A transcription enhancer acts in vitro over distances of hundreds of base-pairs on both circular and linear templates but not on chromatin-reconstituted DNA

[57] Sequencing end-labeled DNA with base-specific chemical cleavages

1980 • 15,302 citations

The pUC plasmids, an M13mp7-derived system for insertion mutagenesis and sequencing with synthetic universal primers

1982 • 6,153 citations

High resolution two-dimensional electrophoresis of basic as well as acidic proteins

1977 • 3,556 citations

Ribonucleic acid isolated by cesium chloride centrifugation

1974 • 2,263 citations

Chromosomal Subunits in Active Genes Have an Altered Conformation

1976 • 1,842 citations

Expression of a β-globin gene is enhanced by remote SV40 DNA sequences

1981 • 1,677 citations

The promoter-specific transcription factor Sp1 binds to upstream sequences in the SV40 early promoter

1983 • 1,471 citations

A lymphocyte-specific cellular enhancer is located downstream of the joining region in immunoglobulin heavy chain genes

1983 • 1,449 citations

A tissue-specific transcription enhancer element is located in the major intron of a rearranged immunoglobulin heavy chain gene

1983 • 1,418 citations

Mapping of RNA by a modification of the Berk-Sharp procedure: the 5′ termini of 15 S β-globin mRNA precursor and mature 10 S β-globin mRNA have identical map coordinates

1979 • 1,286 citations

In vivo sequence requirements of the SV40 early promoter region

1981 • 1,156 citations

Multiple Point Mutations Affecting the Simian Virus 40 Enhancer

1983 • 883 citations

Immunoglobulin gene transcription is activated by downstream sequence elements

1983 • 830 citations

Isolation of transcription factors that discriminate between different promoters recognized by RNA polymerase II

1983 • 779 citations

The SV40 72 base repair repeat has a striking effect on gene expression both in SV40 and other chimeric recombinants

1981 • 776 citations

pBR322 restriction map derived from the DNA sequence: accurate DNA size markers up to 4361 nucleotide pairs long

1978 • 768 citations

Nucleosomes are assembled by an acidic protein which binds histones and transfers them to DNA

1978 • 763 citations

Analysis of transcriptional regulatory signals of the HSV thymidine kinase gene: Identification of an upstream control region

1981 • 646 citations

Identification of DNA sequences required for transcription of the human α1-globin gene in a new SV40 host-vector system

1981 • 624 citations

Three regions upstream from the cap site are required for efficient and accurate transcription of the rabbit β-globin gene in mouse 3T6 cells

1983 • 596 citations

The binding site on SV40 DNA for a T antigen-related protein

1978 • 542 citations

Multiple factors required for accurate initiation of transcription by purified RNA polymerase II.

1980 • 541 citations

Formation of stable preinitiation complexes between eukaryotic class B transcription factors and promoter sequences

1983 • 477 citations

The adenovirus type 5 E1A transcriptional control region contains a duplicated enhancer element

1983 • 467 citations

Expression and regulation of immunoglobulin heavy chain gene transfected into lymphoid cells.

1983 • 457 citations

A lymphocyte-specific enhancer in the mouse immunoglobulin κ gene

1984 • 410 citations

DNAase I-hypersensitive sites of chromatin

1981 • 410 citations

Chromatin assembly in Xenopus oocytes: In vivo studies

1984 • 404 citations

The chromatin structure of specific genes: II. Disruption of chromatin structure during gene activity

1979 • 389 citations

Specific interaction between enhancer-containing molecules and cellular components

1984 • 374 citations

Absence of nucleosomes in a fraction of SV40 chromatin between the origin of replication and the region coding for the late leader RNA

1980 • 372 citations

Assembly of SV40 chromatin in a cell-free system from Xenopus eggs

1977 • 358 citations

A small segment of polyoma virus DNA enhances the expression of a cloned β-globin gene over a distance of 1400 base pairs

1981 • 339 citations

Separation and characterization of factors mediating accurate transcription by RNA polymerase II.

1982 • 314 citations

The SV40 72 bp repeat preferentially potentiates transcription starting from proximal natural or substitute promoter elements

1983 • 299 citations

DNA sequences necessary for transcription of the rabbit β-globin gene in vivo

1982 • 298 citations

Activation of the SV40 late promoter: Direct effects of T antigen in the absence of viral DNA replication

1984 • 292 citations

Structure of Transcribing Chromatin

1980 • 281 citations

Activation of SV40 genome by 72-base pair tandem repeats of Moloney sarcoma virus

1982 • 276 citations

Simplified quantitative electron microscopy of biopolymers

1970 • 270 citations

Splicing of in vitro synthesized messenger RNA precursors in HeLa cell extracts

1983 • 255 citations

The repeated GC-rich motifs upstream from the TATA box are important elements of the SV40 early promoter

1983 • 241 citations

Location and function of retroviral and SV40 sequences that enhance biochemical transformation after microinjection of DNA

1983 • 232 citations

Chromatin assembly in Xenopus oocytes: In vitro studies

1984 • 230 citations

An SV40 “enhancer trap” incorporates exogenous enhancers or generates enhancers from its own sequences

1984 • 223 citations

Induction of altered chromatin structures by simian virus 40 enhancer and promoter elements

1984 • 217 citations

Assembly of transcriptionally active 5S RNA gene chromatin in vitro

1982 • 195 citations

The number of superhelical turns in native Virion SV40 DNA and Minicol DNA determined by the band counting method

1976 • 187 citations

Chromatin Structure and Gene Activity: The Role of Nonhistone Chromosomal Protein

1982 • 184 citations

Transcriptional ‘enhancers’ from SV40 and polyoma virus show a cell type preference

1982 • 177 citations

Bovine papilloma virus contains an activator of gene expression at the distal end of the early transcription unit.

1983 • 176 citations

BK Viral Enhancer Element and a Human Cellular Homolog

1983 • 175 citations

Differences in human α-, β- and δ-globin gene expression in monkey kidney cells

1982 • 172 citations

Higher Order Structure of Simian Virus 40 Chromatin

1978 • 169 citations

E1A Control of Gene Expression Is Mediated by Sequences 5′ to the Transcriptional Starts of the Early Viral Genes

1983 • 169 citations

Changes of nucleosome frequency in nucleolar and non-nucleolar chromatin as a function of transcription: an electron microscopic study

1978 • 161 citations

Simian virus 40 early- and late-region promoter functions are enhanced by the 72-base-pair repeat inserted at distant locations and inverted orientations.

1983 • 149 citations

Chromatin structure of hsp 70 genes, activated by heat shock: Selective removal of histones from the coding region and their absence from the 5′ region

1984 • 136 citations

Elastic torsional strain in DNA within a fraction of SV40 minichromosomes: relation to transcriptionally active chromatin.

1982 • 134 citations

An enhancer element is located 340 base pairs upstream from the adenovirus-2 E1A capsite

1983 • 116 citations

Chromatin fine structure of active and repressed genes

1981 • 114 citations

Structure of the active nucleolar chromatin of Xenopus laevis oocytes

1982 • 89 citations

Ribonucleic acid and other polyanions facilitate chromatin assembly in vitro

1981 • 88 citations

Fine structure of the regulatory region of simian virus 40 minichromosomes revealed by DNAase I digestion

1982 • 84 citations

Splicing of adenovirus 2 early region 1A mRNAs is non-sequential

1983 • 83 citations

Transcription by Eukaryotic RNA Polymerases A and B of Chromatin Assembled in vitro

1979 • 80 citations

Analysis of the chromatin assembled in germinal vesicles of Xenopus oocytes

1983 • 54 citations

Effect of topological constraint on transcription of ribosomal DNA in Xenopus oocytes

1984 • 51 citations

E1A control of gene expression is mediated by sequences 5' to the transcriptional starts of the early viral genes.

1983 • 46 citations

Efficient Transcription of a Compact Nucleoprotein Complex Isolated from Purified Simian Virus 40 Virions

1980 • 41 citations

Catenation of DNA by eucaryotic topoisomerase II associated with simian virus 40 minichromosomes.

1983 • 15 citations

Accurate transcription of simian virus 40 chromatin in a HeLa cell extract

1982 • 12 citations