Zinc, Insulin and Diabetes

The structure of 2Zn pig insulin crystals at 1.5 Å resolution

1988 • 662 citations

Abnormal zinc metabolism in type II diabetes mellitus

1984 • 279 citations

Video image analysis of labile zinc in viable pancreatic islet cells using a specific fluorescent probe for zinc.

1994 • 273 citations

Insulin Structure and Stability

1993 • 266 citations

Human pancreatic islet beta-cell destruction by cytokines involves oxygen free radicals and aldehyde production.

1996 • 160 citations

Prevention of diabetes-associated embryopathy by overexpression of the free radical scavenger copper zinc superoxide dismutase in transgenic mouse embryos

1995 • 152 citations

Oxygen free radical scavengers protect rat islet cells from damage by cytokines

1989 • 146 citations

Hyperzincuria in individuals with insulin-dependent diabetes mellitus: Concurrent zinc status and the effect of high-dose zinc supplementation

1994 • 138 citations

The reduced secretion of, and sensitivity to insulin in zinc-deficient rats

1966 • 126 citations

Lipid peroxidation in insulin-dependent diabetic patients with early retina degenerative lesions: effects of an oral zinc supplementation.

1995 • 124 citations

The Effect of Zinc on Insulin Metabolism*

1978 • 102 citations

Tissue zinc status of genetically diabetic and streptozotocin-induced diabetic mice

1983 • 101 citations

Molecular Structure of insulin: The insulin monomer and its assembly

1989 • 98 citations

Urinary Excretion of Zinc, Copper and Iron in the Streptozotocin-Diabetic Rat

1984 • 83 citations

Hyperzincuria in insulin treated diabetes mellitus—its relation to glucose homeostasis and insulin administration

1981 • 80 citations

Zinc, copper and magnesium status in insulin-dependent diabetes.

1994 • 71 citations

Protective effects of metallothionein on streptozotocin-induced diabetes in rats

1994 • 71 citations

Insulin hexamers: new conformations and applications

1991 • 69 citations

Hypozincemia in diabetes mellitus.

1994 • 66 citations

Human pancreatic islet beta-cell destruction by cytokines involves oxygen free radicals and aldehyde production

1996 • 65 citations

Plasma, granulocyte and mononuclear cell copper and zinc in patients with diabetes mellitus

1995 • 55 citations

Type II diabetes mellitus, congestive heart failure, and zinc metabolism

1993 • 55 citations

Effect of diabetic state and related disorders on the urinary excretion of magnesium and zinc in patients.

1993 • 51 citations

Diabetes can be prevented by reducing insulin production

1994 • 44 citations

Influence of Spontaneous Diabetes on Tissue Status of Zinc, Copper, and Manganese in the BB Wistar Rat

1985 • 37 citations

Metallothionein in isolated pancreatic islets of mice: Induction by zinc and streptozotocin, a naturally occurring diabetogen

1993 • 34 citations

Effects of diabetes type and treatment on zinc status in diabetes mellitus

1992 • 33 citations

Effects of zinc ion on the conformation of antigenic determinants on insulin

1978 • 32 citations

Role of Metallothionein and Cysteine-Rich Intestinal Protein in the Regulation of Zinc Absorption by Diabetic Rats

1995 • 28 citations

Recombinant-DNA-derived insulin analogues as potentially useful therapeutic agents

1993 • 27 citations

Zinc content in selected tissues in streptozotocin-diabetic rats after maximal exercise

1994 • 23 citations

Pancreatic Antioxidant Enzyme Activity in Normoglycemic Diabetic Prone BB Rats

1995 • 22 citations

Altered tissue content of trace metals in diabetic hyperinsulinaemic sand rats (psammomys obesus)

1988 • 20 citations

[The functional behaviour of zinc and insulin contained in the pancreatic beta-cells of rats].

1970 • 9 citations

Renal Changes of Streptozotocin-Induced Diabetic Rats Fed a Low-Zinc Diet

1995 • 8 citations

[Insulin biosynthesis, storage and secretion. 8. Pancreatic-islet tissue and heavy metals--some ultrastructural and experimental observations].

1968 • 7 citations