Protein-tyrosine phosphatase-1B acts as a negative regulator of insulin signal transduction.

SH2 and SH3 Domains: Elements that Control Interactions of Cytoplasmic Signaling Proteins

1991 • 1,931 citations

Insulin Stimulates the Phosphorylation of the 95,000-Dalton Subunit of Its Own Receptor

1982 • 1,138 citations

Structural basis for the binding of proline-rich peptides to SH3 domains

1994 • 1,016 citations

Insulin Action and the Insulin Signaling Network*

1995 • 823 citations

Two Binding Orientations for Peptides to the Src SH3 Domain: Development of a General Model for SH3-Ligand Interactions

1994 • 800 citations

Development of “substrate-trapping” mutants to identify physiological substrates of protein tyrosine phosphatases

1997 • 774 citations

Crystal Structure of Human Protein Tyrosine Phosphatase 1B

1994 • 747 citations

After Insulin Binds

1987 • 687 citations

Receptor and postreceptor defects contribute to the insulin resistance in noninsulin-dependent diabetes mellitus.

1981 • 628 citations

The nontransmembrane tyrosine phosphatase PTP-1B localizes to the endoplasmic reticulum via its 35 amino acid C-terminal sequence

1992 • 593 citations

Structural Basis for Phosphotyrosine Peptide Recognition by Protein Tyrosine Phosphatase 1B

1995 • 575 citations

Purification of the major protein-tyrosine-phosphatases of human placenta.

1988 • 564 citations

Characterization of the major protein-tyrosine-phosphatases of human placenta.

1988 • 554 citations

Evidence for protein-tyrosine-phosphatase catalysis proceeding via a cysteine-phosphate intermediate.

1991 • 468 citations

The insulin receptor and the molecular mechanism of insulin action.

1988 • 426 citations

Protein-tyrosine Phosphatase 1B Is a Negative Regulator of Insulin- and Insulin-like Growth Factor-I-stimulated Signaling

1996 • 424 citations

Distinct functional roles of the two intracellular phosphatase like domains of the receptor-linked protein tyrosine phosphatases LCA and LAR.

1990 • 365 citations

Insulin receptor kinase in human skeletal muscle from obese subjects with and without noninsulin dependent diabetes.

1987 • 344 citations

Point mutations in the abl SH2 domain coordinately impair phosphotyrosine binding in vitro and transforming activity in vivo.

1992 • 295 citations

Protein Tyrosine Phosphatase 1B Interacts With the Activated Insulin Receptor

1996 • 293 citations

The Insulin Receptor: Molecular Biology and Transmembrane Signaling*

1987 • 285 citations

Human placenta protein-tyrosine-phosphatase: amino acid sequence and relationship to a family of receptor-like proteins.

1989 • 276 citations

Direct Binding of the Proline-rich Region of Protein Tyrosine Phosphatase 1B to the Src Homology 3 Domain of p130Cas

1996 • 272 citations

Protein-Tyrosine Phosphatase 1B Complexes with the Insulin Receptor in Vivo and Is Tyrosine-phosphorylated in the Presence of Insulin

1997 • 252 citations

Decreased kinase activity of insulin receptors from adipocytes of non-insulin-dependent diabetic subjects.

1987 • 228 citations

Osmotic Loading of Neutralizing Antibodies Demonstrates a Role for Protein-tyrosine Phosphatase 1B in Negative Regulation of the Insulin Action Pathway

1995 • 224 citations

Cloning and expression of a protein-tyrosine-phosphatase.

1990 • 215 citations

Studies on the mechanism of insulin resistance in the liver from humans with noninsulin-dependent diabetes. Insulin action and binding in isolated hepatocytes, insulin receptor structure, and kinase activity.

1986 • 214 citations

Microinjection of a protein-tyrosine-phosphatase inhibits insulin action in Xenopus oocytes.

1990 • 151 citations

The Insulin Receptor: A Multifunctional Protein

1990 • 149 citations

The dephosphorylation of insulin and epidermal growth factor receptors. Role of endosome-associated phosphotyrosine phosphatase(s).

1992 • 134 citations

Protein-tyrosine Phosphatases PTP1B and Syp Are Modulators of Insulin-stimulated Translocation of GLUT4 in Transfected Rat Adipose Cells

1997 • 127 citations

[10] Design and use of peptide substrates for protein kinases

1991 • 125 citations

Increased abundance of specific skeletal muscle protein-tyrosine phosphatases in a genetic model of insulin-resistant obesity and diabetes mellitus

1995 • 125 citations

Skeletal muscle protein tyrosine phosphatase activity and tyrosine phosphatase 1B protein content are associated with insulin action and resistance.

1994 • 122 citations

Abnormal Regulation of Protein Tyrosine Phosphatase Activities in Skeletal Muscle of Insulin-Resistant Humans

1991 • 108 citations

Effect of Microinjection of a Low-M_r Human Placenta Protein Tyrosine Phosphatase on Induction of Meiotic Cell Division in Xenopus Oocytes

1990 • 99 citations

The Insulin Receptor and Its Substrate: Molecular Determinants of Early Events in Insulin Action

1993 • 92 citations

The insulin receptor

1984 • 91 citations

Insulin-Receptor Kinase Activity of Adipose Tissue From Morbidly Obese Humans With and Without NIDDM

1987 • 86 citations

Cellular mechanisms of insulin resistance in non-insulin-dependent (type II) diabetes

1988 • 86 citations

Thiazolidine Derivatives Ameliorate High Glucose-induced Insulin Resistance via the Normalization of Protein-tyrosine Phosphatase Activities

1995 • 85 citations

Regulation of protein tyrosine phosphatases by insulin and insulin-like growth factor I.

1993 • 78 citations

Decrease in beta-subunit phosphotyrosine correlates with internalization and activation of the endosomal insulin receptor kinase.

1992 • 76 citations

Point Mutations in theablSH2 Domain Coordinately Impair Phosphotyrosine Binding In Vitro and Transforming Activity In Vivo

1992 • 70 citations

Alterations in specific protein-tyrosine phosphatases accompany insulin resistance of streptozotocin diabetes

1995 • 62 citations

A synthetic tris-sulfotyrosyl dodecapeptide analogue of the insulin receptor 1146-kinase domain inhibits tyrosine dephosphorylation of the insulin receptor in situ.

1994 • 55 citations

Insulin resistance: Receptor and post-binding defects in human obesity and non-insulin-dependent diabetes mellitus

1985 • 51 citations

Protein-tyrosine Phosphatase 1D Modulates Its Own State of Tyrosine Phosphorylation

1995 • 47 citations

Altered basal and insulin-stimulated phosphotyrosine phosphatase (PTPase) activity in skeletal muscle from NIDDM patients compared with control subjects

1996 • 41 citations

Insulin receptor dephosphorylation by phosphotyrosine phosphatases obtained from insulin-resistant obese mice

1994 • 15 citations