The BRCA 2 gene product functionally interacts with p53 and RAD51

p53, the Cellular Gatekeeper for Growth and Division

1997 • 7,621 citations

A Strong Candidate for the Breast and Ovarian Cancer Susceptibility Gene BRCA1

1994 • 5,994 citations

Identification of the breast cancer susceptibility gene BRCA2

1995 • 3,581 citations

Genetic Heterogeneity and Penetrance Analysis of the BRCA1 and BRCA2 Genes in Breast Cancer Families

1998 • 2,920 citations

Localization of a Breast Cancer Susceptibility Gene, BRCA2 , to Chromosome 13q12-13

1994 • 1,884 citations

BRCA1 Mutations in Primary Breast and Ovarian Carcinomas

1994 • 1,205 citations

Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2

1997 • 1,055 citations

Genetic analysis of breast cancer in the cancer and steroid hormone study.

1991 • 915 citations

Dynamic Changes of BRCA1 Subnuclear Location and Phosphorylation State Are Initiated by DNA Damage

1997 • 910 citations

The complete BRCA2 gene and mutations in chromosome 13q-linked kindreds

1996 • 849 citations

Targeted disruption of the Rad51 gene leads to lethality in embryonic mice.

1996 • 789 citations

A Mutation in Mouse rad51 Results in an Early Embryonic Lethal That Is Suppressed by a Mutation in p53

1996 • 692 citations

The Tumor Suppressor Gene Brca1 Is Required for Embryonic Cellular Proliferation in the Mouse

1996 • 652 citations

Germline BRCA2 gene mutations in patients with apparently sporadic pancreatic carcinomas.

1996 • 637 citations

Confirmation of BRCA1 by analysis of germline mutations linked to breast and ovarian cancer in ten families

1994 • 626 citations

Involvement of Brca2 in DNA Repair

1998 • 624 citations

Targeted mutations of breast cancer susceptibility gene homologs in mice: lethal phenotypes of Brca1, Brca2, Brca1/Brca2, Brca1/p53, and Brca2/p53 nullizygous embryos.

1997 • 537 citations

RAD51 Interacts with the Evolutionarily Conserved BRC Motifs in the Human Breast Cancer Susceptibility Gene brca2

1997 • 531 citations

Brca1 deficiency results in early embryonic lethality characterized by neuroepithelial abnormalities

1996 • 468 citations

Evidence for a transcriptional activation function of BRCA1 C-terminal region

1996 • 443 citations

Tumorigenesis and a DNA repair defect in mice with a truncating Brca2 mutation

1997 • 426 citations

The BRC repeats in BRCA2 are critical for RAD51 binding and resistance to methyl methanesulfonate treatment

1998 • 389 citations

Mutations in the BRCA1 gene in families with early-onset breast and ovarian cancer

1994 • 389 citations

BRCA2 mutations in primary breast and ovarian cancers

1996 • 365 citations

p53 is linked directly to homologous recombination processes via RAD51/RecA protein interaction.

1996 • 346 citations

The developmental pattern of Brca1 expression implies a role in differentiation of the breast and other tissues

1995 • 345 citations

A human RNA polymerase II complex associated with SRB and DNA-repair proteins

1996 • 341 citations

Common origins of BRCA1 mutations in Canadian breast and ovarian cancer families

1994 • 334 citations

Brca2 is required for embryonic cellular proliferation in the mouse.

1997 • 285 citations

Mutation analysis in the BRCA2 gene in primary breast cancers

1996 • 283 citations

Mutation analysis of the BRCA2 gene in 49 site–specific breast cancer families

1996 • 261 citations

Partial rescue of Brca15–6 early embryonic lethality by p53 or p21 null mutation

1997 • 253 citations

RAB22 and RAB163/mouse BRCA2: Proteins that specifically interact with the RAD51 protein

1997 • 236 citations

Brca2 is coordinately regulated with Brca1 during proliferation and differentiation in mammary epithelial cells

1996 • 224 citations

Interaction of p53 with the Human Rad51 Protein

1997 • 212 citations

Expression of Brca1 is associated with terminal differentiation of ectodermally and mesodermally derived tissues in mice.

1995 • 200 citations

Low incidence of BRCA2 mutations in breast carcinoma and other cancers

1996 • 176 citations

The BRC repeats are conserved in mammalian BRCA2 proteins

1997 • 173 citations

Developmental Expression ofBrca2Colocalizes withBrca1and Is Associated with Proliferation and Differentiation in Multiple Tissues

1997 • 160 citations

Cell cycle regulation of BRCA1 messenger RNA in human breast epithelial cells.

1996 • 146 citations

BRCA1, BRCA2, and DNA Damage Response: Collision or Collusion?

1998 • 137 citations

The ins and outs of RB: coupling gene expression to the cell cycle clock

1994 • 137 citations

Cell cycle control of BRCA2.

1996 • 133 citations

Mutations of the BRCA2 gene in ovarian carcinomas.

1996 • 119 citations

Nuclear location and cell cycle regulation of the BRCA2 protein.

1997 • 106 citations

Facts and Artifacts of Ancient DNA

1997 • 102 citations

Characterization of the rat and mouse homologues of the BRCA2 breast cancer susceptibility gene.

1997 • 41 citations