratio of NADH/NAD+

1992 • 105 citations

Intracellular signaling of transcription and secretion of type IV collagen after angiotensin II-induced cellular hypertrophy in cultured proximal tubular cells.

1991 • 77 citations

The influence of glucose concentration on angiotensin II-induced hypertrophy of proximal tubular cells in culture

1991 • 72 citations

Angiotensin II as a hypertrophogenic cytokine for proximal tubular cells.

1993 • 72 citations

Reversal of Glomerular Hyperfiltration and Renal Hypertrophy by Blood Glucose Normalization in Diabetic Rats

1990 • 61 citations

Inhibition of MAP kinase blocks insulin‐mediated DNA synthesis and transcriptional activation of c‐fos by Elk‐1 in vascular smooth muscle cells

1997 • 58 citations

Renin and angiotensinogen gene expression in experimental diabetes mellitus

1992 • 56 citations

The renin-angiotensin system in streptozotocin-induced diabetes mellitus in the rat.

1993 • 56 citations

Insulin Down-Regulates Angiotensinogen Gene Expression and Angiotensinogen Secretion in Cultured Adipose Cells

1998 • 56 citations

A conditionally immortalized cell line from murine proximal tubule

1997 • 53 citations

Insulin-induced egr-1 and c-fos Expression in 32D Cells Requires Insulin Receptor, Shc, and Mitogen-activated Protein Kinase, but Not Insulin Receptor Substrate-1 and Phosphatidylinositol 3-Kinase Activation

1996 • 51 citations

Synergistic effect of dexamethasone and isoproterenol on the expression of angiotensinogen in immortalized rat proximal tubular cells

1998 • 42 citations

Phosphorylation of cAMP responsive element binding protein after treatment of mesangial cells with high glucose plus TGFβ or PMA

1996 • 42 citations

Effect of glucose on the expression of the angiotensinogen gene in opossum kidney cells

1998 • 34 citations

Molecular cloning and expression of the rat angiotensinogen gene

1990 • 28 citations

Angiotensinogen mRNA. Regulation by cell cycle and growth factors.

1988 • 25 citations

Angiotensinogen gene expression is stimulated by the cAMP-responsive element binding protein in opossum kidney cells.

1997 • 24 citations

Angiotensin converting enzyme inhibitors in diabetic patients with microalbuminuria or normoalbuminuria.

1997 • 23 citations

Immortalized rat proximal tubule cell lines expressing components of the renin-angiotensin system.

1994 • 19 citations

Benefits and cost of antihypertensive treatment in incipient and overt diabetic nephropathy.

1998 • 13 citations

Identification of a novel mouse hepatic 52 kDa protein that interacts with the cAMP reponse element of the rat angiotensinogen gene

1998 • 11 citations