Molecular Cloning of Gene Sequences Regulated by Tumor Promoters and Mitogens through Protein Kinase C

Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease

1979 • 22,482 citations

Labeling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase I

1977 • 12,015 citations

The role of protein kinase C in cell surface signal transduction and tumour promotion

1984 • 7,521 citations

Purification of Biologically Active Globin Messenger RNA by Chromatography on Oligothymidylic acid-Cellulose

1972 • 6,922 citations

Inositol trisphosphate, a novel second messenger in cellular signal transduction

1984 • 6,088 citations

Studies and Perspectives of Protein Kinase C

1986 • 5,148 citations

Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters.

1982 • 4,786 citations

Screening λgt Recombinant Clones by Hybridization to Single Plaques in Situ

1977 • 4,696 citations

A simple and very efficient method for generating cDNA libraries

1983 • 4,606 citations

Stimulation of 3T3 cells induces transcription of the c-fos proto-oncogene

1984 • 3,150 citations

Isoquinolinesulfonamides, novel and potent inhibitors of cyclic nucleotide-dependent protein kinase and protein kinase C

1984 • 2,728 citations

Release of Ca2+ from a nonmitochondrial intracellular store in pancreatic acinar cells by inositol-1,4,5-trisphosphate

1983 • 2,596 citations

Cell-specific regulation of the c-myc gene by lymphocyte mitogens and platelet-derived growth factor

1983 • 2,350 citations

Early Signals in the Mitogenic Response

1986 • 1,498 citations

Induction of c-fos gene and protein by growth factors precedes activation of c-myc

1984 • 1,463 citations

Synthesis and Processing of Asparagine-Linked Oligosaccharides

1981 • 1,403 citations

Molecular cloning of gene sequences regulated by platelet-derived growth factor

1983 • 989 citations

The Complete Primary Structure of Protein Kinase C—the Major Phorbol Ester Receptor

1986 • 878 citations

Compilation of published signal sequences

1984 • 784 citations

High-efficiency cloning of full-length cDNA.

1982 • 763 citations

The Function and Mechanism of Promoters of Carcinogenesis

1973 • 759 citations

A lymphoid-specific protein binding to the octamer motif of immunoglobulin genes

1986 • 740 citations

Transcriptional and posttranscriptional regulation of interferon-induced gene expression in human cells

1984 • 729 citations

Sequence of human tissue inhibitor of metalloproteinases and its identity to erythroid-potentiating activity

1985 • 702 citations

Identification of a set of genes expressed during the G0/G1 transition of cultured mouse cells.

1985 • 589 citations

Induction of β2-interferon by tumor necrosis factor: A homeostatic mechanism in the control of cell proliferation

1986 • 577 citations

In vitro studies on the mode of action of the phorbol esters, potent tumor promoters: Part 1

1980 • 477 citations

Phorbol esters, phospholipase C, and growth factors rapidly stimulate the phosphorylation of a Mr 80,000 protein in intact quiescent 3T3 cells.

1983 • 377 citations

Human platelet-derived growth factor. Purification and resolution into two active protein fractions.

1981 • 353 citations

Molecular characterization and expression of the gene encoding human erythroid-potentiating activity

1985 • 279 citations

Platelet-derived growth factor and double-stranded ribonucleic acids stimulate expression of the same genes in 3T3 cells

1985 • 263 citations

Bryostatin, an activator of the calcium phospholipid-dependent protein kinase, blocks phorbol ester-induced differentiation of human promyelocytic leukemia cells HL-60.

1986 • 255 citations

Diacylglycerols mimic phorbol diester induction of leukemic cell differentiation.

1985 • 234 citations

Biosynthesis of tissue inhibitor of metalloproteinases by human fibroblasts in culture. Stimulation by 12-O-tetradecanoylphorbol 13-acetate and interleukin 1 in parallel with collagenase.

1985 • 220 citations

Specific stimulation of actin gene transcription by epidermal growth factor and cycloheximide.

1984 • 215 citations

Epidermal growth factor rapidly stimulates prolactin gene transcription

1982 • 208 citations

Phosphatidylinositol turnover in platelet activation; Calcium mobilization and protein phosphorylation

1982 • 193 citations

Nucleotide sequence of a growth-related mRNA encoding a member of the prolactin-growth hormone family.

1984 • 179 citations

Structure and expression of a cloned cDNA for mouse interferon-beta.

1983 • 157 citations

T-Cell Growth Factor Gene: Lack of Expression in Human T-Cell Leukemia-Lymphoma Virus-Infected Cells

1984 • 145 citations

Tumor promoters and kirsten sarcoma virus increase synthesis of a secreted glycoprotein by regulating levels of translatable mRNA

1980 • 130 citations

Growth factors, oncogenes, and multistage carcinogenesis

1987 • 121 citations

Phorbol ester tumor promoters induce epidermal transglutaminase activity

1980 • 117 citations

Human T-cell growth factor: partial amino acid sequence, cDNA cloning, and organization and expression in normal and leukemic cells.

1984 • 101 citations

Polypeptide hormone regulation of gene transcription: specific 5' genomic sequences are required for epidermal growth factor and phorbol ester regulation of prolactin gene expression.

1984 • 73 citations

Induction of cytoskeletal vimentin and actin gene expression by a tumor-promoting phorbol ester in the human leukemic cell line K562.

1985 • 66 citations

Tumor promoters and cell transformation

1984 • 63 citations

Molecular cloning of partial cDNA copies of two distinct mouse IFN-β mRNAs

1982 • 47 citations

Regulation of glycophorin gene expression by a tumor-promoting phorbol ester in human leukemic K562 cells.

1985 • 42 citations

Cellular uptake and localization of fluorescent derivatives of phorbol ester tumor promoters

1985 • 34 citations

Inhibitors of 12‐O‐tetradecanoylphorbol‐13‐acetate (TPA)‐induced multinucleated cell formation and HTLV‐I p19 antigen expression in HTLV‐I‐infected T‐cell line KH‐2Lo

1986 • 19 citations