Familial Breast Cancer

Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

2005 • 6,083 citations

A Strong Candidate for the Breast and Ovarian Cancer Susceptibility Gene BRCA1

1994 • 5,994 citations

Tamoxifen for Prevention of Breast Cancer: Report of the National Surgical Adjuvant Breast and Bowel Project P-1 Study

1998 • 5,487 citations

Average Risks of Breast and Ovarian Cancer Associated with BRCA1 or BRCA2 Mutations Detected in Case Series Unselected for Family History: A Combined Analysis of 22 Studies

2003 • 3,497 citations

Projecting Individualized Probabilities of Developing Breast Cancer for White Females Who Are Being Examined Annually

1989 • 3,239 citations

Genetic Heterogeneity and Penetrance Analysis of the BRCA1 and BRCA2 Genes in Breast Cancer Families

1998 • 2,920 citations

Linkage of Early-Onset Familial Breast Cancer to Chromosome 17q21

1990 • 2,505 citations

Genome-wide association study identifies novel breast cancer susceptibility loci

2007 • 2,342 citations

Efficacy of MRI and Mammography for Breast-Cancer Screening in Women with a Familial or Genetic Predisposition

2004 • 1,687 citations

Effects of Tamoxifen vs Raloxifene on the Risk of Developing Invasive Breast Cancer and Other Disease Outcomes<SUBTITLE>The NSABP Study of Tamoxifen and Raloxifene (STAR) P-2 Trial</SUBTITLE>

2006 • 1,621 citations

Prophylactic Oophorectomy in Carriers ofBRCA1orBRCA2Mutations

2002 • 1,448 citations

Efficacy of Bilateral Prophylactic Mastectomy in Women with a Family History of Breast Cancer

1999 • 1,404 citations

Association of Risk-Reducing Surgery in <emph type="ital">BRCA1</emph> or <emph type="ital">BRCA2</emph> Mutation Carriers With Cancer Risk and Mortality

2010 • 1,361 citations

BRCA1 and BRCA2: different roles in a common pathway of genome protection

2011 • 1,280 citations

A breast cancer prediction model incorporating familial and personal risk factors

2004 • 1,203 citations

Surveillance of <EMPH TYPE="ITAL">BRCA1</EMPH> and <EMPH TYPE="ITAL">BRCA2</EMPH> Mutation Carriers With Magnetic Resonance Imaging, Ultrasound, Mammography, and Clinical Breast Examination

2004 • 1,170 citations

Low-penetrance susceptibility to breast cancer due to CHEK2*1100delC in noncarriers of BRCA1 or BRCA2 mutations

2002 • 1,081 citations

Olaparib in patients with recurrent high-grade serous or poorly differentiated ovarian carcinoma or triple-negative breast cancer: a phase 2, multicentre, open-label, non-randomised study

2011 • 1,080 citations

Cancer Incidence in BRCA1 Mutation Carriers

2002 • 1,064 citations

Screening with magnetic resonance imaging and mammography of a UK population at high familial risk of breast cancer: a prospective multicentre cohort study (MARIBS)

2005 • 1,020 citations

PALB2, which encodes a BRCA2-interacting protein, is a breast cancer susceptibility gene

2006 • 965 citations

Genetic analysis of breast cancer in the cancer and steroid hormone study.

1991 • 915 citations

Exemestane for Breast-Cancer Prevention in Postmenopausal Women

2011 • 893 citations

Meta-analysis of Risk Reduction Estimates Associated With Risk-Reducing Salpingo-oophorectomy in BRCA1 or BRCA2 Mutation Carriers

2009 • 868 citations

Prevalence of BRCA1 and BRCA2 Gene Mutations in Patients With Early-Onset Breast Cancer

1999 • 866 citations

Dual Effects of Weight and Weight Gain on Breast Cancer Risk

1997 • 813 citations

Exomic Sequencing Identifies PALB2 as a Pancreatic Cancer Susceptibility Gene

2009 • 798 citations

Common variants on chromosomes 2q35 and 16q12 confer susceptibility to estrogen receptor–positive breast cancer

2007 • 793 citations

Iniparib plus Chemotherapy in Metastatic Triple-Negative Breast Cancer

2011 • 785 citations

Determining Carrier Probabilities for Breast Cancer–Susceptibility Genes BRCA1 and BRCA2

1998 • 743 citations

First results from the International Breast Cancer Intervention Study (IBIS-I): a randomised prevention trial

2002 • 731 citations

Breast and Other Cancers in Families with Ataxia-Telangiectasia

1987 • 730 citations

ATM mutations that cause ataxia-telangiectasia are breast cancer susceptibility alleles

2006 • 721 citations

Germline mutations in breast and ovarian cancer pedigrees establish RAD51C as a human cancer susceptibility gene

2010 • 707 citations

Truncating mutations in the Fanconi anemia J gene BRIP1 are low-penetrance breast cancer susceptibility alleles

2006 • 699 citations

Multifactorial Analysis of Differences Between Sporadic Breast Cancers and Cancers Involving BRCA1 and BRCA2 Mutations

1998 • 695 citations

Genome-wide association study identifies five new breast cancer susceptibility loci

2010 • 694 citations

Update of the National Surgical Adjuvant Breast and Bowel Project Study of Tamoxifen and Raloxifene (STAR) P-2 Trial: Preventing Breast Cancer

2010 • 614 citations

Prediction of BRCA1 Status in Patients with Breast Cancer Using Estrogen Receptor and Basal Phenotype

2005 • 610 citations

A common coding variant in CASP8 is associated with breast cancer risk

2007 • 608 citations

Prevalence and penetrance of BRCA1 and BRCA2 mutations in a population-based series of breast cancer cases

2000 • 559 citations

Genome-wide association study identifies a new breast cancer susceptibility locus at 6q25.1

2009 • 540 citations

A multistage genome-wide association study in breast cancer identifies two new risk alleles at 1p11.2 and 14q24.1 (RAD51L1)

2009 • 540 citations

Association of BRCA1 and BRCA2 Mutations With Survival, Chemotherapy Sensitivity, and Gene Mutator Phenotype in Patients With Ovarian Cancer

2011 • 527 citations

Long-Term Results of Tamoxifen Prophylaxis for Breast Cancer--96-Month Follow-up of the Randomized IBIS-I Trial

2007 • 524 citations

Cancer Risks and Mortality in Heterozygous ATM Mutation Carriers

2005 • 518 citations

Inheritance of human breast cancer: evidence for autosomal dominant transmission in high-risk families.

1988 • 510 citations

The BOADICEA model of genetic susceptibility to breast and ovarian cancers: updates and extensions

2008 • 501 citations

Germline mutations in RAD51D confer susceptibility to ovarian cancer

2011 • 498 citations

Newly discovered breast cancer susceptibility loci on 3p24 and 17q23.2

2009 • 483 citations

The emerging landscape of breast cancer susceptibility

2007 • 481 citations

Assessing Women at High Risk of Breast Cancer: A Review of Risk Assessment Models

2010 • 459 citations

Common variants on chromosome 5p12 confer susceptibility to estrogen receptor–positive breast cancer

2008 • 458 citations

Variation of risks of breast and ovarian cancer associated with different germline mutations of the BRCA2 gene

1997 • 437 citations

Central obesity and breast cancer risk: a systematic review

2003 • 382 citations

Mutations in BRIP1 confer high risk of ovarian cancer

2011 • 366 citations

International variation in rates of uptake of preventive options in BRCA1 and BRCA2 mutation carriers

2008 • 332 citations

Large genomic deletions and duplications in the BRCA1 gene identified by a novel quantitative method.

2003 • 320 citations

Characterization ofBRCA1andBRCA2Mutations in a Large United States Sample

2006 • 319 citations

Evaluation of breast cancer risk assessment packages in the family history evaluation and screening programme

2003 • 304 citations

High constant incidence in twins and other relatives of women with breast cancer

2000 • 294 citations

Common Breast Cancer-Predisposition Alleles Are Associated with Breast Cancer Risk in BRCA1 and BRCA2 Mutation Carriers

2008 • 281 citations

Genome-wide association analysis identifies three new breast cancer susceptibility loci

2012 • 277 citations

Risk of cancer other than breast or ovarian in individuals with BRCA1 and BRCA2 mutations

2011 • 275 citations

A new scoring system for the chances of identifying a BRCA1/2 mutation outperforms existing models including BRCAPRO

2004 • 254 citations

Pathology of Ovarian Cancers in BRCA1 and BRCA2 Carriers

2004 • 247 citations

Penetrance estimates for BRCA1 and BRCA2based on genetic testing in a Clinical Cancer Genetics service setting: Risks of breast/ovarian cancer quoted should reflect the cancer burden in the family

2008 • 221 citations

Women with neurofibromatosis 1 are at a moderately increased risk of developing breast cancer and should be considered for early screening

2007 • 220 citations

BRCA1 and BRCA2 mutations across race and ethnicity: distribution and clinical implications

2009 • 202 citations

Prediction of pathogenic mutations in patients with early-onset breast cancer by family history

2003 • 201 citations

BRCA1 and BRCA2 mutations in a population-based study of male breast cancer

2001 • 187 citations

Common Breast Cancer Susceptibility Alleles and the Risk of Breast Cancer for BRCA1 and BRCA2 Mutation Carriers: Implications for Risk Prediction

2010 • 179 citations

Assessment of Clinical Validity of a Breast Cancer Risk Model Combining Genetic and Clinical Information

2010 • 167 citations

The psychosocial impact of bilateral prophylactic mastectomy: prospective study using questionnaires and semistructured

2001 • 159 citations

An international initiative to identify genetic modifiers of cancer risk in BRCA1 and BRCA2 mutation carriers: the Consortium of Investigators of Modifiers of BRCA1 and BRCA2 (CIMBA)

2007 • 155 citations

Uptake of Risk-Reducing Surgery in Unaffected Women at High Risk of Breast and Ovarian Cancer Is Risk, Age, and Time Dependent

2009 • 143 citations

Screening for familial ovarian cancer: poor survival of BRCA1/2 related cancers

2008 • 133 citations

RAD51C is a susceptibility gene for ovarian cancer

2011 • 132 citations

Risk of breast cancer in male BRCA2 carriers

2010 • 121 citations

On the origin and diffusion of BRCA1 c.5266dupC (5382insC) in European populations

2010 • 120 citations

Risk of Estrogen Receptor–Positive and –Negative Breast Cancer and Single–Nucleotide Polymorphism 2q35-rs13387042

2009 • 107 citations

Addition of pathology and biomarker information significantly improves the performance of the Manchester scoring system for BRCA1 and BRCA2 testing

2009 • 93 citations

Risk reducing mastectomy: outcomes in 10 European centres

2008 • 86 citations

Common alleles at 6q25.1 and 1p11.2 are associated with breast cancer risk for BRCA1 and BRCA2 mutation carriers

2011 • 76 citations

CHEK2*1100delC homozygosity is associated with a high breast cancer risk in women

2011 • 71 citations

Menopausal symptoms and bone health in women undertaking risk reducing bilateral salpingo-oophorectomy: significant bone health issues in those not taking HRT

2011 • 69 citations

Mammographic surveillance in women younger than 50 years who have a family history of breast cancer: tumour characteristics and projected effect on mortality in the prospective, single-arm, FH01 study

2010 • 63 citations

Probability of BRCA1/2 mutation varies with ovarian histology: results from screening 442 ovarian cancer families

2008 • 37 citations

A protocol for preventative mastectomy in women with an increased lifetime risk of breast cancer

2000 • 35 citations

Surveillance of women at increased risk of breast cancer using mammography and clinical breast examination: Further evidence of benefit

2011 • 30 citations

Deleted Work

1955 • 0 citations