Regulation of the gastrin promoter by epidermal growth factor and neuropeptides.

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells.

1982 • 8,069 citations

Physiology of the Gastrointestinal Tract

2006 • 4,704 citations

The molecular heterogeneity of protein kinase C and its implications for cellular regulation

1988 • 4,243 citations

Recombinant Genomes Which Express Chloramphenicol Acetyltransferase in Mammalian Cells

1982 • 3,106 citations

Transcription factor AP-2 mediates induction by two different signal-transduction pathways: Protein kinase C and cAMP

1987 • 1,391 citations

Cyclic AMP and the induction of eukaryotic gene transcription.

1988 • 1,041 citations

High level transient expression of a chloramphenicol acetyl transferase gene by DEAE-dextran mediated DNA transfection coupled with a dimethyl sulfoxide or glycerol shock treatment

1984 • 898 citations

Requirement for intrinsic protein tyrosine kinase in the immediate and late actions of the EGF receptor

1987 • 609 citations

Physiology of the Gastrointestinal Tract

1988 • 438 citations

Efficient infection of monkey cells with DNA of simian virus 40.

1981 • 419 citations

The neuronal origin of bombesin-like immunoreactivity in the rat gastrointestinal tract

1979 • 325 citations

Sp1 transcription factor binds DNA and activates transcription even when the binding site is CpG methylated.

1988 • 308 citations

Gastrin

1975 • 301 citations

Characterization of functional receptors for somatostatin in rat pituitary cells in culture.

1978 • 290 citations

Independent effects of growth hormone releasing factor on growth hormone release and gene transcription

1985 • 286 citations

New Aspects of the Trophic Action Of Gastrointestinal Hormones

1977 • 227 citations

Epidermal growth factor and thyrotropin-releasing hormone act similarly on a clonal pituitary cell strain. Modulation of hormone production and inhibition of cell proliferation

1980 • 226 citations

Receptors for Thyrotropin-releasing Hormone in Prolactin-producing Rat Pituitary Cells in Culture

1973 • 206 citations

Epidermal growth factor stimulates the rapid accumulation of inositol (1,4,5)-trisphosphate and a rise in cytosolic calcium mobilized from intracellular stores in A431 cells.

1987 • 202 citations

Thyrotropin-releasing hormone activates a Ca2+-dependent polyphosphoinositide phosphodiesterase in permeable GH3 cells. GTP gamma S potentiation by a cholera and pertussis toxin-insensitive mechanism.

1986 • 197 citations

Pertussis toxin blocks both cyclic AMP-mediated and cyclic AMP-independent actions of somatostatin. Evidence for coupling of Ni to decreases in intracellular free calcium.

1985 • 190 citations

CAT vectors for analysis of eukaryotic promoters and enhancers

1986 • 184 citations

The effects of bombesin on polyphosphoinositide and calcium metabolism in Swiss 3T3 cells.

1987 • 175 citations

Reciprocal regulation of antral gastrin and somatostatin gene expression by omeprazole-induced achlorhydria.

1988 • 167 citations

Two Different cis -Active Elements Transfer the Transcriptional Effects of Both EGF and Phorbol Esters

1986 • 161 citations

A Possible Role of Cyclic AMP in Mediating the Effects of Thyrotropin-Releasing Hormone on Prolactin Release and on Prolactin and Growth Hormone Synthesis in Pituitary Cells in Culture

1976 • 157 citations

Effects of Intraluminal Epidermal Growth Factor on Mucosal Proliferation in the Small Intestine of Adult Rats

1986 • 145 citations

Phorbol Esters Stimulate Growth and Inhibit Differentiation in Cultured Thyroid Cells*

1985 • 142 citations

Thyrotropin-releasing hormone induces redistribution of protein kinase C in GH4C1 rat pituitary cells.

1985 • 140 citations

Differential gastrin gene expression in rat gastrointestinal tract and pancreas during neonatal development.

1988 • 137 citations

Cell-specific expression of the human complement protein Factor B gene: Evidence for the role of two distinct 5′-flanking elements

1987 • 128 citations

Antagonistic effects of thyrotropin and epidermal growth factor on thyroglobulin mRNA level in cultured thyroid cells

1985 • 118 citations

Specific receptors for epidermal growth factor in rat intestinal microvillus membranes

1988 • 107 citations

Epidermal growth factor and thyrotropin-releasing hormone interact synergistically with calcium to regulate prolactin mRNA levels.

1983 • 106 citations

Bombesin Stimulates Prolactin and Growth Hormone Release by Pituitary Cells in Culture*

1982 • 104 citations

Repression mediates cell-type-specific expression of the rat growth hormone gene.

1986 • 99 citations

The identification of urogastrone in serum, saliva, and gastric juice

1979 • 98 citations

Voltage-dependent calcium channels in pituitary cells in culture. II. Participation in thyrotropin-releasing hormone action on prolactin release.

1984 • 97 citations

Effect of Pentagastrin on Gastric Mucosal Cells Grown in Tissue Culture

1973 • 95 citations

Somatostatin Inhibits Vasoactive Intestinal Peptide-Stimulated Cyclic Adenosine Monophosphate Accumulation in GH Pituitary Cells^*

1983 • 93 citations

Epidermal growth factor (EGF) promotes phosphorylation at threonine-654 of the EGF receptor: possible role of protein kinase C in homologous regulation of the EGF receptor.

1986 • 89 citations

Accumulation of nonamidated preprogastrin and preprocholecystokinin products in porcine pituitary corticotrophs. Evidence of post-translational control of cell differentiation.

1986 • 84 citations

trans-acting factors interact with a cyclic AMP response element to modulate expression of the human gonadotropin alpha gene.

1987 • 78 citations

Pertussis toxin blocks the inhibitory effects of somatostatin on cAMP-dependent vasoactive intestinal peptide and cAMP-independent thyrotropin releasing hormone-stimulated prolactin secretion of GH3 cells.

1986 • 78 citations

Structural analysis of the gene encoding human gastrin: the large intron contains an Alu sequence.

1984 • 77 citations

Stimulation of gastrin release by bombesin and canine gastrin-releasing peptides. Studies with isolated canine G cells in primary culture.

1987 • 77 citations

Regulated expression of the tyrosine hydroxylase gene by epidermal growth factor.

1987 • 73 citations

Polypeptide hormone regulation of gene transcription: specific 5' genomic sequences are required for epidermal growth factor and phorbol ester regulation of prolactin gene expression.

1984 • 73 citations

Epidermal Growth Factor: Its Biologic and Metabolic Effects With Emphasis on the Hepatocyte

1982 • 66 citations

Bombesin stimulation of gastrin release from canine gastrin cells in primary culture

1987 • 63 citations

Thyrotropin-Releasing Hormone and Epidermal Growth Factor Stimulate Prolactin Synthesis by a Pathway(s) that Differs from that Used by Phorbol Esters: Dissociation of Actions by Calcium Dependency and Additivity*

1985 • 43 citations

Peptide secretory pathways in GI tract: cytochemical contributions to regulatory physiology of the gut

1980 • 33 citations

Canine bombesin‐like gastrin releasing peptides stimulate gastrin release and acid secretion in the dog.

1985 • 28 citations

A gastrin gene is expressed in both porcine pituitary and antral mucosal tissues

1985 • 23 citations

Regulated Expression of the Tyrosine Hydroxylase Gene by Epidermal Growth Factor

1987 • 15 citations

trans-Acting Factors Interact with a Cyclic AMP Response element to Modulate Expression of the Human Gonadotropin α Gene

1987 • 8 citations

Induction of Glucagon Sensitivity in a Transformed Kidney Cell Line by Prostaglandin E₂ and Its Inhibition by Epidermal Growth Factor

1987 • 5 citations